Showing entry for Thromboxane-A synthase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008976
Protein NameThromboxane-A synthase
Uniport IdP24557
GeneTBXAS1
Gene Id6916
Domainp450
Pfam PF00067  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00590 Arachidonic acid metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
5. Organismal Systems 5.1 Immune system hsa04611 Platelet activation
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0019371 cyclooxygenase pathway
Biological Process GO:0006690 icosanoid metabolic process
Biological Process GO:0001516 prostaglandin biosynthetic process
molecular function GO:0036134 12-hydroxyheptadecatrienoic acid synthase activity
molecular function GO:0020037 heme binding
molecular function GO:0005506 iron ion binding
molecular function GO:0004497 monooxygenase activity
molecular function GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
molecular function GO:0004796 thromboxane-A synthase activity
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0016021 integral component of membrane
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1643685 Disease
R-HSA-211859 Biological oxidations
R-HSA-211897 Cytochrome P450 - arranged by substrate type
R-HSA-211945 Phase I - Functionalization of compounds
R-HSA-211979 Eicosanoids
R-HSA-2142753 Arachidonic acid metabolism
R-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
R-HSA-556833 Metabolism of lipids
R-HSA-5579029 Metabolic disorders of biological oxidation enzymes
R-HSA-5579032 Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
R-HSA-5668914 Diseases of metabolism
R-HSA-8978868 Fatty acid metabolism
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001815 BXGD000078 Primary Myelofibrosis Hemic and Lymphatic Diseases
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0002893 BXGD000150 Refractory anemias Hemic and Lymphatic Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004059 BXGD000250 aspirin intolerance
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004135 BXGD000257 Ataxia Telangiectasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0011989 BXGD000765 Camurati-Engelmann Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0013182 BXGD000803 Drug Allergy Immune System Diseases; Chemically-Induced Disorders
C0013491 BXGD000847 Ecchymosis Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0014591 BXGD000938 Epistaxis Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0017658 BXGD001138 Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0017665 BXGD001141 Membranous glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Immune System Diseases
C0020295 BXGD001372 Hydronephrosis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0023440 BXGD001646 Acute Erythroblastic Leukemia Neoplasms; Hemic and Lymphatic Diseases
C0023508 BXGD001675 White Blood Cell Count procedure
C0023896 BXGD001718 Alcoholic Liver Diseases Digestive System Diseases; Chemically-Induced Disorders
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0025500 BXGD001874 Mesothelioma Neoplasms
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0029464 BXGD002161 Osteosclerosis Musculoskeletal Diseases
C0030312 BXGD002207 Pancytopenia Hemic and Lymphatic Diseases
C0032019 BXGD002321 Pituitary Neoplasms Neoplasms; Nervous System Diseases; Endocrine System Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0034065 BXGD002454 Pulmonary Embolism Respiratory Tract Diseases; Cardiovascular Diseases
C0035126 BXGD002509 Reperfusion Injury Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0037822 BXGD002706 Speech Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038002 BXGD002723 Splenomegaly Pathological Conditions, Signs and Symptoms
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0040034 BXGD002836 Thrombocytopenia Hemic and Lymphatic Diseases
C0040053 BXGD002839 Thrombosis Cardiovascular Diseases
C0151529 BXGD003433 Prolonged bleeding time
C0200638 BXGD004043 Eosinophil count procedure
C0202236 BXGD004086 Triglycerides measurement
C0267941 BXGD005793 Pancreatitis, Acute Necrotizing Digestive System Diseases
C0282193 BXGD006798 Iron Overload Nutritional and Metabolic Diseases
C0345967 BXGD007756 Malignant mesothelioma Neoplasms; Respiratory Tract Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0376618 BXGD008003 Endotoxemia Pathological Conditions, Signs and Symptoms; Infections
C0398635 BXGD008206 Thromboxane synthetase deficiency Hemic and Lymphatic Diseases
C0423798 BXGD008510 Increased tendency to bruise Wounds and Injuries
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0751955 BXGD010652 Brain Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0812413 BXGD010847 Malignant Pleural Mesothelioma Neoplasms; Respiratory Tract Diseases
C0871470 BXGD011316 Systolic Pressure
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1835473 BXGD014033 Diaphyseal thickening
C1839326 BXGD014367 Abnormal form of the vertebral bodies
C1840404 BXGD014465 Hyperostosis Cranialis Interna Musculoskeletal Diseases
C1855340 BXGD015490 Bowing of the long bones
C1855710 BXGD015534 Bone marrow hypocellularity
C1856465 BXGD015610 Ghosal Hematodiaphyseal Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Hemic and Lymphatic Diseases
C1868085 BXGD016486 Craniofacial hyperostosis
C2347748 BXGD017041 Adult Erythroleukemia
C3279980 BXGD018791 Decreased serum thromboxane B2
C4016444 BXGD020336 GHOSAL HEMATODIAPHYSEAL SYNDROME
C4020847 BXGD020486 Abnormality of pelvic girdle bone morphology
C4021741 BXGD020749 Abnormal cortical bone morphology
C4021750 BXGD020755 Abnormality of femur morphology
C4023616 BXGD021229 Abnormality of immune system physiology
C4025630 BXGD021703 Abnormal bone structure
C4025663 BXGD021717 Abnormality of tibia morphology
C4025814 BXGD021806 Abnormality of the metaphysis
C4277682 BXGD022376 Chemical and Drug Induced Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C4520840 BXGD023041 Erythroleukemia (Erythroid/Myeloid) Neoplasms; Hemic and Lymphatic Diseases
C4551852 BXGD023420 Diaphyseal dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C4699512 BXGD023639 Large-artery atherosclerosis (embolus/thrombosis)
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000130 Estradiol 272.38
BXGC0000202 Papaverine 339.39
BXGC0000204 Theophylline 180.16
BXGC0000226 Glycine 75.07
BXGC0000284 alpha-Tocopherol 430.71
BXGC0000286 L-DOPA 197.19
BXGC0000433 Triacetin 218.2
BXGC0000434 Ethanol 46.07
BXGC0000439 Chloroform 119.38
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0000528 Salicylic acid 138.12
BXGC0000536 Phenol 94.11
BXGC0000537 Acetylsalicylic acid 180.16
BXGC0000622 Nicotinic acid 123.11
BXGC0000663 Papain 206.28
BXGC0000759 Arabinan 243.22
BXGC0000764 L-Ascorbic acid 176.12
BXGC0000894 2-Methylthioribosyl-trans-zeatin 323.8
BXGC0001000 4,8,5'-Trimethylpsoralen 228.24
BXGC0001002 1,2-Benzenediol 110.11
BXGC0001325 Progesterone 314.46
BXGC0001502 Caffeine 194.19
BXGC0001550 Ficus Latex peptide 2 244.26
BXGC0001767 (E)-Resveratrol 228.25
BXGC0002012 (Z)-Isoeugenol 164.2
BXGC0002402 Ethyl carbamate 89.09
BXGC0002437 Lactic acid 90.08
BXGC0002441 Hydroxyacetic acid 76.05
BXGC0002627 17alpha-ethynylestradiol 296.4
BXGC0002796 Nicotine 162.23
BXGC0002867 Lappaurin 284.74
BXGC0002906 Caffeic acid ester 284.31
BXGC0002916 Melatonin 232.28
BXGC0002992 2-Methylpyridine 93.13
BXGC0003004 3-Methylpyridine 93.13
BXGC0003010 4-Methylpyridine 93.13
BXGC0003066 Phenols 199.27
BXGC0003131 N,N-Dimethylformamide 73.09
BXGC0003501 Parthenolide 248.32
BXGC0003502 Phenylhydrazine 108.14
BXGC0003611 Latex 416.57
BXGC0003690 Glucokinin 764.94
BXGC0003707 Estrogen 268.36
BXGC0003773 Estriol 288.38
BXGC0003956 Fenugrin E 178.19
BXGC0004261 Propylene glycol 76.09
BXGC0004287 Allyl alcohol 58.08
BXGC0004556 1,2,3-Benzenetriol 126.11
BXGC0004560 Benzoic acid 122.12
BXGC0004565 Benzyl alcohol 108.14
BXGC0004587 (E)-3-Phenyl-2-propenal 132.16
BXGC0004712 Methylparaben 152.15
BXGC0005398 (-)-alpha-Narcotine 413.42
BXGC0005508 Safrole 162.19
BXGC0005624 Genistein 270.24
BXGC0005702 2H-1-Benzopyran-2-one 146.15
BXGC0005879 Eugenol 164.2
BXGC0005995 Imidazole 68.08
BXGC0006105 Methyl salicylate 152.15
BXGC0006110 Pyrazine 80.09
BXGC0006115 Xanthotoxin 216.19
BXGC0006125 Nicotinamide 122.12
BXGC0006156 Dicoumarol 336.3
BXGC0006198 Citric acid 192.12
BXGC0006243 Piperidine 85.15
BXGC0006362 Estrone 270.37
BXGC0006366 trans-Ferulic acid 194.18
BXGC0006372 Ergocalciferol 396.65
BXGC0006389 Rotenone 394.42
BXGC0006391 Benzene 78.11
BXGC0006422 Mercenene 214.05
BXGC0006982 Geraniol 154.25
BXGC0007601 1,8-Cineole 154.25
BXGC0007666 Pyrrole 67.09
BXGC0007675 Pyridine 79.1
BXGC0012228 Vitamin D 384.64
BXGC0012243 Ukonan D 151.16
BXGC0013452 Dioctyl phthalate 390.28
BXGC0013482 polythiophene 84
BXGC0014695 Loratadine 382.14
BXGC0015594 4-Nonylphenol 220.18
BXGC0015987 L-Mimosine 198.06
BXGC0016470 Camptothecin 348.11
BXGC0016671 Leucovorin 473.17
BXGC0016747 Camphor 152.12
BXGC0016891 Nortriptyline 263.17
BXGC0017115 Cephalexin 347.09
BXGC0017719 Strychnine 334.17
BXGC0018403 Hydroxyprogesterone 330.22
BXGC0018491 Methylprednisolone 374.21
BXGC0019117 Tannic Acid 1700.17
BXGC0019164 Raloxifene 473.17
BXGC0020355 Fomepizole 82.05
BXGC0020800 Testosterone 288.21
BXGC0021077 Aconitine 645.31
BXGC0021478 Lipoic Acid 206.04
BXGC0022544 Digoxin 780.43
BXGC0024141 Hydrocortisone 362.21
BXGC0024386 Atractyloside 724.21
BXGC0024413 Emetine 480.3
BXGC0024729 Mercaptopurine 152.02
BXGC0024988 Nifedipine 346.12
BXGC0025658 Vinblastine 810.42
BXGC0026391 Naloxone 327.15
BXGC0026595 Glycyrrhizin 822.4
BXGC0027374 Glyburide 493.14
BXGC0027421 Paclitaxel 853.33
BXGC0027854 Ethosuximide 141.08
BXGC0028885 Secobarbital 238.13
BXGC0030138 Colchicine 399.17
BXGC0030663 Metformin 129.1
BXGC0030685 Physostigmine 275.16
BXGC0031384 Epinephrine 183.09
BXGC0031622 Podofilox 414.13
BXGC0032368 Sparteine 234.21
BXGC0033776 Cycloheximide 281.16
BXGC0034035 Capsaicin 305.2
BXGC0034768 Vincristine 824.4
BXGC0034778 Artemisinin 282.15
BXGC0034783 Doxorubicin 543.17
BXGC0035519 Amygdalin 457.16
BXGC0037718 Ethacrynic Acid 302.01
BXGC0038963 Dichlorvos 219.95
BXGC0039601 Levocarnitine 161.11
BXGC0039684 Berberine Chloride 336.12
BXGC0040042 Warfarin 308.1
BXGC0040462 Aminosalicylic Acid 153.04
BXGC0041240 Atenolol 266.16
BXGC0042127 Oxyquinoline 145.05
BXGC0042179 Atropine 289.17
BXGC0042211 4-Octylphenol 206.17
BXGC0042222 Propranolol 259.16
BXGC0042339 Terbutaline 225.14
BXGC0042452 Panthenol 205.13
BXGC0042510 Fluoxetine 309.13
BXGC0042519 Glimepiride 490.22
BXGC0042596 Isoniazid 137.06
BXGC0043648 (-)-Camphor 152.12
BXGC0044017 Verapamil 454.28
BXGC0044810 Lamivudine 229.05
BXGC0045812 Trifluoperazine 407.16
BXGC0046139 Aminoglutethimide 232.12
BXGC0046755 Yohimbine 354.19
BXGC0046862 Benzo[Def]Chrysene 252.09
BXGC0046996 Thioguanine 167.03
BXGC0047126 Artemether 298.18
BXGC0049391 Betadex 1134.37
BXGC0049738 Dexibuprofen 206.13
BXGC0050471 Fluorouracil 130.02
BXGC0050816 Galantamine 287.15
BXGC0051524 Ouabain 584.28
BXGC0051982 Mannitol 182.08
BXGC0052021 (R)-Ibuprophen 206.13
BXGC0052374 Reserpine 608.27
BXGC0052878 Bisphenol A 228.12
BXGC0053118 Streptomycin 581.27
BXGC0053261 Antimycin A 548.27
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein