Showing entry for Muscarinic acetylcholine receptor M4


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006738
Protein NameMuscarinic acetylcholine receptor M4
Uniport IdP08173
GeneCHRM4
Gene Id1132
Domain7tm_1
Pfam PF00001  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
5. Organismal Systems 5.6 Nervous system hsa04725 Cholinergic synapse
4. Cellular Processes 4.5 Cell motility hsa04810 Regulation of actin cytoskeleton
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
Biological Process GO:0007166 cell surface receptor signaling pathway
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:0007213 G protein-coupled acetylcholine receptor signaling pathway
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
Biological Process GO:0040012 regulation of locomotion
Biological Process GO:0007165 signal transduction
molecular function GO:0016907 G protein-coupled acetylcholine receptor activity
molecular function GO:0004930 G protein-coupled receptor activity
molecular function GO:0004993 G protein-coupled serotonin receptor activity
molecular function GO:0030594 neurotransmitter receptor activity
cellular component GO:0030425 dendrite
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0045211 postsynaptic membrane
cellular component GO:0045202 synapse
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-372790 Signaling by GPCR
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-375280 Amine ligand-binding receptors
R-HSA-388396 GPCR downstream signalling
R-HSA-390648 Muscarinic acetylcholine receptors
R-HSA-418594 G alpha (i) signalling events
R-HSA-500792 GPCR ligand binding
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004936 BXGD000295 Mental disorders Mental Disorders
C0007398 BXGD000465 Catatonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0040822 BXGD002885 Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0040827 BXGD002886 Saturnine Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0149840 BXGD003371 Senile Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0234370 BXGD004653 Persistent Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234371 BXGD004654 Continuous Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234372 BXGD004655 Intermittent Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234373 BXGD004656 Fine Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234374 BXGD004657 Coarse Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234375 BXGD004658 Massive Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234376 BXGD004659 Action Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234377 BXGD004660 Passive Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234378 BXGD004661 Static Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234379 BXGD004662 Resting Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234381 BXGD004663 Darkness Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235078 BXGD004719 Tremor, Perioral Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235081 BXGD004720 Tremor, Limb Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235082 BXGD004721 Tremor, Muscle Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235083 BXGD004722 Nerve Tremors Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235843 BXGD004777 Tremor, Neonatal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0338650 BXGD007210 Catatonia, Organic Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0600427 BXGD009706 Cocaine Dependence Chemically-Induced Disorders; Mental Disorders
C0750992 BXGD010278 Catatonia, Malignant Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0750993 BXGD010279 Schizophreniform Catatonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0751564 BXGD010502 Pill Rolling Tremor Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751565 BXGD010503 Tremor, Semirhythmic Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1527384 BXGD013283 Involuntary Quiver Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000130 Estradiol 272.38
BXGC0000202 Papaverine 339.39
BXGC0000204 Theophylline 180.16
BXGC0000226 Glycine 75.07
BXGC0000284 alpha-Tocopherol 430.71
BXGC0000286 L-DOPA 197.19
BXGC0000433 Triacetin 218.2
BXGC0000434 Ethanol 46.07
BXGC0000439 Chloroform 119.38
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0000528 Salicylic acid 138.12
BXGC0000536 Phenol 94.11
BXGC0000537 Acetylsalicylic acid 180.16
BXGC0000622 Nicotinic acid 123.11
BXGC0000651 Harmalan 184.24
BXGC0000663 Papain 206.28
BXGC0000759 Arabinan 243.22
BXGC0000764 L-Ascorbic acid 176.12
BXGC0000894 2-Methylthioribosyl-trans-zeatin 323.8
BXGC0000982 L-Homocysteine 135.19
BXGC0001000 4,8,5'-Trimethylpsoralen 228.24
BXGC0001002 1,2-Benzenediol 110.11
BXGC0001325 Progesterone 314.46
BXGC0001502 Caffeine 194.19
BXGC0001545 Harmine 212.25
BXGC0001550 Ficus Latex peptide 2 244.26
BXGC0001589 Arecoline 155.19
BXGC0001767 (E)-Resveratrol 228.25
BXGC0002012 (Z)-Isoeugenol 164.2
BXGC0002402 Ethyl carbamate 89.09
BXGC0002437 Lactic acid 90.08
BXGC0002441 Hydroxyacetic acid 76.05
BXGC0002627 17alpha-ethynylestradiol 296.4
BXGC0002796 Nicotine 162.23
BXGC0002852 Atropine 289.37
BXGC0002867 Lappaurin 284.74
BXGC0002906 Caffeic acid ester 284.31
BXGC0002916 Melatonin 232.28
BXGC0003066 Phenols 199.27
BXGC0003102 Acetylcholine 146.21
BXGC0003131 N,N-Dimethylformamide 73.09
BXGC0003196 Aripiprazole 448.39
BXGC0003501 Parthenolide 248.32
BXGC0003502 Phenylhydrazine 108.14
BXGC0003611 Latex 416.57
BXGC0003690 Glucokinin 764.94
BXGC0003707 Estrogen 268.36
BXGC0003773 Estriol 288.38
BXGC0003956 Fenugrin E 178.19
BXGC0004261 Propylene glycol 76.09
BXGC0004287 Allyl alcohol 58.08
BXGC0004556 1,2,3-Benzenetriol 126.11
BXGC0004560 Benzoic acid 122.12
BXGC0004565 Benzyl alcohol 108.14
BXGC0004587 (E)-3-Phenyl-2-propenal 132.16
BXGC0004712 Methylparaben 152.15
BXGC0005398 (-)-alpha-Narcotine 413.42
BXGC0005508 Safrole 162.19
BXGC0005624 Genistein 270.24
BXGC0005683 Quercetin 302.24
BXGC0005702 2H-1-Benzopyran-2-one 146.15
BXGC0005874 Racemethionine 149.21
BXGC0005879 Eugenol 164.2
BXGC0006105 Methyl salicylate 152.15
BXGC0006115 Xanthotoxin 216.19
BXGC0006125 Nicotinamide 122.12
BXGC0006156 Dicoumarol 336.3
BXGC0006183 L-Cystine 240.3
BXGC0006198 Citric acid 192.12
BXGC0006362 Estrone 270.37
BXGC0006366 trans-Ferulic acid 194.18
BXGC0006372 Ergocalciferol 396.65
BXGC0006389 Rotenone 394.42
BXGC0006422 Mercenene 214.05
BXGC0006982 Geraniol 154.25
BXGC0007601 1,8-Cineole 154.25
BXGC0012228 Vitamin D 384.64
BXGC0012243 Ukonan D 151.16
BXGC0013452 Dioctyl phthalate 390.28
BXGC0014695 Loratadine 382.14
BXGC0015594 4-Nonylphenol 220.18
BXGC0015987 L-Mimosine 198.06
BXGC0016470 Camptothecin 348.11
BXGC0016671 Leucovorin 473.17
BXGC0016747 Camphor 152.12
BXGC0016891 Nortriptyline 263.17
BXGC0017115 Cephalexin 347.09
BXGC0017369 N-Methyllaurotetanine 341.16
BXGC0017719 Strychnine 334.17
BXGC0018403 Hydroxyprogesterone 330.22
BXGC0018491 Methylprednisolone 374.21
BXGC0019117 Tannic Acid 1700.17
BXGC0019164 Raloxifene 473.17
BXGC0019600 xanthene-9-carboxylic acid 226.06
BXGC0020355 Fomepizole 82.05
BXGC0020583 Brucine 394.19
BXGC0020800 Testosterone 288.21
BXGC0021077 Aconitine 645.31
BXGC0021478 Lipoic Acid 206.04
BXGC0022544 Digoxin 780.43
BXGC0024141 Hydrocortisone 362.21
BXGC0024386 Atractyloside 724.21
BXGC0024413 Emetine 480.3
BXGC0024729 Mercaptopurine 152.02
BXGC0024926 Scopolamine 303.15
BXGC0024988 Nifedipine 346.12
BXGC0025658 Vinblastine 810.42
BXGC0026391 Naloxone 327.15
BXGC0026595 Glycyrrhizin 822.4
BXGC0027374 Glyburide 493.14
BXGC0027421 Paclitaxel 853.33
BXGC0027854 Ethosuximide 141.08
BXGC0028104 Hyoscyamine 289.17
BXGC0028885 Secobarbital 238.13
BXGC0030138 Colchicine 399.17
BXGC0030663 Metformin 129.1
BXGC0030685 Physostigmine 275.16
BXGC0030978 Cremastrine 255.18
BXGC0031080 Scopolamine 303.15
BXGC0031384 Epinephrine 183.09
BXGC0031622 Podofilox 414.13
BXGC0032368 Sparteine 234.21
BXGC0033776 Cycloheximide 281.16
BXGC0034035 Capsaicin 305.2
BXGC0034768 Vincristine 824.4
BXGC0034778 Artemisinin 282.15
BXGC0034783 Doxorubicin 543.17
BXGC0035519 Amygdalin 457.16
BXGC0037718 Ethacrynic Acid 302.01
BXGC0038837 Pseudohypericin 520.08
BXGC0038963 Dichlorvos 219.95
BXGC0039319 Muscarine 174.15
BXGC0039601 Levocarnitine 161.11
BXGC0039684 Berberine Chloride 336.12
BXGC0040042 Warfarin 308.1
BXGC0040462 Aminosalicylic Acid 153.04
BXGC0040582 nantenine 339.15
BXGC0041240 Atenolol 266.16
BXGC0042114 Solifenacin 362.2
BXGC0042127 Oxyquinoline 145.05
BXGC0042179 Atropine 289.17
BXGC0042211 4-Octylphenol 206.17
BXGC0042222 Propranolol 259.16
BXGC0042339 Terbutaline 225.14
BXGC0042452 Panthenol 205.13
BXGC0042462 Cysteine 121.02
BXGC0042510 Fluoxetine 309.13
BXGC0042519 Glimepiride 490.22
BXGC0042596 Isoniazid 137.06
BXGC0043126 Nicardipine 479.21
BXGC0043587 Scopolamine 303.15
BXGC0043648 (-)-Camphor 152.12
BXGC0044017 Verapamil 454.28
BXGC0044810 Lamivudine 229.05
BXGC0045812 Trifluoperazine 407.16
BXGC0046139 Aminoglutethimide 232.12
BXGC0046518 Chloroquine 319.18
BXGC0046755 Yohimbine 354.19
BXGC0046862 Benzo[Def]Chrysene 252.09
BXGC0046996 Thioguanine 167.03
BXGC0047126 Artemether 298.18
BXGC0049391 Betadex 1134.37
BXGC0049738 Dexibuprofen 206.13
BXGC0050471 Fluorouracil 130.02
BXGC0050816 Galantamine 287.15
BXGC0051524 Ouabain 584.28
BXGC0051982 Mannitol 182.08
BXGC0052021 (R)-Ibuprophen 206.13
BXGC0052374 Reserpine 608.27
BXGC0052878 Bisphenol A 228.12
BXGC0053118 Streptomycin 581.27
BXGC0053261 Antimycin A 548.27
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein