Showing entry for Glucokinase regulatory protein


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013467
Protein NameGlucokinase regulatory protein
Uniport IdQ14397
GeneGCKR
Gene Id2646
Domain-
Pfam -  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:1901135 carbohydrate derivative metabolic process
Biological Process GO:0005975 carbohydrate metabolic process
Biological Process GO:0042593 glucose homeostasis
Biological Process GO:0033132 negative regulation of glucokinase activity
Biological Process GO:0006606 protein import into nucleus
Biological Process GO:0006110 regulation of glycolytic process
Biological Process GO:0009750 response to fructose
Biological Process GO:0070328 triglyceride homeostasis
Biological Process GO:0046415 urate metabolic process
molecular function GO:0030246 carbohydrate binding
molecular function GO:0019899 enzyme binding
molecular function GO:0004857 enzyme inhibitor activity
molecular function GO:0070095 fructose-6-phosphate binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005739 mitochondrion
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1643685 Disease
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-5619102 SLC transporter disorders
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
R-HSA-5619115 Disorders of transmembrane transporters
R-HSA-70171 Glycolysis
R-HSA-70326 Glucose metabolism
R-HSA-71387 Metabolism of carbohydrates
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001948 BXGD000091 Alcohol consumption Behavior and Behavior Mechanisms
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003868 BXGD000233 Arthritis, Gouty Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0005823 BXGD000339 Blood Pressure
C0005890 BXGD000345 Body Height
C0005893 BXGD000346 Body mass index procedure
C0005938 BXGD000351 Bone Density
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0008313 BXGD000528 Cholangitis, Sclerosing Digestive System Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014772 BXGD000948 Red Blood Cell Count measurement
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0017654 BXGD001136 Glomerular Filtration Rate
C0017741 BXGD001149 Glucose tolerance test
C0018099 BXGD001172 Gout Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018935 BXGD001252 Hematocrit procedure
C0019158 BXGD001293 Hepatitis Digestive System Diseases
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020557 BXGD001432 Hypertriglyceridemia Nutritional and Metabolic Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0021670 BXGD001509 insulinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023508 BXGD001675 White Blood Cell Count procedure
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027794 BXGD002036 Neural Tube Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0032181 BXGD002332 Platelet Count measurement
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0036836 BXGD002637 Serum total protein measurement
C0038013 BXGD002725 Ankylosing spondylitis Musculoskeletal Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0080178 BXGD003107 Spina Bifida Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0085207 BXGD003140 Gestational Diabetes Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0155601 BXGD003804 Hypertensive heart and renal disease Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Cardiovascular Diseases
C0200633 BXGD004040 Neutrophil count (procedure)
C0200635 BXGD004041 Lymphocyte Count measurement
C0200638 BXGD004043 Eosinophil count procedure
C0200641 BXGD004044 Blood basophil count (lab test)
C0201657 BXGD004051 C-reactive protein measurement
C0201874 BXGD004054 Amino acids measurement
C0201925 BXGD004058 Calcium measurement
C0201952 BXGD004060 Chloride measurement
C0201976 BXGD004063 Creatinine measurement, serum (procedure)
C0202100 BXGD004071 Insulin C-peptide measurement
C0202115 BXGD004073 Lactic acid measurement
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0202177 BXGD004079 Phospholipid measurement
C0202202 BXGD004082 Protein measurement
C0202218 BXGD004083 Sex hormone binding globulin measurement
C0202236 BXGD004086 Triglycerides measurement
C0202239 BXGD004087 Uric acid measurement (procedure)
C0205734 BXGD004115 Diabetes, Autoimmune Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0206161 BXGD004167 Reticulocyte count (procedure)
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0236664 BXGD004818 Alcohol-Related Disorders Chemically-Induced Disorders; Mental Disorders
C0236734 BXGD004823 Caffeine related disorders
C0236970 BXGD004843 Alcohol-Induced Disorders Chemically-Induced Disorders
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0242216 BXGD005141 Biliary calculi Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0242339 BXGD005150 Dyslipidemias Nutritional and Metabolic Diseases
C0271650 BXGD006227 Impaired glucose tolerance Nutritional and Metabolic Diseases
C0278498 BXGD006521 Malignant neoplasm of stomach stage IV
C0337434 BXGD007157 Estradiol measurement
C0337438 BXGD007159 Glucose measurement
C0337443 BXGD007161 Sodium measurement
C0342276 BXGD007449 Maturity onset diabetes mellitus in young Nutritional and Metabolic Diseases; Endocrine System Diseases
C0342277 BXGD007450 Diabetes mellitus autosomal dominant type II (disorder) Nutritional and Metabolic Diseases; Endocrine System Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0392885 BXGD008071 High density lipoprotein measurement
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0424678 BXGD008537 Lean body mass
C0427460 BXGD008616 Red cell distribution width determination
C0428302 BXGD008625 Calcium level result
C0428474 BXGD008631 Serum LDL cholesterol measurement
C0428568 BXGD008633 Fasting blood glucose measurement
C0428883 BXGD008639 Diastolic blood pressure
C0451641 BXGD008821 Urolithiasis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0489786 BXGD009018 Height
C0495706 BXGD009038 elevated blood glucose level
C0523465 BXGD009209 Serum albumin measurement
C0523744 BXGD009217 Lipids measurement
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0578022 BXGD009541 Finding of body mass index
C0728877 BXGD009918 Serum albumin level
C0740394 BXGD009989 Hyperuricemia Pathological Conditions, Signs and Symptoms
C0857490 BXGD011150 Granulocyte count
C0871470 BXGD011316 Systolic Pressure
C0877008 BXGD011325 Enzyme inhibition disorder
C0919677 BXGD011435 Protein C measurement
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1168438 BXGD011793 Protein C antigen measurement
C1168443 BXGD011794 Pseudocholinesterase Measurement
C1261430 BXGD011853 Fasting blood sugar result
C1278049 BXGD012114 Serum gamma-glutamyl transferase measurement
C1281901 BXGD012133 Fatty acid measurement
C1295176 BXGD012240 Leptin measurement
C1304746 BXGD012343 RDW - Red blood cell distribution width result
C1305855 BXGD012348 Body mass index
C1443016 BXGD013067 Estradiol level result
C1445957 BXGD013081 Serum total cholesterol measurement
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1561826 BXGD013364 Overweight and obesity
C1565489 BXGD013401 Renal Insufficiency Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1611184 BXGD013455 Calcification of coronary artery Nutritional and Metabolic Diseases; Cardiovascular Diseases
C1821417 BXGD013764 RESTING HEART RATE
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1960636 BXGD016668 Dysglycemia
C2316810 BXGD017030 Chronic kidney disease stage 5 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2362324 BXGD017091 Pediatric Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2825856 BXGD017776 Factor VII measurement
C2985280 BXGD018223 Blood Protein Measurement
C3150714 BXGD018326 FASTING PLASMA GLUCOSE LEVEL QUANTITATIVE TRAIT LOCUS 5
C3160761 BXGD018475 Diabetic dyslipidaemia
C3888631 BXGD019983 Monogenic diabetes Nutritional and Metabolic Diseases; Endocrine System Diseases
C4529962 BXGD023178 Fatty Liver Disease
C4728082 BXGD023886 Severe hypoglycaemia
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002586 Calcium 40.08
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein