Showing entry for Cobalamin binding intrinsic factor


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009174
Protein NameCobalamin binding intrinsic factor
Uniport IdP27352
GeneCBLIF
Gene Id2694
DomainCobalamin_bind; DUF4430
Pfam PF01122   PF14478  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.4 Digestive system hsa04977 Vitamin digestion and absorption
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0009235 cobalamin metabolic process
Biological Process GO:0015889 cobalamin transport
Biological Process GO:0006824 cobalt ion transport
molecular function GO:0031419 cobalamin binding
cellular component GO:0016324 apical plasma membrane
cellular component GO:0005768 endosome
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0043202 lysosomal lumen
cellular component GO:0005902 microvillus
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1643685 Disease
R-HSA-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism
R-HSA-196849 Metabolism of water-soluble vitamins and cofactors
R-HSA-196854 Metabolism of vitamins and cofactors
R-HSA-3296469 Defects in cobalamin (B12) metabolism
R-HSA-3296482 Defects in vitamin and cofactor metabolism
R-HSA-3359457 Defective GIF causes intrinsic factor deficiency
R-HSA-3359462 Defective AMN causes hereditary megaloblastic anemia 1
R-HSA-3359463 Defective CUBN causes hereditary megaloblastic anemia 1
R-HSA-5668914 Diseases of metabolism
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0002874 BXGD000134 Aplastic Anemia Hemic and Lymphatic Diseases
C0002888 BXGD000145 Anemia, Megaloblastic Hemic and Lymphatic Diseases
C0002892 BXGD000149 Anemia, Pernicious Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0002895 BXGD000152 Anemia, Sickle Cell Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006309 BXGD000392 Brucellosis Infections
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0010692 BXGD000686 Cystitis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0011195 BXGD000702 Dejerine-Sottas Disease (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0011265 BXGD000708 Presenile dementia Nervous System Diseases; Mental Disorders
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0013370 BXGD000822 Amebic colitis Digestive System Diseases; Infections
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0014378 BXGD000912 Enterovirus Infections Infections
C0016382 BXGD001054 Flushing Pathological Conditions, Signs and Symptoms
C0017152 BXGD001096 Gastritis Digestive System Diseases
C0017160 BXGD001099 Gastroenteritis Digestive System Diseases
C0017185 BXGD001104 Gastrointestinal Neoplasms Digestive System Diseases; Neoplasms
C0018536 BXGD001201 Hallux Valgus Musculoskeletal Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0018834 BXGD001238 Heartburn Pathological Conditions, Signs and Symptoms
C0019100 BXGD001283 Severe Dengue Infections
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0020580 BXGD001435 Hypesthesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0021053 BXGD001476 Immune System Diseases Immune System Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0021831 BXGD001516 Intestinal Diseases Digestive System Diseases
C0022104 BXGD001529 Irritable Bowel Syndrome Digestive System Diseases
C0022408 BXGD001544 Arthropathy Musculoskeletal Diseases
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0024131 BXGD001736 Lupus Vulgaris Infections; Skin and Connective Tissue Diseases
C0024138 BXGD001738 Lupus Erythematosus, Discoid Skin and Connective Tissue Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024282 BXGD001755 Lymphocytosis Hemic and Lymphatic Diseases
C0024523 BXGD001781 Malabsorption Syndrome Digestive System Diseases; Nutritional and Metabolic Diseases
C0024790 BXGD001804 Paroxysmal nocturnal hemoglobinuria Hemic and Lymphatic Diseases
C0025007 BXGD001821 Measles Infections
C0025202 BXGD001832 melanoma Neoplasms
C0026272 BXGD001898 Mixed Connective Tissue Disease Skin and Connective Tissue Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027059 BXGD001965 Myocarditis Cardiovascular Diseases
C0027430 BXGD001988 Nasal Polyps Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027794 BXGD002036 Neural Tube Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030319 BXGD002208 Panic Disorder Mental Disorders
C0030389 BXGD002216 Parainfluenza Infections
C0030554 BXGD002239 Paresthesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0030920 BXGD002263 Peptic Ulcer Digestive System Diseases
C0032461 BXGD002356 Polycythemia Hemic and Lymphatic Diseases
C0032463 BXGD002357 Polycythemia Vera Neoplasms; Hemic and Lymphatic Diseases
C0033141 BXGD002400 Cardiomyopathies, Primary Cardiovascular Diseases
C0033770 BXGD002417 Prune Belly Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0034186 BXGD002469 Pyelonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0035078 BXGD002505 Kidney Failure Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0035222 BXGD002513 Respiratory Distress Syndrome, Adult Respiratory Tract Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0040034 BXGD002836 Thrombocytopenia Hemic and Lymphatic Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0041326 BXGD002915 Pleural Tuberculosis Infections; Respiratory Tract Diseases
C0041696 BXGD002932 Unipolar Depression Mental Disorders
C0041912 BXGD002937 Upper Respiratory Infections Infections; Respiratory Tract Diseases
C0042847 BXGD003006 Vitamin B 12 Deficiency Nutritional and Metabolic Diseases
C0151779 BXGD003473 Cutaneous Melanoma Neoplasms; Skin and Connective Tissue Diseases
C0151825 BXGD003481 Bone pain Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0158458 BXGD003886 Acquired hallux valgus Musculoskeletal Diseases
C0162429 BXGD003942 Malnutrition Nutritional and Metabolic Diseases
C0206064 BXGD004150 Microvascular Angina Cardiovascular Diseases
C0206142 BXGD004161 Eosinophilic leukemia Hemic and Lymphatic Diseases
C0220766 BXGD004341 Congenital hypoplasia of adrenal gland Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Endocrine System Diseases
C0238198 BXGD004893 Gastrointestinal Stromal Tumors Digestive System Diseases; Neoplasms
C0238644 BXGD004949 Anemia, severe Hemic and Lymphatic Diseases
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0262988 BXGD005278 Vasculitis of the skin Skin and Connective Tissue Diseases; Cardiovascular Diseases
C0265656 BXGD005560 Congenital hallux valgus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0267446 BXGD005749 Acute gastroenteritis Digestive System Diseases
C0267454 BXGD005751 Necrotic enteritis Digestive System Diseases
C0275518 BXGD006375 Acute infectious disease Pathological Conditions, Signs and Symptoms; Infections
C0275524 BXGD006376 Coinfection Infections
C0275544 BXGD006377 Congenital infectious disease Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Infections
C0277302 BXGD006463 Infection by Strongyloides stercoralis Infections
C0278007 BXGD006490 Normal bowel habits
C0302845 BXGD006856 MCV - raised
C0333516 BXGD006957 Tumor necrosis Pathological Conditions, Signs and Symptoms
C0339143 BXGD007226 Thyroid associated opthalmopathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Immune System Diseases; Endocrine System Diseases
C0339901 BXGD007289 Acute respiratory infections Infections; Respiratory Tract Diseases
C0340643 BXGD007357 Dissection of aorta Cardiovascular Diseases
C0340782 BXGD007365 Hyperplastic lymph node
C0340957 BXGD007376 Congenital deficiency of intrinsic factor Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0342482 BXGD007486 X-linked Adrenal Hypoplasia Endocrine System Diseases
C0342701 BXGD007529 Transcobalamin II deficiency
C0343401 BXGD007623 MRSA - Methicillin resistant Staphylococcus aureus infection Infections
C0343641 BXGD007636 Human papilloma virus infection Infections
C0343752 BXGD007642 Acute HIV infection Infections; Immune System Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0346421 BXGD007827 Chronic eosinophilic leukemia Neoplasms; Hemic and Lymphatic Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0393591 BXGD008102 AICARDI-GOUTIERES SYNDROME Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Nervous System Diseases
C0409974 BXGD008401 Lupus Erythematosus Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases; Immune System Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0524909 BXGD009247 Hepatitis B, Chronic Digestive System Diseases; Infections
C0524910 BXGD009248 Hepatitis C, Chronic Digestive System Diseases; Infections
C0543641 BXGD009287 Megaloblastic anemia, secondary Hemic and Lymphatic Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600041 BXGD009685 Infective cystitis Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0679407 BXGD009772 Gastrointestinal dysfunction Digestive System Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0740985 BXGD010018 Acute anaemia
C0742343 BXGD010061 Acute Chest Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Hemic and Lymphatic Diseases
C0748355 BXGD010195 Acute respiratory distress Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0750292 BXGD010232 Malabsorption of Vitamin B12
C0815107 BXGD010861 psychological distress
C0848771 BXGD010886 neurological disability
C0854441 BXGD011020 Gastric mucosal lesion
C0948089 BXGD011504 Acute Coronary Syndrome Cardiovascular Diseases
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1270972 BXGD012006 Mild cognitive disorder Mental Disorders
C1292772 BXGD012232 Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative Neoplasms; Hemic and Lymphatic Diseases
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1306856 BXGD012378 Megaloblastic anemia due to inborn errors of metabolism Hemic and Lymphatic Diseases
C1334688 BXGD012728 Megaloblastic erythroid hyperplasia
C1394891 BXGD012987 Intrinsic Factor Deficiency Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C1449563 BXGD013086 Cardiomyopathy, Familial Idiopathic Cardiovascular Diseases
C1535939 BXGD013323 Pneumocystis jiroveci pneumonia Infections; Respiratory Tract Diseases
C1720830 BXGD013687 Painful Bladder Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1720983 BXGD013698 Channelopathies Pathological Conditions, Signs and Symptoms
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C1840264 BXGD014439 IMMUNE SUPPRESSION
C1848296 BXGD014918 DOSAGE-SENSITIVE SEX REVERSAL Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C1857276 BXGD015688 Trichohepatoenteric Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1963165 BXGD016685 Malabsorption, CTCAE
C2004461 BXGD016872 Bowel dysfunction Digestive System Diseases
C2062441 BXGD016897 Influenza A
C2316810 BXGD017030 Chronic kidney disease stage 5 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2363741 BXGD017100 HIV-1 infection
C2607914 BXGD017148 Allergic rhinitis (disorder) Respiratory Tract Diseases; Immune System Diseases; Otorhinolaryngologic Diseases
C3272399 BXGD018620 Gastric Neuroendocrine Tumor Digestive System Diseases; Neoplasms; Endocrine System Diseases
C3714745 BXGD019427 Malabsorption Digestive System Diseases
C3812396 BXGD019665 Chronic idiopathic pulmonary fibrosis Respiratory Tract Diseases
C3853540 BXGD019820 Aspirin exacerbated respiratory disease Pathological Conditions, Signs and Symptoms; Infections; Respiratory Tract Diseases; Immune System Diseases; Chemically-Induced Disorders; Otorhinolaryngologic Diseases
C3887639 BXGD019907 Autoimmune gastritis Digestive System Diseases
C4021641 BXGD020714 Absence of intrinsic factor
C4021753 BXGD020758 Abnormality of the immune system
C4021768 BXGD020766 Abnormality of metabolism/homeostasis
C4048329 BXGD021904 Immunosuppression
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4523989 BXGD023084 Occult hepatitis B
C4551825 BXGD023413 Megaloblastic Anemia 1 Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Hemic and Lymphatic Diseases
C4704753 BXGD023679 Urinary Bladder, Underactive Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0018397 beta-1,4-mannan 180.06
BXGC0050194 alpha-D-Mannose 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein