Showing entry for Polycomb protein SUZ12


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013523
Protein NamePolycomb protein SUZ12
Uniport IdQ15022
GeneSUZ12
Gene Id23512
DomainVEFS-Box
Pfam PF09733  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0070734 histone H3-K27 methylation
Biological Process GO:0016574 histone ubiquitination
Biological Process GO:0045596 negative regulation of cell differentiation
Biological Process GO:0070317 negative regulation of G0 to G1 transition
Biological Process GO:0045814 negative regulation of gene expression, epigenetic
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0008284 positive regulation of cell population proliferation
molecular function GO:0031490 chromatin DNA binding
molecular function GO:0042054 histone methyltransferase activity
molecular function GO:0046872 metal ion binding
molecular function GO:0035064 methylated histone binding
molecular function GO:1990841 promoter-specific chromatin binding
molecular function GO:0003723 RNA binding
molecular function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
molecular function GO:0001226 RNA polymerase II transcription corepressor binding
cellular component GO:0035098 ESC/E(Z) complex
cellular component GO:0016604 nuclear body
cellular component GO:0005730 nucleolus
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0032993 protein-DNA complex
cellular component GO:0001739 sex chromatin
Reactome
Pathway Id Pathway Name
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1266738 Developmental Biology
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-212165 Epigenetic regulation of gene expression
R-HSA-212300 PRC2 methylates histones and DNA
R-HSA-212436 Generic Transcription Pathway
R-HSA-2262752 Cellular responses to stress
R-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-2559583 Cellular Senescence
R-HSA-2990846 SUMOylation
R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins
R-HSA-3214841 PKMTs methylate histone lysines
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-392499 Metabolism of proteins
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4839726 Chromatin organization
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-5619507 Activation of HOX genes during differentiation
R-HSA-5663205 Infectious disease
R-HSA-597592 Post-translational protein modification
R-HSA-6807070 PTEN Regulation
R-HSA-6807070 PTEN Regulation
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-8943724 Regulation of PTEN gene transcription
R-HSA-8943724 Regulation of PTEN gene transcription
R-HSA-8953750 Transcriptional Regulation by E2F6
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-9609646 HCMV Infection
R-HSA-9609690 HCMV Early Events
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001430 BXGD000054 Adenoma Neoplasms
C0002793 BXGD000130 Anaplasia Pathological Conditions, Signs and Symptoms; Neoplasms
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005699 BXGD000325 Blast Phase Pathological Conditions, Signs and Symptoms; Neoplasms; Hemic and Lymphatic Diseases
C0006118 BXGD000372 Brain Neoplasms Neoplasms; Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0008626 BXGD000559 Congenital chromosomal disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0009081 BXGD000581 Congenital clubfoot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0014170 BXGD000902 Endometrial Neoplasms Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0014599 BXGD000939 Epithelial hyperplasia Pathological Conditions, Signs and Symptoms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019294 BXGD001314 Hernia, Inguinal Pathological Conditions, Signs and Symptoms
C0019825 BXGD001349 Hoarseness Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C0020534 BXGD001421 Orbital separation excessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0023487 BXGD001669 Acute Promyelocytic Leukemia Neoplasms
C0023524 BXGD001681 Leukoencephalopathy, Progressive Multifocal Infections; Nervous System Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024301 BXGD001759 Lymphoma, Follicular Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0025990 BXGD001884 Micrognathism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027022 BXGD001962 Myeloproliferative disease Hemic and Lymphatic Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027809 BXGD002040 Neurilemmoma Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0027830 BXGD002046 neurofibroma Neoplasms; Nervous System Diseases
C0027831 BXGD002047 Neurofibromatosis 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0027962 BXGD002064 Melanocytic nevus Neoplasms
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0035411 BXGD002547 Rhabdomyoma Neoplasms
C0035412 BXGD002548 Rhabdomyosarcoma Neoplasms
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0039273 BXGD002806 Talipes cavus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0042063 BXGD002953 Urogenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0079772 BXGD003099 T-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0080178 BXGD003107 Spina Bifida Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0152421 BXGD003586 Macrotia
C0162298 BXGD003933 Joint stiffness Musculoskeletal Diseases
C0162678 BXGD003974 Neurofibromatoses Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0205646 BXGD004098 Adenoma, Basal Cell Neoplasms
C0205647 BXGD004099 Follicular adenoma Neoplasms
C0205648 BXGD004100 Adenoma, Microcystic Neoplasms
C0205649 BXGD004101 Adenoma, Monomorphic Neoplasms
C0205650 BXGD004102 Papillary adenoma Neoplasms
C0205651 BXGD004103 Adenoma, Trabecular Neoplasms
C0206630 BXGD004195 Endometrial Stromal Sarcoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0206727 BXGD004272 Nerve Sheath Tumors Neoplasms; Nervous System Diseases
C0206728 BXGD004273 Plexiform Neurofibroma Neoplasms; Nervous System Diseases
C0220611 BXGD004295 Childhood Rhabdomyosarcoma Neoplasms
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0220668 BXGD004317 Congenital contractural arachnodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0220765 BXGD004340 Weaver-Like Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0221352 BXGD004444 Syndactyly of fingers Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases
C0221355 BXGD004447 Macrocephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0239479 BXGD004982 Round face
C0241240 BXGD005089 Tall stature
C0242596 BXGD005181 Neoplasm, Residual Pathological Conditions, Signs and Symptoms; Neoplasms
C0259783 BXGD005221 mixed gliomas Neoplasms
C0265210 BXGD005463 Weaver syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0266435 BXGD005668 Congenital hypoplasia of penis Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0279550 BXGD006635 Adult Rhabdomyosarcoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0334485 BXGD007086 Endometrial stromal nodule Neoplasms
C0334486 BXGD007087 Low Grade Endometrial Stromal Sarcoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0334588 BXGD007128 Giant Cell Glioblastoma Neoplasms
C0334634 BXGD007144 Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0334695 BXGD007152 Endometrial Stromal Tumors Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0349566 BXGD007928 Squamous cell carcinoma of tongue Neoplasms; Stomatognathic Diseases
C0409348 BXGD008384 Flexion contracture of proximal interphalangeal joint
C0423110 BXGD008471 Downward slant of palpebral fissure
C0423823 BXGD008515 Thin nails Pathological Conditions, Signs and Symptoms
C0423867 BXGD008517 Fine hair
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0426870 BXGD008592 Large hand
C0426891 BXGD008595 Broad thumbs
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0545053 BXGD009323 Advanced bone age
C0553580 BXGD009399 Ewings sarcoma Neoplasms
C0555198 BXGD009432 Malignant Glioma Neoplasms
C0557874 BXGD009444 Global developmental delay
C0581342 BXGD009560 Redundant skin Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0677886 BXGD009734 Epithelial ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0751374 BXGD010418 Schwannomatosis, Plexiform Neoplasms
C0751689 BXGD010552 Peripheral Nerve Sheath Neoplasm Neoplasms; Nervous System Diseases
C0751690 BXGD010553 Malignant Peripheral Nerve Sheath Tumor Neoplasms; Nervous System Diseases
C0751691 BXGD010554 Perineurioma Neoplasms; Nervous System Diseases
C0936223 BXGD011477 Metastatic Prostate Carcinoma Neoplasms; Male Urogenital Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1261473 BXGD011855 Sarcoma Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1282496 BXGD012147 Metastasis from malignant tumor of prostate
C1292778 BXGD012237 Chronic myeloproliferative disorder Neoplasms; Hemic and Lymphatic Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1608408 BXGD013434 Malignant transformation
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1837279 BXGD014217 Hypoplastic toenails
C1839797 BXGD014409 Deep philtrum
C1840069 BXGD014433 Sandal gap
C1842581 BXGD014525 Abnormal corpus callosum morphology Pathological Conditions, Signs and Symptoms
C1849089 BXGD015004 Broad forehead
C1849265 BXGD015028 Overgrowth
C1857486 BXGD015710 Low-set, posteriorly rotated ears
C1865014 BXGD016282 Long philtrum
C1866241 BXGD016389 Broad foot Musculoskeletal Diseases
C1961099 BXGD016672 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2239246 BXGD016968 Endometrial stromal sarcoma, high grade Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C2347761 BXGD017049 Childhood Myelodysplastic Syndrome Hemic and Lymphatic Diseases
C2674608 BXGD017250 Feeding difficulties in infancy
C2745900 BXGD017568 Promyelocytic leukemia
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3277753 BXGD018722 Deep-set nails
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C3494422 BXGD018966 Retrognathia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C3553764 BXGD019187 Joint hyperflexibility
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3888194 BXGD019955 MIXED LINEAGE LEUKEMIA
C3900098 BXGD020106 Adult Myelodysplastic Syndrome Hemic and Lymphatic Diseases
C4018871 BXGD020463 Abnormality of the respiratory system
C4021664 BXGD020727 Abnormality of the abdominal wall Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C4021790 BXGD020782 Abnormality of the skeletal system
C4023915 BXGD021274 Abnormally low-pitched voice
C4025814 BXGD021806 Abnormality of the metaphysis
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4049796 BXGD021951 Abnormality of cardiovascular system morphology Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4284031 BXGD022430 Benign endometrial stromal neoplasm
C4287594 BXGD022471 Uterine Corpus High Grade Endometrial Stromal Sarcoma
C4551686 BXGD023391 Malignant neoplasm of soft tissue Neoplasms
C4551838 BXGD023417 Talipes transversoplanus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C4553743 BXGD023548 Spasticity, CTCAE
C4721414 BXGD023738 Mantle cell lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0012404 Tanshindiol C 312.1
BXGC0018374 Methyl Tanshinonate 338.12
BXGC0018607 Tanshinone Iib 310.12
BXGC0037599 Tanshinone Iia 294.13
BXGC0040070 Tanshindiol B 312.1
BXGC0052948 Tanshinone I 276.08
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein