Showing entry for Troponin C, slow skeletal and cardiac muscles


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011517
Protein NameTroponin C, slow skeletal and cardiac muscles
Uniport IdP63316
GeneTNNC1
Gene Id7134
DomainEF-hand_7
Pfam PF13499  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04020 Calcium signaling pathway
5. Organismal Systems 5.3 Circulatory system hsa04260 Cardiac muscle contraction
5. Organismal Systems 5.3 Circulatory system hsa04261 Adrenergic signaling in cardiomyocytes
6. Human Diseases 6.6 Cardiovascular diseases hsa05410 Hypertrophic cardiomyopathy (HCM)
6. Human Diseases 6.6 Cardiovascular diseases hsa05414 Dilated cardiomyopathy (DCM)
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0060048 cardiac muscle contraction
Biological Process GO:0002086 diaphragm contraction
Biological Process GO:0030049 muscle filament sliding
Biological Process GO:0043462 regulation of ATPase activity
Biological Process GO:0006937 regulation of muscle contraction
Biological Process GO:0032972 regulation of muscle filament sliding speed
Biological Process GO:0010038 response to metal ion
Biological Process GO:0003009 skeletal muscle contraction
Biological Process GO:0014883 transition between fast and slow fiber
Biological Process GO:0055010 ventricular cardiac muscle tissue morphogenesis
molecular function GO:0051015 actin filament binding
molecular function GO:0048306 calcium-dependent protein binding
molecular function GO:0005509 calcium ion binding
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0031013 troponin I binding
molecular function GO:0031014 troponin T binding
cellular component GO:1990584 cardiac Troponin complex
cellular component GO:0005829 cytosol
cellular component GO:0005861 troponin complex
Reactome
Pathway Id Pathway Name
R-HSA-390522 Striated Muscle Contraction
R-HSA-397014 Muscle contraction
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007193 BXGD000451 Cardiomyopathy, Dilated Cardiovascular Diseases
C0007194 BXGD000452 Hypertrophic Cardiomyopathy Cardiovascular Diseases
C0007196 BXGD000453 Restrictive cardiomyopathy Cardiovascular Diseases
C0008031 BXGD000511 Chest Pain Pathological Conditions, Signs and Symptoms
C0011436 BXGD000726 Dentinogenesis Imperfecta Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0013404 BXGD000833 Dyspnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0022408 BXGD001544 Arthropathy Musculoskeletal Diseases
C0023787 BXGD001698 Lipodystrophy Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0024232 BXGD001751 Lymphatic Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0027430 BXGD001988 Nasal Polyps Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0039070 BXGD002787 Syncope Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0042510 BXGD002987 Ventricular Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0153349 BXGD003621 Malignant neoplasm of tongue Neoplasms; Stomatognathic Diseases
C0206139 BXGD004159 Lichen Planus, Oral Skin and Connective Tissue Diseases; Stomatognathic Diseases
C0241005 BXGD005072 Creatine phosphokinase serum increased
C0281788 BXGD006786 Biventricular hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0340427 BXGD007329 Familial dilated cardiomyopathy Cardiovascular Diseases
C0427515 BXGD008619 Neutrophil abnormality
C0442887 BXGD008816 Septal hypertrophy
C0476403 BXGD008992 Electromyogram abnormal
C0520887 BXGD009119 ST segment depression (finding) Cardiovascular Diseases
C0558353 BXGD009451 Tongue Carcinoma Neoplasms; Stomatognathic Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C0949658 BXGD011582 Cardiomyopathy, Hypertrophic, Familial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1280433 BXGD012125 Lipoatrophy Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1449563 BXGD013086 Cardiomyopathy, Familial Idiopathic Cardiovascular Diseases
C2678475 BXGD017414 Cardiomyopathy, Dilated, 1z Cardiovascular Diseases
C2750472 BXGD017665 Cardiomyopathy, Familial Hypertrophic, 13 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C4551472 BXGD023303 Hypertrophic obstructive cardiomyopathy Cardiovascular Diseases
C4551675 BXGD023384 Keratoderma, Palmoplantar Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0001767 (E)-Resveratrol 228.25
BXGC0002586 Calcium 40.08
BXGC0022009 (9R)-9-[(9R)-2-Carboxy-4-Hydroxy-10-Oxo-5-[(3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]Oxy-9H-Anthracen-9-Yl]-4-Hydroxy-10-Oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]Oxy-9H-Anthracene-2-Carboxylic Acid 862.2
BXGC0033310 Epigalocatechin Gallate 458.08
BXGC0045812 Trifluoperazine 407.16
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein