protein

Showing entry for Solute carrier family 12 member 5

General Target Information
BXGT Id	BXGT020459
Protein Name	Solute carrier family 12 member 5
Uniport Id	Q9H2X9
Gene	SLC12A5
Gene Id	57468
Domain	_permease; SLC12
Pfam	PF00324 PF03522
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name
5. Organismal Systems	5.6 Nervous system	hsa04727	GABAergic synapse

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0030644	cellular chloride ion homeostasis
Biological Process	GO:0006873	cellular ion homeostasis
Biological Process	GO:0006884	cell volume homeostasis
Biological Process	GO:0007268	chemical synaptic transmission
Biological Process	GO:0055064	chloride ion homeostasis
Biological Process	GO:1902476	chloride transmembrane transport
Biological Process	GO:0060996	dendritic spine development
Biological Process	GO:0006971	hypotonic response
Biological Process	GO:0006811	ion transport
Biological Process	GO:0007612	learning
Biological Process	GO:0035264	multicellular organism growth
Biological Process	GO:0055075	potassium ion homeostasis
Biological Process	GO:1990573	potassium ion import across plasma membrane
Biological Process	GO:0042493	response to drug
Biological Process	GO:0040040	thermosensory behavior
molecular function	GO:0015108	chloride transmembrane transporter activity
molecular function	GO:0015379	potassium:chloride symporter activity
molecular function	GO:0019901	protein kinase binding
cellular component	GO:0071944	cell periphery
cellular component	GO:0016021	integral component of membrane
cellular component	GO:0005887	integral component of plasma membrane
cellular component	GO:0043025	neuronal cell body
cellular component	GO:0043005	neuron projection
cellular component	GO:0005886	plasma membrane
cellular component	GO:0045202	synapse

Reactome

Pathway Id	Pathway Name
R-HSA-382551	Transport of small molecules
R-HSA-425393	Transport of inorganic cations/anions and amino acids/oligopeptides
R-HSA-425407	SLC-mediated transmembrane transport
R-HSA-426117	Cation-coupled Chloride cotransporters

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0002736	BXGD000127	Amyotrophic Lateral Sclerosis	Nutritional and Metabolic Diseases; Nervous System Diseases
C0003578	BXGD000211	Apnea	Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0004352	BXGD000269	Autistic Disorder	Mental Disorders
C0004936	BXGD000295	Mental disorders	Mental Disorders
C0006118	BXGD000372	Brain Neoplasms	Neoplasms; Nervous System Diseases
C0007102	BXGD000425	Malignant tumor of colon	Digestive System Diseases; Neoplasms
C0007682	BXGD000471	CNS disorder	Nervous System Diseases
C0007785	BXGD000485	Cerebral Infarction	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0007789	BXGD000488	Cerebral Palsy	Nervous System Diseases
C0009402	BXGD000605	Colorectal Carcinoma	Digestive System Diseases; Neoplasms
C0009952	BXGD000639	Febrile Convulsions	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0010633	BXGD000679	Cystadenoma	Neoplasms
C0011119	BXGD000698	Decompression Sickness	Wounds and Injuries
C0013080	BXGD000797	Down Syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0013132	BXGD000799	Drooling	Stomatognathic Diseases
C0013421	BXGD000837	Dystonia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014070	BXGD000887	Encephalomyelitis	Infections; Nervous System Diseases
C0014544	BXGD000926	Epilepsy	Nervous System Diseases
C0014556	BXGD000932	Epilepsy, Temporal Lobe	Nervous System Diseases
C0014558	BXGD000933	Uncinate Epilepsy	Nervous System Diseases
C0020072	BXGD001357	Hereditary Sensory Autonomic Neuropathy, Type 2	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0020179	BXGD001363	Huntington Disease	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020429	BXGD001378	Hyperalgesia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0022333	BXGD001534	Jacksonian Seizure	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0022660	BXGD001571	Kidney Failure, Acute	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023186	BXGD001613	Learning Disorders	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0026838	BXGD001938	Muscle Spasticity	Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027627	BXGD002006	Neoplasm Metastasis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651	BXGD002009	Neoplasms	Neoplasms
C0027765	BXGD002033	nervous system disorder	Nervous System Diseases
C0027796	BXGD002037	Neuralgia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0029925	BXGD002181	Ovarian Carcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0030193	BXGD002191	Pain	Pathological Conditions, Signs and Symptoms
C0035372	BXGD002544	Rett Syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0036341	BXGD002600	Schizophrenia	Mental Disorders
C0036572	BXGD002625	Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037036	BXGD002661	Sialorrhea	Stomatognathic Diseases
C0038220	BXGD002740	Status Epilepticus	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038454	BXGD002760	Cerebrovascular accident	Nervous System Diseases; Cardiovascular Diseases
C0041341	BXGD002918	Tuberous Sclerosis	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0086237	BXGD003273	Epilepsy, Cryptogenic	Nervous System Diseases
C0149958	BXGD003395	Complex partial seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0150055	BXGD003401	Chronic pain	Pathological Conditions, Signs and Symptoms
C0152013	BXGD003516	Adenocarcinoma of lung (disorder)	Neoplasms
C0153676	BXGD003679	Secondary malignant neoplasm of lung	Neoplasms; Respiratory Tract Diseases
C0159020	BXGD003919	Convulsions in the newborn	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0178874	BXGD004037	Tumor Progression	Pathological Conditions, Signs and Symptoms
C0233514	BXGD004584	Abnormal behavior	Behavior and Behavior Mechanisms
C0233794	BXGD004618	Memory impairment	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0234132	BXGD004623	Pyramidal sign	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234251	BXGD004645	Inflammatory pain	Pathological Conditions, Signs and Symptoms
C0234533	BXGD004687	Generalized seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234535	BXGD004688	Clonic Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235946	BXGD004789	Cerebral atrophy	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0236018	BXGD004804	Aura	Nervous System Diseases
C0270823	BXGD006112	Petit mal status	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270824	BXGD006113	Visual seizure	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270844	BXGD006115	Tonic Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270846	BXGD006116	Epileptic drop attack	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270850	BXGD006117	Idiopathic generalized epilepsy	Nervous System Diseases
C0270853	BXGD006119	Juvenile Myoclonic Epilepsy	Nervous System Diseases
C0279530	BXGD006628	Malignant Bone Neoplasm	Neoplasms; Musculoskeletal Diseases
C0279680	BXGD006680	Transitional cell carcinoma of bladder	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0311335	BXGD006877	Grand Mal Status Epilepticus	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0342418	BXGD007478	Hypothalamic hamartomas	Neoplasms; Nervous System Diseases
C0393593	BXGD008103	Dystonia Disorders	Nervous System Diseases
C0393672	BXGD008115	Epilepsy, Benign Psychomotor, Childhood	Nervous System Diseases
C0393682	BXGD008117	Epilepsy, Lateral Temporal	Nervous System Diseases
C0393734	BXGD008131	Complex Partial Status Epilepticus	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422850	BXGD008457	Seizures, Somatosensory	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422852	BXGD008458	Seizures, Auditory	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422853	BXGD008459	Olfactory seizure	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422854	BXGD008460	Gustatory seizure	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422855	BXGD008461	Vertiginous seizure	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0424295	BXGD008524	Hyperactive behavior	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0424605	BXGD008535	Developmental delay (disorder)	Mental Disorders
C0458247	BXGD008904	Allodynia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0494475	BXGD009030	Tonic - clonic seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0525045	BXGD009255	Mood Disorders	Mental Disorders
C0543888	BXGD009300	Epileptic encephalopathy	Nervous System Diseases
C0557874	BXGD009444	Global developmental delay
C0585442	BXGD009593	Osteosarcoma of bone	Neoplasms
C0596263	BXGD009639	Carcinogenesis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0596887	BXGD009648	mathematical ability
C0699790	BXGD009866	Colon Carcinoma	Digestive System Diseases; Neoplasms
C0751056	BXGD010306	Non-epileptic convulsion	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751110	BXGD010318	Single Seizure	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751111	BXGD010319	Awakening Epilepsy	Nervous System Diseases
C0751122	BXGD010325	Infantile Severe Myoclonic Epilepsy	Nervous System Diseases
C0751123	BXGD010326	Atonic Absence Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751211	BXGD010350	Hyperalgesia, Primary	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751212	BXGD010351	Hyperalgesia, Secondary	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751213	BXGD010352	Tactile Allodynia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751214	BXGD010353	Hyperalgesia, Thermal	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751494	BXGD010472	Convulsive Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751495	BXGD010473	Seizures, Focal	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751496	BXGD010474	Seizures, Sensory	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751522	BXGD010488	Status Epilepticus, Subclinical	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751523	BXGD010489	Non-Convulsive Status Epilepticus	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751524	BXGD010490	Simple Partial Status Epilepticus	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0877017	BXGD011329	Generalized tonic-clonic seizures with focal onset	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1096063	BXGD011600	Drug Resistant Epilepsy	Nervous System Diseases
C1140680	BXGD011718	Malignant neoplasm of ovary	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1269683	BXGD012001	Major Depressive Disorder	Mental Disorders
C1269955	BXGD012005	Tumor Cell Invasion
C1504404	BXGD013141	Hippocampal sclerosis
C1510586	BXGD013176	Autism Spectrum Disorders	Mental Disorders
C1535926	BXGD013322	Neurodevelopmental Disorders	Mental Disorders
C1562113	BXGD013372	Fleck corneal dystrophy	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1836830	BXGD014165	Developmental regression	Mental Disorders
C1839333	BXGD014369	EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 2	Nervous System Diseases
C1846620	BXGD014832	Hemiclonic seizures	Nervous System Diseases
C1847514	BXGD014868	Postnatal microcephaly
C2936719	BXGD018130	Mechanical Allodynia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2938983	BXGD018170	Focal cortical dysplasia	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C2939419	BXGD018178	Secondary Neoplasm	Pathological Conditions, Signs and Symptoms; Neoplasms
C2985280	BXGD018223	Blood Protein Measurement
C3495874	BXGD019008	Nonepileptic Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3714756	BXGD019429	Intellectual Disability	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3899267	BXGD020077	Encephalopathy of Prematurity
C4021758	BXGD020761	Delayed CNS myelination
C4021759	BXGD020762	Generalized myoclonic seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4048158	BXGD021890	Convulsions	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4225245	BXGD022190	EPILEPSY, IDIOPATHIC GENERALIZED, SUSCEPTIBILITY TO, 14
C4225257	BXGD022195	EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 34
C4316903	BXGD022711	Absence Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4317109	BXGD022725	Epileptic Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4317123	BXGD022727	Myoclonic Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4505072	BXGD022953	Epileptic Syndromes	Nervous System Diseases
C4505436	BXGD022962	Generalized Absence Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4518639	BXGD023031	Epilepsy of infancy with migrating focal seizures	Nervous System Diseases
C4521042	BXGD023055	Complete Trisomy 21 Syndrome	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4721453	BXGD023744	Peripheral Nervous System Diseases	Nervous System Diseases
C4721610	BXGD023760	Carcinoma, Ovarian Epithelial	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085	BXGD023788	Malignant neoplasm of colon and/or rectum

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0025757	Calcimycin		523.27

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}