Showing entry for Tyrosine-protein kinase BTK


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT012860
Protein NameTyrosine-protein kinase BTK
Uniport IdQ06187
GeneBTK
Gene Id695
DomainBTK; PH; Pkinase_Tyr; SH2; SH3_1
Pfam PF00779   PF00169   PF07714   PF00017   PF00018  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04064 NF-kappa B signaling pathway
5. Organismal Systems 5.8 Development hsa04380 Osteoclast differentiation
5. Organismal Systems 5.1 Immune system hsa04611 Platelet activation
5. Organismal Systems 5.1 Immune system hsa04662 B cell receptor signaling pathway
5. Organismal Systems 5.1 Immune system hsa04664 Fc epsilon RI signaling pathway
6. Human Diseases 6.9 Infectious diseases: Viral hsa05169 Epstein-Barr virus infection
6. Human Diseases 6.3 Immune diseases hsa05340 Primary immunodeficiency
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0002250 adaptive immune response
Biological Process GO:0097190 apoptotic signaling pathway
Biological Process GO:0042113 B cell activation
Biological Process GO:0002344 B cell affinity maturation
Biological Process GO:0050853 B cell receptor signaling pathway
Biological Process GO:0019722 calcium-mediated signaling
Biological Process GO:0048469 cell maturation
Biological Process GO:0098761 cellular response to interleukin-7
Biological Process GO:0071226 cellular response to molecule of fungal origin
Biological Process GO:0034614 cellular response to reactive oxygen species
Biological Process GO:0038095 Fc-epsilon receptor signaling pathway
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0002553 histamine secretion by mast cell
Biological Process GO:0007249 I-kappaB kinase/NF-kappaB signaling
Biological Process GO:0045087 innate immune response
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0007498 mesoderm development
Biological Process GO:0002755 MyD88-dependent toll-like receptor signaling pathway
Biological Process GO:0030889 negative regulation of B cell proliferation
Biological Process GO:0001818 negative regulation of cytokine production
Biological Process GO:0018108 peptidyl-tyrosine phosphorylation
Biological Process GO:0045579 positive regulation of B cell differentiation
Biological Process GO:0051092 positive regulation of NF-kappaB transcription factor activity
Biological Process GO:0001812 positive regulation of type I hypersensitivity
Biological Process GO:0001805 positive regulation of type III hypersensitivity
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0002902 regulation of B cell apoptotic process
Biological Process GO:0002721 regulation of B cell cytokine production
molecular function GO:0005524 ATP binding
molecular function GO:0042802 identical protein binding
molecular function GO:0046872 metal ion binding
molecular function GO:0004715 non-membrane spanning protein tyrosine kinase activity
molecular function GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
molecular function GO:0004713 protein tyrosine kinase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0031410 cytoplasmic vesicle
cellular component GO:0005829 cytosol
cellular component GO:0042629 mast cell granule
cellular component GO:0045121 membrane raft
cellular component GO:0005634 nucleus
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1236974 ER-Phagosome pathway
R-HSA-1236975 Antigen processing-Cross presentation
R-HSA-1280218 Adaptive Immune System
R-HSA-1280218 Adaptive Immune System
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade
R-HSA-168249 Innate Immune System
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-168256 Immune System
R-HSA-168898 Toll-like Receptor Cascades
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade
R-HSA-194315 Signaling by Rho GTPases
R-HSA-195258 RHO GTPase Effectors
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-2172127 DAP12 interactions
R-HSA-2424491 DAP12 signaling
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-397795 G-protein beta:gamma signalling
R-HSA-416476 G alpha (q) signalling events
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-5260271 Diseases of Immune System
R-HSA-5602358 Diseases associated with the TLR signaling cascade
R-HSA-5602498 MyD88 deficiency (TLR2/4)
R-HSA-5603041 IRAK4 deficiency (TLR2/4)
R-HSA-5663205 Infectious disease
R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs
R-HSA-8964315 G beta:gamma signalling through BTK
R-HSA-9658195 Leishmania infection
R-HSA-9664407 Parasite infection
R-HSA-9664417 Leishmania phagocytosis
R-HSA-9664422 FCGR3A-mediated phagocytosis
R-HSA-983169 Class I MHC mediated antigen processing & presentation
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
R-HSA-983705 Signaling by the B Cell Receptor (BCR)
R-HSA-983705 Signaling by the B Cell Receptor (BCR)
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001430 BXGD000054 Adenoma Neoplasms
C0001768 BXGD000075 Agammaglobulinemia Immune System Diseases; Hemic and Lymphatic Diseases
C0002170 BXGD000105 Alopecia Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002792 BXGD000129 anaphylaxis Immune System Diseases
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0002874 BXGD000134 Aplastic Anemia Hemic and Lymphatic Diseases
C0002893 BXGD000150 Refractory anemias Hemic and Lymphatic Diseases
C0002895 BXGD000152 Anemia, Sickle Cell Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0002986 BXGD000165 Fabry Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Cardiovascular Diseases
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0003907 BXGD000240 Arthus Reaction Immune System Diseases
C0004030 BXGD000246 Aspergillosis Infections
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0004368 BXGD000271 Autoimmune state
C0004623 BXGD000282 Bacterial Infections Infections
C0004943 BXGD000297 Behcet Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Skin and Connective Tissue Diseases; Stomatognathic Diseases; Cardiovascular Diseases
C0005779 BXGD000336 Blood Coagulation Disorders Hemic and Lymphatic Diseases
C0005940 BXGD000352 Bone Diseases Musculoskeletal Diseases
C0006111 BXGD000369 Brain Diseases Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006413 BXGD000397 Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007642 BXGD000469 Cellulitis Pathological Conditions, Signs and Symptoms; Infections; Skin and Connective Tissue Diseases
C0007820 BXGD000491 Cerebrovascular Disorders Nervous System Diseases; Cardiovascular Diseases
C0008684 BXGD000562 Chronic gingivitis Infections; Stomatognathic Diseases
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009447 BXGD000613 Common Variable Immunodeficiency Immune System Diseases
C0009763 BXGD000628 Conjunctivitis Eye Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0013170 BXGD000802 Drug habituation Chemically-Induced Disorders; Mental Disorders
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013338 BXGD000816 Pituitary dwarfism Musculoskeletal Diseases; Nervous System Diseases; Endocrine System Diseases
C0013423 BXGD000838 Dystonia Musculorum Deformans Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0014038 BXGD000878 Encephalitis Nervous System Diseases
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0014534 BXGD000924 Epididymitis Male Urogenital Diseases
C0015230 BXGD000969 Exanthema Skin and Connective Tissue Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0018133 BXGD001176 Graft-vs-Host Disease Immune System Diseases
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018916 BXGD001245 Hemangioma Neoplasms
C0018920 BXGD001246 Hemangioma, Cavernous Neoplasms; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0019069 BXGD001277 Hemophilia A Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0019158 BXGD001293 Hepatitis Digestive System Diseases
C0019348 BXGD001325 Herpes Simplex Infections Infections; Skin and Connective Tissue Diseases
C0019829 BXGD001350 Hodgkin Disease Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0020598 BXGD001440 Hypocalcemia Nutritional and Metabolic Diseases
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0021053 BXGD001476 Immune System Diseases Immune System Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023440 BXGD001646 Acute Erythroblastic Leukemia Neoplasms; Hemic and Lymphatic Diseases
C0023443 BXGD001648 Hairy Cell Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023448 BXGD001649 Lymphoid leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023461 BXGD001653 Leukemia, Mast-Cell Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023485 BXGD001667 Precursor B-Cell Lymphoblastic Leukemia-Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023530 BXGD001683 Leukopenia Hemic and Lymphatic Diseases
C0024131 BXGD001736 Lupus Vulgaris Infections; Skin and Connective Tissue Diseases
C0024138 BXGD001738 Lupus Erythematosus, Discoid Skin and Connective Tissue Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024143 BXGD001741 Lupus Nephritis Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Male Urogenital Diseases; Immune System Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024301 BXGD001759 Lymphoma, Follicular Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024302 BXGD001760 Reticulosarcoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024305 BXGD001763 Lymphoma, Non-Hodgkin Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024312 BXGD001766 Lymphopenia Immune System Diseases; Hemic and Lymphatic Diseases
C0024419 BXGD001769 Waldenstrom Macroglobulinemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0024523 BXGD001781 Malabsorption Syndrome Digestive System Diseases; Nutritional and Metabolic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025289 BXGD001851 Meningitis Nervous System Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027697 BXGD002022 Nephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0027947 BXGD002061 Neutropenia Hemic and Lymphatic Diseases
C0029443 BXGD002152 Osteomyelitis Infections; Musculoskeletal Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0029882 BXGD002177 Otitis Media Otorhinolaryngologic Diseases
C0030297 BXGD002204 Pancreatic Neoplasm Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0030312 BXGD002207 Pancytopenia Hemic and Lymphatic Diseases
C0031030 BXGD002272 Periapical Periodontitis Stomatognathic Diseases
C0032131 BXGD002330 Plasmacytoma Neoplasms; Immune System Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0033581 BXGD002410 prostatitis Male Urogenital Diseases
C0034072 BXGD002459 Cor pulmonale Cardiovascular Diseases
C0034212 BXGD002473 Pyoderma Skin and Connective Tissue Diseases
C0035222 BXGD002513 Respiratory Distress Syndrome, Adult Respiratory Tract Diseases
C0035288 BXGD002524 Reticuloendotheliosis, X-linked Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0037199 BXGD002671 Sinusitis Infections; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0037284 BXGD002679 Skin lesion Skin and Connective Tissue Diseases
C0037299 BXGD002685 Skin Ulcer Skin and Connective Tissue Diseases
C0040034 BXGD002836 Thrombocytopenia Hemic and Lymphatic Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0043194 BXGD003036 Wiskott-Aldrich Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079745 BXGD003091 Lymphoma, Large-Cell, Follicular Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085110 BXGD003126 Severe Combined Immunodeficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0086438 BXGD003283 Hypogammaglobulinemia Immune System Diseases; Hemic and Lymphatic Diseases
C0151449 BXGD003419 Primary Sjögren's syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C0155626 BXGD003806 Acute myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0162429 BXGD003942 Malnutrition Nutritional and Metabolic Diseases
C0162539 BXGD003955 IgG Deficiency disorder Immune System Diseases; Hemic and Lymphatic Diseases
C0162871 BXGD003996 Aortic Aneurysm, Abdominal Cardiovascular Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0205944 BXGD004141 Sarcoma, Epithelioid Neoplasms
C0206172 BXGD004168 Diabetic Foot Skin and Connective Tissue Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0206180 BXGD004170 Ki-1+ Anaplastic Large Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0220597 BXGD004292 Adult Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0220605 BXGD004294 Adult Non-Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0220612 BXGD004296 Childhood Non-Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0220644 BXGD004306 Childhood Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0221026 BXGD004371 X-linked agammaglobulinemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238790 BXGD004956 bone destruction
C0241932 BXGD005126 X-linked hypogammaglobulinemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C0242596 BXGD005181 Neoplasm, Residual Pathological Conditions, Signs and Symptoms; Neoplasms
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0262655 BXGD005264 Recurrent urinary tract infection Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0263338 BXGD005290 Chronic urticaria Skin and Connective Tissue Diseases; Immune System Diseases
C0267048 BXGD005728 Glossoptosis Stomatognathic Diseases
C0268390 BXGD005929 Muckle-Wells Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0270710 BXGD006088 Bing-Neel syndrome Neoplasms; Immune System Diseases; Nervous System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0271441 BXGD006203 Chronic otitis media Otorhinolaryngologic Diseases
C0271561 BXGD006213 Somatotropin deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Endocrine System Diseases
C0272322 BXGD006343 Severe hereditary factor VIII deficiency disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0278764 BXGD006581 Adult Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0278791 BXGD006587 Chronic lymphocytic leukaemia refractory Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0278879 BXGD006610 Childhood Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0280100 BXGD006713 Solid Neoplasm Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0280803 BXGD006766 Primary central nervous system lymphoma Neoplasms; Immune System Diseases; Nervous System Diseases; Hemic and Lymphatic Diseases
C0333209 BXGD006934 Platelet thrombus Cardiovascular Diseases
C0333516 BXGD006957 Tumor necrosis Pathological Conditions, Signs and Symptoms
C0334633 BXGD007143 Malignant lymphoma - lymphoplasmacytic Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0334634 BXGD007144 Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0334663 BXGD007149 Histiocytic sarcoma Neoplasms; Hemic and Lymphatic Diseases
C0342649 BXGD007522 Vascular calcification Nutritional and Metabolic Diseases
C0345958 BXGD007751 Large cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0349588 BXGD007933 Short stature
C0349631 BXGD007938 Richter's syndrome Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0349632 BXGD007939 Splenic Marginal Zone B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0376544 BXGD008001 Hematopoietic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0376545 BXGD008002 Hematologic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0398686 BXGD008215 Primary immune deficiency disorder Immune System Diseases
C0398689 BXGD008216 Hyper-IgM Immunodeficiency Syndrome, Type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C0398712 BXGD008221 Anti-polysaccharide antibody deficiency
C0401151 BXGD008274 Chronic diarrhea Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0403529 BXGD008291 Anti-Glomerular Basement Membrane Disease Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Respiratory Tract Diseases; Immune System Diseases
C0409974 BXGD008401 Lupus Erythematosus Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases; Immune System Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0432408 BXGD008785 Trisomy 12 Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0454644 BXGD008850 Delayed speech and language development Behavior and Behavior Mechanisms
C0472813 BXGD008926 X-linked agammaglobulinemia with growth hormone deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Immune System Diseases; Nervous System Diseases; Endocrine System Diseases; Hemic and Lymphatic Diseases
C0472814 BXGD008927 Autosomal agammaglobulinemia with absent B-cells Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C0496956 BXGD009052 Neoplasm of uncertain or unknown behavior of breast Neoplasms; Skin and Connective Tissue Diseases
C0497156 BXGD009053 Lymphadenopathy Hemic and Lymphatic Diseases
C0522274 BXGD009200 Humoral immune defect Immune System Diseases; Hemic and Lymphatic Diseases
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0541764 BXGD009259 Delayed bone age
C0546837 BXGD009343 Malignant neoplasm of esophagus Digestive System Diseases; Neoplasms
C0553580 BXGD009399 Ewings sarcoma Neoplasms
C0559260 BXGD009466 Congenital scoliosis Musculoskeletal Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677932 BXGD009736 Progressive Neoplastic Disease
C0677936 BXGD009737 Refractory cancer Neoplasms
C0677949 BXGD009740 Stage III Colorectal Cancer Digestive System Diseases; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0694550 BXGD009852 Recurrent pneumonia Infections; Respiratory Tract Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0745242 BXGD010123 Immunoglobulin deficiency Immune System Diseases
C0746757 BXGD010149 Chronic nasal congestion
C0751606 BXGD010523 Adult Acute Lymphocytic Leukemia
C0751753 BXGD010576 Carbamoyl-Phosphate Synthase I Deficiency Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0796074 BXGD010793 MOHR-TRANEBJAERG SYNDROME Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases; Mental Disorders; Otorhinolaryngologic Diseases; Behavior and Behavior Mechanisms
C0854802 BXGD011036 Recurrent Chronic Lymphoid Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0855090 BXGD011070 B-cell lymphoma refractory Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0855095 BXGD011071 Small Lymphocytic Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0855138 BXGD011075 Mantle cell lymphoma refractory
C0856742 BXGD011111 Post MI Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0858252 BXGD011172 Breast adenocarcinoma Neoplasms; Skin and Connective Tissue Diseases
C0865214 BXGD011281 Autosomal recessive agammaglobulinemia
C0867389 BXGD011300 Chronic graft-versus-host disease Immune System Diseases
C0877008 BXGD011325 Enzyme inhibition disorder
C1262313 BXGD011881 Invasive Fungal Infections Infections
C1262477 BXGD011882 Weight decreased Pathological Conditions, Signs and Symptoms
C1269955 BXGD012005 Tumor Cell Invasion
C1279481 BXGD012123 X-Linked Combined Immunodeficiency Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases
C1292769 BXGD012230 Precursor B-cell lymphoblastic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1302547 BXGD012305 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1328587 BXGD012473 Panhypogammaglobulinemia
C1332201 BXGD012502 Adult Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332225 BXGD012515 Aggressive Non-Hodgkin Lymphoma
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1333296 BXGD012615 Activated B-cell type diffuse large B-cell lymphoma
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1399819 BXGD013008 Humoral immunodeficiency Immune System Diseases
C1405308 BXGD013026 Vaccine associated paralytic poliomyelitis Infections; Nervous System Diseases
C1456868 BXGD013128 Diabetic foot ulcer Skin and Connective Tissue Diseases; Endocrine System Diseases; Cardiovascular Diseases
C1457897 BXGD013133 Congenital hypogammaglobulinemia Immune System Diseases; Hemic and Lymphatic Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1527336 BXGD013271 Sjogren's Syndrome Eye Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases; Stomatognathic Diseases
C1535939 BXGD013323 Pneumocystis jiroveci pneumonia Infections; Respiratory Tract Diseases
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1608408 BXGD013434 Malignant transformation
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1692886 BXGD013495 Arthritis, Bacterial Infections; Musculoskeletal Diseases
C1708350 BXGD013598 Hereditary Leiomyomatosis and Renal Cell Cancer Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C1740827 BXGD013746 CLL progression
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1836735 BXGD014155 hypopigmented skin patch Skin and Connective Tissue Diseases
C1843995 BXGD014622 Enteroviral hepatitis
C1844383 BXGD014628 Recurrent bacterial infection Infections
C1845977 BXGD014769 X- linked recessive
C1863715 BXGD016190 Severe B lymphocytopenia
C1868683 BXGD016526 B-CELL MALIGNANCY, LOW-GRADE
C1961102 BXGD016673 Precursor Cell Lymphoblastic Leukemia Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1963165 BXGD016685 Malabsorption, CTCAE
C1963943 BXGD016706 Atherothrombosis
C2004493 BXGD016875 Leukemia, B-Cell Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2347748 BXGD017041 Adult Erythroleukemia
C2895206 BXGD017852 Autoimmune disease (systemic) NOS
C2919142 BXGD017867 Short Stature, CTCAE
C2936664 BXGD018125 Acquired Hypogammaglobulinemia Immune System Diseases
C3146250 BXGD018259 Stage III Colorectal Cancer AJCC v7
C3152144 BXGD018460 AGAMMAGLOBULINEMIA 1, AUTOSOMAL RECESSIVE
C3203655 BXGD018570 Autoimmune aplastic anaemia
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3275069 BXGD018658 Chronic Total Occlusion Vessel
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C3495801 BXGD019004 Granulomatosis with polyangiitis Respiratory Tract Diseases; Immune System Diseases; Cardiovascular Diseases
C3539781 BXGD019086 Progressive cGVHD
C3714745 BXGD019427 Malabsorption Digestive System Diseases
C3714796 BXGD019434 Isolated somatotropin deficiency
C3806482 BXGD019514 Recurrent respiratory infections Infections; Respiratory Tract Diseases
C3806660 BXGD019523 Enteroviral dermatomyositis syndrome
C3888789 BXGD019985 Pancreatic toxicity
C3896960 BXGD020042 Childhood Pre-B Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C3896961 BXGD020043 Adult Pre-B Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C4021957 BXGD020840 Recurrent cutaneous abscess formation
C4021975 BXGD020851 Abnormality of the tonsils
C4025681 BXGD021730 Recurrent enteroviral infections
C4025683 BXGD021732 Lymph node hypoplasia
C4048270 BXGD021897 Decreased antibody level in blood
C4048329 BXGD021904 Immunosuppression
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4087393 BXGD022145 Marginal zone lymphoma refractory
C4520840 BXGD023041 Erythroleukemia (Erythroid/Myeloid) Neoplasms; Hemic and Lymphatic Diseases
C4551538 BXGD023340 refractory multiple myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C4721414 BXGD023738 Mantle cell lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C4721532 BXGD023752 Lymphoma, Non-Hodgkin, Familial Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C4727151 BXGD023858 Recurrent Hemophagocytic Lymphohistiocytosis Hemic and Lymphatic Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000441 Dimethyl sulfoxide 78.13
BXGC0003705 Chloride 35.45
BXGC0004266 2-Propanol 60.1
BXGC0009040 Epicatechin-(2beta->7,4beta->8)-epicatechin-(4beta->8)-epicatechin 864.77
BXGC0012352 Chelerythrine 348.12
BXGC0013109 4-[2-(3,5-Dihydroxyphenyl)Ethenyl]Benzene-1,2-Diol 244.07
BXGC0017933 Sulfuretin 270.05
BXGC0024554 D-luciferin 280
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein