Showing entry for Death domain-associated protein 6


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021672
Protein NameDeath domain-associated protein 6
Uniport IdQ9UER7
GeneDAXX
Gene Id1616
DomainDaxx
Pfam PF03344  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04010 MAPK signaling pathway
4. Cellular Processes 4.2 Cell growth and death hsa04210 Apoptosis
6. Human Diseases 6.4 Neurodegenerative diseases hsa05014 Amyotrophic lateral sclerosis (ALS)
6. Human Diseases 6.9 Infectious diseases: Viral hsa05168 Herpes simplex virus 1 infection
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007257 activation of JUN kinase activity
Biological Process GO:0030521 androgen receptor signaling pathway
Biological Process GO:0071276 cellular response to cadmium ion
Biological Process GO:0071280 cellular response to copper ion
Biological Process GO:0072738 cellular response to diamide
Biological Process GO:0034605 cellular response to heat
Biological Process GO:1903936 cellular response to sodium arsenite
Biological Process GO:0034620 cellular response to unfolded protein
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
Biological Process GO:0045892 negative regulation of transcription, DNA-templated
Biological Process GO:0006334 nucleosome assembly
Biological Process GO:1901216 positive regulation of neuron death
Biological Process GO:0045860 positive regulation of protein kinase activity
Biological Process GO:0001934 positive regulation of protein phosphorylation
Biological Process GO:0042981 regulation of apoptotic process
Biological Process GO:0031396 regulation of protein ubiquitination
Biological Process GO:0006355 regulation of transcription, DNA-templated
Biological Process GO:0016032 viral process
molecular function GO:0050681 androgen receptor binding
molecular function GO:0140416 DNA-binding transcription factor inhibitor activity
molecular function GO:0019899 enzyme binding
molecular function GO:0031072 heat shock protein binding
molecular function GO:0042393 histone binding
molecular function GO:0002039 p53 binding
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0030295 protein kinase activator activity
molecular function GO:0019901 protein kinase binding
molecular function GO:0047485 protein N-terminus binding
molecular function GO:0140037 sumo-dependent protein binding
molecular function GO:0003713 transcription coactivator activity
molecular function GO:0003714 transcription corepressor activity
molecular function GO:0008134 transcription factor binding
molecular function GO:0031625 ubiquitin protein ligase binding
cellular component GO:0000775 chromosome, centromeric region
cellular component GO:0005829 cytosol
cellular component GO:0016604 nuclear body
cellular component GO:0005730 nucleolus
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0016605 PML body
Reactome
Pathway Id Pathway Name
R-HSA-157579 Telomere Maintenance
R-HSA-1640170 Cell Cycle
R-HSA-1643685 Disease
R-HSA-212436 Generic Transcription Pathway
R-HSA-2990846 SUMOylation
R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-3899300 SUMOylation of transcription cofactors
R-HSA-392499 Metabolism of proteins
R-HSA-5633007 Regulation of TP53 Activity
R-HSA-5663205 Infectious disease
R-HSA-597592 Post-translational protein modification
R-HSA-6804757 Regulation of TP53 Degradation
R-HSA-6806003 Regulation of TP53 Expression and Degradation
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-73886 Chromosome Maintenance
R-HSA-74160 Gene expression (Transcription)
R-HSA-9609646 HCMV Infection
R-HSA-9609690 HCMV Early Events
R-HSA-9670095 Inhibition of DNA recombination at telomere
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0002312 BXGD000107 alpha-Thalassemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003123 BXGD000178 Anorexia Pathological Conditions, Signs and Symptoms
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0006266 BXGD000382 Bronchospasm Respiratory Tract Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007787 BXGD000487 Transient Ischemic Attack Nervous System Diseases; Cardiovascular Diseases
C0008479 BXGD000544 Chondrosarcoma Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011311 BXGD000714 Dengue Fever Infections
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0014474 BXGD000917 Ependymoma Neoplasms
C0015625 BXGD001006 Fanconi Anemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0017689 BXGD001148 Glucagonoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0018206 BXGD001186 granulosa cell tumor Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0018923 BXGD001248 Hemangiosarcoma Neoplasms
C0018926 BXGD001250 Hematemesis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0019348 BXGD001325 Herpes Simplex Infections Infections; Skin and Connective Tissue Diseases
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020649 BXGD001459 Hypotension Cardiovascular Diseases
C0022660 BXGD001571 Kidney Failure, Acute Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023487 BXGD001669 Acute Promyelocytic Leukemia Neoplasms
C0023524 BXGD001681 Leukoencephalopathy, Progressive Multifocal Infections; Nervous System Diseases
C0023827 BXGD001707 liposarcoma Neoplasms
C0024312 BXGD001766 Lymphopenia Immune System Diseases; Hemic and Lymphatic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0025222 BXGD001838 Melena Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0025267 BXGD001845 Multiple Endocrine Neoplasia Type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Endocrine System Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027498 BXGD001994 Nausea and vomiting Pathological Conditions, Signs and Symptoms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0030252 BXGD002199 Palpitations Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0030297 BXGD002204 Pancreatic Neoplasm Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0030421 BXGD002218 Paraganglioma Neoplasms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0032000 BXGD002318 Pituitary Adenoma Neoplasms; Nervous System Diseases; Endocrine System Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0035335 BXGD002540 Retinoblastoma Neoplasms; Eye Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036980 BXGD002649 Shock, Cardiogenic Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0040961 BXGD002891 Tricuspid Valve Insufficiency Cardiovascular Diseases
C0042133 BXGD002960 Uterine Fibroids Neoplasms
C0042769 BXGD002999 Virus Diseases Infections
C0043515 BXGD003049 Zollinger-Ellison syndrome Digestive System Diseases; Neoplasms
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085605 BXGD003200 Liver Failure Digestive System Diseases
C0149782 BXGD003365 Squamous cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0149925 BXGD003387 Small cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0162316 BXGD003936 Iron deficiency anemia Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0205824 BXGD004128 Liposarcoma, Dedifferentiated Neoplasms
C0206064 BXGD004150 Microvascular Angina Cardiovascular Diseases
C0206650 BXGD004214 Fibroadenoma Neoplasms
C0206659 BXGD004222 Embryonal Carcinoma Neoplasms
C0206686 BXGD004241 Adrenocortical carcinoma Neoplasms; Endocrine System Diseases
C0206708 BXGD004256 Cervical Intraepithelial Neoplasia Neoplasms
C0206754 BXGD004289 Neuroendocrine Tumors Neoplasms
C0232462 BXGD004542 Decrease in appetite Digestive System Diseases; Nervous System Diseases; Mental Disorders
C0235527 BXGD004753 Heart Failure, Right-Sided Cardiovascular Diseases
C0239181 BXGD004970 Intermittent diarrhea Pathological Conditions, Signs and Symptoms
C0242363 BXGD005156 Islet Cell Tumor Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0242994 BXGD005205 Hantavirus Infections Infections
C0278704 BXGD006567 Malignant Childhood Neoplasm Neoplasms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0280631 BXGD006752 Leiomyosarcoma of uterus Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0346429 BXGD007828 Multiple malignancy Neoplasms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0375024 BXGD007971 Hantavirus infection in conditions classified elsewhere and of unspecified site
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0426636 BXGD008573 Urgent desire for stool Digestive System Diseases
C0473133 BXGD008932 Protracted diarrhea Pathological Conditions, Signs and Symptoms
C0555198 BXGD009432 Malignant Glioma Neoplasms
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0752308 BXGD010715 Hypoxia-Ischemia, Brain Nervous System Diseases; Cardiovascular Diseases
C0858684 BXGD011186 Facial telangiectasia Cardiovascular Diseases
C0877243 BXGD011344 Increased serum serotonin
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1136249 BXGD011715 Mental Retardation, X-Linked Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1261473 BXGD011855 Sarcoma Neoplasms
C1262477 BXGD011882 Weight decreased Pathological Conditions, Signs and Symptoms
C1266129 BXGD011970 Atypical Lipoma Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1328479 BXGD012467 Pancreatic Endocrine Carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1332922 BXGD012556 Cervical Squamous Intraepithelial Neoplasia Pathological Conditions, Signs and Symptoms; Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1335302 BXGD012775 Pancreatic Ductal Adenocarcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1337011 BXGD012874 Well Differentiated Pancreatic Endocrine Tumor Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1368683 BXGD012900 Epithelioma Neoplasms
C1456873 BXGD013129 alpha^+^ Thalassemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C1608408 BXGD013434 Malignant transformation
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1704272 BXGD013537 Benign Prostatic Hyperplasia Male Urogenital Diseases
C1839780 BXGD014405 FRAGILE X TREMOR/ATAXIA SYNDROME Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1845055 BXGD014705 ALPHA-THALASSEMIA/MENTAL RETARDATION SYNDROME, NONDELETION TYPE, X-LINKED Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Hemic and Lymphatic Diseases
C1848701 BXGD014967 Elevated hepatic transaminase
C1858970 BXGD015835 Chronic noninfectious lymphadenopathy Hemic and Lymphatic Diseases
C2745900 BXGD017568 Promyelocytic leukemia
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C2939447 BXGD018179 Right ventricular failure Cardiovascular Diseases
C3160712 BXGD018467 Palpitations, CTCAE
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3469521 BXGD018910 FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3714514 BXGD019409 Infection Infections
C3808022 BXGD019536 Episodic abdominal pain Pathological Conditions, Signs and Symptoms
C4021740 BXGD020748 Increased circulating ACTH level
C4022606 BXGD020935 Lack of bowel sounds
C4025812 BXGD021804 Dermatological manifestations of systemic disorders
C4072942 BXGD022027 Atypical pulmonary carcinoid tumor
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4531035 BXGD023181 Abnormal pulmonary valve cusp morphology
C4551686 BXGD023391 Malignant neoplasm of soft tissue Neoplasms
C4721414 BXGD023738 Mantle cell lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0003705 Chloride 35.45
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein