Showing entry for Motor Neuron Disease


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD003121
Disease NameMotor Neuron Disease
Disease CUI IdC0085084
MeSH Codes C10  
Disease Class NameNervous System Diseases
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id DOID:630   DOID:7  
Disease Ontology Class Namegenetic disease; disease of anatomical entity
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
O43524 BXGT004599 Forkhead box protein O3 2309 reviewed
O94811 BXGT005336 Tubulin polymerization-promoting protein 11076 reviewed Cellular structure
O95831 BXGT005399 Apoptosis-inducing factor 1, mitochondrial 9131 reviewed Enzyme
P00441 BXGT005540 Superoxide dismutase [Cu-Zn] 6647 reviewed Enzyme
P01308 BXGT005749 Insulin 3630 reviewed
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P02649 BXGT005909 Apolipoprotein E 348 reviewed
P03950 BXGT006116 Angiogenin 283 reviewed
P04040 BXGT006132 Catalase 847 reviewed Enzyme
P04083 BXGT006147 Annexin A1 301 reviewed
P04179 BXGT006163 Superoxide dismutase [Mn], mitochondrial 6648 reviewed Enzyme
P04271 BXGT006177 Protein S100-B 6285 reviewed Calcium-binding protein
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P04792 BXGT006264 Heat shock protein beta-1 3315 reviewed
P05067 BXGT006306 Amyloid-beta precursor protein 351 reviewed Enzyme modulator
P07686 BXGT006657 Beta-hexosaminidase subunit beta 3074 reviewed Enzyme
P07737 BXGT006663 Profilin-1 5216 reviewed
P07741 BXGT006666 Adenine phosphoribosyltransferase 353 reviewed
P07998 BXGT006711 Ribonuclease pancreatic 6035 reviewed
P08670 BXGT006810 Vimentin 7431 reviewed
P09211 BXGT006869 Glutathione S-transferase P 2950 reviewed
P09488 BXGT006899 Glutathione S-transferase Mu 1 2944 reviewed
P09936 BXGT006943 Ubiquitin carboxyl-terminal hydrolase isozyme L1 7345 reviewed Enzyme
P10275 BXGT007552 Androgen receptor 367 reviewed Nuclear receptor
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P10636 BXGT007596 Microtubule-associated protein tau 4137 reviewed
P11940 BXGT007762 Polyadenylate-binding protein 1 26986 reviewed
P14210 BXGT007994 Hepatocyte growth factor 3082 reviewed Enzyme
P15151 BXGT008089 Poliovirus receptor 5817 reviewed
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P15924 BXGT008171 Desmoplakin 1832 reviewed Cellular structure
P20339 BXGT008565 Ras-related protein Rab-5A 5868 reviewed
P20810 BXGT008602 Calpastatin 831 reviewed
P21589 BXGT008669 5'-nucleotidase 4907 reviewed Enzyme
P22303 BXGT008751 Acetylcholinesterase 43 reviewed Enzyme
P22626 BXGT008787 Heterogeneous nuclear ribonucleoproteins A2/B1 3181 reviewed
P23560 BXGT008883 Brain-derived neurotrophic factor 627 reviewed Signaling
P25713 BXGT009062 Metallothionein-3 4504 reviewed
P27169 BXGT009161 Serum paraoxonase/arylesterase 1 5444 reviewed
P30711 BXGT009460 Glutathione S-transferase theta-1 2952 reviewed
P35754 BXGT009863 Glutaredoxin-1 2745 reviewed
P35858 BXGT009876 Insulin-like growth factor-binding protein complex acid labile subunit 3483 reviewed Receptor
P37840 BXGT010015 Alpha-synuclein 6622 reviewed Transporter
P40763 BXGT010202 Signal transducer and activator of transcription 3 6774 reviewed Nucleic acid binding
P42262 BXGT010294 Glutamate receptor 2 2891 reviewed Ion channel
P43003 BXGT010347 Excitatory amino acid transporter 1 6507 reviewed Transporter
P43004 BXGT010348 Excitatory amino acid transporter 2 6506 reviewed Transporter
P49768 BXGT010740 Presenilin-1 5663 reviewed Enzyme
P52789 BXGT010954 Hexokinase-2 3099 reviewed Kinase
P54764 BXGT011078 Ephrin type-A receptor 4 2043 reviewed Kinase
P55042 BXGT011100 GTP-binding protein RAD 6236 reviewed
P55072 BXGT011103 Transitional endoplasmic reticulum ATPase 7415 reviewed
P60709 BXGT011322 Actin, cytoplasmic 1 60 reviewed Cellular structure
P62753 BXGT011454 40S ribosomal protein S6 6194 reviewed Nucleic acid binding
P62826 BXGT011463 GTP-binding nuclear protein Ran 5901 reviewed Enzyme modulator
P62942 BXGT011474 Peptidyl-prolyl cis-trans isomerase FKBP1A 2280 reviewed Enzyme
P80188 BXGT011882 Neutrophil gelatinase-associated lipocalin 3934 reviewed Enzyme
Q00535 BXGT012534 Cyclin-dependent-like kinase 5 1020 reviewed Kinase
Q07889 BXGT012946 Son of sevenless homolog 1 6654 reviewed Enzyme modulator
Q13075 BXGT013308 Baculoviral IAP repeat-containing protein 1 4671 reviewed
Q13148 BXGT013318 TAR DNA-binding protein 43 23435 reviewed
Q13501 BXGT013365 Sequestosome-1 8878 reviewed
Q13510 BXGT013367 Acid ceramidase 427 reviewed Enzyme
Q13526 BXGT013369 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 5300 reviewed
Q14203 BXGT013455 Dynactin subunit 1 1639 reviewed Chaperone
Q14204 BXGT013456 Cytoplasmic dynein 1 heavy chain 1 1778 reviewed Enzyme
Q14416 BXGT013468 Metabotropic glutamate receptor 2 2912 reviewed G-protein coupled receptor
Q15078 BXGT013534 Cyclin-dependent kinase 5 activator 1 8851 reviewed Enzyme modulator
Q15485 BXGT013574 Ficolin-2 2220 reviewed Signaling
Q15599 BXGT013583 Na(+)/H(+) exchange regulatory cofactor NHE-RF2 9351 reviewed
Q16637 BXGT013646 Survival motor neuron protein 6607 reviewed Epigenetic regulator
Q16698 BXGT013659 2,4-dienoyl-CoA reductase, mitochondrial 1666 reviewed Enzyme
Q5S007 BXGT015650 Leucine-rich repeat serine/threonine-protein kinase 2 120892 reviewed Kinase
Q8IXI2 BXGT018361 Mitochondrial Rho GTPase 1 55288 reviewed Enzyme modulator
Q8WXF7 BXGT019011 Atlastin-1 51062 reviewed Enzyme modulator
Q96EB6 BXGT019646 NAD-dependent protein deacetylase sirtuin-1 23411 reviewed Epigenetic regulator
Q96PY6 BXGT019712 Serine/threonine-protein kinase Nek1 4750 reviewed Kinase
Q99497 BXGT019926 Protein/nucleic acid deglycase DJ-1 11315 reviewed Enzyme
Q99700 BXGT019949 Ataxin-2 6311 reviewed Nucleic acid binding
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 10280 reviewed
Q99986 BXGT019980 Serine/threonine-protein kinase VRK1 7443 reviewed Kinase
Q9NZJ5 BXGT021275 Eukaryotic translation initiation factor 2-alpha kinase 3 9451 reviewed Kinase
Q9UBN7 BXGT021658 Histone deacetylase 6 10013 reviewed Epigenetic regulator
Q9UHD2 BXGT021697 Serine/threonine-protein kinase TBK1 29110 reviewed Kinase
Q9Y2Q3 BXGT022242 Glutathione S-transferase kappa 1 373156 reviewed
Q9Y5S8 BXGT022302 NADPH oxidase 1 27035 reviewed
P04439 BXGT022649 HLA class I histocompatibility antigen, A-3 alpha chain 3105 reviewed
P00738 BXGT022874 Haptoglobin 3240 reviewed Enzyme
O60502 BXGT023392 Protein O-GlcNAcase 10724 reviewed
P00395 BXGT023596 Cytochrome c oxidase subunit 1 4512 reviewed Enzyme
Q9UBP0 BXGT023601 Spastin 6683 reviewed Cellular structure
Q53GS7 BXGT023762 Nucleoporin GLE1 2733 reviewed Transporter
O95140 BXGT024482 Mitofusin-2 9927 reviewed Enzyme
Q6SZW1 BXGT025034 NAD(+) hydrolase SARM1 23098 reviewed
Q8IUN9 BXGT025263 C-type lectin domain family 10 member A 10462 reviewed Receptor
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease