Showing entry for Tight junction protein ZO-1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT012920
Protein NameTight junction protein ZO-1
Uniport IdQ07157
GeneTJP1
Gene Id7082
DomainGuanylate_kin; PDZ; SH3_2; ZU5
Pfam PF00625   PF00595   PF07653   PF00791  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04520 Adherens junction
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04530 Tight junction
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04540 Gap junction
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05110 Vibrio cholerae infection
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05120 Epithelial cell signaling in Helicobacter pylori infection
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05132 Salmonella infection
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0031032 actomyosin structure organization
Biological Process GO:0034334 adherens junction maintenance
Biological Process GO:0007043 cell-cell junction assembly
Biological Process GO:0045216 cell-cell junction organization
Biological Process GO:0090557 establishment of endothelial intestinal barrier
Biological Process GO:0035329 hippo signaling
Biological Process GO:0035633 maintenance of blood-brain barrier
Biological Process GO:2000250 negative regulation of actin cytoskeleton reorganization
Biological Process GO:0051497 negative regulation of stress fiber assembly
Biological Process GO:1905605 positive regulation of blood-brain barrier permeability
Biological Process GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin
Biological Process GO:0030335 positive regulation of cell migration
Biological Process GO:1903672 positive regulation of sprouting angiogenesis
Biological Process GO:0071896 protein localization to adherens junction
Biological Process GO:1902396 protein localization to bicellular tight junction
Biological Process GO:0150105 protein localization to cell-cell junction
Biological Process GO:2000810 regulation of bicellular tight junction assembly
Biological Process GO:1901888 regulation of cell junction assembly
Biological Process GO:0051493 regulation of cytoskeleton organization
molecular function GO:0045296 cadherin binding
molecular function GO:0005516 calmodulin binding
cellular component GO:0005912 adherens junction
cellular component GO:0043296 apical junction complex
cellular component GO:0045177 apical part of cell
cellular component GO:0016323 basolateral plasma membrane
cellular component GO:0005923 bicellular tight junction
cellular component GO:0030054 cell junction
cellular component GO:0042995 cell projection
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005921 gap junction
cellular component GO:0005886 plasma membrane
cellular component GO:0002102 podosome
cellular component GO:0032991 protein-containing complex
cellular component GO:0070160 tight junction
Reactome
Pathway Id Pathway Name
R-HSA-109581 Apoptosis
R-HSA-111465 Apoptotic cleavage of cellular proteins
R-HSA-157858 Gap junction trafficking and regulation
R-HSA-157858 Gap junction trafficking and regulation
R-HSA-162582 Signal Transduction
R-HSA-191650 Regulation of gap junction activity
R-HSA-191650 Regulation of gap junction activity
R-HSA-199991 Membrane Trafficking
R-HSA-199991 Membrane Trafficking
R-HSA-2028269 Signaling by Hippo
R-HSA-212436 Generic Transcription Pathway
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins
R-HSA-5357801 Programmed Cell Death
R-HSA-5653656 Vesicle-mediated transport
R-HSA-5653656 Vesicle-mediated transport
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-75153 Apoptotic execution phase
R-HSA-8878171 Transcriptional regulation by RUNX1
R-HSA-8935964 RUNX1 regulates expression of components of tight junctions
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002793 BXGD000130 Anaplasia Pathological Conditions, Signs and Symptoms; Neoplasms
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006111 BXGD000369 Brain Diseases Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007133 BXGD000442 Carcinoma, Papillary Neoplasms
C0007193 BXGD000451 Cardiomyopathy, Dilated Cardiovascular Diseases
C0007570 BXGD000467 Celiac Disease Digestive System Diseases; Nutritional and Metabolic Diseases
C0007786 BXGD000486 Brain Ischemia Nervous System Diseases; Cardiovascular Diseases
C0008370 BXGD000534 Cholestasis Digestive System Diseases
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0011195 BXGD000702 Dejerine-Sottas Disease (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0012236 BXGD000772 DiGeorge Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0013146 BXGD000801 Drug abuse Chemically-Induced Disorders; Mental Disorders
C0014038 BXGD000878 Encephalitis Nervous System Diseases
C0014869 BXGD000966 Peptic Esophagitis Digestive System Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0020443 BXGD001385 Hypercholesterolemia Nutritional and Metabolic Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024305 BXGD001763 Lymphoma, Non-Hodgkin Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0025286 BXGD001850 Meningioma Neoplasms; Nervous System Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027404 BXGD001984 Narcolepsy Nervous System Diseases; Mental Disorders
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0035126 BXGD002509 Reperfusion Injury Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0038525 BXGD002768 Subarachnoid Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0042164 BXGD002965 Uveitis Eye Diseases
C0042514 BXGD002989 Tachycardia, Ventricular Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0085584 BXGD003195 Encephalopathies Nervous System Diseases
C0149925 BXGD003387 Small cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0152459 BXGD003600 Linear atrophy Pathological Conditions, Signs and Symptoms
C0162309 BXGD003934 Adrenoleukodystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Endocrine System Diseases
C0162635 BXGD003964 Angelman Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0178664 BXGD004032 Glomerulosclerosis (disorder) Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Cardiovascular Diseases
C0220605 BXGD004294 Adult Non-Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0220612 BXGD004296 Childhood Non-Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0278877 BXGD006608 Adult Meningioma Neoplasms; Nervous System Diseases
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0332853 BXGD006901 Anastomosis
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0346976 BXGD007838 Secondary malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0348898 BXGD007884 Irritable bowel syndrome with diarrhea Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0349788 BXGD007956 Arrhythmogenic Right Ventricular Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0400821 BXGD008257 Colitis, Microscopic Digestive System Diseases
C0520459 BXGD009084 Necrotizing Enterocolitis Digestive System Diseases
C0524957 BXGD009252 Corneal Topography
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0740391 BXGD009987 Middle Cerebral Artery Occlusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0853662 BXGD010975 Oestrogen deficiency
C0858252 BXGD011172 Breast adenocarcinoma Neoplasms; Skin and Connective Tissue Diseases
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C0917996 BXGD011425 Cerebral Aneurysm Nervous System Diseases; Cardiovascular Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1512409 BXGD013188 Hepatocarcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1720164 BXGD013666 Central corneal thickness
C1762616 BXGD013753 Meningioma, benign, no ICD-O subtype Neoplasms; Nervous System Diseases
C1848296 BXGD014918 DOSAGE-SENSITIVE SEX REVERSAL Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3250443 BXGD018584 MYOTONIC DYSTROPHY 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C4721532 BXGD023752 Lymphoma, Non-Hodgkin, Familial Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0004277 Acetic acid 60.05
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein