Showing entry for Protein artemis


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT025929
Protein NameProtein artemis
Uniport IdQ96SD1
GeneDCLRE1C
Gene Id64421
DomainDRMBL; Lactamase_B_2
Pfam PF07522   PF12706  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.4 Replication and repair hsa03450 Non-homologous end-joining
6. Human Diseases 6.3 Immune diseases hsa05340 Primary immunodeficiency
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0002250 adaptive immune response
Biological Process GO:0030183 B cell differentiation
Biological Process GO:0006303 double-strand break repair via nonhomologous end joining
Biological Process GO:0036297 interstrand cross-link repair
Biological Process GO:0031848 protection from non-homologous end joining at telomere
Biological Process GO:0010212 response to ionizing radiation
Biological Process GO:0033151 V(D)J recombination
molecular function GO:0035312 5'-3' exodeoxyribonuclease activity
molecular function GO:0008409 5'-3' exonuclease activity
molecular function GO:0003684 damaged DNA binding
molecular function GO:0004519 endonuclease activity
molecular function GO:0000014 single-stranded DNA endodeoxyribonuclease activity
cellular component GO:0005794 Golgi apparatus
cellular component GO:0070419 nonhomologous end joining complex
cellular component GO:0000784 nuclear chromosome, telomeric region
cellular component GO:0005654 nucleoplasm
Reactome
Pathway Id Pathway Name
R-HSA-5693532 DNA Double-Strand Break Repair
R-HSA-5693571 Nonhomologous End-Joining (NHEJ)
R-HSA-73894 DNA Repair
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0001768 BXGD000075 Agammaglobulinemia Immune System Diseases; Hemic and Lymphatic Diseases
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0002170 BXGD000105 Alopecia Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0002438 BXGD000113 Amebiasis Infections
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004368 BXGD000271 Autoimmune state
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006413 BXGD000397 Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011606 BXGD000735 Exfoliative dermatitis Skin and Connective Tissue Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0013370 BXGD000822 Amebic colitis Digestive System Diseases; Infections
C0013604 BXGD000859 Edema Pathological Conditions, Signs and Symptoms
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0014457 BXGD000915 Eosinophilia Hemic and Lymphatic Diseases
C0015230 BXGD000969 Exanthema Skin and Connective Tissue Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0019348 BXGD001325 Herpes Simplex Infections Infections; Skin and Connective Tissue Diseases
C0020639 BXGD001457 Hypoproteinemia Hemic and Lymphatic Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023485 BXGD001667 Precursor B-Cell Lymphoblastic Leukemia-Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024312 BXGD001766 Lymphopenia Immune System Diseases; Hemic and Lymphatic Diseases
C0024314 BXGD001767 Lymphoproliferative Disorders Immune System Diseases; Hemic and Lymphatic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027726 BXGD002030 Nephrotic Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0029227 BXGD002123 Delirium, Dementia, Amnestic, Cognitive Disorders Mental Disorders
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0029882 BXGD002177 Otitis Media Otorhinolaryngologic Diseases
C0029925 BXGD002181 Ovarian Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0033774 BXGD002419 Pruritus Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0038002 BXGD002723 Splenomegaly Pathological Conditions, Signs and Symptoms
C0040034 BXGD002836 Thrombocytopenia Hemic and Lymphatic Diseases
C0040147 BXGD002847 Thyroiditis Endocrine System Diseases
C0042900 BXGD003012 Vitiligo Skin and Connective Tissue Diseases
C0043037 BXGD003023 Common wart Neoplasms; Infections; Skin and Connective Tissue Diseases
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085110 BXGD003126 Severe Combined Immunodeficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0149745 BXGD003356 Oral Ulcer Stomatognathic Diseases
C0149931 BXGD003388 Migraine Disorders Nervous System Diseases
C0151281 BXGD003409 Genital ulcers
C0151908 BXGD003502 Dry skin Skin and Connective Tissue Diseases
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0206019 BXGD004144 HIV Encephalopathy Infections; Immune System Diseases; Nervous System Diseases; Mental Disorders
C0221277 BXGD004434 Atypical lymphocyte
C0241165 BXGD005083 Thick skin
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0268124 BXGD005825 Adenosine deaminase deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0276548 BXGD006430 HIV encephalitis Infections; Immune System Diseases; Nervous System Diseases; Mental Disorders
C0278764 BXGD006581 Adult Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0278879 BXGD006610 Childhood Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0392607 BXGD008057 Severe combined immunodeficiency due to adenosine deaminase deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases; Hemic and Lymphatic Diseases
C0401151 BXGD008274 Chronic diarrhea Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0451693 BXGD008823 Severe combined immunodeficiency with low T- and B-cell numbers Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0494261 BXGD009023 Combined immunodeficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0497156 BXGD009053 Lymphadenopathy Hemic and Lymphatic Diseases
C0576999 BXGD009530 Tonsil absent
C0581381 BXGD009567 Recurrent upper respiratory tract infection Infections; Respiratory Tract Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677607 BXGD009721 Hashimoto Disease Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0685891 BXGD009824 Congenital hypoplasia of thymus Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0685894 BXGD009825 Congenital absence of thymus Immune System Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0863094 BXGD011271 Recurrent respiratory tract infections
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1261473 BXGD011855 Sarcoma Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1279481 BXGD012123 X-Linked Combined Immunodeficiency Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases
C1292769 BXGD012230 Precursor B-cell lymphoblastic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1328587 BXGD012473 Panhypogammaglobulinemia
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1335302 BXGD012775 Pancreatic Ductal Adenocarcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1519670 BXGD013241 Tumor Angiogenesis Pathological Conditions, Signs and Symptoms
C1611743 BXGD013456 Familial (FPAH)
C1619738 BXGD013464 Immune Reconstitution Inflammatory Syndrome Immune System Diseases
C1744558 BXGD013748 T-lymphocyte deficiency
C1832324 BXGD013828 Recurrent opportunistic infections Infections
C1836195 BXGD014094 Short toe
C1837066 BXGD014190 Recurrent viral infection Infections
C1842714 BXGD014535 Desquamation of skin soon after birth
C1842777 BXGD014537 Recurrent upper and lower respiratory tract infections
C1844383 BXGD014628 Recurrent bacterial infection Infections
C1844384 BXGD014629 Recurrent fungal infections
C1849236 BXGD015026 Severe combined immunodeficiency, atypical Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C1863715 BXGD016190 Severe B lymphocytopenia
C1865370 BXGD016320 Severe combined immunodeficiency with sensitivity to ionizing radiation Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C1865371 BXGD016321 SEVERE COMBINED IMMUNODEFICIENCY, ATHABASKAN-TYPE
C1865372 BXGD016322 Athabaskan severe combined immunodeficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C1865373 BXGD016323 SEVERE COMBINED IMMUNODEFICIENCY, PARTIAL
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1963094 BXGD016681 Dry Skin, CTCAE
C2700553 BXGD017472 Omenn Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C2931689 BXGD018049 Dystrophia myotonica 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C2931884 BXGD018088 Reticuloendotheliosis, familial, with eosinophilia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases; Hemic and Lymphatic Diseases
C2937365 BXGD018161 Recurrent aphthous ulcer Stomatognathic Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3495559 BXGD018994 Juvenile arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C3665596 BXGD019295 Warts Infections; Skin and Connective Tissue Diseases
C3714757 BXGD019430 Juvenile rheumatoid arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C3808828 BXGD019554 Recurrent gastroenteritis
C3896960 BXGD020042 Childhood Pre-B Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C3896961 BXGD020043 Adult Pre-B Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C4021956 BXGD020839 Aplasia/Hypoplasia of the eyebrow
C4023438 BXGD021185 Recurrent mycobacterial infections
C4024599 BXGD021333 Chronic oral candidiasis Infections; Skin and Connective Tissue Diseases
C4025683 BXGD021732 Lymph node hypoplasia
C4025814 BXGD021806 Abnormality of the metaphysis
C4041080 BXGD021873 Neurocognitive Disorders Mental Disorders
C4087504 BXGD022156 Peritoneal dissemination
C4477053 BXGD022911 Decreased proportion of CD3-positive T cells Immune System Diseases; Hemic and Lymphatic Diseases
C4551686 BXGD023391 Malignant neoplasm of soft tissue Neoplasms
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4721779 BXGD023769 Ovarian cancer stage IV
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein