Showing entry for Sodium- and chloride-dependent GABA transporter 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009432
Protein NameSodium- and chloride-dependent GABA transporter 1
Uniport IdP30531
GeneSLC6A1
Gene Id6529
DomainSNF
Pfam PF00209  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.6 Nervous system hsa04721 Synaptic vesicle cycle
5. Organismal Systems 5.6 Nervous system hsa04727 GABAergic synapse
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0008306 associative learning
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:1902476 chloride transmembrane transport
Biological Process GO:0051939 gamma-aminobutyric acid import
Biological Process GO:0098658 inorganic anion import across plasma membrane
Biological Process GO:0007613 memory
Biological Process GO:0032229 negative regulation of synaptic transmission, GABAergic
Biological Process GO:0098810 neurotransmitter reuptake
Biological Process GO:0014054 positive regulation of gamma-aminobutyric acid secretion
Biological Process GO:0051592 response to calcium ion
Biological Process GO:0042220 response to cocaine
Biological Process GO:0032355 response to estradiol
Biological Process GO:0010035 response to inorganic substance
Biological Process GO:0010288 response to lead ion
Biological Process GO:0014074 response to purine-containing compound
Biological Process GO:0009744 response to sucrose
Biological Process GO:0009636 response to toxic substance
Biological Process GO:0098719 sodium ion import across plasma membrane
Biological Process GO:0050808 synapse organization
Biological Process GO:0150104 transport across blood-brain barrier
molecular function GO:0005332 gamma-aminobutyric acid:sodium symporter activity
molecular function GO:0015185 gamma-aminobutyric acid transmembrane transporter activity
molecular function GO:0042802 identical protein binding
molecular function GO:0046872 metal ion binding
molecular function GO:0042165 neurotransmitter binding
molecular function GO:0015378 sodium:chloride symporter activity
cellular component GO:0030424 axon
cellular component GO:0009986 cell surface
cellular component GO:0098982 GABA-ergic synapse
cellular component GO:0016021 integral component of membrane
cellular component GO:0099055 integral component of postsynaptic membrane
cellular component GO:0099056 integral component of presynaptic membrane
cellular component GO:0016020 membrane
cellular component GO:0043025 neuronal cell body
cellular component GO:0043005 neuron projection
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-112310 Neurotransmitter release cycle
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-382551 Transport of small molecules
R-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds
R-HSA-425407 SLC-mediated transmembrane transport
R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters
R-HSA-888590 GABA synthesis, release, reuptake and degradation
R-HSA-888593 Reuptake of GABA
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001807 BXGD000077 Aggressive behavior Behavior and Behavior Mechanisms
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0007786 BXGD000486 Brain Ischemia Nervous System Diseases; Cardiovascular Diseases
C0007787 BXGD000487 Transient Ischemic Attack Nervous System Diseases; Cardiovascular Diseases
C0009952 BXGD000639 Febrile Convulsions Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0010414 BXGD000669 Infection by Cryptococcus neoformans Infections
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014548 BXGD000928 Epilepsy, Generalized Nervous System Diseases
C0014553 BXGD000931 Absence Epilepsy Nervous System Diseases
C0014556 BXGD000932 Epilepsy, Temporal Lobe Nervous System Diseases
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0018572 BXGD001206 Hand, Foot and Mouth Disease Infections
C0021125 BXGD001483 Impulsive Behavior Behavior and Behavior Mechanisms
C0022333 BXGD001534 Jacksonian Seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027066 BXGD001966 Myoclonus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038220 BXGD002740 Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038436 BXGD002755 Post-Traumatic Stress Disorder Mental Disorders
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0038587 BXGD002773 Substance Withdrawal Syndrome Chemically-Induced Disorders; Mental Disorders
C0085281 BXGD003152 Addictive Behavior Behavior and Behavior Mechanisms
C0085584 BXGD003195 Encephalopathies Nervous System Diseases
C0085648 BXGD003221 Synovial Cyst Neoplasms
C0086189 BXGD003268 Drug Withdrawal Symptoms Chemically-Induced Disorders; Mental Disorders
C0086237 BXGD003273 Epilepsy, Cryptogenic Nervous System Diseases
C0086769 BXGD003310 Panic Attacks Mental Disorders
C0087169 BXGD003321 Withdrawal Symptoms Chemically-Induced Disorders; Mental Disorders
C0149958 BXGD003395 Complex partial seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0162635 BXGD003964 Angelman Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0234533 BXGD004687 Generalized seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234535 BXGD004688 Clonic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234985 BXGD004708 Mental deterioration Mental Disorders
C0236018 BXGD004804 Aura Nervous System Diseases
C0236734 BXGD004823 Caffeine related disorders
C0238111 BXGD004877 Lennox-Gastaut syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0270549 BXGD006079 Generalized Anxiety Disorder Mental Disorders
C0270824 BXGD006113 Visual seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270844 BXGD006115 Tonic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270846 BXGD006116 Epileptic drop attack Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0376532 BXGD008000 Epilepsy, Rolandic Nervous System Diseases
C0393554 BXGD008087 Amyotrophic Lateral Sclerosis With Dementia Nutritional and Metabolic Diseases; Nervous System Diseases
C0393702 BXGD008124 Myoclonic Astatic Epilepsy Nervous System Diseases
C0422850 BXGD008457 Seizures, Somatosensory Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422852 BXGD008458 Seizures, Auditory Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422853 BXGD008459 Olfactory seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422854 BXGD008460 Gustatory seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422855 BXGD008461 Vertiginous seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0424101 BXGD008519 Inattention
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0432072 BXGD008718 Dysmorphic features
C0494475 BXGD009030 Tonic - clonic seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0524528 BXGD009229 Pervasive Development Disorder Mental Disorders
C0543859 BXGD009298 Amyotrophic Lateral Sclerosis, Guam Form Nutritional and Metabolic Diseases; Nervous System Diseases
C0543888 BXGD009300 Epileptic encephalopathy Nervous System Diseases
C0557874 BXGD009444 Global developmental delay
C0751056 BXGD010306 Non-epileptic convulsion Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751110 BXGD010318 Single Seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751111 BXGD010319 Awakening Epilepsy Nervous System Diseases
C0751123 BXGD010326 Atonic Absence Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751349 BXGD010399 Myoclonus, Eyelid Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751494 BXGD010472 Convulsive Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751495 BXGD010473 Seizures, Focal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751496 BXGD010474 Seizures, Sensory Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751863 BXGD010617 Lead Poisoning, Nervous System, Adult Nervous System Diseases; Chemically-Induced Disorders
C0856975 BXGD011127 Autistic behavior Behavior and Behavior Mechanisms
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1258666 BXGD011825 Myxoid cyst Neoplasms; Skin and Connective Tissue Diseases
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1535926 BXGD013322 Neurodevelopmental Disorders Mental Disorders
C1836830 BXGD014165 Developmental regression Mental Disorders
C1846131 BXGD014783 Photosensitive tonic-clonic seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2936719 BXGD018130 Mechanical Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2945698 BXGD018188 panic symptoms
C3495874 BXGD019008 Nonepileptic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4022798 BXGD021001 Abnormal brain FDG positron emission tomography
C4023471 BXGD021196 EEG with abnormally slow frequencies
C4023684 BXGD021241 EEG with spike-wave complexes (>3.5 Hz)
C4048158 BXGD021890 Convulsions Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4085238 BXGD022111 MYOCLONIC-ATONIC EPILEPSY
C4281785 BXGD022415 Childhood Absence Epilepsy Nervous System Diseases
C4316903 BXGD022711 Absence Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4317109 BXGD022725 Epileptic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4317123 BXGD022727 Myoclonic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4505436 BXGD022962 Generalized Absence Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4727877 BXGD023875 Epilepsy with myoclonic-atonic seizures
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0004665 4-Aminobutyric acid 103.12
BXGC0026092 Hinokinin 354.11
BXGC0044598 Guvacine 127.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein