Showing entry for Tyrosine-protein kinase Fes/Fps


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006601
Protein NameTyrosine-protein kinase Fes/Fps
Uniport IdP07332
GeneFES
Gene Id2242
DomainPkinase_Tyr; SH2
Pfam PF07714   PF00017  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.8 Development hsa04360 Axon guidance
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007155 cell adhesion
Biological Process GO:0030154 cell differentiation
Biological Process GO:0071305 cellular response to vitamin D
Biological Process GO:0007098 centrosome cycle
Biological Process GO:0006935 chemotaxis
Biological Process GO:0045087 innate immune response
Biological Process GO:0001578 microtubule bundle formation
Biological Process GO:0038083 peptidyl-tyrosine autophosphorylation
Biological Process GO:0018108 peptidyl-tyrosine phosphorylation
Biological Process GO:2000251 positive regulation of actin cytoskeleton reorganization
Biological Process GO:0031116 positive regulation of microtubule polymerization
Biological Process GO:0045657 positive regulation of monocyte differentiation
Biological Process GO:0045639 positive regulation of myeloid cell differentiation
Biological Process GO:0010976 positive regulation of neuron projection development
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0030155 regulation of cell adhesion
Biological Process GO:0045595 regulation of cell differentiation
Biological Process GO:2000145 regulation of cell motility
Biological Process GO:0042127 regulation of cell population proliferation
Biological Process GO:0008360 regulation of cell shape
Biological Process GO:0043304 regulation of mast cell degranulation
Biological Process GO:0060627 regulation of vesicle-mediated transport
Biological Process GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
molecular function GO:0005524 ATP binding
molecular function GO:0034987 immunoglobulin receptor binding
molecular function GO:0008017 microtubule binding
molecular function GO:0004715 non-membrane spanning protein tyrosine kinase activity
molecular function GO:0035091 phosphatidylinositol binding
molecular function GO:0004713 protein tyrosine kinase activity
molecular function GO:0005102 signaling receptor binding
cellular component GO:0005737 cytoplasm
cellular component GO:0031410 cytoplasmic vesicle
cellular component GO:0005829 cytosol
cellular component GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
cellular component GO:0005925 focal adhesion
cellular component GO:0005794 Golgi apparatus
cellular component GO:0015630 microtubule cytoskeleton
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-1266738 Developmental Biology
R-HSA-1433557 Signaling by SCF-KIT
R-HSA-162582 Signal Transduction
R-HSA-373755 Semaphorin interactions
R-HSA-373755 Semaphorin interactions
R-HSA-399954 Sema3A PAK dependent Axon repulsion
R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-HSA-399956 CRMPs in Sema3A signaling
R-HSA-422475 Axon guidance
R-HSA-422475 Axon guidance
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9675108 Nervous system development
R-HSA-9675108 Nervous system development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001948 BXGD000091 Alcohol consumption Behavior and Behavior Mechanisms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002895 BXGD000152 Anemia, Sickle Cell Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0005612 BXGD000317 Birth Weight Pathological Conditions, Signs and Symptoms
C0005823 BXGD000339 Blood Pressure
C0005859 BXGD000342 Bloom Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases
C0006111 BXGD000369 Brain Diseases Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0010278 BXGD000660 Craniosynostosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0012833 BXGD000795 Dizziness Pathological Conditions, Signs and Symptoms
C0014335 BXGD000908 Enteritis Digestive System Diseases
C0015468 BXGD000995 Facial Pain Pathological Conditions, Signs and Symptoms
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0016053 BXGD001041 Fibromyalgia Musculoskeletal Diseases; Nervous System Diseases
C0018081 BXGD001171 Gonorrhea Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023448 BXGD001649 Lymphoid leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023470 BXGD001659 Myeloid Leukemia Neoplasms
C0023508 BXGD001675 White Blood Cell Count procedure
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024790 BXGD001804 Paroxysmal nocturnal hemoglobinuria Hemic and Lymphatic Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030552 BXGD002238 Paresis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0034067 BXGD002456 Pulmonary Emphysema Respiratory Tract Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0038525 BXGD002768 Subarachnoid Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0042571 BXGD002991 Vertigo Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0086025 BXGD003262 Codependency Behavior and Behavior Mechanisms
C0151650 BXGD003454 Renal fibrosis Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0153690 BXGD003684 Secondary malignant neoplasm of bone Pathological Conditions, Signs and Symptoms; Neoplasms; Musculoskeletal Diseases
C0184567 BXGD004039 Acute onset pain Pathological Conditions, Signs and Symptoms
C0238461 BXGD004936 Anaplastic thyroid carcinoma Neoplasms
C0266631 BXGD005703 Accessory spleen Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0278488 BXGD006515 Carcinoma breast stage IV
C0280100 BXGD006713 Solid Neoplasm Neoplasms
C0281361 BXGD006774 Adenocarcinoma of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0334463 BXGD007076 Malignant Fibrous Histiocytoma Neoplasms
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0349204 BXGD007892 Nonorganic psychosis Mental Disorders
C0376544 BXGD008001 Hematopoietic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0428883 BXGD008639 Diastolic blood pressure
C0428886 BXGD008640 Mean blood pressure
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0677932 BXGD009736 Progressive Neoplastic Disease
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0856169 BXGD011096 Endothelial dysfunction
C0871470 BXGD011316 Systolic Pressure
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1261473 BXGD011855 Sarcoma Neoplasms
C1305849 BXGD012347 Diastolic blood pressure measurement
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306620 BXGD012371 Systolic blood pressure measurement
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1608408 BXGD013434 Malignant transformation
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1960398 BXGD016658 HER2-positive carcinoma of breast Neoplasms; Skin and Connective Tissue Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2827407 BXGD017795 Infectious Otitis Media Otorhinolaryngologic Diseases
C2936719 BXGD018130 Mechanical Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2938924 BXGD018167 Oestrogen receptor positive breast cancer
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3489532 BXGD018934 Cone-Rod Dystrophy 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C3539781 BXGD019086 Progressive cGVHD
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
C3825414 BXGD019695 Pain in children Pathological Conditions, Signs and Symptoms
C3839507 BXGD019774 Diminished ovarian reserve Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4721773 BXGD023768 Postoperative cognitive dysfunction
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
BXGC0004580 Carbanilide 212.25
BXGC0004705 Diphenylamine 169.22
BXGC0012352 Chelerythrine 348.12
BXGC0023872 Adenine 135.05
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
BXGC0050099 (2E,5S,6S,8Z,11S)-5,6,15-Trihydroxy-17-Methoxy-11-Methyl-12-Oxabicyclo[12.4.0]Octadeca-1(14),2,8,15,17-Pentaene-7,13-Dione 362.14
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein