Showing entry for N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008618
Protein NameN(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
Uniport IdP20933
GeneAGA
Gene Id175
DomainAsparaginase_2
Pfam PF01112  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.7 Glycan biosynthesis and metabolism hsa00511 Other glycan degradation
4. Cellular Processes 4.1 Transport and catabolism hsa04142 Lysosome
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0006517 protein deglycosylation
molecular function GO:0003948 N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity
molecular function GO:0008233 peptidase activity
molecular function GO:0043621 protein self-association
cellular component GO:0035578 azurophil granule lumen
cellular component GO:0005737 cytoplasm
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0005764 lysosome
Reactome
Pathway Id Pathway Name
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-6798695 Neutrophil degranulation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002170 BXGD000105 Alopecia Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0002986 BXGD000165 Fabry Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Cardiovascular Diseases
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0004031 BXGD000247 Aspergillosis, Allergic Bronchopulmonary Infections; Respiratory Tract Diseases; Immune System Diseases
C0007570 BXGD000467 Celiac Disease Digestive System Diseases; Nutritional and Metabolic Diseases
C0008325 BXGD000529 Cholecystitis Digestive System Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0011334 BXGD000716 Dental caries Stomatognathic Diseases
C0011608 BXGD000736 Dermatitis Herpetiformis Skin and Connective Tissue Diseases; Immune System Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0013080 BXGD000797 Down Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013384 BXGD000826 Dyskinetic syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013395 BXGD000831 Dyspepsia Pathological Conditions, Signs and Symptoms
C0014038 BXGD000878 Encephalitis Nervous System Diseases
C0014848 BXGD000955 Esophageal Achalasia Digestive System Diseases
C0014852 BXGD000958 Esophageal Diseases Digestive System Diseases
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0016202 BXGD001050 Flatfoot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0016663 BXGD001071 Pathological fracture Wounds and Injuries
C0019187 BXGD001296 Hepatitis, Alcoholic Digestive System Diseases; Chemically-Induced Disorders
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0019270 BXGD001311 Hernia Pathological Conditions, Signs and Symptoms
C0019294 BXGD001314 Hernia, Inguinal Pathological Conditions, Signs and Symptoms
C0019825 BXGD001349 Hoarseness Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C0020534 BXGD001421 Orbital separation excessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0022104 BXGD001529 Irritable Bowel Syndrome Digestive System Diseases
C0022821 BXGD001590 Kyphosis deformity of spine Musculoskeletal Diseases
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0024143 BXGD001741 Lupus Nephritis Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Male Urogenital Diseases; Immune System Diseases
C0024421 BXGD001770 Macroglossia Stomatognathic Diseases
C0024433 BXGD001771 Macrostomia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0024523 BXGD001781 Malabsorption Syndrome Digestive System Diseases; Nutritional and Metabolic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026266 BXGD001895 Mitral Valve Insufficiency Cardiovascular Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027612 BXGD002003 Congenital, Hereditary, and Neonatal Diseases and Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0027651 BXGD002009 Neoplasms Neoplasms
C0027947 BXGD002061 Neutropenia Hemic and Lymphatic Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0036337 BXGD002598 Schizoaffective Disorder Mental Disorders
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037317 BXGD002689 Sleep disturbances Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0037822 BXGD002706 Speech Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038002 BXGD002723 Splenomegaly Pathological Conditions, Signs and Symptoms
C0038016 BXGD002727 Spondylolisthesis Musculoskeletal Diseases
C0038018 BXGD002729 Spondylolysis Musculoskeletal Diseases
C0040128 BXGD002844 Thyroid Diseases Endocrine System Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0041324 BXGD002913 Tuberculosis, Osteoarticular Infections; Musculoskeletal Diseases
C0041671 BXGD002930 Attention Deficit Disorder Mental Disorders
C0085078 BXGD003118 Lysosomal Storage Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0085207 BXGD003140 Gestational Diabetes Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0086437 BXGD003282 Joint laxity Musculoskeletal Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0086795 BXGD003311 Pfaundler-Hurler Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0152423 BXGD003587 Congenital small ears Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Otorhinolaryngologic Diseases
C0156173 BXGD003840 Functional diarrhea Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0158731 BXGD003902 Congenital pectus carinatum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0162298 BXGD003933 Joint stiffness Musculoskeletal Diseases
C0162311 BXGD003935 Androgenetic Alopecia Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0162819 BXGD003984 Skin Diseases, Vascular Skin and Connective Tissue Diseases
C0221356 BXGD004448 Brachycephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0234221 BXGD004633 Acroparesthesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235946 BXGD004789 Cerebral atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0267971 BXGD005798 Storage disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0268225 BXGD005857 Aspartylglucosaminuria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0271441 BXGD006203 Chronic otitis media Otorhinolaryngologic Diseases
C0279671 BXGD006677 Cervical Squamous Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0282577 BXGD006816 Congenital Disorders of Glycosylation Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0282666 BXGD006824 Very Low Birth Weight
C0341106 BXGD007389 Eosinophilic esophagitis Digestive System Diseases; Immune System Diseases; Hemic and Lymphatic Diseases
C0343386 BXGD007620 Clostridium difficile infection Infections
C0343641 BXGD007636 Human papilloma virus infection Infections
C0349588 BXGD007933 Short stature
C0376480 BXGD007998 Gingival Overgrowth Stomatognathic Diseases
C0399526 BXGD008251 Class III malocclusion Stomatognathic Diseases
C0426576 BXGD008571 Gastrointestinal symptom Pathological Conditions, Signs and Symptoms
C0454644 BXGD008850 Delayed speech and language development Behavior and Behavior Mechanisms
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0524910 BXGD009248 Hepatitis C, Chronic Digestive System Diseases; Infections
C0541764 BXGD009259 Delayed bone age
C0566602 BXGD009489 Primary sclerosing cholangitis Digestive System Diseases
C0580413 BXGD009558 Prothrombin time low
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0700201 BXGD009880 Dyssomnias Nervous System Diseases; Mental Disorders
C0702166 BXGD009912 Acne Skin and Connective Tissue Diseases
C0740651 BXGD010004 Abdominal symptom
C0851578 BXGD010925 Sleep Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C1263023 BXGD011888 Macroorchidism
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1306503 BXGD012363 Congenital exomphalos Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1321756 BXGD012440 Achalasia
C1328440 BXGD012466 Abnormality of amino acid metabolism
C1623038 BXGD013475 Cirrhosis Pathological Conditions, Signs and Symptoms
C1832648 BXGD013865 Hypoparathyroidism familial isolated Endocrine System Diseases
C1836542 BXGD014129 Depressed nasal bridge
C1836543 BXGD014130 Thick vermilion border
C1836830 BXGD014165 Developmental regression Mental Disorders
C1836855 BXGD014170 Vacuolated lymphocytes
C1839739 BXGD014400 Thick lower lip vermilion
C1840077 BXGD014434 Anteverted nostril
C1844704 BXGD014665 Platyspondyly
C1845847 BXGD014760 Coarse facial features Pathological Conditions, Signs and Symptoms
C1849367 BXGD015046 Nasal bridge wide
C1854114 BXGD015383 Short nose
C1856599 BXGD015619 Beaking of vertebral bodies
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1858452 BXGD015796 Thickened calvaria
C1859680 BXGD015917 Broad face
C1859682 BXGD015918 Hypoplastic frontal sinuses
C1864172 BXGD016217 Peroxisome Biogenesis Disorder, Complementation Group G Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C1868889 BXGD016540 Irritable bowel syndrome characterized by constipation Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C1963165 BXGD016685 Malabsorption, CTCAE
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2748652 BXGD017604 Large face
C2919142 BXGD017867 Short Stature, CTCAE
C2931840 BXGD018075 Aspartylglucosamidase (AGA) deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C3714745 BXGD019427 Malabsorption Digestive System Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3806482 BXGD019514 Recurrent respiratory infections Infections; Respiratory Tract Diseases
C3845502 BXGD019809 Myocardial infarction, stroke
C4017301 BXGD020435 ASPARTYLGLUCOSAMINURIA, FINNISH TYPE
C4021541 BXGD020662 Anterior beaking of lumbar vertebrae
C4021741 BXGD020749 Abnormal cortical bone morphology
C4021768 BXGD020766 Abnormality of metabolism/homeostasis
C4025662 BXGD021716 Abnormality of the ulna
C4049006 BXGD021912 Selective immunoglobulin A deficiency
C4083212 BXGD022105 Alopecia, Male Pattern Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C4317149 BXGD022731 Vacuolated Lymphocyte Count
C4521042 BXGD023055 Complete Trisomy 21 Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4553743 BXGD023548 Spasticity, CTCAE
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0001380 Succinic acid 118.09
BXGC0006186 L-Aspartic acid 133.1
BXGC0018397 beta-1,4-mannan 180.06
BXGC0019284 methylsuccinic acid 132.04
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein