Showing entry for Pre-mRNA-processing-splicing factor 8


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT016446
Protein NamePre-mRNA-processing-splicing factor 8
Uniport IdQ6P2Q9
GenePRPF8
Gene Id10594
DomainJAB; PRO8NT; PROCN; PROCT; PRP8_domainIV; RRM_4; U5_2-snRNA_bdg; U6-snRNA_bdg
Pfam PF01398   PF08082   PF08083   PF08084   PF12134   PF10598   PF10597   PF10596  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.1 Transcription hsa03040 Spliceosome
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0071222 cellular response to lipopolysaccharide
Biological Process GO:0071356 cellular response to tumor necrosis factor
Biological Process GO:0006397 mRNA processing
Biological Process GO:0000398 mRNA splicing, via spliceosome
Biological Process GO:0008380 RNA splicing
Biological Process GO:0000375 RNA splicing, via transesterification reactions
Biological Process GO:0000244 spliceosomal tri-snRNP complex assembly
molecular function GO:0070122 isopeptidase activity
molecular function GO:0070530 K63-linked polyubiquitin modification-dependent protein binding
molecular function GO:0097157 pre-mRNA intronic binding
molecular function GO:0003723 RNA binding
molecular function GO:0000386 second spliceosomal transesterification activity
molecular function GO:0030619 U1 snRNA binding
molecular function GO:0030620 U2 snRNA binding
molecular function GO:0030623 U5 snRNA binding
molecular function GO:0017070 U6 snRNA binding
cellular component GO:0071013 catalytic step 2 spliceosome
cellular component GO:0016020 membrane
cellular component GO:0016607 nuclear speck
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0071006 U2-type catalytic step 1 spliceosome
cellular component GO:0071007 U2-type catalytic step 2 spliceosome
cellular component GO:0071005 U2-type precatalytic spliceosome
cellular component GO:0046540 U4/U6 x U5 tri-snRNP complex
cellular component GO:0005682 U5 snRNP
Reactome
Pathway Id Pathway Name
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72165 mRNA Splicing - Minor Pathway
R-HSA-72172 mRNA Splicing
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA
R-HSA-8953854 Metabolism of RNA
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0010414 BXGD000669 Infection by Cryptococcus neoformans Infections
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0015397 BXGD000983 Disorder of eye Eye Diseases
C0017601 BXGD001125 Glaucoma Eye Diseases
C0018777 BXGD001217 Conductive hearing loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0020619 BXGD001447 Hypogonadism Endocrine System Diseases
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0022578 BXGD001557 Keratoconus Eye Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023524 BXGD001681 Leukoencephalopathy, Progressive Multifocal Infections; Nervous System Diseases
C0027022 BXGD001962 Myeloproliferative disease Hemic and Lymphatic Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0028077 BXGD002069 Nyctalopia Eye Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029089 BXGD002107 Ophthalmoplegia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0029124 BXGD002113 Optic Atrophy Eye Diseases; Nervous System Diseases
C0031036 BXGD002273 Polyarteritis Nodosa Skin and Connective Tissue Diseases; Cardiovascular Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0035304 BXGD002528 Retinal Degeneration Eye Diseases
C0035334 BXGD002539 Retinitis Pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0085636 BXGD003218 Photophobia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0087012 BXGD003318 Ataxia, Spinocerebellar Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151891 BXGD003499 Retinal depigmentation Pathological Conditions, Signs and Symptoms; Eye Diseases; Skin and Connective Tissue Diseases
C0154860 BXGD003752 Hereditary retinal dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0162666 BXGD003967 Mitochondrial Encephalomyopathies Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0235095 BXGD004723 Visual field constriction Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0266435 BXGD005668 Congenital hypoplasia of penis Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0334070 BXGD006986 Maturation defect
C0339525 BXGD007258 Autosomal dominant retinitis pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0339527 BXGD007260 Leber Congenital Amaurosis Eye Diseases
C0339573 BXGD007271 Glaucoma, Primary Open Angle Eye Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0410000 BXGD008406 Overlap syndrome Skin and Connective Tissue Diseases; Immune System Diseases
C0456909 BXGD008883 Blindness Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0476397 BXGD008991 Electroretinogram abnormal
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0751956 BXGD010653 Acute Cerebrovascular Accidents Nervous System Diseases; Cardiovascular Diseases
C0752125 BXGD010673 Spinocerebellar Ataxia Type 7 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0854723 BXGD011026 Retinal Dystrophies Eye Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1838702 BXGD014339 Retinitis Pigmentosa 13 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1840077 BXGD014434 Anteverted nostril
C1849367 BXGD015046 Nasal bridge wide
C1849394 BXGD015048 Enhanced S-Cone Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases
C1854065 BXGD015379 LATE-ONSET RETINAL DEGENERATION (disorder) Eye Diseases
C1862475 BXGD016132 Abnormality of retinal pigmentation
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C2062441 BXGD016897 Influenza A
C2985280 BXGD018223 Blood Protein Measurement
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3887654 BXGD019912 POLYARTERITIS NODOSA, CHILDHOOD-ONSET Skin and Connective Tissue Diseases; Cardiovascular Diseases
C4021786 BXGD020779 Atypical scarring of skin Pathological Conditions, Signs and Symptoms
C4024818 BXGD021428 Progressive night blindness Eye Diseases
C4505456 BXGD022964 HIV Coinfection Infections; Immune System Diseases
C4551714 BXGD023398 Rod-Cone Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000140 Phytic acid 660.04
BXGC0000436 Glycerol 92.09
BXGC0002588 Magnesium 24.31
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein