Showing entry for Athraquinones A


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0039397
Compound NameAthraquinones A
Structure
FormulaC14H8O4
InchiKeyRGCKGOZRHPZPFP-UHFFFAOYSA-N
SMILESO=C1c2ccccc2C(=O)c2c1ccc(c2O)O
InchiInChI=1S/C14H8O4/c15-10-6-5-9-11(14(10)18)13(17)8-4-2-1-3-7(8)12(9)16/h1-6,15,18H
IUPAC1,2-dihydroxyanthracene-9,10-dione
Molecular Weight240.04
Pubchem Id6293
Chembl IdCHEMBL55814
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 50206434
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT007567 Apoptosis regulator Bcl-2 reviewed Signaling BCL2 1150 - - -
reviewed BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 1620 - - -
CHEMBL CHEMBL55814
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
Q13951 BXGT013407 Core-binding factor subunit beta reviewed - CBFB Potency - 8912 nM
Q01196 BXGT012575 Runt-related transcription factor 1 reviewed Transcription factor RUNX1 Potency - 8912 nM
Q13148 BXGT013318 TAR DNA-binding protein 43 reviewed - TARDBP Potency - 39810 nM
P08659 BXGT006805 Luciferin 4-monooxygenase reviewed - Potency - 25574 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 8912 nM
Q9HAW8 BXGT020509 UDP-glucuronosyltransferase 1-10 reviewed - UGT1A10 Activity '=' 205 pm/min/mg
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 35481 nM
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 Activity '=' 160 pm/min/mg
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 39810 nM
P97697 BXGT012214 Inositol monophosphatase 1 reviewed - Impa1 Potency '=' 12589 nM
Q5VLE3 BXGT015884 RmtA unreviewed - rmtA IC50 '=' 1220000 nM
P19224 BXGT008468 UDP-glucuronosyltransferase 1-6 reviewed - UGT1A6 Activity '=' 0 pm/min/mg
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 63095 nM
P97697 BXGT012214 Inositol monophosphatase 1 reviewed - Impa1 Potency '=' 15848 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Control '<' 143 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Control '<' 143 %
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 28183 nM
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 Activity '=' 120 pm/min/mg
P35503 BXGT009840 UDP-glucuronosyltransferase 1-3 reviewed - UGT1A3 Activity '=' 1072 pm/min/mg
Q14145 BXGT013448 Kelch-like ECH-associated protein 1 reviewed - KEAP1 AC50 '>' 52000 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 AC50 '>' 52000 nM
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Potency '=' 31622 nM
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 31622 nM
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 50118 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 14125 nM
P39748 BXGT010134 Flap endonuclease 1 reviewed Enzyme FEN1 Potency - 7943 nM
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 35481 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 31622 nM
O75164 BXGT005104 Lysine-specific demethylase 4A reviewed - KDM4A Potency - 50118 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 125892 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 125892 nM
Q9Y253 BXGT022216 DNA polymerase eta reviewed - POLH Potency - 56234 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Control '<' 157 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Control '<' 157 %
O15296 BXGT004148 Arachidonate 15-lipoxygenase B reviewed Enzyme ALOX15B Potency - 15848 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 28183 nM
P54855 BXGT011088 UDP-glucuronosyltransferase 2B15 reviewed - UGT2B15 Activity '=' 11 pm/min/mg
P18054 BXGT008370 Arachidonate 12-lipoxygenase, 12S-type reviewed Enzyme ALOX12 Potency '=' 15848 nM
Q13526 BXGT013369 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 reviewed - PIN1 Potency - 28183 nM
P22310 BXGT008754 UDP-glucuronosyltransferase 1-4 reviewed - UGT1A4 Activity '=' 0 pm/min/mg
O60656 BXGT004889 UDP-glucuronosyltransferase 1-9 reviewed - UGT1A9 Activity '=' 0 pm/min/mg
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 84 %
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 177827 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 177827 nM
Q14145 BXGT013448 Kelch-like ECH-associated protein 1 reviewed - KEAP1 Max_Activity_Concent - 26 uM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 19952 nM
Q63470 BXGT016073 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed - Dyrk1a AC50 '=' 4543 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 31622 nM
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 Potency '=' 5011 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 39810 nM
Q99873 BXGT019972 Protein arginine N-methyltransferase 1 reviewed Epigenetic regulator PRMT1 IC50 '=' 1160000 nM
P46063 BXGT010501 ATP-dependent DNA helicase Q1 reviewed Enzyme RECQL Potency '=' 15848 nM
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 28183 nM
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 Potency '=' 10000 nM
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 Activity '=' 0 pm/min/mg
Q77YF9 BXGT016886 Protein Vpr unreviewed - vpr Potency - 12589 nM
Q9Y253 BXGT022216 DNA polymerase eta reviewed - POLH Potency - 75686 nM
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Potency '=' 10000 nM
Q16637 BXGT013646 Survival motor neuron protein reviewed Epigenetic regulator SMN1 Potency '=' 22387 nM
Q9HAW9 BXGT020510 UDP-glucuronosyltransferase 1-8 reviewed - UGT1A8 Activity '=' 843 pm/min/mg
Q99816 BXGT019966 Tumor susceptibility gene 101 protein reviewed Enzyme TSG101 Potency - 50118 nM
Q72547 BXGT016709 Reverse transcriptase/RNaseH unreviewed - pol IC50 '>' 100000 nM
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Potency '=' 15848 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 15848 nM
Q14191 BXGT013452 Werner syndrome ATP-dependent helicase reviewed Enzyme WRN Potency - 44668 nM
Q99816 BXGT019966 Tumor susceptibility gene 101 protein reviewed Enzyme TSG101 Potency - 32609 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 3662 nM
Q4GZG4 BXGT014813 Phosphoglycerate kinase unreviewed - PGKC Potency - 20574 nM
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency '=' 15848 nM
O60656 BXGT004889 UDP-glucuronosyltransferase 1-9 reviewed - UGT1A9 Activity '=' 1900 pm/min/mg
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 12589 nM
P07378 BXGT006616 Phosphoglycerate kinase, glycosomal reviewed - Potency - 25118 nM
P10415 BXGT007567 Apoptosis regulator Bcl-2 reviewed Signaling BCL2 Ki '=' 1150 nM
Q9HAW9 BXGT020510 UDP-glucuronosyltransferase 1-8 reviewed - UGT1A8 Activity '=' 1500 pm/min/mg
Q92830 BXGT019379 Histone acetyltransferase KAT2A reviewed - KAT2A Potency - 28183 nM
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 84367 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 18869 nM
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA IC50 '=' 30100 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 12589 nM
O95149 BXGT005350 Snurportin-1 reviewed - SNUPN Potency - 141253 nM
Q14974 BXGT013516 Importin subunit beta-1 reviewed Transporter KPNB1 Potency - 141253 nM
Q16678 BXGT013656 Cytochrome P450 1B1 reviewed Enzyme CYP1B1 Ki '=' 500 nM
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 93 %
Q99700 BXGT019949 Ataxin-2 reviewed Nucleic acid binding ATXN2 Potency - 22387 nM
P83916 BXGT012025 Chromobox protein homolog 1 reviewed Epigenetic regulator CBX1 Potency - 7079 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Control '<' 130 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Control '<' 130 %
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 316227 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 316227 nM
P39748 BXGT010134 Flap endonuclease 1 reviewed Enzyme FEN1 Potency - 7568 nM
Q07820 BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 Ki '=' 1620 nM
P53350 BXGT010984 Serine/threonine-protein kinase PLK1 reviewed Kinase PLK1 Potency - 23778 nM
P27338 BXGT009172 Amine oxidase [flavin-containing] B reviewed - MAOB IC50 '>' 60000 nM
P04585 BXGT006234 Gag-Pol polyprotein reviewed - gag-pol IC50 '=' 79000 nM
P27338 BXGT009172 Amine oxidase [flavin-containing] B reviewed - MAOB Inhibition '=' 16 %
P63092 BXGT011495 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short reviewed - GNAS Potency - 39810 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00853 Rubia tinctorum Rubia tinctorum Medicinal Plant
BXGF01126 Polygonum cuspidatum Polygonum cuspidatum Medicinal Plant
BXGF01868 Vitex negundo Vitex negundo Medicinal Plant
BXGF02158 Croton penduliflorus Croton penduliflorus Others
BXGF02459 Asperula odorata Asperula odorata Medicinal Plant
BXGF02953 Populus tomentosa Populus tomentosa Medicinal Plant
BXGF03007 Litsea konishii Litsea konishii Others
BXGF03102 Vepris louisii Vepris louisii Medicinal Plant
BXGF03143 Asperula odora Asperula odora Medicinal Plant
BXGF03158 Rheum officinale Rheum officinale Medicinal Plant
BXGF03210 Alangium platanifolium Alangium platanifolium Medicinal Plant
BXGF03988 Rheum coreanum Rheum coreanum Others
BXGF04258 Rubia cordifolia Rubia cordifolia Medicinal Plant
BXGF04539 Rheum palmatum Rheum palmatum Medicinal Plant
BXGF04573 Rubia akane Rubia akane Medicinal Plant
BXGF04952 Morinda umbellata Morinda umbellata Medicinal Plant
BXGF05257 Morinda citrifolia Morinda citrifolia Medicinal Plant
BXGF05877 Rheum tanguticum Rheum tanguticum Medicinal Plant
BXGF05950 Lychnophora columnaris Lychnophora columnaris Others
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease