Showing entry for N-formyl peptide receptor 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT025102
Protein NameN-formyl peptide receptor 2
Uniport IdP25090
GeneFPR2
Gene Id2358
Domain7tm_1
Pfam PF00001  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05150 Staphylococcus aureus infection
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Biological Process GO:0048143 astrocyte activation
Biological Process GO:0019722 calcium-mediated signaling
Biological Process GO:0007155 cell adhesion
Biological Process GO:0007166 cell surface receptor signaling pathway
Biological Process GO:1904646 cellular response to amyloid-beta
Biological Process GO:0006935 chemotaxis
Biological Process GO:0002430 complement receptor mediated signaling pathway
Biological Process GO:0042742 defense response to bacterium
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0002768 immune response-regulating cell surface receptor signaling pathway
Biological Process GO:0006954 inflammatory response
Biological Process GO:0001774 microglial cell activation
Biological Process GO:0050728 negative regulation of inflammatory response
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
Biological Process GO:0050918 positive chemotaxis
Biological Process GO:0061903 positive regulation of 1-phosphatidylinositol-3-kinase activity
Biological Process GO:0007204 positive regulation of cytosolic calcium ion concentration
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:0045089 positive regulation of innate immune response
Biological Process GO:0090026 positive regulation of monocyte chemotaxis
Biological Process GO:0050766 positive regulation of phagocytosis
Biological Process GO:0001934 positive regulation of protein phosphorylation
Biological Process GO:0032930 positive regulation of superoxide anion generation
Biological Process GO:0006898 receptor-mediated endocytosis
molecular function GO:0001540 amyloid-beta binding
molecular function GO:0038024 cargo receptor activity
molecular function GO:0004875 complement receptor activity
molecular function GO:0004930 G protein-coupled receptor activity
molecular function GO:0004982 N-formyl peptide receptor activity
molecular function GO:0005124 scavenger receptor binding
molecular function GO:0038023 signaling receptor activity
cellular component GO:0005737 cytoplasm
cellular component GO:0101003 ficolin-1-rich granule membrane
cellular component GO:0016021 integral component of membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0035579 specific granule membrane
cellular component GO:0070821 tertiary granule membrane
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-372790 Signaling by GPCR
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-388396 GPCR downstream signalling
R-HSA-416476 G alpha (q) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-444473 Formyl peptide receptors bind formyl peptides and many other ligands
R-HSA-500792 GPCR ligand binding
R-HSA-6798695 Neutrophil degranulation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004114 BXGD000255 Astrocytoma Neoplasms
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004936 BXGD000295 Mental disorders Mental Disorders
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007124 BXGD000437 Noninfiltrating Intraductal Carcinoma Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007682 BXGD000471 CNS disorder Nervous System Diseases
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009766 BXGD000629 Allergic Conjunctivitis Eye Diseases; Immune System Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011644 BXGD000744 Scleroderma Skin and Connective Tissue Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0017638 BXGD001132 Glioma Neoplasms
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0020507 BXGD001413 Hyperplasia Pathological Conditions, Signs and Symptoms
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021368 BXGD001502 Inflammation Pathological Conditions, Signs and Symptoms
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0022660 BXGD001571 Kidney Failure, Acute Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023281 BXGD001628 Leishmaniasis Infections; Skin and Connective Tissue Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0026277 BXGD001899 Mixed Salivary Gland Tumor Neoplasms
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0032051 BXGD002326 Placental Insufficiency Female Urogenital Diseases and Pregnancy Complications
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0035204 BXGD002511 Respiration Disorders Respiratory Tract Diseases
C0035243 BXGD002522 Respiratory Tract Infections Infections; Respiratory Tract Diseases
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0037023 BXGD002660 Sialadenitis Stomatognathic Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0038525 BXGD002768 Subarachnoid Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0085437 BXGD003178 Meningitis, Bacterial Infections; Nervous System Diseases
C0151785 BXGD003474 Disease of mucous membrane Pathological Conditions, Signs and Symptoms
C0153349 BXGD003621 Malignant neoplasm of tongue Neoplasms; Stomatognathic Diseases
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0156147 BXGD003838 Crohn's disease of large bowel Digestive System Diseases
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0236734 BXGD004823 Caffeine related disorders
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0264714 BXGD005416 Acute heart failure Cardiovascular Diseases
C0267380 BXGD005743 Crohn's disease of the ileum Digestive System Diseases
C0267465 BXGD005753 Stenosis of intestine Digestive System Diseases
C0268287 BXGD005884 Deficiency of steroid 21-monooxygenase Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0275518 BXGD006375 Acute infectious disease Pathological Conditions, Signs and Symptoms; Infections
C0278134 BXGD006498 Absence of sensation Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0333463 BXGD006954 Senile Plaques Pathological Conditions, Signs and Symptoms
C0340537 BXGD007342 Pulmonary fat embolism Respiratory Tract Diseases; Cardiovascular Diseases
C0346398 BXGD007822 Mixed follicular and papillary thyroid carcinoma
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0520679 BXGD009101 Sleep Apnea, Obstructive Respiratory Tract Diseases; Nervous System Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0558353 BXGD009451 Tongue Carcinoma Neoplasms; Stomatognathic Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0677886 BXGD009734 Epithelial ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0678202 BXGD009747 Regional enteritis Digestive System Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0740391 BXGD009987 Middle Cerebral Artery Occlusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0852654 BXGD010947 21-hydroxylase deficiency
C0853879 BXGD010982 Invasive carcinoma of breast Neoplasms; Skin and Connective Tissue Diseases
C0854211 BXGD011008 Bacterial keratitis Pathological Conditions, Signs and Symptoms; Infections; Eye Diseases
C0856742 BXGD011111 Post MI Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0936248 BXGD011480 Chondroma Neoplasms
C0949272 BXGD011573 IIeocolitis Digestive System Diseases
C1096063 BXGD011600 Drug Resistant Epilepsy Nervous System Diseases
C1260899 BXGD011841 Anemia, Diamond-Blackfan Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1270972 BXGD012006 Mild cognitive disorder Mental Disorders
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1395512 BXGD012989 Placental dysfunction
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1519666 BXGD013240 Tumor-Associated Vasculature
C1519670 BXGD013241 Tumor Angiogenesis Pathological Conditions, Signs and Symptoms
C1519680 BXGD013244 Tumor Immunity Pathological Conditions, Signs and Symptoms
C1527336 BXGD013271 Sjogren's Syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C1845050 BXGD014703 PIGMENTARY DISORDER, RETICULATE, WITH SYSTEMIC MANIFESTATIONS Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C1883018 BXGD016594 Severe Aplastic Anemia Hemic and Lymphatic Diseases
C2062441 BXGD016897 Influenza A
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2936858 BXGD018147 Congenital adrenal hyperplasia due to 21 hydroxylase deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3541994 BXGD019100 Drug Hypersensitivity Syndrome Skin and Connective Tissue Diseases; Immune System Diseases; Chemically-Induced Disorders
C3544347 BXGD019116 Intestinal fibrosis
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C4048329 BXGD021904 Immunosuppression
C4086152 BXGD022123 Childhood Astrocytoma Neoplasms
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0005513 Hexadecanoic acid 256.42
BXGC0038316 Cholesterol 386.35
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein