Showing entry for Galantamine


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0050816
Compound NameGalantamine
Structure
FormulaC17H21NO3
InchiKeyASUTZQLVASHGKV-JDFRZJQESA-N
SMILESCOc1ccc2c3c1O[C@@H]1[C@@]3(CCN(C2)C)C=C[C@@H](C1)O
InchiInChI=1S/C17H21NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,12,14,19H,7-10H2,1-2H3/t12-,14-,17-/m0/s1
IUPAC
Molecular Weight287.15
Pubchem Id9651
Chembl IdCHEMBL659
Targets of Information Source
DrugBank DB00674
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE approved inhibitor
P36544 BXGT009926 Neuronal acetylcholine receptor subunit alpha-7 reviewed - CHRNA7 approved allosteric modulator
A9X444 BXGT022677 Muscle nicotinic acetylcholine receptor (Fragment) unreviewed - - approved allosteric modulator
P06276 BXGT006430 Cholinesterase reviewed - BCHE approved inhibitor
PDB GNT
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P04058 BXGT006139 Acetylcholinesterase reviewed ache - - - - -
P04058 BXGT006139 Acetylcholinesterase reviewed ache - - 702 - -
Q8WSF8 BXGT018982 Soluble acetylcholine receptor unreviewed - - - - -
P22303 BXGT008751 Acetylcholinesterase reviewed ACHE Enzyme - - - -
Binding DB 10404
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT006139 Acetylcholinesterase reviewed ache - 418 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 614 - -
reviewed BXGT006139 Acetylcholinesterase reviewed ache - 360 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 800 - -
reviewed BXGT006430 Cholinesterase reviewed BCHE - 7300 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 360 - -
reviewed BXGT006430 Cholinesterase reviewed BCHE - >10000 - -
reviewed BXGT006139 Acetylcholinesterase reviewed ache 190 - - -
reviewed BXGT006430 Cholinesterase reviewed BCHE - 8500 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 4000 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 2410 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 665 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 3500 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 540 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 2600 - -
reviewed BXGT006430 Cholinesterase reviewed BCHE - 66500 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 1540 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 400 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 530 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 700 - -
reviewed BXGT006430 Cholinesterase reviewed BCHE - 21900 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - - - 1100
reviewed BXGT009967 Acetylcholinesterase reviewed Ache - 538 - -
reviewed BXGT009967 Acetylcholinesterase reviewed Ache - 750 - -
reviewed BXGT006430 Cholinesterase reviewed BCHE - 8000 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 500 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 1100 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 2090 - -
reviewed BXGT011959 Cholinesterase reviewed BCHE - 19340 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 550 - -
reviewed BXGT011959 Cholinesterase reviewed BCHE - 12700 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 2670 - -
reviewed BXGT011959 Cholinesterase reviewed BCHE 9370 - - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache 540 - - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 980 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 35000 - -
reviewed BXGT006430 Cholinesterase reviewed BCHE - 18000 - -
reviewed BXGT008694 Acetylcholinesterase reviewed Ache - 2080 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 2000 - -
reviewed BXGT006430 Cholinesterase reviewed BCHE - 12700 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 2670 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE 62 - - -
reviewed BXGT006430 Cholinesterase reviewed BCHE 193 - - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 3200 - -
reviewed BXGT006430 Cholinesterase reviewed BCHE - 0.38 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache 440 - - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache 1560 - - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 2200 - -
reviewed BXGT011959 Cholinesterase reviewed BCHE - 16900 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE 250 - - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 640 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 600 - -
reviewed BXGT006430 Cholinesterase reviewed BCHE - 8400 - -
reviewed BXGT011959 Cholinesterase reviewed BCHE - 8500 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 3180 - -
reviewed BXGT006139 Acetylcholinesterase reviewed ache - 550 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 90000 - -
reviewed BXGT006139 Acetylcholinesterase reviewed ache - 1069 - -
reviewed BXGT011959 Cholinesterase reviewed BCHE - 17380 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 1820 - -
reviewed BXGT009967 Acetylcholinesterase reviewed Ache - 1165 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 500 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 350 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 2010 - -
reviewed BXGT009967 Acetylcholinesterase reviewed Ache - 1030000 - -
reviewed BXGT011959 Cholinesterase reviewed BCHE - 28300 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 300 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 550 - -
reviewed BXGT011959 Cholinesterase reviewed BCHE - 14400 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 73900 - -
reviewed BXGT006430 Cholinesterase reviewed BCHE - 50900 - -
reviewed BXGT006430 Cholinesterase reviewed BCHE 28290 - - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 480 - -
reviewed BXGT011959 Cholinesterase reviewed BCHE - 22390 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 3120 - -
reviewed BXGT011959 Cholinesterase reviewed BCHE - 15800 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 12730 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 610 - -
reviewed BXGT006430 Cholinesterase reviewed BCHE - 10000 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 1300 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 4480 - -
reviewed BXGT011959 Cholinesterase reviewed BCHE - 46030 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 560 - -
reviewed BXGT011959 Cholinesterase reviewed BCHE 2070 - - -
reviewed BXGT011959 Cholinesterase reviewed BCHE - 11900 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 2050 - -
reviewed BXGT011959 Cholinesterase reviewed BCHE - 18130 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 623 - -
reviewed BXGT011959 Cholinesterase reviewed BCHE - 15700 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 636 - -
reviewed BXGT011959 Cholinesterase reviewed BCHE - 8404 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 670 - -
reviewed BXGT011959 Cholinesterase reviewed BCHE - 1520 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache 428 - - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE 300 - - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 530 - -
reviewed BXGT011959 Cholinesterase reviewed BCHE - 3200 - -
reviewed BXGT011959 Cholinesterase reviewed BCHE - 8400 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 3800 - -
reviewed BXGT006430 Cholinesterase reviewed BCHE - 18600 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 7300 - -
reviewed BXGT011959 Cholinesterase reviewed BCHE - 12600 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 100 - -
reviewed BXGT009967 Acetylcholinesterase reviewed Ache - 1760 - -
reviewed BXGT009967 Acetylcholinesterase reviewed Ache - 630 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 590 - -
reviewed BXGT006430 Cholinesterase reviewed BCHE - 20700 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 1070 - -
reviewed BXGT009967 Acetylcholinesterase reviewed Ache - 920 - -
reviewed BXGT011959 Cholinesterase reviewed BCHE - 15240 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache 450 - - -
reviewed BXGT006139 Acetylcholinesterase reviewed ache - 6.5 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 3.5 - -
reviewed BXGT006430 Cholinesterase reviewed BCHE - 19 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 3200 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 1180 - -
reviewed BXGT006139 Acetylcholinesterase reviewed ache - 590 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 2100 - -
reviewed BXGT008908 Acetylcholinesterase reviewed ACHE - 8700 - -
reviewed BXGT011959 Cholinesterase reviewed BCHE - 24400 - -
reviewed BXGT011959 Cholinesterase reviewed BCHE - 12000 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 2000 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 600 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 1000 - -
reviewed BXGT006430 Cholinesterase reviewed BCHE 192 - - -
reviewed BXGT012555 Glutamate receptor ionotropic, NMDA 2B reviewed Grin2b >100000 - - -
reviewed BXGT009967 Acetylcholinesterase reviewed Ache - 2550 - -
reviewed BXGT006430 Cholinesterase reviewed BCHE - 7000 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache 1060 - - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 7440 - -
reviewed BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE - 2090 - -
reviewed BXGT011959 Cholinesterase reviewed BCHE - 7960 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 1450 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 4420 - -
reviewed BXGT008694 Acetylcholinesterase reviewed Ache - 2500 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 2400 - -
reviewed BXGT004559 Acetylcholinesterase reviewed ache - 10530 - -
reviewed BXGT011959 Cholinesterase reviewed BCHE - 39030 - -
CHEMBL CHEMBL659
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 7300 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 2090 nM
P41968 BXGT010275 Melanocortin receptor 3 reviewed G-protein coupled receptor MC3R IC50 - - -
P41968 BXGT010275 Melanocortin receptor 3 reviewed G-protein coupled receptor MC3R Ki - - -
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 IC50 - - -
P25024 BXGT009005 C-X-C chemokine receptor type 1 reviewed G-protein coupled receptor CXCR1 IC50 - - -
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 IC50 - - -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 Ki - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 IC50 - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ki - - -
P37136 BXGT009967 Acetylcholinesterase reviewed - Ache IC50 '=' 1760 nM
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b Ki - - -
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 12730 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 550 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Inhibition '=' 61 %
Q9N1N9 BXGT021115 Carboxylic ester hydrolase unreviewed - BCHE Ki '=' 8000 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 '=' 12700 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 635 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Ki '=' 61 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 90000 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 350 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 '=' 8400 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Ratio IC50 '=' 9 -
P06276 BXGT006430 Cholinesterase reviewed - BCHE Ratio IC50 '=' 9 -
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 560 nM
Q9N1N9 BXGT021115 Carboxylic ester hydrolase unreviewed - BCHE IC50 '=' 8394 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 980 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 '=' 15700 nM
P13945 BXGT007972 Beta-3 adrenergic receptor reviewed G-protein coupled receptor ADRB3 IC50 - - -
P41597 BXGT010268 C-C chemokine receptor type 2 reviewed - CCR2 IC50 - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 Ki - - -
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D Ki - - -
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B IC50 - - -
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 10530 nM
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 Ki - - -
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 Ki - - -
P15207 BXGT008096 Androgen receptor reviewed - Ar IC50 - - -
P24557 BXGT008976 Thromboxane-A synthase reviewed - TBXAS1 Ki - - -
P37288 BXGT009977 Vasopressin V1a receptor reviewed G-protein coupled receptor AVPR1A IC50 - - -
P03956 BXGT006120 Interstitial collagenase reviewed Enzyme MMP1 Ki - - -
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C reviewed Enzyme PTPRC Ki - - -
P49146 BXGT010681 Neuropeptide Y receptor type 2 reviewed G-protein coupled receptor NPY2R IC50 - - -
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - PDE5A IC50 - - -
P07943 BXGT006700 Aldo-keto reductase family 1 member B1 reviewed - Akr1b1 Ki - - -
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 IC50 - - -
P25024 BXGT009005 C-X-C chemokine receptor type 1 reviewed G-protein coupled receptor CXCR1 Ki - - -
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 IC50 - - -
Q01959 BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 IC50 - - -
Q01959 BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 Ki - - -
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 IC50 - - -
Q9Y271 BXGT022222 Cysteinyl leukotriene receptor 1 reviewed G-protein coupled receptor CYSLTR1 IC50 - - -
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 Ki - - -
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 640 nM
P06276 BXGT006430 Cholinesterase reviewed - BCHE Ki '=' 28290 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 2670 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Ki - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Inhibition '=' 97 %
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 2200 nM
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 6 ug.mL-1
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 15800 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 530 nM
P37136 BXGT009967 Acetylcholinesterase reviewed - Ache IC50 '=' 538 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 3200 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 623 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE MIC '=' 0 ug
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 '=' 19340 nM
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 Ki - - -
P20781 BXGT008598 Glycine receptor subunit beta reviewed - Glrb IC50 - - -
P07727 BXGT006662 Glycine receptor subunit alpha-1 reviewed - Glra1 IC50 - - -
P24524 BXGT008974 Glycine receptor subunit alpha-3 reviewed - Glra3 IC50 - - -
P22771 BXGT008806 Glycine receptor subunit alpha-2 reviewed - Glra2 IC50 - - -
P12530 BXGT007827 Arachidonate 15-lipoxygenase reviewed - ALOX15 Ki - - -
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 Ki - - -
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 '=' 39030 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 '=' 13610 nM
Q13224 BXGT013328 Glutamate receptor ionotropic, NMDA 2B reviewed Ion channel GRIN2B Activity '=' 93 %
Q05586 BXGT012826 Glutamate receptor ionotropic, NMDA 1 reviewed Ion channel GRIN1 Activity '=' 93 %
P30988 BXGT009491 Calcitonin receptor reviewed G-protein coupled receptor CALCR Ki - - -
P51679 BXGT010877 C-C chemokine receptor type 4 reviewed G-protein coupled receptor CCR4 IC50 - - -
P51681 BXGT010878 C-C chemokine receptor type 5 reviewed G-protein coupled receptor CCR5 Ki - - -
P11509 BXGT007716 Cytochrome P450 2A6 reviewed - CYP2A6 IC50 - - -
P37136 BXGT009967 Acetylcholinesterase reviewed - Ache IC50 '=' 920 nM
P23975 BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 Ki - - -
P51681 BXGT010878 C-C chemokine receptor type 5 reviewed G-protein coupled receptor CCR5 IC50 - - -
P25025 BXGT009006 C-X-C chemokine receptor type 2 reviewed G-protein coupled receptor CXCR2 Ki - - -
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Ki - - -
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 Ki - - -
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a Ki - - -
P25105 BXGT009021 Platelet-activating factor receptor reviewed G-protein coupled receptor PTAFR IC50 - - -
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 IC50 - - -
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 Ki - - -
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B IC50 - - -
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Ki - - -
Q9Y271 BXGT022222 Cysteinyl leukotriene receptor 1 reviewed G-protein coupled receptor CYSLTR1 Ki - - -
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 IC50 - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 2090 nM
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 IC50 - - -
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 IC50 - - -
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR Ki - - -
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 reviewed Kinase FLT1 Ki - - -
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 Ki - - -
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 IC50 - - -
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform reviewed - PPP3CA Ki - - -
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 3200 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 2000 nM
Q12879 BXGT013275 Glutamate receptor ionotropic, NMDA 2A reviewed Ion channel GRIN2A Activity '=' 96 %
Q05586 BXGT012826 Glutamate receptor ionotropic, NMDA 1 reviewed Ion channel GRIN1 Activity '=' 96 %
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 73900 nM
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A IC50 - - -
P51679 BXGT010877 C-C chemokine receptor type 4 reviewed G-protein coupled receptor CCR4 Ki - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 IC50 - - -
P32245 BXGT009614 Melanocortin receptor 4 reviewed G-protein coupled receptor MC4R IC50 - - -
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 636 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 500 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 2770 nM
P08588 BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 IC50 - - -
P23975 BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 IC50 - - -
P41597 BXGT010268 C-C chemokine receptor type 2 reviewed - CCR2 Ki - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 - - -
A6XA80 BXGT001522 Leukotriene C4 synthase reviewed - LTC4S Ki - - -
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA IC50 - - -
P21836 BXGT008694 Acetylcholinesterase reviewed - Ache IC50 '=' 2500 nM
P21836 BXGT008694 Acetylcholinesterase reviewed - Ache Inhibition '=' 91 %
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 2010 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 635 nM
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 Ki - - -
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 Ki - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 800 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Selectivity '=' 9 -
P06276 BXGT006430 Cholinesterase reviewed - BCHE Selectivity '=' 9 -
Q690N0 BXGT016199 Progesterone receptor unreviewed - PGR IC50 - - -
P12822 BXGT007850 Angiotensin-converting enzyme reviewed - ACE Ki - - -
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 Ki - - -
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A IC50 - - -
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C IC50 - - -
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 IC50 - - -
P15207 BXGT008096 Androgen receptor reviewed - Ar Ki - - -
P37136 BXGT009967 Acetylcholinesterase reviewed - Ache IC50 '=' 750 nM
P21836 BXGT008694 Acetylcholinesterase reviewed - Ache IC50 '=' 2080 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE MIC '=' 0 nM
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 8500 nM
P37136 BXGT009967 Acetylcholinesterase reviewed - Ache IC50 '=' 1030000 nM
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Inhibition '<' 5 %
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 500 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE EC50 '=' 1100 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Inhibition - - -
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 35000 nM
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Ki - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 1070 nM
Q9N1N9 BXGT021115 Carboxylic ester hydrolase unreviewed - BCHE IC50 '=' 1 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 15848 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 2400 nM
Q9N1N9 BXGT021115 Carboxylic ester hydrolase unreviewed - BCHE IC50 '=' 14400 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 600 nM
Q9N1N9 BXGT021115 Carboxylic ester hydrolase unreviewed - BCHE IC50 '=' 15240 nM
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 Ki - - -
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Ki '=' 1560 nM
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE Ki - - -
P06241 BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN IC50 - - -
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 IC50 - - -
P06276 BXGT006430 Cholinesterase reviewed - BCHE Selectivity '=' 53 -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Ki - - -
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Ki - - -
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Ki - - -
Q9N1N9 BXGT021115 Carboxylic ester hydrolase unreviewed - BCHE IC50 '=' 15700 nM
P06276 BXGT006430 Cholinesterase reviewed - BCHE Ki '=' 192 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 2600 nM
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 66500 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 2670 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 100 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Inhibition '=' 17 %
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 8394 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 '=' 3200 nM
P37136 BXGT009967 Acetylcholinesterase reviewed - Ache IC50 '=' 630 nM
P04058 BXGT006139 Acetylcholinesterase reviewed - ache IC50 '=' 590 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 665 nM
P04058 BXGT006139 Acetylcholinesterase reviewed - ache IC50 '=' 550 nM
P04058 BXGT006139 Acetylcholinesterase reviewed - ache IC50 '=' 652 nM
Q13224 BXGT013328 Glutamate receptor ionotropic, NMDA 2B reviewed Ion channel GRIN2B IC50 - - -
Q05586 BXGT012826 Glutamate receptor ionotropic, NMDA 1 reviewed Ion channel GRIN1 IC50 - - -
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 '=' 8404 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Ki '=' 300 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 1300 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 '=' 22390 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 89125 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 1100 nM
P30988 BXGT009491 Calcitonin receptor reviewed G-protein coupled receptor CALCR IC50 - - -
P15127 BXGT008085 Insulin receptor reviewed - Insr IC50 - - -
P32245 BXGT009614 Melanocortin receptor 4 reviewed G-protein coupled receptor MC4R Ki - - -
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 Ki - - -
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - PDE5A Ki - - -
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 '=' 8394 nM
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 18000 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Ki '=' 440 nM
P37136 BXGT009967 Acetylcholinesterase reviewed - Ache ID50 '>' 30 mg.kg-1
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 20700 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 360 nM
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 IC50 - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Activity '=' 0 ug
Q9JKC1 BXGT020830 Carboxylic ester hydrolase unreviewed - Bche IC50 '=' 5900 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 1156 nM
P56817 BXGT011200 Beta-secretase 1 reviewed Enzyme BACE1 IC50 - - -
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 550 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 300 nM
P32238 BXGT009611 Cholecystokinin receptor type A reviewed G-protein coupled receptor CCKAR Ki - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 IC50 - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 IC50 - - -
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 IC50 - - -
P04035 BXGT006129 3-hydroxy-3-methylglutaryl-coenzyme A reductase reviewed - HMGCR IC50 - - -
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A IC50 - - -
P25025 BXGT009006 C-X-C chemokine receptor type 2 reviewed G-protein coupled receptor CXCR2 IC50 - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE MIC '=' 0 ug
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 18600 nM
P32241 BXGT009613 Vasoactive intestinal polypeptide receptor 1 reviewed G-protein coupled receptor VIPR1 Ki - - -
P37288 BXGT009977 Vasopressin V1a receptor reviewed G-protein coupled receptor AVPR1A Ki - - -
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 IC50 - - -
P21452 BXGT008653 Substance-K receptor reviewed G-protein coupled receptor TACR2 IC50 - - -
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 7000 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE MIC '=' 1 ng
Q00960 BXGT012555 Glutamate receptor ionotropic, NMDA 2B reviewed - Grin2b Ki '>' 100000 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 2050 nM
Q92887 BXGT019389 Canalicular multispecific organic anion transporter 1 reviewed Transporter ABCC2 IC50 '=' 133000 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 7300 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Ki '=' 428 nM
Q9N1N9 BXGT021115 Carboxylic ester hydrolase unreviewed - BCHE IC50 '=' 8500 nM
Q9N1N9 BXGT021115 Carboxylic ester hydrolase unreviewed - BCHE IC50 - - -
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 50900 nM
P37136 BXGT009967 Acetylcholinesterase reviewed - Ache IC50 '=' 1165 nM
P25929 BXGT009078 Neuropeptide Y receptor type 1 reviewed G-protein coupled receptor NPY1R IC50 - - -
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 Ki - - -
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 IC50 - - -
P25105 BXGT009021 Platelet-activating factor receptor reviewed G-protein coupled receptor PTAFR Ki - - -
P12822 BXGT007850 Angiotensin-converting enzyme reviewed - ACE IC50 - - -
P03956 BXGT006120 Interstitial collagenase reviewed Enzyme MMP1 IC50 - - -
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR IC50 - - -
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a Ki - - -
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B Ki - - -
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 Ki - - -
P25103 BXGT009020 Substance-P receptor reviewed G-protein coupled receptor TACR1 IC50 - - -
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 Ki - - -
P25929 BXGT009078 Neuropeptide Y receptor type 1 reviewed G-protein coupled receptor NPY1R Ki - - -
P29476 BXGT009354 Nitric oxide synthase, brain reviewed - Nos1 Ki - - -
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 IC50 - - -
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 Ki - - -
Q690N0 BXGT016199 Progesterone receptor unreviewed - PGR Ki - - -
P08311 BXGT006762 Cathepsin G reviewed Enzyme CTSG Ki - - -
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 IC50 - - -
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 Ki - - -
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 Ki - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '~' 500 nM
P04058 BXGT006139 Acetylcholinesterase reviewed - ache IC50 '=' 360 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 4000 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 3180 nM
Q13627 BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed Kinase DYRK1A Inhibition - - -
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 610 nM
P11509 BXGT007716 Cytochrome P450 2A6 reviewed - CYP2A6 Ki - - -
P15127 BXGT008085 Insulin receptor reviewed - Insr Ki - - -
A6XA80 BXGT001522 Leukotriene C4 synthase reviewed - LTC4S IC50 - - -
P50052 BXGT010768 Type-2 angiotensin II receptor reviewed G-protein coupled receptor AGTR2 Ki - - -
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 Ki - - -
P06276 BXGT006430 Cholinesterase reviewed - BCHE Inhibition '=' 29 %
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 600 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition '=' 100 %
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 IC50 - - -
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 Ki - - -
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 8000 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 1000 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 - - -
O35492 BXGT004531 Dual specificity protein kinase CLK3 reviewed - Clk3 Inhibition - - -
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition '=' 50 %
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 480 nM
P29476 BXGT009354 Nitric oxide synthase, brain reviewed - Nos1 IC50 - - -
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE IC50 - - -
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Ki - - -
P06241 BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN Ki - - -
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a IC50 - - -
P28564 BXGT009272 5-hydroxytryptamine receptor 1B reviewed - Htr1b IC50 - - -
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A Ki - - -
P25103 BXGT009020 Substance-P receptor reviewed G-protein coupled receptor TACR1 Ki - - -
P32241 BXGT009613 Vasoactive intestinal polypeptide receptor 1 reviewed G-protein coupled receptor VIPR1 IC50 - - -
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 1820 nM
Q12879 BXGT013275 Glutamate receptor ionotropic, NMDA 2A reviewed Ion channel GRIN2A IC50 - - -
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 35481 nM
O95342 BXGT005373 Bile salt export pump reviewed Transporter ABCB11 IC50 '>' 135000 nM
P06276 BXGT006430 Cholinesterase reviewed - BCHE Inhibition - - -
P06276 BXGT006430 Cholinesterase reviewed - BCHE Inhibition '>' 40 %
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition '=' 6 %
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '>' 10000 nM
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 18600000 nM
O95342 BXGT005373 Bile salt export pump reviewed Transporter ABCB11 IC50 '=' 133000 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 2100 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 1180 nM
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 Ki - - -
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 Ki - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Ki - - -
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ki - - -
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 Ki - - -
P33032 BXGT009689 Melanocortin receptor 5 reviewed G-protein coupled receptor MC5R IC50 - - -
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA Ki - - -
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 '=' 14400 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 '=' 12000 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition '=' 91 %
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 590 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 '=' 19780 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition '=' 85 %
O15439 BXGT004169 Multidrug resistance-associated protein 4 reviewed Transporter ABCC4 IC50 '=' 133000 nM
P32238 BXGT009611 Cholecystokinin receptor type A reviewed G-protein coupled receptor CCKAR IC50 - - -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 - - -
Q92630 BXGT019360 Dual specificity tyrosine-phosphorylation-regulated kinase 2 reviewed Kinase DYRK2 Inhibition - - -
P25101 BXGT009018 Endothelin-1 receptor reviewed G-protein coupled receptor EDNRA IC50 - - -
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 IC50 - - -
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Ki - - -
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b IC50 - - -
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 IC50 - - -
P13945 BXGT007972 Beta-3 adrenergic receptor reviewed G-protein coupled receptor ADRB3 Ki - - -
P07943 BXGT006700 Aldo-keto reductase family 1 member B1 reviewed - Akr1b1 IC50 - - -
P50052 BXGT010768 Type-2 angiotensin II receptor reviewed G-protein coupled receptor AGTR2 IC50 - - -
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 Ki - - -
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 Ki - - -
P12530 BXGT007827 Arachidonate 15-lipoxygenase reviewed - ALOX15 IC50 - - -
P33032 BXGT009689 Melanocortin receptor 5 reviewed G-protein coupled receptor MC5R Ki - - -
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 IC50 - - -
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 IC50 - - -
P49146 BXGT010681 Neuropeptide Y receptor type 2 reviewed G-protein coupled receptor NPY2R Ki - - -
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 IC50 - - -
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK Ki - - -
P21452 BXGT008653 Substance-K receptor reviewed G-protein coupled receptor TACR2 Ki - - -
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 '=' 11900 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 0 ug.mL-1
P22518 BXGT008779 Dual specificity protein kinase CLK1 reviewed - Clk1 Inhibition - - -
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Ki '=' 1060 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Ki - - -
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 IC50 - - -
P25101 BXGT009018 Endothelin-1 receptor reviewed G-protein coupled receptor EDNRA Ki - - -
P20781 BXGT008598 Glycine receptor subunit beta reviewed - Glrb Ki - - -
P07727 BXGT006662 Glycine receptor subunit alpha-1 reviewed - Glra1 Ki - - -
P24524 BXGT008974 Glycine receptor subunit alpha-3 reviewed - Glra3 Ki - - -
P22771 BXGT008806 Glycine receptor subunit alpha-2 reviewed - Glra2 Ki - - -
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C IC50 - - -
P08588 BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 Ki - - -
P30411 BXGT009424 B2 bradykinin receptor reviewed G-protein coupled receptor BDKRB2 IC50 - - -
P30411 BXGT009424 B2 bradykinin receptor reviewed G-protein coupled receptor BDKRB2 Ki - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Ki - - -
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 IC50 - - -
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 IC50 - - -
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 IC50 - - -
P04035 BXGT006129 3-hydroxy-3-methylglutaryl-coenzyme A reductase reviewed - HMGCR Ki - - -
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 Ki - - -
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Inhibition '=' 96 %
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 2000 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 1900 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Inhibition '=' 90 %
P81908 BXGT011959 Cholinesterase reviewed - BCHE Inhibition '=' 96 %
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Inhibition '=' 54 %
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D IC50 - - -
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a IC50 - - -
Q9N1N9 BXGT021115 Carboxylic ester hydrolase unreviewed - BCHE IC50 '=' 8400 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 4480 nM
P37136 BXGT009967 Acetylcholinesterase reviewed - Ache IC50 '=' 2550 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 '=' 7960 nM
P23795 BXGT008908 Acetylcholinesterase reviewed - ACHE IC50 '=' 8700 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 '=' 24400 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE Inhibition '=' 80 %
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 '=' 12600 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition '=' 35 %
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition '=' 68 %
P05067 BXGT006306 Amyloid-beta precursor protein reviewed Enzyme modulator APP Activity - - -
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition '=' 0 %
P04762 BXGT006259 Catalase reviewed - Cat EC50 '=' 5 ug.mL-1
P81908 BXGT011959 Cholinesterase reviewed - BCHE Inhibition '=' 63 %
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C reviewed Enzyme PTPRC IC50 - - -
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 IC50 - - -
P24557 BXGT008976 Thromboxane-A synthase reviewed - TBXAS1 IC50 - - -
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 reviewed Kinase FLT1 IC50 - - -
P81908 BXGT011959 Cholinesterase reviewed - BCHE Inhibition '=' 78 %
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 '=' 40720 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Inhibition '=' 99 %
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 Ki - - -
P81908 BXGT011959 Cholinesterase reviewed - BCHE Inhibition '=' 80 %
P81908 BXGT011959 Cholinesterase reviewed - BCHE Inhibition '=' 13 %
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 8000 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 2800 nM
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 12700 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 1450 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE Inhibition '=' 55 %
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 10000 nM
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 IC50 - - -
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 IC50 - - -
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 IC50 - - -
P08311 BXGT006762 Cathepsin G reviewed Enzyme CTSG IC50 - - -
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA IC50 - - -
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA Ki - - -
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform reviewed - PPP3CA IC50 - - -
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK IC50 - - -
P28564 BXGT009272 5-hydroxytryptamine receptor 1B reviewed - Htr1b Ki - - -
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C Ki - - -
O70528 BXGT005068 5-hydroxytryptamine receptor 4 reviewed - HTR4 IC50 - - -
O70528 BXGT005068 5-hydroxytryptamine receptor 4 reviewed - HTR4 Ki - - -
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 IC50 - - -
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 Ki - - -
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 170 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition '=' 13 %
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 8400 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 '=' 17380 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 8500 nM
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 0 ug.mL-1
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 '=' 18130 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 '=' 15800 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 3120 nM
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 21900 nM
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 1200 nM
P06276 BXGT006430 Cholinesterase reviewed - BCHE Ki '=' 192 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 2410 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Ki '=' 250 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 '=' 28100 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 1020 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 700 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 355 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE Inhibition '=' 11 %
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 3570 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 7440 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Ki '=' 61 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 '=' 46030 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE Inhibition '=' 21 %
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 1270 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 '=' 28300 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition '=' 43 %
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition '=' 94 %
P81908 BXGT011959 Cholinesterase reviewed - BCHE Inhibition '=' 85 %
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 2000 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 '=' 13900 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 '=' 21850 nM
O15438 BXGT004168 Canalicular multispecific organic anion transporter 2 reviewed Transporter ABCC3 IC50 '=' 133000 nM
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 19100 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 21820 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition '=' 80 %
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 250 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 '=' 3310 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE IC50 '=' 9400 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 1670 nM
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 3720 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache IC50 '=' 1700 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF01038 Eupatorium laevigatum Eupatorium laevigatum Medicinal Plant
BXGF01150 Viburnum lantana Viburnum lantana Medicinal Plant
BXGF01558 Ferula persica Ferula persica Medicinal Plant
BXGF01769 Artemisia juncea Artemisia juncea Others
BXGF02466 Ligularia przewalskii Ligularia przewalskii Others
BXGF02688 Salvia yunnanensis Salvia yunnanensis Medicinal Plant
BXGF02919 Stachys aegyptiaca Stachys aegyptiaca Others
BXGF02952 Hesperocyparis arizonica Hesperocyparis arizonica Others
BXGF03795 Neorautanenia mitis Neorautanenia mitis Medicinal Plant
BXGF04272 Aralia subcapitata Aralia subcapitata Others
BXGF04281 Pteroxygonum giraldii Pteroxygonum giraldii Others
BXGF04386 Pittosporum eugenioides Pittosporum eugenioides Medicinal Plant
BXGF05066 amaryllidaceae amaryllidaceae Others
BXGF05126 Crotalaria crispata Crotalaria crispata Medicinal Plant
BXGF06163 Atriplex parvifolia Atriplex parvifolia Others
BXGF06231 Haplopappus deserticola Haplopappus deserticola Medicinal Plant
BXGF06311 Crinum asiaticum Crinum asiaticum Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease