Showing entry for 5'-AMP-activated protein kinase subunit gamma-2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021683
Protein Name5'-AMP-activated protein kinase subunit gamma-2
Uniport IdQ9UGJ0
GenePRKAG2
Gene Id51422
DomainCBS
Pfam PF00571  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04068 FoxO signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04152 AMPK signaling pathway
5. Organismal Systems 5.9 Aging hsa04211 Longevity regulating pathway
5. Organismal Systems 5.9 Aging hsa04213 Longevity regulating pathway - multiple species
3. Environmental Information Processing 3.2 Signal transduction hsa04371 Apelin signaling pathway
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04530 Tight junction
5. Organismal Systems 5.10 Environmental adaptation hsa04710 Circadian rhythm
5. Organismal Systems 5.10 Environmental adaptation hsa04714 Thermogenesis
5. Organismal Systems 5.2 Endocrine system hsa04910 Insulin signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04920 Adipocytokine signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04921 Oxytocin signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04922 Glucagon signaling pathway
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04931 Insulin resistance
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04932 Non-alcoholic fatty liver disease (NAFLD)
6. Human Diseases 6.6 Cardiovascular diseases hsa05410 Hypertrophic cardiomyopathy (HCM)
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006754 ATP biosynthetic process
Biological Process GO:0006853 carnitine shuttle
Biological Process GO:0007050 cell cycle arrest
Biological Process GO:0042149 cellular response to glucose starvation
Biological Process GO:0006633 fatty acid biosynthetic process
Biological Process GO:0005977 glycogen metabolic process
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0016236 macroautophagy
Biological Process GO:0006469 negative regulation of protein kinase activity
Biological Process GO:0010800 positive regulation of peptidyl-threonine phosphorylation
Biological Process GO:0045860 positive regulation of protein kinase activity
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0050790 regulation of catalytic activity
Biological Process GO:0042304 regulation of fatty acid biosynthetic process
Biological Process GO:0019217 regulation of fatty acid metabolic process
Biological Process GO:0046320 regulation of fatty acid oxidation
Biological Process GO:0046324 regulation of glucose import
Biological Process GO:0006110 regulation of glycolytic process
Biological Process GO:0016241 regulation of macroautophagy
Biological Process GO:1901796 regulation of signal transduction by p53 class mediator
Biological Process GO:0016126 sterol biosynthetic process
molecular function GO:0043531 ADP binding
molecular function GO:0004679 AMP-activated protein kinase activity
molecular function GO:0016208 AMP binding
molecular function GO:0005524 ATP binding
molecular function GO:0004862 cAMP-dependent protein kinase inhibitor activity
molecular function GO:0008603 cAMP-dependent protein kinase regulator activity
molecular function GO:0008607 phosphorylase kinase regulator activity
molecular function GO:0030295 protein kinase activator activity
molecular function GO:0019901 protein kinase binding
molecular function GO:0019887 protein kinase regulator activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005615 extracellular space
cellular component GO:0005654 nucleoplasm
cellular component GO:0031588 nucleotide-activated protein kinase complex
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-1430728 Metabolism
R-HSA-1430728 Metabolism
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-1592230 Mitochondrial biogenesis
R-HSA-162582 Signal Transduction
R-HSA-1632852 Macroautophagy
R-HSA-1632852 Macroautophagy
R-HSA-163680 AMPK inhibits chREBP transcriptional activation activity
R-HSA-163680 AMPK inhibits chREBP transcriptional activation activity
R-HSA-163685 Integration of energy metabolism
R-HSA-163685 Integration of energy metabolism
R-HSA-165159 MTOR signalling
R-HSA-1852241 Organelle biogenesis and maintenance
R-HSA-199991 Membrane Trafficking
R-HSA-200425 Carnitine metabolism
R-HSA-212436 Generic Transcription Pathway
R-HSA-2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK
R-HSA-438064 Post NMDA receptor activation events
R-HSA-442755 Activation of NMDA receptors and postsynaptic events
R-HSA-556833 Metabolism of lipids
R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-5633007 Regulation of TP53 Activity
R-HSA-5653656 Vesicle-mediated transport
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-8978868 Fatty acid metabolism
R-HSA-9612973 Autophagy
R-HSA-9612973 Autophagy
R-HSA-9613354 Lipophagy
R-HSA-9619483 Activation of AMPK downstream of NMDARs
R-HSA-9663891 Selective autophagy
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0002986 BXGD000165 Fabry Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Cardiovascular Diseases
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003868 BXGD000233 Arthritis, Gouty Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0003962 BXGD000244 Ascites Pathological Conditions, Signs and Symptoms
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004245 BXGD000264 Atrioventricular Block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0005845 BXGD000341 Blood urea nitrogen measurement
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007113 BXGD000430 Rectal Carcinoma Digestive System Diseases; Neoplasms
C0007194 BXGD000452 Hypertrophic Cardiomyopathy Cardiovascular Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0008626 BXGD000559 Congenital chromosomal disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0010520 BXGD000675 Cyanosis Pathological Conditions, Signs and Symptoms
C0011615 BXGD000738 Dermatitis, Atopic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014772 BXGD000948 Red Blood Cell Count measurement
C0017612 BXGD001129 Glaucoma, Open-Angle Eye Diseases
C0017654 BXGD001136 Glomerular Filtration Rate
C0017919 BXGD001150 Glycogen Storage Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0017921 BXGD001152 Glycogen storage disease type II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0018099 BXGD001172 Gout Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0018790 BXGD001221 Cardiac Arrest Cardiovascular Diseases
C0018794 BXGD001222 Heart Block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0018800 BXGD001225 Cardiomegaly Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0018935 BXGD001252 Hematocrit procedure
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020649 BXGD001459 Hypotension Cardiovascular Diseases
C0022650 BXGD001568 Kidney Calculi Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023211 BXGD001615 Left Bundle-Branch Block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030252 BXGD002199 Palpitations Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0030590 BXGD002246 Paroxysmal supraventricular tachycardia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0032915 BXGD002380 Preexcitation Syndrome Cardiovascular Diseases
C0034063 BXGD002453 Pulmonary Edema Respiratory Tract Diseases
C0034885 BXGD002490 Rectal Neoplasms Digestive System Diseases; Neoplasms
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0040420 BXGD002861 Tonometry
C0042510 BXGD002987 Ventricular Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0043202 BXGD003037 Wolff-Parkinson-White Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0085298 BXGD003155 Sudden Cardiac Death Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0085610 BXGD003202 Sinus bradycardia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0149721 BXGD003349 Left Ventricular Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0151236 BXGD003407 Conduction system abnormalities
C0154830 BXGD003746 Proliferative diabetic retinopathy Pathological Conditions, Signs and Symptoms; Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0158986 BXGD003916 Neonatal hypoglycemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0162770 BXGD003980 Right Ventricular Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0201874 BXGD004054 Amino acids measurement
C0201976 BXGD004063 Creatinine measurement, serum (procedure)
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0202202 BXGD004082 Protein measurement
C0202239 BXGD004087 Uric acid measurement (procedure)
C0205700 BXGD004111 Asymmetric Septal Hypertrophy Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0232197 BXGD004536 Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0235475 BXGD004750 Wide QRS complex
C0235480 BXGD004751 Paroxysmal atrial fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0263630 BXGD005335 Hypertrophic disorder of skin, unspecified Skin and Connective Tissue Diseases
C0264886 BXGD005432 Conduction disorder of the heart Cardiovascular Diseases
C0268147 BXGD005837 Glycogen storage disease, type IX Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0281788 BXGD006786 Biventricular hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0340279 BXGD007314 Ventricular hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0340420 BXGD007327 Cardiac glycogenosis
C0342751 BXGD007542 Generalized glycogen storage disease of infants Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0344917 BXGD007708 Left ventricular outflow tract obstruction
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0349788 BXGD007956 Arrhythmogenic Right Ventricular Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0392525 BXGD008052 Nephrolithiasis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0392885 BXGD008071 High density lipoprotein measurement
C0427460 BXGD008616 Red cell distribution width determination
C0428472 BXGD008630 Serum HDL cholesterol measurement
C0428474 BXGD008631 Serum LDL cholesterol measurement
C0428883 BXGD008639 Diastolic blood pressure
C0428977 BXGD008644 Bradycardia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0455273 BXGD008853 Serum urea measurement
C0518015 BXGD009068 Hemoglobin measurement
C0520878 BXGD009117 Shortened PR interval Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0546466 BXGD009339 Idiopathic cardiac hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0559106 BXGD009465 Ventricular preexcitation Pathological Conditions, Signs and Symptoms
C0596887 BXGD009648 mathematical ability
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0854110 BXGD011000 Insulin-resistant diabetes mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0871470 BXGD011316 Systolic Pressure
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C0878677 BXGD011386 Glycogen Storage Disease Type IIb Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Cardiovascular Diseases
C0949658 BXGD011582 Cardiomyopathy, Hypertrophic, Familial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1304746 BXGD012343 RDW - Red blood cell distribution width result
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1445957 BXGD013081 Serum total cholesterol measurement
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1611743 BXGD013456 Familial (FPAH)
C1833236 BXGD013905 CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 6 (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1849813 BXGD015087 Glycogen Storage Disease of Heart, Lethal Congenital Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Cardiovascular Diseases
C1854776 BXGD015430 Infantile cardiomyopathy
C1963175 BXGD016687 Sinus Bradycardia, CTCAE
C2108093 BXGD016919 continuous electrocardiogram - paroxysmal supraventricular tachycardia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C2108107 BXGD016920 continuous electrocardiogram sinus bradycardia (finding)
C2239101 BXGD016963 Hemoglobin, CTCAE
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2936458 BXGD018121 Fasciculoventricular Accessory Pathway Pathological Conditions, Signs and Symptoms
C2936459 BXGD018122 Nodoventricular Accessory Pathway Pathological Conditions, Signs and Symptoms
C3160712 BXGD018467 Palpitations, CTCAE
C3671015 BXGD019328 Myofiber disarray
C3825246 BXGD019686 Diabetes in old age
C4016809 BXGD020377 WOLFF-PARKINSON-WHITE SYNDROME, CHILDHOOD-ONSET
C4025004 BXGD021522 Ventricular preexcitation with multiple accessory pathways
C4528257 BXGD023159 Corpuscular Hemoglobin Concentration Mean
C4551472 BXGD023303 Hypertrophic obstructive cardiomyopathy Cardiovascular Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000528 Salicylic acid 138.12
BXGC0000537 Acetylsalicylic acid 180.16
BXGC0002750 Vicenin 626.52
BXGC0002953 2-Phenethyl isothiocyanate 163.24
BXGC0003631 Phytosterol 414.72
BXGC0005793 Baicalein 270.24
BXGC0006466 Oleanolic acid 456.71
BXGC0012352 Chelerythrine 348.12
BXGC0014173 petasin 316.2
BXGC0016548 30-Norhederagenin 456.32
BXGC0024261 Adenosine Phosphate 347.06
BXGC0024554 D-luciferin 280
BXGC0030663 Metformin 129.1
BXGC0031558 Baicalin 446.08
BXGC0032381 Daucosterol 576.44
BXGC0034941 Combretastatin A4 316.13
BXGC0035226 Betulinic Acid 456.36
BXGC0037499 Palbinone 358.21
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047088 Ursolic Acid 456.36
BXGC0047281 Berberine 336.12
BXGC0047692 Gefitinib 446.15
BXGC0053261 Antimycin A 548.27
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein