Showing entry for Alpha-tocopherol transfer protein


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010720
Protein NameAlpha-tocopherol transfer protein
Uniport IdP49638
GeneTTPA
Gene Id7274
DomainCRAL_TRIO; CRAL_TRIO_N
Pfam PF00650   PF03765  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0001324 age-dependent response to oxidative stress involved in chronological cell aging
Biological Process GO:0001892 embryonic placenta development
Biological Process GO:0120009 intermembrane lipid transfer
Biological Process GO:0051452 intracellular pH reduction
Biological Process GO:0006629 lipid metabolic process
Biological Process GO:0060548 negative regulation of cell death
Biological Process GO:0090212 negative regulation of establishment of blood-brain barrier
Biological Process GO:1900223 positive regulation of amyloid-beta clearance
Biological Process GO:0007584 response to nutrient
Biological Process GO:0009268 response to pH
Biological Process GO:0009636 response to toxic substance
Biological Process GO:0042360 vitamin E metabolic process
Biological Process GO:0051180 vitamin transport
molecular function GO:0120013 lipid transfer activity
molecular function GO:0043325 phosphatidylinositol-3,4-bisphosphate binding
molecular function GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
molecular function GO:1902936 phosphatidylinositol bisphosphate binding
molecular function GO:0008431 vitamin E binding
cellular component GO:0005829 cytosol
cellular component GO:0005770 late endosome
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-196854 Metabolism of vitamins and cofactors
R-HSA-6806667 Metabolism of fat-soluble vitamins
R-HSA-8877627 Vitamin E
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004138 BXGD000258 Ataxias, Hereditary Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007194 BXGD000452 Hypertrophic Cardiomyopathy Cardiovascular Diseases
C0007758 BXGD000475 Cerebellar Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0009090 BXGD000586 Cluttering Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013421 BXGD000837 Dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0016719 BXGD001074 Friedreich Ataxia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0018536 BXGD001201 Hallux Valgus Musculoskeletal Diseases
C0018975 BXGD001259 Hemeralopia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0020443 BXGD001385 Hypercholesterolemia Nutritional and Metabolic Diseases
C0020557 BXGD001432 Hypertriglyceridemia Nutritional and Metabolic Diseases
C0022340 BXGD001536 Late-Infantile Neuronal Ceroid Lipfuscinosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0024437 BXGD001772 Macular degeneration Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0024530 BXGD001783 Malaria Infections
C0026034 BXGD001887 Microstomia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0026106 BXGD001889 Mild Mental Retardation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026826 BXGD001935 Muscle Hypertonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026846 BXGD001939 Muscular Atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0028077 BXGD002069 Nyctalopia Eye Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0034933 BXGD002496 Reflex, Abnormal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0035334 BXGD002539 Retinitis Pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0037822 BXGD002706 Speech Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0039273 BXGD002806 Talipes cavus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0042035 BXGD002952 Urination Disorders Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0042790 BXGD003002 Vision Disorders Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0042875 BXGD003009 Vitamin E Deficiency Nutritional and Metabolic Diseases
C0087012 BXGD003318 Ataxia, Spinocerebellar Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0151313 BXGD003413 Sensory neuropathy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151572 BXGD003442 Reflex, Corneal, Decreased Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0151888 BXGD003497 Hyporeflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0155210 BXGD003780 Eyelid Xanthoma Nutritional and Metabolic Diseases; Eye Diseases
C0155536 BXGD003799 Paracousis Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0221253 BXGD004422 Xanthoma tendinosum Nutritional and Metabolic Diseases
C0233726 BXGD004606 Aprosodia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0233769 BXGD004613 Micropsia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0233771 BXGD004614 Macropsia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0234132 BXGD004623 Pyramidal sign Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234146 BXGD004626 Absent reflex Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234162 BXGD004627 Cerebellar Dysmetria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234366 BXGD004652 Ataxic
C0234784 BXGD004696 Reflex, Gag, Absent Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234979 BXGD004707 Dysdiadochokinesis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234985 BXGD004708 Mental deterioration Mental Disorders
C0235031 BXGD004714 Neurologic Symptoms Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0241772 BXGD005112 Reflex, Deep Tendon, Absent Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0242706 BXGD005191 Hyperoxia Pathological Conditions, Signs and Symptoms
C0260662 BXGD005228 Hearing problem Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0265610 BXGD005555 Clinodactyly of fingers Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0270948 BXGD006137 Neurogenic Muscular Atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0271185 BXGD006170 Metamorphopsia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0277839 BXGD006481 Hoffman's Reflex Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0277850 BXGD006482 Reflex, Pendular Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0278211 BXGD006507 Reflex, Corneal, Absent Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0302314 BXGD006837 Xanthoma Nutritional and Metabolic Diseases
C0347959 BXGD007865 Lactic acidemia
C0349588 BXGD007933 Short stature
C0375206 BXGD007973 Hemiplegia/hemiparesis
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0424503 BXGD008532 Dysmorphic facies
C0431478 BXGD008692 Posteriorly rotated ear
C0442874 BXGD008814 Neuropathy Nervous System Diseases
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0522214 BXGD009196 Abnormal visual evoked potential Nervous System Diseases
C0522345 BXGD009201 Reflex, Acoustic, Abnormal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0541794 BXGD009262 Skeletal muscle atrophy
C0549399 BXGD009376 Low density lipoprotein increased Nutritional and Metabolic Diseases
C0557874 BXGD009444 Global developmental delay
C0558845 BXGD009459 Reflex, Ankle, Absent Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0558846 BXGD009460 Reflex, Triceps, Absent Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0558847 BXGD009461 Reflex, Biceps, Absent Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0575081 BXGD009512 Gait abnormality Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0576612 BXGD009529 Reflex, Anal, Absent Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598589 BXGD009667 Inherited neuropathies Nervous System Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0743002 BXGD010072 Abnormal Deep Tendon Reflex Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751468 BXGD010453 Bulbocavernosus Reflex, Decreased Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751469 BXGD010454 Bulbocavernousus Reflex Absent Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751470 BXGD010455 Palmo-Mental Reflex Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751471 BXGD010456 Reflex, Anal, Decreased Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751472 BXGD010457 Reflex, Ankle, Abnormal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751473 BXGD010458 Reflex, Ankle, Decreased Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751474 BXGD010459 Reflex, Biceps, Abnormal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751475 BXGD010460 Reflex, Biceps, Decreased Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751476 BXGD010461 Reflex, Gag, Decreased Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751477 BXGD010462 Reflex, Knee, Abnormal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751478 BXGD010463 Reflex, Knee, Decreased Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751479 BXGD010464 Reflex, Moro, Asymmetric Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751480 BXGD010465 Reflex, Triceps, Abnormal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751481 BXGD010466 Reflex, Triceps, Decreased Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751512 BXGD010485 Dysglossia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751513 BXGD010486 Rhinolalia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751514 BXGD010487 Verbal Fluency Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0752255 BXGD010702 Impairment, Light Touch Sensation Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0752256 BXGD010703 Pain Sensation Diminished Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0752257 BXGD010704 Pinprick Sensation Diminished Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0752258 BXGD010705 Position Sense Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0752260 BXGD010706 Proprioceptive Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0752261 BXGD010707 Thermal Sensation Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0752262 BXGD010708 Somatosensory Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0877848 BXGD011360 Distorted hearing Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1136179 BXGD011712 Hammer Toe Musculoskeletal Diseases
C1262477 BXGD011882 Weight decreased Pathological Conditions, Signs and Symptoms
C1285498 BXGD012171 Vegetation
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1318485 BXGD012394 Liver regeneration disorder Digestive System Diseases
C1333419 BXGD012624 Liver and Intrahepatic Bile Duct Epithelial Neoplasm
C1333976 BXGD012662 Liver and Intrahepatic Bile Duct Neoplasm Digestive System Diseases
C1510450 BXGD013166 Dysacusis Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1512409 BXGD013188 Hepatocarcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1563937 BXGD013397 Atherogenesis Cardiovascular Diseases
C1836830 BXGD014165 Developmental regression Mental Disorders
C1848533 BXGD014936 Ataxia with vitamin E deficiency Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Nervous System Diseases
C1853761 BXGD015359 SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1862475 BXGD016132 Abnormality of retinal pigmentation
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2985280 BXGD018223 Blood Protein Measurement
C3489704 BXGD018940 Vision Disability Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3495145 BXGD018980 Dyslalia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3665347 BXGD019279 Visual Impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C4016662 BXGD020357 ATAXIA, FRIEDREICH-LIKE, WITH ISOLATED VITAMIN E DEFICIENCY
C4016663 BXGD020358 ATAXIA AND RETINITIS PIGMENTOSA WITH ISOLATED VITAMIN E DEFICIENCY
C4021866 BXGD020823 obsolete Abnormal heart morphology
C4551563 BXGD023351 Microcephaly (physical finding)
C4551915 BXGD023441 Gait Disturbance, CTCAE
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000284 alpha-Tocopherol 430.71
BXGC0000446 2-Aminoethanol 61.08
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein