Showing entry for Hexokinase-1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008476
Protein NameHexokinase-1
Uniport IdP19367
GeneHK1
Gene Id3098
DomainHexokinase_1; Hexokinase_2
Pfam PF00349   PF03727  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.1 Carbohydrate metabolism hsa00010 Glycolysis / Gluconeogenesis
1. Metabolism 1.1 Carbohydrate metabolism hsa00051 Fructose and mannose metabolism
1. Metabolism 1.1 Carbohydrate metabolism hsa00052 Galactose metabolism
1. Metabolism 1.1 Carbohydrate metabolism hsa00500 Starch and sucrose metabolism
1. Metabolism 1.1 Carbohydrate metabolism hsa00520 Amino sugar and nucleotide sugar metabolism
1. Metabolism 1.10 Biosynthesis of other secondary metabolites hsa00524 Neomycin, kanamycin and gentamicin biosynthesis
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
1. Metabolism 1.0 Global and overview maps hsa01200 Carbon metabolism
3. Environmental Information Processing 3.2 Signal transduction hsa04066 HIF-1 signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04910 Insulin signaling pathway
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04930 Type II diabetes mellitus
5. Organismal Systems 5.4 Digestive system hsa04973 Carbohydrate digestion and absorption
6. Human Diseases 6.1 Cancers: Overview hsa05230 Central carbon metabolism in cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0061621 canonical glycolysis
Biological Process GO:0046835 carbohydrate phosphorylation
Biological Process GO:0001678 cellular glucose homeostasis
Biological Process GO:0072655 establishment of protein localization to mitochondrion
Biological Process GO:0006002 fructose 6-phosphate metabolic process
Biological Process GO:0051156 glucose 6-phosphate metabolic process
Biological Process GO:0006096 glycolytic process
Biological Process GO:0006954 inflammatory response
Biological Process GO:0045087 innate immune response
Biological Process GO:0072656 maintenance of protein location in mitochondrion
Biological Process GO:0006013 mannose metabolic process
Biological Process GO:0002720 positive regulation of cytokine production involved in immune response
Biological Process GO:0032731 positive regulation of interleukin-1 beta production
molecular function GO:0005524 ATP binding
molecular function GO:0008865 fructokinase activity
molecular function GO:0004340 glucokinase activity
molecular function GO:0005536 glucose binding
molecular function GO:0004396 hexokinase activity
molecular function GO:0042802 identical protein binding
molecular function GO:0019158 mannokinase activity
molecular function GO:0042834 peptidoglycan binding
cellular component GO:0005829 cytosol
cellular component GO:0045121 membrane raft
cellular component GO:0005741 mitochondrial outer membrane
cellular component GO:0005739 mitochondrion
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1643685 Disease
R-HSA-5619056 Defective HK1 causes hexokinase deficiency (HK deficiency)
R-HSA-5619102 SLC transporter disorders
R-HSA-5619115 Disorders of transmembrane transporters
R-HSA-70171 Glycolysis
R-HSA-70326 Glucose metabolism
R-HSA-71387 Metabolism of carbohydrates
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002152 BXGD000104 Alloxan Diabetes Nutritional and Metabolic Diseases; Endocrine System Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0002878 BXGD000137 Anemia, Hemolytic Hemic and Lymphatic Diseases
C0002881 BXGD000140 Anemia, Hemolytic, Congenital Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007959 BXGD000507 Charcot-Marie-Tooth Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0008312 BXGD000527 Primary biliary cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0008325 BXGD000529 Cholecystitis Digestive System Diseases
C0008350 BXGD000531 Cholelithiasis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014772 BXGD000948 Red Blood Cell Count measurement
C0015396 BXGD000982 Eye Color
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0016057 BXGD001042 Fibrosarcoma Neoplasms
C0016506 BXGD001062 Foot Deformities Musculoskeletal Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0018564 BXGD001204 Hand deformities Musculoskeletal Diseases
C0018935 BXGD001252 Hematocrit procedure
C0020433 BXGD001379 Hyperbilirubinemia Pathological Conditions, Signs and Symptoms
C0020542 BXGD001425 Pulmonary Hypertension Respiratory Tract Diseases
C0020615 BXGD001445 Hypoglycemia Nutritional and Metabolic Diseases
C0021670 BXGD001509 insulinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0022346 BXGD001537 Icterus Pathological Conditions, Signs and Symptoms
C0022353 BXGD001539 Neonatal Jaundice Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0023418 BXGD001642 leukemia Neoplasms
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024198 BXGD001743 Lyme Disease Infections
C0024530 BXGD001783 Malaria Infections
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0027888 BXGD002056 Hereditary Motor and Sensory Neuropathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0028077 BXGD002069 Nyctalopia Eye Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0033740 BXGD002416 Protozoan Infections Infections
C0035334 BXGD002539 Retinitis Pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0037822 BXGD002706 Speech Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037889 BXGD002709 Hereditary spherocytosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0038002 BXGD002723 Splenomegaly Pathological Conditions, Signs and Symptoms
C0038433 BXGD002754 Streptozotocin Diabetes Nutritional and Metabolic Diseases; Endocrine System Diseases
C0040517 BXGD002872 Gilles de la Tourette syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0042961 BXGD003017 Intestinal Volvulus Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0080178 BXGD003107 Spina Bifida Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0085577 BXGD003189 Normocytic anemia Hemic and Lymphatic Diseases
C0085636 BXGD003218 Photophobia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0151888 BXGD003497 Hyporeflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0153633 BXGD003674 Malignant neoplasm of brain Neoplasms; Nervous System Diseases
C0162323 BXGD003937 Polyarthritis Musculoskeletal Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206157 BXGD004165 Myopathies, Nemaline Musculoskeletal Diseases; Nervous System Diseases
C0206160 BXGD004166 Reticulocytosis Pathological Conditions, Signs and Symptoms
C0206161 BXGD004167 Reticulocyte count (procedure)
C0206624 BXGD004190 Hepatoblastoma Neoplasms
C0206702 BXGD004252 Klatskin Tumor Neoplasms
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0234632 BXGD004691 Reduced visual acuity Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0235095 BXGD004723 Visual field constriction Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0235983 BXGD004798 Normochromic anemia Hemic and Lymphatic Diseases
C0238190 BXGD004890 Inclusion Body Myositis (disorder) Musculoskeletal Diseases; Nervous System Diseases
C0241910 BXGD005123 Autoimmune Chronic Hepatitis Digestive System Diseases; Immune System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0278595 BXGD006545 Adult Fibrosarcoma Neoplasms
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0280100 BXGD006713 Solid Neoplasm Neoplasms
C0311394 BXGD006884 Difficulty walking Pathological Conditions, Signs and Symptoms
C0339525 BXGD007258 Autosomal dominant retinitis pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0340968 BXGD007377 Deficiency of pyruvate kinase Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0342276 BXGD007449 Maturity onset diabetes mellitus in young Nutritional and Metabolic Diseases; Endocrine System Diseases
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0349566 BXGD007928 Squamous cell carcinoma of tongue Neoplasms; Stomatognathic Diseases
C0376618 BXGD008003 Endotoxemia Pathological Conditions, Signs and Symptoms; Infections
C0398563 BXGD008192 Deficiency of hexokinase (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0423421 BXGD008484 Atrophic macular change
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0427065 BXGD008604 Distal muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0427460 BXGD008616 Red cell distribution width determination
C0472792 BXGD008922 Hemolytic anemia due to hexokinase deficiency Hemic and Lymphatic Diseases
C0518015 BXGD009068 Hemoglobin measurement
C0520572 BXGD009093 Enzymopathy Nutritional and Metabolic Diseases
C0521158 BXGD009130 Recurrent tumor
C0522224 BXGD009198 Paralysed Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0524587 BXGD009232 Mean Corpuscular Volume (result)
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0554970 BXGD009428 Pallor of optic disc
C0555198 BXGD009432 Malignant Glioma Neoplasms
C0557874 BXGD009444 Global developmental delay
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598589 BXGD009667 Inherited neuropathies Nervous System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0730285 BXGD009943 Diabetic macular edema Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0751606 BXGD010523 Adult Acute Lymphocytic Leukemia
C0752335 BXGD010720 Neuropsychiatric Systemic Lupus Erythematosus Infections; Skin and Connective Tissue Diseases; Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
C0852413 BXGD010943 Abnormal muscle tone Nervous System Diseases
C1257958 BXGD011816 Glucose Metabolism Disorders Nutritional and Metabolic Diseases
C1261502 BXGD011856 Finding of Mean Corpuscular Hemoglobin
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1281911 BXGD012134 Hemoglobin A measurement
C1288283 BXGD012175 Atrophoderma maculatum Skin and Connective Tissue Diseases
C1304746 BXGD012343 RDW - Red blood cell distribution width result
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1335302 BXGD012775 Pancreatic Ductal Adenocarcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1531624 BXGD013300 Cardioembolic stroke
C1608408 BXGD013434 Malignant transformation
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1854449 BXGD015403 Neuropathy, hereditary motor and sensory, Russe type Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1854454 BXGD015404 Axonal regeneration
C1858729 BXGD015825 Decreased motor nerve conduction velocity
C1859606 BXGD015914 Decreased number of large peripheral myelinated nerve fibers
C1879344 BXGD016574 Biliary papillomatosis Digestive System Diseases; Neoplasms
C2239101 BXGD016963 Hemoglobin, CTCAE
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2932678 BXGD018098 Inherited Peripheral Neuropathy Nervous System Diseases
C2939465 BXGD018182 Deficiency of glucose-6-phosphate dehydrogenase Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C3150343 BXGD018301 HEMOLYTIC ANEMIA, NONSPHEROCYTIC, DUE TO HEXOKINASE DEFICIENCY
C3665347 BXGD019279 Visual Impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4021768 BXGD020766 Abnormality of metabolism/homeostasis
C4022737 BXGD020973 Neurodevelopmental abnormality
C4024927 BXGD021479 Peripheral hypomyelination
C4025735 BXGD021767 Nonspherocytic hemolytic anemia Hemic and Lymphatic Diseases
C4479526 BXGD022940 RETINITIS PIGMENTOSA 79
C4528257 BXGD023159 Corpuscular Hemoglobin Concentration Mean
C4721209 BXGD023734 Metastatic human epidermal growth factor 2 positive carcinoma of breast Neoplasms; Skin and Connective Tissue Diseases
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
C4721555 BXGD023755 Autoimmune hepatitis Digestive System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
BXGC0002588 Magnesium 24.31
BXGC0002591 Potassium 39.1
BXGC0005620 beta-D-Glucopyranose 180.16
BXGC0005625 alpha-D-Glucopyranose 180.16
BXGC0006198 Citric acid 192.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein