Showing entry for Proprotein convertase subtilisin/kexin type 9


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT018541
Protein NameProprotein convertase subtilisin/kexin type 9
Uniport IdQ8NBP7
GenePCSK9
Gene Id255738
DomainInhibitor_I9; PCSK9_C1; PCSK9_C2; PCSK9_C3; Peptidase_S8
Pfam PF05922   PF18459   PF18464   PF18463   PF00082  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.4 Digestive system hsa04979 Cholesterol metabolism
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006915 apoptotic process
Biological Process GO:0044267 cellular protein metabolic process
Biological Process GO:0032869 cellular response to insulin stimulus
Biological Process GO:0009267 cellular response to starvation
Biological Process GO:0042632 cholesterol homeostasis
Biological Process GO:0008203 cholesterol metabolic process
Biological Process GO:0001822 kidney development
Biological Process GO:0042157 lipoprotein metabolic process
Biological Process GO:0001889 liver development
Biological Process GO:0034383 low-density lipoprotein particle clearance
Biological Process GO:0032802 low-density lipoprotein particle receptor catabolic process
Biological Process GO:0007041 lysosomal transport
Biological Process GO:0010989 negative regulation of low-density lipoprotein particle clearance
Biological Process GO:1905596 negative regulation of low-density lipoprotein particle receptor binding
Biological Process GO:1905598 negative regulation of low-density lipoprotein receptor activity
Biological Process GO:1905601 negative regulation of receptor-mediated endocytosis involved in cholesterol transport
Biological Process GO:0001920 negative regulation of receptor recycling
Biological Process GO:2000650 negative regulation of sodium ion transmembrane transporter activity
Biological Process GO:0022008 neurogenesis
Biological Process GO:0030182 neuron differentiation
Biological Process GO:0006644 phospholipid metabolic process
Biological Process GO:0032805 positive regulation of low-density lipoprotein particle receptor catabolic process
Biological Process GO:0043525 positive regulation of neuron apoptotic process
Biological Process GO:0002092 positive regulation of receptor internalization
Biological Process GO:0043687 post-translational protein modification
Biological Process GO:0016540 protein autoprocessing
Biological Process GO:0043523 regulation of neuron apoptotic process
Biological Process GO:0010469 regulation of signaling receptor activity
Biological Process GO:0006641 triglyceride metabolic process
molecular function GO:0034185 apolipoprotein binding
molecular function GO:0034190 apolipoprotein receptor binding
molecular function GO:0030169 low-density lipoprotein particle binding
molecular function GO:0050750 low-density lipoprotein particle receptor binding
molecular function GO:0043621 protein self-association
molecular function GO:0030547 receptor inhibitor activity
molecular function GO:0003723 RNA binding
molecular function GO:0004252 serine-type endopeptidase activity
molecular function GO:0019871 sodium channel inhibitor activity
molecular function GO:0034189 very-low-density lipoprotein particle binding
molecular function GO:0070326 very-low-density lipoprotein particle receptor binding
cellular component GO:0009986 cell surface
cellular component GO:0030134 COPII-coated ER to Golgi transport vesicle
cellular component GO:0005737 cytoplasm
cellular component GO:0005769 early endosome
cellular component GO:0036020 endolysosome membrane
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005788 endoplasmic reticulum lumen
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0031232 extrinsic component of external side of plasma membrane
cellular component GO:0005794 Golgi apparatus
cellular component GO:0005770 late endosome
cellular component GO:0005765 lysosomal membrane
cellular component GO:0005764 lysosome
cellular component GO:1990667 PCSK9-AnxA2 complex
cellular component GO:1990666 PCSK9-LDLR complex
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0005886 plasma membrane
cellular component GO:0005791 rough endoplasmic reticulum
Reactome
Pathway Id Pathway Name
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-382551 Transport of small molecules
R-HSA-392499 Metabolism of proteins
R-HSA-597592 Post-translational protein modification
R-HSA-8866427 VLDLR internalisation and degradation
R-HSA-8957275 Post-translational protein phosphorylation
R-HSA-8964038 LDL clearance
R-HSA-8964043 Plasma lipoprotein clearance
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000744 BXGD000006 Abetalipoproteinemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0001430 BXGD000054 Adenoma Neoplasms
C0001948 BXGD000091 Alcohol consumption Behavior and Behavior Mechanisms
C0001956 BXGD000092 Alcohol Use Disorder Chemically-Induced Disorders; Mental Disorders
C0002382 BXGD000109 Alveolar Bone Loss Musculoskeletal Diseases; Stomatognathic Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0002962 BXGD000160 Angina Pectoris Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003499 BXGD000201 Supravalvular aortic stenosis Cardiovascular Diseases
C0003507 BXGD000203 Aortic Valve Stenosis Cardiovascular Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003862 BXGD000230 Arthralgia Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004610 BXGD000281 Bacteremia Pathological Conditions, Signs and Symptoms; Infections
C0004623 BXGD000282 Bacterial Infections Infections
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007194 BXGD000452 Hypertrophic Cardiomyopathy Cardiovascular Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007282 BXGD000458 Carotid Stenosis Nervous System Diseases; Cardiovascular Diseases
C0007787 BXGD000487 Transient Ischemic Attack Nervous System Diseases; Cardiovascular Diseases
C0007820 BXGD000491 Cerebrovascular Disorders Nervous System Diseases; Cardiovascular Diseases
C0008031 BXGD000511 Chest Pain Pathological Conditions, Signs and Symptoms
C0008350 BXGD000531 Cholelithiasis Digestive System Diseases
C0008370 BXGD000534 Cholestasis Digestive System Diseases
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0010051 BXGD000646 Coronary Aneurysm Cardiovascular Diseases
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011265 BXGD000708 Presenile dementia Nervous System Diseases; Mental Disorders
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013404 BXGD000833 Dyspnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0016667 BXGD001072 Fragile X Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0018808 BXGD001229 Heart murmur Pathological Conditions, Signs and Symptoms
C0019158 BXGD001293 Hepatitis Digestive System Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0020428 BXGD001377 Hyperaldosteronism Endocrine System Diseases
C0020443 BXGD001385 Hypercholesterolemia Nutritional and Metabolic Diseases
C0020445 BXGD001386 Hypercholesterolemia, Familial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0020473 BXGD001396 Hyperlipidemia Nutritional and Metabolic Diseases
C0020474 BXGD001397 Hyperlipidemia, Familial Combined Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020476 BXGD001398 Hyperlipoproteinemias Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020557 BXGD001432 Hypertriglyceridemia Nutritional and Metabolic Diseases
C0020597 BXGD001439 Hypobetalipoproteinemias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0023896 BXGD001718 Alcoholic Liver Diseases Digestive System Diseases; Chemically-Induced Disorders
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024143 BXGD001741 Lupus Nephritis Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Male Urogenital Diseases; Immune System Diseases
C0024530 BXGD001783 Malaria Infections
C0024809 BXGD001808 Marijuana Abuse Chemically-Induced Disorders; Mental Disorders
C0025202 BXGD001832 melanoma Neoplasms
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0026266 BXGD001895 Mitral Valve Insufficiency Cardiovascular Diseases
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0026850 BXGD001942 Muscular Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027708 BXGD002025 Nephroblastoma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027726 BXGD002030 Nephrotic Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027794 BXGD002036 Neural Tube Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0028756 BXGD002083 Obesity, Morbid Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029132 BXGD002117 Disorder of the optic nerve Eye Diseases; Nervous System Diseases
C0030499 BXGD002232 Parasitic Diseases Infections
C0030920 BXGD002263 Peptic Ulcer Digestive System Diseases
C0031090 BXGD002280 Periodontal Diseases Stomatognathic Diseases
C0031099 BXGD002282 Periodontitis Stomatognathic Diseases
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0033847 BXGD002437 Pseudoxanthoma Elasticum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0034067 BXGD002456 Pulmonary Emphysema Respiratory Tract Diseases
C0035067 BXGD002504 Renal Artery Stenosis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Cardiovascular Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0038436 BXGD002755 Post-Traumatic Stress Disorder Mental Disorders
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0042373 BXGD002978 Vascular Diseases Cardiovascular Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0043325 BXGD003041 Xanthomatosis Nutritional and Metabolic Diseases
C0080178 BXGD003107 Spina Bifida Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0085078 BXGD003118 Lysosomal Storage Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0085096 BXGD003123 Peripheral Vascular Diseases Cardiovascular Diseases
C0085298 BXGD003155 Sudden Cardiac Death Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0085423 BXGD003173 Gram-Negative Bacterial Infections Infections
C0085762 BXGD003251 Alcohol abuse Chemically-Induced Disorders; Mental Disorders
C0086543 BXGD003294 Cataract Eye Diseases
C0149725 BXGD003351 Lower respiratory tract infection Infections; Respiratory Tract Diseases
C0149871 BXGD003375 Deep Vein Thrombosis Cardiovascular Diseases
C0151718 BXGD003464 Hypocholesterolemia Nutritional and Metabolic Diseases
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0152417 BXGD003584 Congenital stenosis of aortic valve Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0154208 BXGD003707 Disorder of endocrine ovary Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0154251 BXGD003710 Lipid Metabolism Disorders Nutritional and Metabolic Diseases
C0155626 BXGD003806 Acute myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0162309 BXGD003934 Adrenoleukodystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Endocrine System Diseases
C0162871 BXGD003996 Aortic Aneurysm, Abdominal Cardiovascular Diseases
C0175754 BXGD004015 Agenesis of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0202236 BXGD004086 Triglycerides measurement
C0206624 BXGD004190 Hepatoblastoma Neoplasms
C0206686 BXGD004241 Adrenocortical carcinoma Neoplasms; Endocrine System Diseases
C0221253 BXGD004422 Xanthoma tendinosum Nutritional and Metabolic Diseases
C0231528 BXGD004496 Myalgia Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0241868 BXGD005118 acute aortic dissection Cardiovascular Diseases
C0242339 BXGD005150 Dyslipidemias Nutritional and Metabolic Diseases
C0242350 BXGD005154 Erectile dysfunction Male Urogenital Diseases; Mental Disorders
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0242698 BXGD005189 Ventricular Dysfunction, Left Cardiovascular Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0264683 BXGD005410 Coronary artery atheroma Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0265987 BXGD005598 Nevus comedonicus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Skin and Connective Tissue Diseases
C0268483 BXGD005959 Tyrosinemias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0268490 BXGD005962 Tyrosinemia, Type I Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0271650 BXGD006227 Impaired glucose tolerance Nutritional and Metabolic Diseases
C0302314 BXGD006837 Xanthoma Nutritional and Metabolic Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0340285 BXGD007315 Triple vessel disease of the heart Cardiovascular Diseases
C0340288 BXGD007316 Stable angina Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0340643 BXGD007357 Dissection of aorta Cardiovascular Diseases
C0342879 BXGD007570 Primary hypercholesterolemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0342880 BXGD007571 Polygenic hypercholesterolemia
C0342881 BXGD007572 Familial hypercholesterolemia - homozygous Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0342882 BXGD007573 Familial hypercholesterolemia - heterozygous Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0342907 BXGD007581 Sitosterolemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0346402 BXGD007823 Malignant neoplasm of adrenal cortex Neoplasms; Endocrine System Diseases
C0349415 BXGD007903 Gram-positive septic shock Pathological Conditions, Signs and Symptoms; Infections; Cardiovascular Diseases
C0362046 BXGD007959 Prediabetes syndrome Nutritional and Metabolic Diseases; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0376545 BXGD008002 Hematologic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0376618 BXGD008003 Endotoxemia Pathological Conditions, Signs and Symptoms; Infections
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0410529 BXGD008431 Hypochondroplasia (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0428474 BXGD008631 Serum LDL cholesterol measurement
C0494165 BXGD009022 Secondary malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0497327 BXGD009061 Dementia Nervous System Diseases; Mental Disorders
C0521707 BXGD009166 Bilateral cataracts (disorder) Eye Diseases
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0549399 BXGD009376 Low density lipoprotein increased Nutritional and Metabolic Diseases
C0555198 BXGD009432 Malignant Glioma Neoplasms
C0577631 BXGD009535 Carotid Atherosclerosis Nervous System Diseases; Cardiovascular Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598608 BXGD009668 Hyperhomocysteinemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0600327 BXGD009704 Toxic Shock Syndrome Pathological Conditions, Signs and Symptoms; Infections
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0740391 BXGD009987 Middle Cerebral Artery Occlusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0741923 BXGD010045 cardiac event
C0742343 BXGD010061 Acute Chest Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Hemic and Lymphatic Diseases
C0745103 BXGD010114 Hyperlipoproteinemia Type IIa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0745744 BXGD010133 End Stage Liver Disease Digestive System Diseases
C0751007 BXGD010287 Intracranial Atherosclerosis Nervous System Diseases; Cardiovascular Diseases
C0751606 BXGD010523 Adult Acute Lymphocytic Leukemia
C0852949 BXGD010957 Arteriopathic disease Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0856169 BXGD011096 Endothelial dysfunction
C0856742 BXGD011111 Post MI Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0917801 BXGD011412 Sleeplessness Nervous System Diseases; Mental Disorders
C0947751 BXGD011494 Vascular inflammations Cardiovascular Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C0948089 BXGD011504 Acute Coronary Syndrome Cardiovascular Diseases
C0948807 BXGD011558 Hepatic impairment
C1096249 BXGD011612 Calcification of the aorta
C1260873 BXGD011835 Aortic valve disorder Cardiovascular Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1290884 BXGD012198 Inflammatory disorder Pathological Conditions, Signs and Symptoms
C1301700 BXGD012296 Cardiovascular morbidity
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332347 BXGD012527 Atypical Ductal Breast Hyperplasia Neoplasms
C1402315 BXGD013017 Vascular lesions
C1445957 BXGD013081 Serum total cholesterol measurement
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1516061 BXGD013211 Astler-Coller B1 Rectal Carcinoma
C1536220 BXGD013341 ST segment elevation myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1561921 BXGD013366 Non-ST elevation (NSTEMI) myocardial infarction
C1565489 BXGD013401 Renal Insufficiency Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1611743 BXGD013456 Familial (FPAH)
C1704417 BXGD013557 Hyperlipoproteinemia Type IIb Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C1704436 BXGD013564 Peripheral Arterial Diseases Cardiovascular Diseases
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C1848486 BXGD014929 Premature arteriosclerosis Cardiovascular Diseases
C1854107 BXGD015380 Hyperaldosteronism, Familial, Type II Endocrine System Diseases
C1860488 BXGD015986 Abnormal internal carotid artery morphology
C1861172 BXGD016016 Venous Thromboembolism Cardiovascular Diseases
C1862596 BXGD016135 Familial hypobetalipoproteinemia Nutritional and Metabolic Diseases
C1863512 BXGD016181 HYPERCHOLESTEROLEMIA, AUTOSOMAL RECESSIVE Nutritional and Metabolic Diseases
C1863551 BXGD016182 HYPERCHOLESTEROLEMIA, AUTOSOMAL DOMINANT, 3 Nutritional and Metabolic Diseases
C1867743 BXGD016470 Premature coronary artery atherosclerosis Cardiovascular Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1960636 BXGD016668 Dysglycemia
C1961102 BXGD016673 Precursor Cell Lymphoblastic Leukemia Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2004493 BXGD016875 Leukemia, B-Cell Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2316810 BXGD017030 Chronic kidney disease stage 5 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2747816 BXGD017577 Complicated malaria Infections
C2919414 BXGD017873 Low density lipoprotein receptor mutation
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3160761 BXGD018475 Diabetic dyslipidaemia
C3178801 BXGD018538 Stroke, Lacunar Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C3241937 BXGD018578 Nonalcoholic Steatohepatitis Digestive System Diseases
C3267047 BXGD018611 Autoimmune necrotizing myopathy Musculoskeletal Diseases; Immune System Diseases; Nervous System Diseases
C3276239 BXGD018686 LOW DENSITY LIPOPROTEIN CHOLESTEROL LEVEL QUANTITATIVE TRAIT LOCUS 1
C3549252 BXGD019123 response to statin
C3665365 BXGD019282 Arteriosclerotic cardiovascular disease, NOS Cardiovascular Diseases
C3845502 BXGD019809 Myocardial infarction, stroke
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C3888506 BXGD019974 LDLR mutation
C4021654 BXGD020722 Precocious atherosclerosis Cardiovascular Diseases
C4021796 BXGD020786 Renal steatosis
C4022811 BXGD021006 Abnormality of nervous system physiology Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4022924 BXGD021040 Abnormal eye physiology
C4024924 BXGD021477 Cerebral artery atherosclerosis Cardiovascular Diseases
C4025000 BXGD021519 Myocardial steatosis
C4025272 BXGD021615 Peripheral arterial stenosis
C4255010 BXGD022310 Non-ST Elevated Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C4310756 BXGD022653 HYPERALDOSTERONISM, FAMILIAL, TYPE IV
C4317295 BXGD022737 Congenital disorder of glycosylation type 1s Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C4324563 BXGD022772 Neutrophil extracellular trap formation
C4505456 BXGD022964 HIV Coinfection Infections; Immune System Diseases
C4524040 BXGD023086 Atherogenic dyslipidaemia
C4529962 BXGD023178 Fatty Liver Disease
C4551472 BXGD023303 Hypertrophic obstructive cardiomyopathy Cardiovascular Diseases
C4699152 BXGD023634 ST-segment elevation myocardial infarction (STEMI)
C4700045 BXGD023640 Non-ST-segment elevation myocardial infarction (NSTEMI)
C4703473 BXGD023650 Atherosclerotic lesion Cardiovascular Diseases
C4707954 BXGD023726 Low density lipoprotein receptor adaptor protein 1 mutation
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
BXGC0004275 Acetaldehyde 44.05
BXGC0018397 beta-1,4-mannan 180.06
BXGC0030612 tetraethylene glycol 194.12
BXGC0050194 alpha-D-Mannose 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein