Showing entry for Mitogen-activated protein kinase 6


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013652
Protein NameMitogen-activated protein kinase 6
Uniport IdQ16659
GeneMAPK6
Gene Id5597
DomainPkinase
Pfam PF00069  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04657 IL-17 signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007049 cell cycle
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0010468 regulation of gene expression
Biological Process GO:0007165 signal transduction
molecular function GO:0005524 ATP binding
molecular function GO:0004707 MAP kinase activity
molecular function GO:0004674 protein serine/threonine kinase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-5683057 MAPK family signaling cascades
R-HSA-5687128 MAPK6/MAPK4 signaling
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003868 BXGD000233 Arthritis, Gouty Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0018099 BXGD001172 Gout Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0018671 BXGD001211 Head and Neck Neoplasms Neoplasms
C0020507 BXGD001413 Hyperplasia Pathological Conditions, Signs and Symptoms
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0202239 BXGD004087 Uric acid measurement (procedure)
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0265783 BXGD005575 Congenital hypoplasia of lung Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases
C0278996 BXGD006621 Malignant Head and Neck Neoplasm Neoplasms
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0345905 BXGD007746 Intrahepatic Cholangiocarcinoma Neoplasms
C0410702 BXGD008447 Adolescent idiopathic scoliosis Musculoskeletal Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1837461 BXGD014234 SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3887461 BXGD019876 Head and Neck Carcinoma Neoplasms
C4021107 BXGD020557 Non-obstructive azoospermia Male Urogenital Diseases
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4049446 BXGD021933 Neointimal hyperplasia
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000537 Acetylsalicylic acid 180.16
BXGC0000933 (-)-Arctigenin 372.41
BXGC0001940 Daphnetin 178.14
BXGC0002071 Apigenin 270.24
BXGC0005624 Genistein 270.24
BXGC0005683 Quercetin 302.24
BXGC0007052 Olomoucine 298.34
BXGC0012706 4-hydroxy-5-nitrophenyl acetic acid 197.03
BXGC0013582 Curcumin 368.13
BXGC0020911 Debromohymenialdisine 245.09
BXGC0042870 Piceatannol 244.07
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
BXGC0051995 Wedelolactone 314.04
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein