Showing entry for Insulin receptor


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008085
Protein NameInsulin receptor
Uniport IdP15127
GeneInsr
Gene Id
Domainfn3; Furin-like; Insulin_TMD; Pkinase_Tyr; Recep_L_domain
Pfam PF00041   PF00757   PF17870   PF07714   PF01030  
OrganismRattus norvegicus (Rat)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0000187 activation of MAPK activity
Biological Process GO:0032147 activation of protein kinase activity
Biological Process GO:0032148 activation of protein kinase B activity
Biological Process GO:0030325 adrenal gland development
Biological Process GO:0000380 alternative mRNA splicing, via spliceosome
Biological Process GO:0097242 amyloid-beta clearance
Biological Process GO:0048856 anatomical structure development
Biological Process GO:0009887 animal organ morphogenesis
Biological Process GO:0071363 cellular response to growth factor stimulus
Biological Process GO:0032869 cellular response to insulin stimulus
Biological Process GO:0021549 cerebellum development
Biological Process GO:0097062 dendritic spine maintenance
Biological Process GO:1990402 embryonic liver development
Biological Process GO:0008544 epidermis development
Biological Process GO:0031017 exocrine pancreas development
Biological Process GO:0045444 fat cell differentiation
Biological Process GO:0042593 glucose homeostasis
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0003007 heart morphogenesis
Biological Process GO:0021766 hippocampus development
Biological Process GO:0008286 insulin receptor signaling pathway
Biological Process GO:0001889 liver development
Biological Process GO:0097421 liver regeneration
Biological Process GO:0008584 male gonad development
Biological Process GO:0030238 male sex determination
Biological Process GO:0007275 multicellular organism development
Biological Process GO:2000252 negative regulation of feeding behavior
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0045719 negative regulation of glycogen biosynthetic process
Biological Process GO:0001933 negative regulation of protein phosphorylation
Biological Process GO:0032410 negative regulation of transporter activity
Biological Process GO:1990535 neuron projection maintenance
Biological Process GO:0038083 peptidyl-tyrosine autophosphorylation
Biological Process GO:0018108 peptidyl-tyrosine phosphorylation
Biological Process GO:0030335 positive regulation of cell migration
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0048639 positive regulation of developmental growth
Biological Process GO:0046326 positive regulation of glucose import
Biological Process GO:0045725 positive regulation of glycogen biosynthetic process
Biological Process GO:0045821 positive regulation of glycolytic process
Biological Process GO:0010560 positive regulation of glycoprotein biosynthetic process
Biological Process GO:0033674 positive regulation of kinase activity
Biological Process GO:0043410 positive regulation of MAPK cascade
Biological Process GO:0051446 positive regulation of meiotic cell cycle
Biological Process GO:0045840 positive regulation of mitotic nuclear division
Biological Process GO:0045429 positive regulation of nitric oxide biosynthetic process
Biological Process GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
Biological Process GO:0042327 positive regulation of phosphorylation
Biological Process GO:0043243 positive regulation of protein-containing complex disassembly
Biological Process GO:0051897 positive regulation of protein kinase B signaling
Biological Process GO:0001934 positive regulation of protein phosphorylation
Biological Process GO:0002092 positive regulation of receptor internalization
Biological Process GO:0060267 positive regulation of respiratory burst
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0006898 receptor-mediated endocytosis
Biological Process GO:0045995 regulation of embryonic development
Biological Process GO:2000194 regulation of female gonad development
Biological Process GO:0006111 regulation of gluconeogenesis
Biological Process GO:0010310 regulation of hydrogen peroxide metabolic process
Biological Process GO:0006355 regulation of transcription, DNA-templated
Biological Process GO:0014823 response to activity
Biological Process GO:0032355 response to estradiol
Biological Process GO:0045471 response to ethanol
Biological Process GO:0032094 response to food
Biological Process GO:0051384 response to glucocorticoid
Biological Process GO:0009749 response to glucose
Biological Process GO:0009725 response to hormone
Biological Process GO:0001666 response to hypoxia
Biological Process GO:0032868 response to insulin
Biological Process GO:0010042 response to manganese ion
Biological Process GO:0031667 response to nutrient levels
Biological Process GO:0010033 response to organic substance
Biological Process GO:1904638 response to resveratrol
Biological Process GO:0033574 response to testosterone
Biological Process GO:0034612 response to tumor necrosis factor
Biological Process GO:1902438 response to vanadate(3-)
Biological Process GO:0033280 response to vitamin D
Biological Process GO:0019087 transformation of host cell by virus
Biological Process GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
molecular function GO:0043423 3-phosphoinositide-dependent protein kinase binding
molecular function GO:0001540 amyloid-beta binding
molecular function GO:0005524 ATP binding
molecular function GO:0038024 cargo receptor activity
molecular function GO:0005525 GTP binding
molecular function GO:0042802 identical protein binding
molecular function GO:0005009 insulin-activated receptor activity
molecular function GO:0043559 insulin binding
molecular function GO:0031994 insulin-like growth factor I binding
molecular function GO:0031995 insulin-like growth factor II binding
molecular function GO:0005159 insulin-like growth factor receptor binding
molecular function GO:0043560 insulin receptor substrate binding
molecular function GO:0031405 lipoic acid binding
molecular function GO:0043548 phosphatidylinositol 3-kinase binding
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0019904 protein domain specific binding
molecular function GO:0004672 protein kinase activity
molecular function GO:0019901 protein kinase binding
molecular function GO:0019903 protein phosphatase binding
molecular function GO:0004713 protein tyrosine kinase activity
molecular function GO:0051425 PTB domain binding
molecular function GO:0005198 structural molecule activity
molecular function GO:0004714 transmembrane receptor protein tyrosine kinase activity
cellular component GO:0030424 axon
cellular component GO:0005901 caveola
cellular component GO:0031410 cytoplasmic vesicle
cellular component GO:0005829 cytosol
cellular component GO:0032590 dendrite membrane
cellular component GO:0005768 endosome
cellular component GO:0009897 external side of plasma membrane
cellular component GO:0005899 insulin receptor complex
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0005770 late endosome
cellular component GO:0005764 lysosome
cellular component GO:0016020 membrane
cellular component GO:0043025 neuronal cell body
cellular component GO:0032809 neuronal cell body membrane
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
cellular component GO:0043235 receptor complex
cellular component GO:0045202 synapse
cellular component GO:0060417 yolk
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000130 Estradiol 272.38
BXGC0000202 Papaverine 339.39
BXGC0000204 Theophylline 180.16
BXGC0000226 Glycine 75.07
BXGC0000284 alpha-Tocopherol 430.71
BXGC0000286 L-DOPA 197.19
BXGC0000433 Triacetin 218.2
BXGC0000434 Ethanol 46.07
BXGC0000439 Chloroform 119.38
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0000528 Salicylic acid 138.12
BXGC0000536 Phenol 94.11
BXGC0000537 Acetylsalicylic acid 180.16
BXGC0000622 Nicotinic acid 123.11
BXGC0000663 Papain 206.28
BXGC0000759 Arabinan 243.22
BXGC0000764 L-Ascorbic acid 176.12
BXGC0000894 2-Methylthioribosyl-trans-zeatin 323.8
BXGC0001000 4,8,5'-Trimethylpsoralen 228.24
BXGC0001002 1,2-Benzenediol 110.11
BXGC0001325 Progesterone 314.46
BXGC0001502 Caffeine 194.19
BXGC0001550 Ficus Latex peptide 2 244.26
BXGC0001767 (E)-Resveratrol 228.25
BXGC0002012 (Z)-Isoeugenol 164.2
BXGC0002402 Ethyl carbamate 89.09
BXGC0002437 Lactic acid 90.08
BXGC0002441 Hydroxyacetic acid 76.05
BXGC0002627 17alpha-ethynylestradiol 296.4
BXGC0002796 Nicotine 162.23
BXGC0002867 Lappaurin 284.74
BXGC0002906 Caffeic acid ester 284.31
BXGC0002916 Melatonin 232.28
BXGC0003066 Phenols 199.27
BXGC0003131 N,N-Dimethylformamide 73.09
BXGC0003501 Parthenolide 248.32
BXGC0003502 Phenylhydrazine 108.14
BXGC0003611 Latex 416.57
BXGC0003690 Glucokinin 764.94
BXGC0003707 Estrogen 268.36
BXGC0003773 Estriol 288.38
BXGC0003956 Fenugrin E 178.19
BXGC0004261 Propylene glycol 76.09
BXGC0004287 Allyl alcohol 58.08
BXGC0004556 1,2,3-Benzenetriol 126.11
BXGC0004560 Benzoic acid 122.12
BXGC0004565 Benzyl alcohol 108.14
BXGC0004587 (E)-3-Phenyl-2-propenal 132.16
BXGC0004712 Methylparaben 152.15
BXGC0005398 (-)-alpha-Narcotine 413.42
BXGC0005508 Safrole 162.19
BXGC0005624 Genistein 270.24
BXGC0005702 2H-1-Benzopyran-2-one 146.15
BXGC0005879 Eugenol 164.2
BXGC0006105 Methyl salicylate 152.15
BXGC0006115 Xanthotoxin 216.19
BXGC0006125 Nicotinamide 122.12
BXGC0006156 Dicoumarol 336.3
BXGC0006198 Citric acid 192.12
BXGC0006362 Estrone 270.37
BXGC0006366 trans-Ferulic acid 194.18
BXGC0006372 Ergocalciferol 396.65
BXGC0006389 Rotenone 394.42
BXGC0006422 Mercenene 214.05
BXGC0006982 Geraniol 154.25
BXGC0007601 1,8-Cineole 154.25
BXGC0012228 Vitamin D 384.64
BXGC0012243 Ukonan D 151.16
BXGC0013452 Dioctyl phthalate 390.28
BXGC0014695 Loratadine 382.14
BXGC0015594 4-Nonylphenol 220.18
BXGC0015987 L-Mimosine 198.06
BXGC0016470 Camptothecin 348.11
BXGC0016671 Leucovorin 473.17
BXGC0016747 Camphor 152.12
BXGC0016891 Nortriptyline 263.17
BXGC0017115 Cephalexin 347.09
BXGC0017719 Strychnine 334.17
BXGC0018403 Hydroxyprogesterone 330.22
BXGC0018491 Methylprednisolone 374.21
BXGC0019117 Tannic Acid 1700.17
BXGC0019164 Raloxifene 473.17
BXGC0020355 Fomepizole 82.05
BXGC0020800 Testosterone 288.21
BXGC0021077 Aconitine 645.31
BXGC0021478 Lipoic Acid 206.04
BXGC0022544 Digoxin 780.43
BXGC0024141 Hydrocortisone 362.21
BXGC0024386 Atractyloside 724.21
BXGC0024413 Emetine 480.3
BXGC0024729 Mercaptopurine 152.02
BXGC0024988 Nifedipine 346.12
BXGC0025658 Vinblastine 810.42
BXGC0026391 Naloxone 327.15
BXGC0026595 Glycyrrhizin 822.4
BXGC0027374 Glyburide 493.14
BXGC0027421 Paclitaxel 853.33
BXGC0027854 Ethosuximide 141.08
BXGC0028885 Secobarbital 238.13
BXGC0030138 Colchicine 399.17
BXGC0030663 Metformin 129.1
BXGC0030685 Physostigmine 275.16
BXGC0031384 Epinephrine 183.09
BXGC0031622 Podofilox 414.13
BXGC0032368 Sparteine 234.21
BXGC0033776 Cycloheximide 281.16
BXGC0034035 Capsaicin 305.2
BXGC0034768 Vincristine 824.4
BXGC0034778 Artemisinin 282.15
BXGC0034783 Doxorubicin 543.17
BXGC0035519 Amygdalin 457.16
BXGC0037718 Ethacrynic Acid 302.01
BXGC0038963 Dichlorvos 219.95
BXGC0039601 Levocarnitine 161.11
BXGC0039684 Berberine Chloride 336.12
BXGC0040042 Warfarin 308.1
BXGC0040462 Aminosalicylic Acid 153.04
BXGC0041240 Atenolol 266.16
BXGC0042127 Oxyquinoline 145.05
BXGC0042179 Atropine 289.17
BXGC0042211 4-Octylphenol 206.17
BXGC0042222 Propranolol 259.16
BXGC0042339 Terbutaline 225.14
BXGC0042452 Panthenol 205.13
BXGC0042510 Fluoxetine 309.13
BXGC0042519 Glimepiride 490.22
BXGC0042596 Isoniazid 137.06
BXGC0043648 (-)-Camphor 152.12
BXGC0044017 Verapamil 454.28
BXGC0044810 Lamivudine 229.05
BXGC0045812 Trifluoperazine 407.16
BXGC0046139 Aminoglutethimide 232.12
BXGC0046755 Yohimbine 354.19
BXGC0046862 Benzo[Def]Chrysene 252.09
BXGC0046996 Thioguanine 167.03
BXGC0047126 Artemether 298.18
BXGC0049391 Betadex 1134.37
BXGC0049738 Dexibuprofen 206.13
BXGC0050471 Fluorouracil 130.02
BXGC0050816 Galantamine 287.15
BXGC0051524 Ouabain 584.28
BXGC0051982 Mannitol 182.08
BXGC0052021 (R)-Ibuprophen 206.13
BXGC0052374 Reserpine 608.27
BXGC0052878 Bisphenol A 228.12
BXGC0053118 Streptomycin 581.27
BXGC0053261 Antimycin A 548.27
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein