Showing entry for Vitamin D


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0012228
Compound NameVitamin D
Structure
FormulaC27H44O
InchiKeyQYSXJUFSXHHAJI-YRZJJWOYSA-N
SMILES[H][C@@]1(CC[C@@]2([H])\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)CCC1=C)[C@H](C)CCCC(C)C
InchiInChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
IUPAC(1S,3Z)-3-{2-[(1R,3aS,4E,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylidenecyclohexan-1-ol
Molecular Weight384.64
Pubchem Id5280795
Chembl IdCHEMBL1042
Targets of Information Source
DrugBank DB00169
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR approved; nutraceutical agonist
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 50030475
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR - - - 0.21
reviewed BXGT008864 Glycine receptor subunit alpha-1 reviewed Ion channel GLRA1 - - - 400
CHEMBL CHEMBL1042
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Activity - - -
P48281 BXGT010625 Vitamin D3 receptor reviewed - Vdr Activity - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Potency - 15848 nM
P25105 BXGT009021 Platelet-activating factor receptor reviewed G-protein coupled receptor PTAFR Ki - - -
P08311 BXGT006762 Cathepsin G reviewed Enzyme CTSG Ki - - -
P25929 BXGT009078 Neuropeptide Y receptor type 1 reviewed G-protein coupled receptor NPY1R IC50 - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 - - -
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 Ki - - -
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A IC50 - - -
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C IC50 - - -
P21452 BXGT008653 Substance-K receptor reviewed G-protein coupled receptor TACR2 Ki - - -
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 reviewed Kinase FLT1 IC50 - - -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 Ki - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Ki - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Ki - - -
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 IC50 - - -
P07943 BXGT006700 Aldo-keto reductase family 1 member B1 reviewed - Akr1b1 Ki - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 29855 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Activity - - -
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma reviewed Nuclear receptor PPARG Potency - 44668 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Ki - - -
P12530 BXGT007827 Arachidonate 15-lipoxygenase reviewed - ALOX15 Ki - - -
P07943 BXGT006700 Aldo-keto reductase family 1 member B1 reviewed - Akr1b1 IC50 - - -
P51681 BXGT010878 C-C chemokine receptor type 5 reviewed G-protein coupled receptor CCR5 IC50 - - -
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B Ki - - -
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 Ki - - -
P12530 BXGT007827 Arachidonate 15-lipoxygenase reviewed - ALOX15 IC50 - - -
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 Ki - - -
P13945 BXGT007972 Beta-3 adrenergic receptor reviewed G-protein coupled receptor ADRB3 IC50 - - -
P30411 BXGT009424 B2 bradykinin receptor reviewed G-protein coupled receptor BDKRB2 IC50 - - -
P41597 BXGT010268 C-C chemokine receptor type 2 reviewed - CCR2 IC50 - - -
P20781 BXGT008598 Glycine receptor subunit beta reviewed - Glrb Ki - - -
P07727 BXGT006662 Glycine receptor subunit alpha-1 reviewed - Glra1 Ki - - -
P24524 BXGT008974 Glycine receptor subunit alpha-3 reviewed - Glra3 Ki - - -
P22771 BXGT008806 Glycine receptor subunit alpha-2 reviewed - Glra2 Ki - - -
P03956 BXGT006120 Interstitial collagenase reviewed Enzyme MMP1 Ki - - -
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK IC50 - - -
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Ki - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 31622 nM
P08588 BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 IC50 - - -
P25025 BXGT009006 C-X-C chemokine receptor type 2 reviewed G-protein coupled receptor CXCR2 Ki - - -
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 11220 nM
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency - 70794 nM
P51449 BXGT010846 Nuclear receptor ROR-gamma reviewed Nuclear receptor RORC Potency - 37578 nM
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a Ki - - -
P32238 BXGT009611 Cholecystokinin receptor type A reviewed G-protein coupled receptor CCKAR Ki - - -
P48281 BXGT010625 Vitamin D3 receptor reviewed - Vdr FC '=' 5786 -
P23415 BXGT008864 Glycine receptor subunit alpha-1 reviewed Ion channel GLRA1 Activity '=' 216 %
P22310 BXGT008754 UDP-glucuronosyltransferase 1-4 reviewed - UGT1A4 Activity '=' 0 pm/min/mg
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 22387 nM
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA Ki - - -
P24557 BXGT008976 Thromboxane-A synthase reviewed - TBXAS1 Ki - - -
P04035 BXGT006129 3-hydroxy-3-methylglutaryl-coenzyme A reductase reviewed - HMGCR Ki - - -
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE IC50 - - -
P48281 BXGT010625 Vitamin D3 receptor reviewed - Vdr FC '=' 764 -
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Activity '>' 100 uM
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 IC50 - - -
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 IC50 - - -
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C reviewed Enzyme PTPRC Ki - - -
P28564 BXGT009272 5-hydroxytryptamine receptor 1B reviewed - Htr1b IC50 - - -
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A Ki - - -
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 IC50 - - -
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 44668 nM
P10275 BXGT007552 Androgen receptor reviewed Nuclear receptor AR Potency - 35481 nM
Q16637 BXGT013646 Survival motor neuron protein reviewed Epigenetic regulator SMN1 Potency '=' 25118 nM
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA IC50 - - -
P25779 BXGT009067 Cruzipain reviewed - Potency '=' 25118 nM
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 IC50 - - -
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 Ki - - -
P20781 BXGT008598 Glycine receptor subunit beta reviewed - Glrb IC50 - - -
P07727 BXGT006662 Glycine receptor subunit alpha-1 reviewed - Glra1 IC50 - - -
P24524 BXGT008974 Glycine receptor subunit alpha-3 reviewed - Glra3 IC50 - - -
P22771 BXGT008806 Glycine receptor subunit alpha-2 reviewed - Glra2 IC50 - - -
P33032 BXGT009689 Melanocortin receptor 5 reviewed G-protein coupled receptor MC5R IC50 - - -
P33032 BXGT009689 Melanocortin receptor 5 reviewed G-protein coupled receptor MC5R Ki - - -
P49146 BXGT010681 Neuropeptide Y receptor type 2 reviewed G-protein coupled receptor NPY2R IC50 - - -
P29476 BXGT009354 Nitric oxide synthase, brain reviewed - Nos1 IC50 - - -
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 IC50 - - -
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 Ki - - -
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform reviewed - PPP3CA IC50 - - -
P25103 BXGT009020 Substance-P receptor reviewed G-protein coupled receptor TACR1 Ki - - -
A6XA80 BXGT001522 Leukotriene C4 synthase reviewed - LTC4S IC50 - - -
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 Ki - - -
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 IC50 - - -
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 31622 nM
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 Ki - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Ki - - -
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 IC50 - - -
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a IC50 - - -
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D Ki - - -
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Ki - - -
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C IC50 - - -
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Ki - - -
P50052 BXGT010768 Type-2 angiotensin II receptor reviewed G-protein coupled receptor AGTR2 IC50 - - -
P41597 BXGT010268 C-C chemokine receptor type 2 reviewed - CCR2 Ki - - -
P51679 BXGT010877 C-C chemokine receptor type 4 reviewed G-protein coupled receptor CCR4 Ki - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Potency - 22387 nM
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 Ki - - -
P15207 BXGT008096 Androgen receptor reviewed - Ar IC50 - - -
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 Ki - - -
P21452 BXGT008653 Substance-K receptor reviewed G-protein coupled receptor TACR2 IC50 - - -
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 IC50 - - -
Q690N0 BXGT016199 Progesterone receptor unreviewed - PGR Ki - - -
P32245 BXGT009614 Melanocortin receptor 4 reviewed G-protein coupled receptor MC4R Ki - - -
O70528 BXGT005068 5-hydroxytryptamine receptor 4 reviewed - HTR4 Ki - - -
P48281 BXGT010625 Vitamin D3 receptor reviewed - Vdr FC '=' 8336 -
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 12589 nM
P48281 BXGT010625 Vitamin D3 receptor reviewed - Vdr Inhibition '=' 8336 %
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 Ki - - -
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 Ki - - -
P08311 BXGT006762 Cathepsin G reviewed Enzyme CTSG IC50 - - -
P23415 BXGT008864 Glycine receptor subunit alpha-1 reviewed Ion channel GLRA1 EC50 '=' 400 nM
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 Ki - - -
P30988 BXGT009491 Calcitonin receptor reviewed G-protein coupled receptor CALCR IC50 - - -
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 Ki - - -
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a IC50 - - -
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 IC50 - - -
P02791 BXGT005965 Ferritin light chain reviewed - FTL Potency '=' 22387 nM
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 IC50 - - -
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 Ki - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ki - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 - - -
P51679 BXGT010877 C-C chemokine receptor type 4 reviewed G-protein coupled receptor CCR4 IC50 - - -
P30988 BXGT009491 Calcitonin receptor reviewed G-protein coupled receptor CALCR Ki - - -
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B IC50 - - -
P23975 BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 IC50 - - -
P32238 BXGT009611 Cholecystokinin receptor type A reviewed G-protein coupled receptor CCKAR IC50 - - -
P25779 BXGT009067 Cruzipain reviewed - Potency '=' 28183 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 IC50 - - -
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A IC50 - - -
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Ki - - -
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 IC50 - - -
P13945 BXGT007972 Beta-3 adrenergic receptor reviewed G-protein coupled receptor ADRB3 Ki - - -
P30411 BXGT009424 B2 bradykinin receptor reviewed G-protein coupled receptor BDKRB2 Ki - - -
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 Ki - - -
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA Ki - - -
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 Ki - - -
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C reviewed Enzyme PTPRC IC50 - - -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 - - -
P15127 BXGT008085 Insulin receptor reviewed - Insr Ki - - -
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 IC50 - - -
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 IC50 - - -
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 IC50 - - -
P48281 BXGT010625 Vitamin D3 receptor reviewed - Vdr FC '=' 8000 -
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D IC50 - - -
P25929 BXGT009078 Neuropeptide Y receptor type 1 reviewed G-protein coupled receptor NPY1R Ki - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 - - -
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 IC50 - - -
P03956 BXGT006120 Interstitial collagenase reviewed Enzyme MMP1 IC50 - - -
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Ki - - -
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR Ki - - -
P06241 BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN Ki - - -
P11509 BXGT007716 Cytochrome P450 2A6 reviewed - CYP2A6 IC50 - - -
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 Ki - - -
P41968 BXGT010275 Melanocortin receptor 3 reviewed G-protein coupled receptor MC3R Ki - - -
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 Ki - - -
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 Ki - - -
Q690N0 BXGT016199 Progesterone receptor unreviewed - PGR IC50 - - -
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE Ki - - -
P25025 BXGT009006 C-X-C chemokine receptor type 2 reviewed G-protein coupled receptor CXCR2 IC50 - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Ki - - -
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 IC50 - - -
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 23715 nM
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 Ki - - -
P11509 BXGT007716 Cytochrome P450 2A6 reviewed - CYP2A6 Ki - - -
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 IC50 - - -
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a Ki - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 IC50 - - -
Q01959 BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 IC50 - - -
P25101 BXGT009018 Endothelin-1 receptor reviewed G-protein coupled receptor EDNRA Ki - - -
P25103 BXGT009020 Substance-P receptor reviewed G-protein coupled receptor TACR1 IC50 - - -
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR FC '=' 4 -
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b IC50 - - -
P50052 BXGT010768 Type-2 angiotensin II receptor reviewed G-protein coupled receptor AGTR2 Ki - - -
P25024 BXGT009005 C-X-C chemokine receptor type 1 reviewed G-protein coupled receptor CXCR1 IC50 - - -
Q01959 BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 Ki - - -
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 IC50 - - -
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 Ki - - -
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 IC50 - - -
P04276 BXGT006181 Vitamin D-binding protein reviewed - Gc B50 '=' 0 M
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 IC50 - - -
P37288 BXGT009977 Vasopressin V1a receptor reviewed G-protein coupled receptor AVPR1A IC50 - - -
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C Ki - - -
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 Ki - - -
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 Ki - - -
P32241 BXGT009613 Vasoactive intestinal polypeptide receptor 1 reviewed G-protein coupled receptor VIPR1 Ki - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 IC50 - - -
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 22387 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 31622 nM
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 IC50 - - -
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 IC50 - - -
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 Ki - - -
P23975 BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 Ki - - -
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 IC50 - - -
P51681 BXGT010878 C-C chemokine receptor type 5 reviewed G-protein coupled receptor CCR5 Ki - - -
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 IC50 - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 IC50 - - -
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 Ki - - -
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 IC50 - - -
P49146 BXGT010681 Neuropeptide Y receptor type 2 reviewed G-protein coupled receptor NPY2R Ki - - -
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 IC50 - - -
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B IC50 - - -
P24557 BXGT008976 Thromboxane-A synthase reviewed - TBXAS1 IC50 - - -
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 reviewed Kinase FLT1 Ki - - -
P23415 BXGT008864 Glycine receptor subunit alpha-1 reviewed Ion channel GLRA1 %max '=' 220 %
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 17782 nM
Q03181 BXGT012701 Peroxisome proliferator-activated receptor delta reviewed Nuclear receptor PPARD Potency - 39810 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR FC '=' 149 -
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 Potency '=' 15848 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 35481 nM
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki - - -
P25101 BXGT009018 Endothelin-1 receptor reviewed G-protein coupled receptor EDNRA IC50 - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ki - - -
P15127 BXGT008085 Insulin receptor reviewed - Insr IC50 - - -
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA IC50 - - -
P29476 BXGT009354 Nitric oxide synthase, brain reviewed - Nos1 Ki - - -
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A IC50 - - -
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b Ki - - -
P08588 BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 Ki - - -
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 4466 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR EC50 '=' 0 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 IC50 - - -
P04035 BXGT006129 3-hydroxy-3-methylglutaryl-coenzyme A reductase reviewed - HMGCR IC50 - - -
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 Ki - - -
P12822 BXGT007850 Angiotensin-converting enzyme reviewed - ACE IC50 - - -
P32241 BXGT009613 Vasoactive intestinal polypeptide receptor 1 reviewed G-protein coupled receptor VIPR1 IC50 - - -
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - PDE5A Ki - - -
Q9Y271 BXGT022222 Cysteinyl leukotriene receptor 1 reviewed G-protein coupled receptor CYSLTR1 IC50 - - -
P12822 BXGT007850 Angiotensin-converting enzyme reviewed - ACE Ki - - -
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Activity '=' 8336 uM
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 Ki - - -
P28564 BXGT009272 5-hydroxytryptamine receptor 1B reviewed - Htr1b Ki - - -
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 25118 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 39810 nM
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 Ki - - -
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 IC50 - - -
A6XA80 BXGT001522 Leukotriene C4 synthase reviewed - LTC4S Ki - - -
Q9Y271 BXGT022222 Cysteinyl leukotriene receptor 1 reviewed G-protein coupled receptor CYSLTR1 Ki - - -
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR IC50 - - -
P37288 BXGT009977 Vasopressin V1a receptor reviewed G-protein coupled receptor AVPR1A Ki - - -
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform reviewed - PPP3CA Ki - - -
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK Ki - - -
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 IC50 - - -
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 3162 nM
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 Ki - - -
P48281 BXGT010625 Vitamin D3 receptor reviewed - Vdr FC '=' 274 -
O70528 BXGT005068 5-hydroxytryptamine receptor 4 reviewed - HTR4 IC50 - - -
P10145 BXGT007542 Interleukin-8 reviewed Signaling CXCL8 Potency - 66824 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 23710 nM
P36544 BXGT009926 Neuronal acetylcholine receptor subunit alpha-7 reviewed - CHRNA7 Activity - - -
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 Activity '=' 0 pm/min/mg
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 35481 nM
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 15848 nM
Q99835 BXGT019969 Smoothened homolog reviewed G-protein coupled receptor SMO Inhibition - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 - - -
P25105 BXGT009021 Platelet-activating factor receptor reviewed G-protein coupled receptor PTAFR IC50 - - -
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR FC '=' 1063 -
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 IC50 - - -
P15207 BXGT008096 Androgen receptor reviewed - Ar Ki - - -
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Ki - - -
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 IC50 - - -
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - PDE5A IC50 - - -
Q96RI1 BXGT019727 Bile acid receptor reviewed Nuclear receptor NR1H4 Potency - 44668 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 44668 nM
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Ki - - -
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 Ki - - -
Q99835 BXGT019969 Smoothened homolog reviewed G-protein coupled receptor SMO Activity '=' 35 %
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 50118 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 42163 nM
P10828 BXGT007624 Thyroid hormone receptor beta reviewed Nuclear receptor THRB Potency - 44668 nM
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 IC50 - - -
P25024 BXGT009005 C-X-C chemokine receptor type 1 reviewed G-protein coupled receptor CXCR1 Ki - - -
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Potency - 50118 nM
P41968 BXGT010275 Melanocortin receptor 3 reviewed G-protein coupled receptor MC3R IC50 - - -
P32245 BXGT009614 Melanocortin receptor 4 reviewed G-protein coupled receptor MC4R IC50 - - -
P06241 BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN IC50 - - -
P19793 BXGT008515 Retinoic acid receptor RXR-alpha reviewed Nuclear receptor RXRA Potency - 19952 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR K '>' 100 uM
P08659 BXGT006805 Luciferin 4-monooxygenase reviewed - Potency - 28695 nM
P48281 BXGT010625 Vitamin D3 receptor reviewed - Vdr Activity '=' 764 %
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00057 Sweet orange Citrus sinensis Fruits
BXGF00072 Wild carrot Daucus carota Vegetables
BXGF00130 Avocado Persea americana Vegetables
BXGF00175 Potato Solanum tuberosum Vegetables
BXGF00181 Dandelion Taraxacum officinale Herbs and Spices
BXGF00230 Carrot Daucus carota ssp. sativus Vegetables
BXGF00249 Other bread Cereals and cereal products
BXGF00250 Breakfast cereal Cereals and cereal products
BXGF00253 Pasta Cereals and cereal products
BXGF00254 Biscuit Cereals and cereal products
BXGF00270 Atlantic herring Clupea harengus harengus Aquatic foods
BXGF00271 Atlantic mackerel Scomber scombrus Aquatic foods
BXGF00272 Painted comber Serranus scriba Aquatic foods
BXGF00273 Atlantic pollock Pollachius pollachius Aquatic foods
BXGF00274 Atlantic wolffish Anarhichas lupus Aquatic foods
BXGF00278 Beluga whale Delphinapterus leucas Aquatic foods
BXGF00282 Northern bluefin tuna Thunnus thynnus Aquatic foods
BXGF00288 Burbot Lota lota Aquatic foods
BXGF00297 Common carp Cyprinus carpio Aquatic foods
BXGF00299 Channel catfish Ictalurus punctatus Aquatic foods
BXGF00308 Cisco Coregonus artedi Aquatic foods
BXGF00311 Pacific cod Gadus macrocephalus Aquatic foods
BXGF00312 Atlantic cod Gadus morhua Aquatic foods
BXGF00313 Common octopus Octopus vulgaris Aquatic foods
BXGF00319 Atlantic croaker Micropogonias undulatus Aquatic foods
BXGF00328 Eastern oyster Crassostrea virginica Aquatic foods
BXGF00329 Freshwater eel Anguilla Aquatic foods
BXGF00332 European anchovy Engraulis encrasicolus Aquatic foods
BXGF00336 Florida pompano Trachinotus carolinus Aquatic foods
BXGF00339 Greenland halibut/turbot Reinhardtius hippoglossoides Aquatic foods
BXGF00342 Haddock Melanogrammus aeglefinus Aquatic foods
BXGF00343 Hippoglossus (Common halibut) Hippoglossus Aquatic foods
BXGF00350 Pacific jack mackerel Trachurus symmetricus Aquatic foods
BXGF00366 American lobster Homarus americanus Aquatic foods
BXGF00379 Striped mullet Mugil cephalus Aquatic foods
BXGF00389 Spotted seal Phoca largha Aquatic foods
BXGF00392 Pacific rockfish Sebastes Aquatic foods
BXGF00395 Northern pike Esox lucius Aquatic foods
BXGF00406 Rainbow smelt Osmerus mordax Aquatic foods
BXGF00407 Rainbow trout Oncorhynchus mykiss Aquatic foods
BXGF00413 Pink salmon Oncorhynchus gorbuscha Aquatic foods
BXGF00414 Chum salmon Oncorhynchus keta Aquatic foods
BXGF00415 Coho salmon Oncorhynchus kisutch Aquatic foods
BXGF00416 Sockeye salmon Oncorhynchus nerka Aquatic foods
BXGF00417 Chinook salmon Oncorhynchus tshawytscha Aquatic foods
BXGF00423 Spanish mackerel Scomberomorus maculatus Aquatic foods
BXGF00424 Pacific sardine Sardinops sagax Aquatic foods
BXGF00425 Scallop Pectinidae Aquatic foods
BXGF00426 Scup Stenotomus chrysops Aquatic foods
BXGF00428 Steller sea lion Eumetopias jubatus Aquatic foods
BXGF00429 Bearded seal Erignathus barbatus Aquatic foods
BXGF00433 American shad Alosa sapidissima Aquatic foods
BXGF00434 Shark Squaliformes Aquatic foods
BXGF00439 Snapper Lutjanidae Aquatic foods
BXGF00444 Greater sturgeon Acipenser Aquatic foods
BXGF00448 Swordfish Xiphias gladius Aquatic foods
BXGF00454 Salmonidae (Salmon, Trout) Salmonidae Aquatic foods
BXGF00455 Cattle (Beef, Veal) Bos taurus Animal foods
BXGF00457 Alaska pollock Theragra chalcogramma Aquatic foods
BXGF00462 Whitefish Coregonus Aquatic foods
BXGF00463 Whiting Merlangius merlangus Aquatic foods
BXGF00470 Yellowfin tuna Thunnus albacares Aquatic foods
BXGF00472 Pollock Pollachius Aquatic foods
BXGF00473 Albacore tuna Thunnus alalunga Aquatic foods
BXGF00474 Gadus (Common cod) Gadus Aquatic foods
BXGF00475 Atlantic halibut Hippoglossus hippoglossus Aquatic foods
BXGF00478 Clupeinae (Herring, Sardine, Sprat) Clupeinae Aquatic foods
BXGF00484 Percoidei (Bass and others) Percoidei Aquatic foods
BXGF00485 Perciformes (Perch-like fishes) Perciformes Aquatic foods
BXGF00489 Bivalvia (Clam, Mussel, Oyster) Bivalvia Aquatic foods
BXGF00491 Shrimp Caridea Aquatic foods
BXGF00492 Crayfish Astacidea Aquatic foods
BXGF00493 Flatfish Pleuronectiformes Aquatic foods
BXGF00494 Domestic pig (Piglet, Pork) Sus scrofa domestica Animal foods
BXGF00499 Quail Phasianidae Animal foods
BXGF00505 Common mushroom Agaricus bisporus Vegetables
BXGF00506 Shiitake Lentinus edodes Vegetables
BXGF00509 Enokitake Flammulina velutipes Vegetables
BXGF00511 Oyster mushroom Pleurotus ostreatus Vegetables
BXGF00513 Maitake Grifola frondosa Vegetables
BXGF00519 Wheat Triticum Cereals and cereal products
BXGF00524 Anchovy Engraulidae Aquatic foods
BXGF00526 Carp bream Abramis brama Aquatic foods
BXGF00527 Chanterelle Cantharellus cibarius Vegetables
BXGF00528 Sturgeon Acipenseridae Aquatic foods
BXGF00529 Charr Salvelinus Aquatic foods
BXGF00532 Common dab Limanda limanda Aquatic foods
BXGF00533 Spiny dogfish Squalus acanthias Aquatic foods
BXGF00534 Anatidae (Duck, Goose, Swan) Anatidae Animal foods
BXGF00535 Anguilliformes (Eel) Anguilliformes Aquatic foods
BXGF00536 True frog Ranidae Aquatic foods
BXGF00537 Garfish Belone belone Aquatic foods
BXGF00540 Lake trout Salvelinus namaycush Aquatic foods
BXGF00543 Lumpsucker Cyclopteridae Aquatic foods
BXGF00544 Scombridae (Bonito, Mackerel, Tuna) Scombridae Aquatic foods
BXGF00550 True oyster Ostreidae Aquatic foods
BXGF00553 Pikeperch Sander lucioperca Aquatic foods
BXGF00554 Pleuronectidae (Dab, Halibut, Plaice) Pleuronectidae Aquatic foods
BXGF00558 True seal Phocidae Aquatic foods
BXGF00562 True sole Soleidae Aquatic foods
BXGF00563 Catfish Siluriformes Aquatic foods
BXGF00565 Thunnus (Common tuna) Thunnus Aquatic foods
BXGF00568 Columbidae (Dove, Pigeon) Columbidae Animal foods
BXGF00574 Cheese Milk and milk products
BXGF00575 Milk (Cow) Milk and milk products
BXGF00576 Eggs Eggs
BXGF00577 Yogurt Milk and milk products
BXGF00581 Ice cream Confectioneries
BXGF00593 Cake Confectioneries
BXGF00595 Ymer Milk and milk products
BXGF00596 Other snack food Snack foods
BXGF00597 Crisp bread Cereals and cereal products
BXGF00598 Pastry Confectioneries
BXGF00602 Salad dressing Baking goods
BXGF00603 Sauce Baking goods
BXGF00605 Butter Milk and milk products
BXGF00607 Cream Milk and milk products
BXGF00609 Sausage Dishes
BXGF00615 Whey Milk and milk products
BXGF00622 Other fish product Aquatic foods
BXGF00623 Milk (Human) Milk and milk products
BXGF00624 Other beverage Beverages
BXGF00625 Baby food Baby foods
BXGF00627 Soup Dishes
BXGF00631 Tallow Fats and oils
BXGF00632 Remoulade Baking goods
BXGF00638 Lard Fats and oils
BXGF00639 Other animal fat Fats and oils
BXGF00641 Cocoa powder Cocoa and cocoa products
BXGF00643 Hot chocolate Cocoa and cocoa products
BXGF00644 Dried milk Milk and milk products
BXGF00645 Milk (Other mammals) Milk and milk products
BXGF00646 Kefir Milk and milk products
BXGF00647 Buttermilk Milk and milk products
BXGF00648 Other fermented milk Milk and milk products
BXGF00651 Tofu Soy
BXGF00653 Roe Aquatic foods
BXGF00654 Cichlidae (Tilapia) Cichlidae Aquatic foods
BXGF00655 Icing Confectioneries
BXGF00656 Snack bar Snack foods
BXGF00659 Burrito Dishes
BXGF00660 Hamburger Dishes
BXGF00662 Chili Dishes
BXGF00663 Taco Dishes
BXGF00666 Processed cheese Milk and milk products
BXGF00667 Salad Dishes
BXGF00669 Dulce de leche Confectioneries
BXGF00670 Topping Baking goods
BXGF00671 Sweet custard Confectioneries
BXGF00672 Egg roll Dishes
BXGF00677 Corn chip Snack foods
BXGF00681 Junket Confectioneries
BXGF00684 Other frozen dessert Confectioneries
BXGF00686 Morchella (Morel) Morchellaceae Vegetables
BXGF00687 Pancake Dishes
BXGF00689 Pudding Confectioneries
BXGF00690 Waffle Dishes
BXGF00691 Soy milk Soy
BXGF00692 Meatloaf Dishes
BXGF00703 Quesadilla Dishes
BXGF00706 Spread Baking goods
BXGF00708 Egg substitute Baking goods
BXGF00709 Nutritional drink Beverages
BXGF00710 Other sandwich Dishes
BXGF00712 Breakfast sandwich Dishes
BXGF00715 Butterfat Milk and milk products
BXGF00722 Soy yogurt Soy
BXGF00724 Cold cut Dishes
BXGF00734 Pie crust Baking goods
BXGF00736 Pie Confectioneries
BXGF00739 Ice cream cone Baking goods
BXGF00741 Cracker Snack foods
BXGF00745 Ravioli Dishes
BXGF00746 Scrapple Dishes
BXGF00747 Other pasta dish Dishes
BXGF00752 Evaporated milk Milk and milk products
BXGF00764 Potato bread Cereals and cereal products
BXGF00774 Fruit-flavor drink Beverages
BXGF00778 Frozen yogurt Confectioneries
BXGF00779 Milkshake Confectioneries
BXGF00781 Dripping Fats and oils
BXGF00789 Other dish Dishes
BXGF00790 Pot pie Dishes
BXGF00791 Stuffing Baking goods
BXGF00794 Candy bar Confectioneries
BXGF00795 Condensed milk Milk and milk products
BXGF00796 Margarine Fats and oils
BXGF00797 Margarine-like spread Fats and oils
BXGF00801 Milk substitute Baking goods
BXGF00841 Cow milk, pasteurized, vitamin A + D added, 0% fat Milk and milk products
BXGF00842 Cow milk, pasteurized, vitamin A + D added, 1% fat Milk and milk products
BXGF00843 Cow milk, pasteurized, vitamin A + D added, 2% fat Milk and milk products
BXGF00844 Cow milk, pasteurized, vitamin D added, 3.25% fat Milk and milk products
BXGF02086 Celastrus vulcanicola Celastrus vulcanicola Others
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease