Showing entry for Hydroquinone


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0000530
Compound NameHydroquinone
Structure
FormulaC6H6O2
InchiKeyQIGBRXMKCJKVMJ-UHFFFAOYSA-N
SMILESOC1=CC=C(O)C=C1
InchiInChI=1S/C6H6O2/c7-5-1-2-6(8)4-3-5/h1-4,7-8H
IUPACbenzene-1,4-diol
Molecular Weight110.11
Pubchem Id785
Chembl IdCHEMBL537
Targets of Information Source
DrugBank DB09526
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
P14679 BXGT008039 Tyrosinase reviewed Enzyme TYR approved; investigational inhibitor
PDB HQE
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
O58586 BXGT004806 Uncharacterized protein PH0856 reviewed PH0856 - - - - -
Q72HI0 BXGT016731 Flavoredoxin unreviewed TT_C1507 - - - - -
P00918 BXGT005690 Carbonic anhydrase 2 reviewed CA2 - 90 - - -
P41020 BXGT010218 Urease subunit alpha reviewed ureC - - - - -
B2ZB02 BXGT002020 Tyrosinase unreviewed - - - 9000 -
Binding DB 26190
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT005689 Carbonic anhydrase 1 reviewed CA1 10700 - - -
reviewed BXGT005690 Carbonic anhydrase 2 reviewed CA2 90 - - -
reviewed BXGT006627 Carbonic anhydrase 3 reviewed CA3 8200 - - -
reviewed BXGT008802 Carbonic anhydrase 4 reviewed CA4 10800 - - -
reviewed BXGT009796 Carbonic anhydrase 5A, mitochondrial reviewed CA5A 14100 - - -
reviewed BXGT022229 Carbonic anhydrase 5B, mitochondrial reviewed CA5B 12500 - - -
reviewed BXGT008844 Carbonic anhydrase 6 reviewed CA6 521000 - - -
reviewed BXGT010364 Carbonic anhydrase 7 reviewed CA7 883000 - - -
reviewed BXGT013670 Carbonic anhydrase 9 reviewed CA9 32500 - - -
reviewed BXGT004601 Carbonic anhydrase 12 reviewed CA12 7800 - - -
reviewed BXGT020260 Carbonic anhydrase 13 reviewed Ca13 74300 - - -
reviewed BXGT021769 Carbonic anhydrase 14 reviewed CA14 42000 - - -
reviewed BXGT007687 Tyrosinase reviewed Tyr - 188200 - -
reviewed BXGT004563 Polyphenol oxidase 2 reviewed PPO2 - 87570 - -
reviewed BXGT008271 Prolyl 4-hydroxylase subunit alpha-1 reviewed P4HA1 14000000 - - -
reviewed BXGT005689 Carbonic anhydrase 1 reviewed CA1 10800 - - -
reviewed BXGT005690 Carbonic anhydrase 2 reviewed CA2 100 - - -
reviewed BXGT008844 Carbonic anhydrase 6 reviewed CA6 524000 - - -
reviewed BXGT004563 Polyphenol oxidase 2 reviewed PPO2 - 4500000 - -
reviewed BXGT004563 Polyphenol oxidase 2 reviewed PPO2 - 33480 - -
reviewed BXGT004563 Polyphenol oxidase 2 reviewed PPO2 - 9810 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache 1.2 - - -
reviewed BXGT004563 Polyphenol oxidase 2 reviewed PPO2 - 4210000 - -
reviewed BXGT004563 Polyphenol oxidase 2 reviewed PPO2 - 37000 - -
reviewed BXGT019994 Carbonic anhydrase 15 reviewed Ca15 10600 - - -
CHEMBL CHEMBL537
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P51151 BXGT010837 Ras-related protein Rab-9A reviewed - RAB9A Potency '=' 58047 nM
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha reviewed Transcription factor HIF1A Potency '=' 1995 nM
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 IC50 '=' 4500000 nM
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 56234 nM
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 Potency '=' 15848 nM
Q9Y2D0 BXGT022229 Carbonic anhydrase 5B, mitochondrial reviewed - CA5B Ki '=' 12500 nM
Q9HAW8 BXGT020509 UDP-glucuronosyltransferase 1-10 reviewed - UGT1A10 Activity '=' 0 pm/min/mg
P19793 BXGT008515 Retinoic acid receptor RXR-alpha reviewed Nuclear receptor RXRA Potency - 11220 nM
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 9466 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 11220 nM
P54132 BXGT011032 Bloom syndrome protein reviewed - BLM Potency '=' 2 nM
Q9D6N1 BXGT020260 Carbonic anhydrase 13 reviewed - Ca13 Ki '=' 74300 nM
P00915 BXGT005689 Carbonic anhydrase 1 reviewed - CA1 Ki '=' 10700 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 1000 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 2113 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 35481 nM
Q01453 BXGT012588 Peripheral myelin protein 22 reviewed Cellular structure PMP22 Potency '=' 21331 nM
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 1778 nM
P51449 BXGT010846 Nuclear receptor ROR-gamma reviewed Nuclear receptor RORC Potency - 10590 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 6309 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 6309 nM
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 Ki '=' 90 nM
Q03181 BXGT012701 Peroxisome proliferator-activated receptor delta reviewed Nuclear receptor PPARD Potency - 22387 nM
P08482 BXGT006775 Muscarinic acetylcholine receptor M1 reviewed - Chrm1 Potency '=' 19952 nM
P23280 BXGT008844 Carbonic anhydrase 6 reviewed - CA6 Ki '=' 521000 nM
P19838 BXGT008526 Nuclear factor NF-kappa-B p105 subunit reviewed Transcription factor NFKB1 Potency '=' 10000 nM
P40225 BXGT010168 Thrombopoietin reviewed - THPO Potency '=' 12589 nM
P43166 BXGT010364 Carbonic anhydrase 7 reviewed - CA7 Ki '=' 883000 nM
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 IC50 '=' 10020 nM
P10275 BXGT007552 Androgen receptor reviewed Nuclear receptor AR Potency - 44668 nM
P22748 BXGT008802 Carbonic anhydrase 4 reviewed - CA4 Ki '=' 10800 nM
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 1258 nM
P10828 BXGT007624 Thyroid hormone receptor beta reviewed Nuclear receptor THRB Potency - 39810 nM
Q9F4F7 BXGT020344 4'-phosphopantetheinyl transferase ffp reviewed - ffp Potency '=' 44668 nM
P68871 BXGT011615 Hemoglobin subunit beta reviewed - HBB Potency '=' 39810 nM
Q99N23 BXGT019994 Carbonic anhydrase 15 reviewed - Ca15 Ki '=' 10600 nM
P39748 BXGT010134 Flap endonuclease 1 reviewed Enzyme FEN1 Potency - 3768 nM
Q9HAW7 BXGT020508 UDP-glucuronosyltransferase 1-7 reviewed - UGT1A7 Activity '=' 0 pm/min/mg
O94925 BXGT005342 Glutaminase kidney isoform, mitochondrial reviewed Enzyme GLS Potency - 11220 nM
P46063 BXGT010501 ATP-dependent DNA helicase Q1 reviewed Enzyme RECQL Potency '=' 35481 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 5623 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 7846 nM
Q99549 BXGT019932 M-phase phosphoprotein 8 reviewed Epigenetic regulator MPHOSPH8 Potency - 89125 nM
Q96RI1 BXGT019727 Bile acid receptor reviewed Nuclear receptor NR1H4 Potency - 14125 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 35481 nM
P42345 BXGT010304 Serine/threonine-protein kinase mTOR reviewed Kinase MTOR Potency '=' 23280 nM
O43570 BXGT004601 Carbonic anhydrase 12 reviewed - CA12 Ki '=' 7800 nM
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 Inhibition - - -
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 2818 nM
P07451 BXGT006627 Carbonic anhydrase 3 reviewed - CA3 Ki '=' 8200 nM
Q2PCB5 BXGT014154 Carbonic anhydrase unreviewed - ca Ki '=' 5930 nM
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 IC50 '=' 1090560 nM
Q96RI1 BXGT019727 Bile acid receptor reviewed Nuclear receptor NR1H4 Potency - 44668 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 14125 nM
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 IC50 '=' 13480 nM
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 IC50 '=' 9810 nM
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 IC50 '=' 37000 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency '=' 25118 nM
P25094 BXGT009014 Peripheral myelin protein 22 reviewed - Pmp22 Potency - 4053 nM
P35869 BXGT009877 Aryl hydrocarbon receptor reviewed Transcription factor AHR Potency - 56234 nM
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 112 %
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 Kcat '=' 101 /s
P42345 BXGT010304 Serine/threonine-protein kinase mTOR reviewed Kinase MTOR Potency '=' 14689 nM
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 398 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 16360 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 10000 nM
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 IC50 '=' 33480 nM
Q16790 BXGT013670 Carbonic anhydrase 9 reviewed - CA9 Ki '=' 32500 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Potency - 50118 nM
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 Inhibition '<' 30 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Potency - 35481 nM
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 5972 nM
Q9ULX7 BXGT021769 Carbonic anhydrase 14 reviewed - CA14 Ki '=' 42000 nM
P19793 BXGT008515 Retinoic acid receptor RXR-alpha reviewed Nuclear receptor RXRA Potency - 8912 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 26608 nM
P03070 BXGT006016 Large T antigen reviewed - IC50 - 7760 nM
P25094 BXGT009014 Peripheral myelin protein 22 reviewed - Pmp22 Potency - 19937 nM
O15118 BXGT004127 NPC intracellular cholesterol transporter 1 reviewed Transporter NPC1 Potency '=' 91999 nM
O15648 BXGT004185 ATP-dependent 6-phosphofructokinase reviewed - pfk Potency - 10691 nM
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 7943 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 20587 nM
P15289 BXGT008102 Arylsulfatase A reviewed Enzyme ARSA Potency - 30131 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 47307 nM
P35218 BXGT009796 Carbonic anhydrase 5A, mitochondrial reviewed - CA5A Ki '=' 14100 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 7943 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 29855 nM
P13267 BXGT007895 DNA polymerase III PolC-type reviewed - polC Potency - 5323 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Ki '=' 1 nM
P68871 BXGT011615 Hemoglobin subunit beta reviewed - HBB Potency '=' 12589 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 7943 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 19952 nM
Q96EB6 BXGT019646 NAD-dependent protein deacetylase sirtuin-1 reviewed Epigenetic regulator SIRT1 Activity - - -
Q03181 BXGT012701 Peroxisome proliferator-activated receptor delta reviewed Nuclear receptor PPARD Potency - 25118 nM
Q99700 BXGT019949 Ataxin-2 reviewed Nucleic acid binding ATXN2 Potency - 39810 nM
P83916 BXGT012025 Chromobox protein homolog 1 reviewed Epigenetic regulator CBX1 Potency - 56234 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 13953 nM
P0A6C1 BXGT007045 Endonuclease 4 reviewed - nfo Potency '=' 10000 nM
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Potency - 14125 nM
P15917 BXGT008169 Lethal factor reviewed - lef Potency '=' 12589 nM
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 Km '=' 920000 nM
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 11220 nM
P10145 BXGT007542 Interleukin-8 reviewed Signaling CXCL8 Potency - 66824 nM
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 IC50 '=' 4210000 nM
Q13526 BXGT013369 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 reviewed - PIN1 Potency - 8492 nM
P49798 BXGT010745 Regulator of G-protein signaling 4 reviewed Enzyme modulator RGS4 Potency - 23778 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 16788 nM
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 Kcat/Km '=' 110 /mM/s
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 20596 nM
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 93 %
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00011 Cashew nut Anacardium occidentale Nuts
BXGF00057 Sweet orange Citrus sinensis Fruits
BXGF00090 Star anise Illicium verum Herbs and Spices
BXGF00122 Sweet marjoram Origanum majorana Herbs and Spices
BXGF00137 Anise Pimpinella anisum Herbs and Spices
BXGF00152 Pear Pyrus communis Fruits
BXGF00193 Bilberry Vaccinium myrtillus Fruits
BXGF00194 Lingonberry Vaccinium vitis-idaea Fruits
BXGF00995 Dalbergia rubiginosa Dalbergia rubiginosa Others
BXGF01324 Albizia julibrissin Albizia julibrissin Medicinal Plant
BXGF01406 Phedimus aizoon Phedimus aizoon Others
BXGF01451 Mesembryanthemum tortuosum Mesembryanthemum tortuosum Medicinal Plant
BXGF01495 Pleione yunnanensis Pleione yunnanensis Others
BXGF01733 Caryopteris mongholica Caryopteris mongholica Others
BXGF01804 Euphorbia kansui Euphorbia kansui Medicinal Plant
BXGF02167 Scutellaria barbata Scutellaria barbata Medicinal Plant
BXGF02200 Mappia foetida Mappia foetida Medicinal Plant
BXGF02496 Pleione bulbocodioides Pleione bulbocodioides Others
BXGF02499 Cremastra appendiculata Cremastra appendiculata Medicinal Plant
BXGF02673 Satureja atropatana Satureja atropatana Others
BXGF02939 Saxifraga stolonifera Saxifraga stolonifera Medicinal Plant
BXGF02984 Curculigo orchioides Curculigo orchioides Medicinal Plant
BXGF03189 Rhododendron dauricum Rhododendron dauricum Medicinal Plant
BXGF03479 Bombax ceiba Bombax ceiba Medicinal Plant
BXGF04087 Erysimum odoratum Erysimum odoratum Others
BXGF04092 Heterotheca inuloides Heterotheca inuloides Medicinal Plant
BXGF04098 Delphinium andersoni Delphinium andersoni Others
BXGF04126 Vismia jefensis Vismia jefensis Others
BXGF04142 Angelica tarokoensis Angelica tarokoensis Others
BXGF04147 Swertia delavayi Swertia delavayi Others
BXGF04165 Epimedium davidii Epimedium davidii Medicinal Plant
BXGF04168 Globba malaccensis Globba malaccensis Medicinal Plant
BXGF04175 Diphasia angolensis Diphasia angolensis Others
BXGF04182 Knightia excelsa Knightia excelsa Medicinal Plant
BXGF04199 Isodon japonicus Isodon japonicus Medicinal Plant
BXGF04207 Solanum acaule Solanum acaule Others
BXGF04209 Chaenomeles sinensis Chaenomeles sinensis Medicinal Plant
BXGF04216 Frullania tamarisci Frullania tamarisci Others
BXGF04221 Alangium premnifolium Alangium premnifolium Others
BXGF04233 Saussurea carthamoides Saussurea carthamoides Others
BXGF04250 Galenia africana Galenia africana Medicinal Plant
BXGF04264 Micromeria pineolens Micromeria pineolens Others
BXGF04269 Gnidia lamprantha Gnidia lamprantha Medicinal Plant
BXGF04276 Ilex amara Ilex amara Others
BXGF04295 Leonurus glaucescens Leonurus glaucescens Medicinal Plant
BXGF04342 Salacia madagascariensis Salacia madagascariensis Human Edible Plant
BXGF04343 Maba buxifolia Maba buxifolia Medicinal Plant
BXGF04777 Quercus sessiliflora Quercus sessiliflora Others
BXGF05160 Chaenomeles speciosa Chaenomeles speciosa Medicinal Plant
BXGF05330 Arum ternatum thunb Arum ternatum thunb Others
BXGF05480 Lepidium draba Lepidium draba Medicinal Plant
BXGF05555 Anchusa officinalis Anchusa officinalis Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease