Showing entry for Bone morphogenetic protein receptor type-2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013398
Protein NameBone morphogenetic protein receptor type-2
Uniport IdQ13873
GeneBMPR2
Gene Id659
DomainActivin_recp; Pkinase
Pfam PF01064   PF00069  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04060 Cytokine-cytokine receptor interaction
3. Environmental Information Processing 3.2 Signal transduction hsa04350 TGF-beta signaling pathway
5. Organismal Systems 5.8 Development hsa04360 Axon guidance
3. Environmental Information Processing 3.2 Signal transduction hsa04390 Hippo signaling pathway
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04550 Signaling pathways regulating pluripotency of stem cells
6. Human Diseases 6.1 Cancers: Overview hsa05206 MicroRNAs in cancer
6. Human Diseases 6.6 Cardiovascular diseases hsa05418 Fluid shear stress and atherosclerosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0009952 anterior/posterior pattern specification
Biological Process GO:0003176 aortic valve development
Biological Process GO:0060840 artery development
Biological Process GO:0060413 atrial septum morphogenesis
Biological Process GO:0001568 blood vessel development
Biological Process GO:0001974 blood vessel remodeling
Biological Process GO:0030509 BMP signaling pathway
Biological Process GO:0007420 brain development
Biological Process GO:0071773 cellular response to BMP stimulus
Biological Process GO:0071363 cellular response to growth factor stimulus
Biological Process GO:0009267 cellular response to starvation
Biological Process GO:0002063 chondrocyte development
Biological Process GO:0003197 endocardial cushion development
Biological Process GO:0060350 endochondral bone morphogenesis
Biological Process GO:0072577 endothelial cell apoptotic process
Biological Process GO:0001935 endothelial cell proliferation
Biological Process GO:0060173 limb development
Biological Process GO:0048286 lung alveolus development
Biological Process GO:0001946 lymphangiogenesis
Biological Process GO:0060836 lymphatic endothelial cell differentiation
Biological Process GO:0001893 maternal placenta development
Biological Process GO:0001707 mesoderm formation
Biological Process GO:0003183 mitral valve morphogenesis
Biological Process GO:0030308 negative regulation of cell growth
Biological Process GO:0003252 negative regulation of cell proliferation involved in heart valve morphogenesis
Biological Process GO:1902731 negative regulation of chondrocyte proliferation
Biological Process GO:2000279 negative regulation of DNA biosynthetic process
Biological Process GO:0003085 negative regulation of systemic arterial blood pressure
Biological Process GO:0045906 negative regulation of vasoconstriction
Biological Process GO:0003151 outflow tract morphogenesis
Biological Process GO:0003148 outflow tract septum morphogenesis
Biological Process GO:0061626 pharyngeal arch artery morphogenesis
Biological Process GO:0048842 positive regulation of axon extension involved in axon guidance
Biological Process GO:0030513 positive regulation of BMP signaling pathway
Biological Process GO:0030501 positive regulation of bone mineralization
Biological Process GO:0061036 positive regulation of cartilage development
Biological Process GO:0010595 positive regulation of endothelial cell migration
Biological Process GO:0001938 positive regulation of endothelial cell proliferation
Biological Process GO:0010634 positive regulation of epithelial cell migration
Biological Process GO:0045778 positive regulation of ossification
Biological Process GO:0045669 positive regulation of osteoblast differentiation
Biological Process GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0030166 proteoglycan biosynthetic process
Biological Process GO:0003177 pulmonary valve development
Biological Process GO:0042127 regulation of cell population proliferation
Biological Process GO:0014916 regulation of lung blood pressure
Biological Process GO:0061298 retina vasculature development in camera-type eye
Biological Process GO:1905314 semi-lunar valve development
Biological Process GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
Biological Process GO:0003186 tricuspid valve morphogenesis
Biological Process GO:0001944 vasculature development
Biological Process GO:0060841 venous blood vessel development
Biological Process GO:0060412 ventricular septum morphogenesis
molecular function GO:0016362 activin receptor activity, type II
molecular function GO:0005524 ATP binding
molecular function GO:0036122 BMP binding
molecular function GO:0098821 BMP receptor activity
molecular function GO:0045296 cadherin binding
molecular function GO:0019838 growth factor binding
molecular function GO:0046872 metal ion binding
molecular function GO:0004674 protein serine/threonine kinase activity
molecular function GO:1990782 protein tyrosine kinase binding
molecular function GO:0005024 transforming growth factor beta-activated receptor activity
cellular component GO:0005912 adherens junction
cellular component GO:0016324 apical plasma membrane
cellular component GO:0009925 basal plasma membrane
cellular component GO:0005901 caveola
cellular component GO:0009986 cell surface
cellular component GO:0005737 cytoplasm
cellular component GO:0030425 dendrite
cellular component GO:0005615 extracellular space
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0043025 neuronal cell body
cellular component GO:0005654 nucleoplasm
cellular component GO:0005886 plasma membrane
cellular component GO:0014069 postsynaptic density
cellular component GO:0043235 receptor complex
cellular component GO:0044214 spanning component of plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-201451 Signaling by BMP
R-HSA-9006936 Signaling by TGFB family members
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002873 BXGD000133 Anemia of chronic disease Hemic and Lymphatic Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006287 BXGD000390 Bronchopulmonary Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007113 BXGD000430 Rectal Carcinoma Digestive System Diseases; Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0008479 BXGD000544 Chondrosarcoma Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009782 BXGD000631 Connective Tissue Diseases Skin and Connective Tissue Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011303 BXGD000712 Demyelinating Diseases Nervous System Diseases
C0011644 BXGD000744 Scleroderma Skin and Connective Tissue Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013404 BXGD000833 Dyspnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0013743 BXGD000862 Eisenmenger Complex Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0014060 BXGD000882 Encephalitis, St. Louis Infections; Nervous System Diseases
C0016667 BXGD001072 Fragile X Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0017638 BXGD001132 Glioma Neoplasms
C0018213 BXGD001187 Graves Disease Eye Diseases; Immune System Diseases; Endocrine System Diseases
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0018816 BXGD001234 Heart Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0018817 BXGD001235 Atrial Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0019079 BXGD001278 Hemoptysis Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0020507 BXGD001413 Hyperplasia Pathological Conditions, Signs and Symptoms
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020542 BXGD001425 Pulmonary Hypertension Respiratory Tract Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0021704 BXGD001510 Intelligence Behavior and Behavior Mechanisms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024790 BXGD001804 Paroxysmal nocturnal hemoglobinuria Hemic and Lymphatic Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0025322 BXGD001863 Premature Menopause Female Urogenital Diseases and Pregnancy Complications
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0026654 BXGD001914 Moyamoya Disease Nervous System Diseases; Cardiovascular Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0034091 BXGD002463 Pulmonary Veno-Occlusive Disease (disorder) Respiratory Tract Diseases; Cardiovascular Diseases
C0035126 BXGD002509 Reperfusion Injury Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0036202 BXGD002581 Sarcoidosis Hemic and Lymphatic Diseases
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0039070 BXGD002787 Syncope Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0039445 BXGD002810 Hereditary hemorrhagic telangiectasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0039446 BXGD002811 Telangiectasis Cardiovascular Diseases
C0085215 BXGD003141 Ovarian Failure, Premature Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0152021 BXGD003520 Congenital heart disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0152171 BXGD003552 Idiopathic pulmonary hypertension Respiratory Tract Diseases; Cardiovascular Diseases
C0154307 BXGD003715 Banti's syndrome Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Hemic and Lymphatic Diseases
C0162770 BXGD003980 Right Ventricular Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0205734 BXGD004115 Diabetes, Autoimmune Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0206081 BXGD004152 Hyperandrogenism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0235527 BXGD004753 Heart Failure, Right-Sided Cardiovascular Diseases
C0235833 BXGD004775 Congenital diaphragmatic hernia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0242669 BXGD005186 Placenta, Retained Female Urogenital Diseases and Pregnancy Complications
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0279680 BXGD006680 Transitional cell carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0339510 BXGD007257 Vitelliform Macular Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0340100 BXGD007304 High altitude pulmonary edema Respiratory Tract Diseases
C0340542 BXGD007343 Sporadic primary pulmonary hypertension Respiratory Tract Diseases
C0340543 BXGD007344 Familial primary pulmonary hypertension Respiratory Tract Diseases
C0340544 BXGD007345 Pulmonary arterial hypertension induced by drug
C0342649 BXGD007522 Vascular calcification Nutritional and Metabolic Diseases
C0345893 BXGD007743 Juvenile polyposis syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0376154 BXGD007980 Skin callus Skin and Connective Tissue Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0392885 BXGD008071 High density lipoprotein measurement
C0427460 BXGD008616 Red cell distribution width determination
C0428472 BXGD008630 Serum HDL cholesterol measurement
C0520861 BXGD009115 Raised jugular venous pressure
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677932 BXGD009736 Progressive Neoplastic Disease
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0679427 BXGD009777 myeloblastosis Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0747845 BXGD010184 early pregnancy
C0856169 BXGD011096 Endothelial dysfunction
C1096458 BXGD011622 Vascular occlusion Cardiovascular Diseases
C1150929 BXGD011768 2-oxo-hept-3-ene-1,7-dioate hydratase activity
C1257931 BXGD011815 Mammary Neoplasms, Human Neoplasms; Skin and Connective Tissue Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1275685 BXGD012092 Avellino corneal dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1304746 BXGD012343 RDW - Red blood cell distribution width result
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1445957 BXGD013081 Serum total cholesterol measurement
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1504382 BXGD013140 Pulmonary arterial medial hypertrophy Respiratory Tract Diseases
C1611743 BXGD013456 Familial (FPAH)
C1629609 BXGD013479 Age at menopause
C1701938 BXGD013524 Associated Pulmonary Arterial Hypertension Respiratory Tract Diseases
C1701939 BXGD013525 Familial pulmonary arterial hypertension
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C1867421 BXGD016451 Elevated right atrial pressure
C1867423 BXGD016452 Increased pulmonary vascular resistance
C1867424 BXGD016453 Pulmonary artery vasoconstriction
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1969342 BXGD016771 PULMONARY HYPERTENSION, PRIMARY, DEXFENFLURAMINE-ASSOCIATED Respiratory Tract Diseases
C1969343 BXGD016772 Pulmonary Hypertension, Primary, Fenfluramine-Associated Respiratory Tract Diseases
C2363973 BXGD017121 Chronic thromboembolic pulmonary hypertension Respiratory Tract Diseases; Cardiovascular Diseases
C2931384 BXGD018014 Moyamoya disease 1 Nervous System Diseases; Cardiovascular Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C2939447 BXGD018179 Right ventricular failure Cardiovascular Diseases
C2973725 BXGD018205 Pulmonary arterial hypertension Respiratory Tract Diseases; Cardiovascular Diseases
C3203102 BXGD018555 Idiopathic pulmonary arterial hypertension Respiratory Tract Diseases
C3278509 BXGD018742 Spinal fusion
C3539781 BXGD019086 Progressive cGVHD
C3665995 BXGD019315 Secondary pulmonary arterial hypertension
C3697119 BXGD019352 Pulmonary arterial hypertension associated with congenital heart disease
C3714844 BXGD019435 Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia Respiratory Tract Diseases
C3806932 BXGD019527 PULMONARY VENOOCCLUSIVE DISEASE 1
C3887658 BXGD019913 PULMONARY VENOOCCLUSIVE DISEASE 1, AUTOSOMAL DOMINANT Respiratory Tract Diseases; Cardiovascular Diseases
C4023403 BXGD021179 Arterial intimal fibrosis
C4025217 BXGD021597 Pulmonary aterial intimal fibrosis
C4025731 BXGD021763 Abnormal thrombosis
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4280802 BXGD022406 Pulmonary venous occlusion
C4527152 BXGD023153 Tricuspid Valve Regurgitation Velocity
C4552070 BXGD023481 Pulmonary Hypertension, Primary, 1 Respiratory Tract Diseases
C4554601 BXGD023566 Amyloidosis cutis dyschromia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C4704874 BXGD023682 Mammary Carcinoma, Human Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein