Showing entry for Cytochrome P450 2J2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010867
Protein NameCytochrome P450 2J2
Uniport IdP51589
GeneCYP2J2
Gene Id1573
Domainp450
Pfam PF00067  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00590 Arachidonic acid metabolism
1. Metabolism 1.3 Lipid metabolism hsa00591 Linoleic acid metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
5. Organismal Systems 5.6 Nervous system hsa04726 Serotonergic synapse
5. Organismal Systems 5.7 Sensory system hsa04750 Inflammatory mediator regulation of TRP channels
5. Organismal Systems 5.2 Endocrine system hsa04913 Ovarian steroidogenesis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0019373 epoxygenase P450 pathway
Biological Process GO:0042738 exogenous drug catabolic process
Biological Process GO:0006690 icosanoid metabolic process
Biological Process GO:0043651 linoleic acid metabolic process
Biological Process GO:0006082 organic acid metabolic process
Biological Process GO:0055114 oxidation-reduction process
Biological Process GO:0008016 regulation of heart contraction
Biological Process GO:0006805 xenobiotic metabolic process
molecular function GO:0008405 arachidonic acid 11,12-epoxygenase activity
molecular function GO:0008404 arachidonic acid 14,15-epoxygenase activity
molecular function GO:0008392 arachidonic acid epoxygenase activity
molecular function GO:0020037 heme binding
molecular function GO:0106255 hydroperoxy icosatetraenoate isomerase activity
molecular function GO:0005506 iron ion binding
molecular function GO:0016853 isomerase activity
molecular function GO:0071614 linoleic acid epoxygenase activity
molecular function GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
molecular function GO:0008395 steroid hydroxylase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0070062 extracellular exosome
cellular component GO:0043231 intracellular membrane-bounded organelle
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-211859 Biological oxidations
R-HSA-211897 Cytochrome P450 - arranged by substrate type
R-HSA-211935 Fatty acids
R-HSA-211945 Phase I - Functionalization of compounds
R-HSA-211981 Xenobiotics
R-HSA-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
R-HSA-2142753 Arachidonic acid metabolism
R-HSA-556833 Metabolism of lipids
R-HSA-8978868 Fatty acid metabolism
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003130 BXGD000183 Anoxia Pathological Conditions, Signs and Symptoms
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004626 BXGD000283 Pneumonia, Bacterial Infections; Respiratory Tract Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0016412 BXGD001058 Folic Acid Deficiency Nutritional and Metabolic Diseases
C0017601 BXGD001125 Glaucoma Eye Diseases
C0017638 BXGD001132 Glioma Neoplasms
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0018939 BXGD001253 Hematological Disease Hemic and Lymphatic Diseases
C0020452 BXGD001389 Hyperemia Cardiovascular Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020544 BXGD001426 Renal hypertension Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Cardiovascular Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027497 BXGD001993 Nausea Pathological Conditions, Signs and Symptoms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027697 BXGD002022 Nephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0029866 BXGD002174 Other ureteric obstruction Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0032914 BXGD002379 Pre-Eclampsia Female Urogenital Diseases and Pregnancy Complications
C0037315 BXGD002687 Sleep Apnea Syndromes Respiratory Tract Diseases; Nervous System Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0042963 BXGD003018 Vomiting Pathological Conditions, Signs and Symptoms
C0085110 BXGD003126 Severe Combined Immunodeficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0155626 BXGD003806 Acute myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0155880 BXGD003831 Intrinsic asthma Respiratory Tract Diseases; Immune System Diseases
C0162871 BXGD003996 Aortic Aneurysm, Abdominal Cardiovascular Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0242339 BXGD005150 Dyslipidemias Nutritional and Metabolic Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0376545 BXGD008002 Hematologic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0494463 BXGD009029 Alzheimer Disease, Late Onset Nervous System Diseases; Mental Disorders
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598608 BXGD009668 Hyperhomocysteinemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0740391 BXGD009987 Middle Cerebral Artery Occlusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0751688 BXGD010551 Malignant Squamous Cell Neoplasm Neoplasms
C0853897 BXGD010985 Diabetic Cardiomyopathies Endocrine System Diseases; Cardiovascular Diseases
C0856169 BXGD011096 Endothelial dysfunction
C0856742 BXGD011111 Post MI Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0947751 BXGD011494 Vascular inflammations Cardiovascular Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1860405 BXGD015983 Snowflake vitreoretinal degeneration Eye Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000663 Papain 206.28
BXGC0005683 Quercetin 302.24
BXGC0012243 Ukonan D 151.16
BXGC0014695 Loratadine 382.14
BXGC0016891 Nortriptyline 263.17
BXGC0018063 Alprenolol 249.17
BXGC0024141 Hydrocortisone 362.21
BXGC0024988 Nifedipine 346.12
BXGC0026391 Naloxone 327.15
BXGC0041820 Schisantherin E 538.22
BXGC0042222 Propranolol 259.16
BXGC0042510 Fluoxetine 309.13
BXGC0043126 Nicardipine 479.21
BXGC0044017 Verapamil 454.28
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein