Showing entry for Retinal dehydrogenase 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005333
Protein NameRetinal dehydrogenase 2
Uniport IdO94788
GeneALDH1A2
Gene Id8854
DomainAldedh
Pfam PF00171  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.8 Metabolism of cofactors and vitamins hsa00830 Retinol metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0042904 9-cis-retinoic acid biosynthetic process
Biological Process GO:0001568 blood vessel development
Biological Process GO:0048738 cardiac muscle tissue development
Biological Process GO:0071300 cellular response to retinoic acid
Biological Process GO:0009855 determination of bilateral symmetry
Biological Process GO:0031076 embryonic camera-type eye development
Biological Process GO:0048566 embryonic digestive tract development
Biological Process GO:0035115 embryonic forelimb morphogenesis
Biological Process GO:0060324 face development
Biological Process GO:0003007 heart morphogenesis
Biological Process GO:0030902 hindbrain development
Biological Process GO:0001822 kidney development
Biological Process GO:0001889 liver development
Biological Process GO:0030324 lung development
Biological Process GO:0007494 midgut development
Biological Process GO:0016331 morphogenesis of embryonic epithelium
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0014032 neural crest cell development
Biological Process GO:0021915 neural tube development
Biological Process GO:0030182 neuron differentiation
Biological Process GO:0031016 pancreas development
Biological Process GO:0021983 pituitary gland development
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0051289 protein homotetramerization
Biological Process GO:0009954 proximal/distal pattern formation
Biological Process GO:0001936 regulation of endothelial cell proliferation
Biological Process GO:0034097 response to cytokine
Biological Process GO:0032355 response to estradiol
Biological Process GO:0033189 response to vitamin A
Biological Process GO:0042574 retinal metabolic process
Biological Process GO:0002138 retinoic acid biosynthetic process
Biological Process GO:0042573 retinoic acid metabolic process
Biological Process GO:0090242 retinoic acid receptor signaling pathway involved in somitogenesis
Biological Process GO:0042572 retinol metabolic process
Biological Process GO:0035799 ureter maturation
Biological Process GO:0006776 vitamin A metabolic process
molecular function GO:0004028 3-chloroallyl aldehyde dehydrogenase activity
molecular function GO:0004029 aldehyde dehydrogenase (NAD+) activity
molecular function GO:0016918 retinal binding
molecular function GO:0001758 retinal dehydrogenase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0048471 perinuclear region of cytoplasm
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-5362517 Signaling by Retinoic Acid
R-HSA-5365859 RA biosynthesis pathway
R-HSA-9006931 Signaling by Nuclear Receptors
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001948 BXGD000091 Alcohol consumption Behavior and Behavior Mechanisms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0002893 BXGD000150 Refractory anemias Hemic and Lymphatic Diseases
C0003868 BXGD000233 Arthritis, Gouty Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004763 BXGD000289 Barrett Esophagus Digestive System Diseases; Neoplasms
C0005823 BXGD000339 Blood Pressure
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0012236 BXGD000772 DiGeorge Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0012242 BXGD000773 Digestive System Disorders Digestive System Diseases
C0014772 BXGD000948 Red Blood Cell Count measurement
C0017178 BXGD001102 Gastrointestinal Diseases Digestive System Diseases
C0018099 BXGD001172 Gout Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0018133 BXGD001176 Graft-vs-Host Disease Immune System Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018935 BXGD001252 Hematocrit procedure
C0021831 BXGD001516 Intestinal Diseases Digestive System Diseases
C0023281 BXGD001628 Leishmaniasis Infections; Skin and Connective Tissue Diseases
C0023508 BXGD001675 White Blood Cell Count procedure
C0025312 BXGD001861 Meningomyelocele Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0026654 BXGD001914 Moyamoya Disease Nervous System Diseases; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027794 BXGD002036 Neural Tube Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0039685 BXGD002825 Tetralogy of Fallot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0042842 BXGD003005 Vitamin A Deficiency Nutritional and Metabolic Diseases
C0080178 BXGD003107 Spina Bifida Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0086664 BXGD003304 Myelocele Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0086743 BXGD003308 Osteoarthrosis Deformans Musculoskeletal Diseases
C0152021 BXGD003520 Congenital heart disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0201657 BXGD004051 C-reactive protein measurement
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0202177 BXGD004079 Phospholipid measurement
C0202236 BXGD004086 Triglycerides measurement
C0205696 BXGD004107 Anaplastic carcinoma Neoplasms
C0206667 BXGD004228 Adrenal Cortical Adenoma Neoplasms; Endocrine System Diseases
C0235833 BXGD004775 Congenital diaphragmatic hernia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0242422 BXGD005163 Parkinsonian Disorders Nervous System Diseases
C0242423 BXGD005164 Ramsay Hunt Paralysis Syndrome Nervous System Diseases
C0263746 BXGD005346 Osteoarthritis of the hand Musculoskeletal Diseases
C0271084 BXGD006159 Exudative age-related macular degeneration Eye Diseases
C0279628 BXGD006659 Adenocarcinoma Of Esophagus Digestive System Diseases; Neoplasms
C0337438 BXGD007159 Glucose measurement
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0392885 BXGD008071 High density lipoprotein measurement
C0409959 BXGD008400 Osteoarthritis, Knee Musculoskeletal Diseases
C0410702 BXGD008447 Adolescent idiopathic scoliosis Musculoskeletal Diseases
C0428472 BXGD008630 Serum HDL cholesterol measurement
C0428883 BXGD008639 Diastolic blood pressure
C0495706 BXGD009038 elevated blood glucose level
C0518015 BXGD009068 Hemoglobin measurement
C0523465 BXGD009209 Serum albumin measurement
C0523677 BXGD009215 Glycine measurement
C0523744 BXGD009217 Lipids measurement
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677886 BXGD009734 Epithelial ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0750929 BXGD010256 Arnold-Chiari Malformation, Type I Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0751316 BXGD010387 Acquired Meningomyelocele Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0752097 BXGD010659 Autosomal Dominant Juvenile Parkinson Disease Nervous System Diseases
C0752098 BXGD010660 Autosomal Dominant Parkinsonism Nervous System Diseases
C0752100 BXGD010661 Autosomal Recessive Parkinsonism Nervous System Diseases
C0752101 BXGD010662 Parkinsonism, Experimental Nervous System Diseases
C0752104 BXGD010663 Familial Juvenile Parkinsonism Nervous System Diseases
C0752105 BXGD010664 Parkinsonism, Juvenile Nervous System Diseases
C0812413 BXGD010847 Malignant Pleural Mesothelioma Neoplasms; Respiratory Tract Diseases
C0871470 BXGD011316 Systolic Pressure
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1168443 BXGD011794 Pseudocholinesterase Measurement
C1275122 BXGD012060 Familial multiple trichoepitheliomata Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Skin and Connective Tissue Diseases
C1305855 BXGD012348 Body mass index
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1445957 BXGD013081 Serum total cholesterol measurement
C1536085 BXGD013334 Geographic Atrophy Eye Diseases
C1611184 BXGD013455 Calcification of coronary artery Nutritional and Metabolic Diseases; Cardiovascular Diseases
C1837461 BXGD014234 SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
C1868675 BXGD016520 PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE Nervous System Diseases
C1961099 BXGD016672 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2237660 BXGD016962 exudative macular degeneration Eye Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2675071 BXGD017268 HIGH DENSITY LIPOPROTEIN CHOLESTEROL LEVEL QUANTITATIVE TRAIT LOCUS 12
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2931384 BXGD018014 Moyamoya disease 1 Nervous System Diseases; Cardiovascular Diseases
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4528257 BXGD023159 Corpuscular Hemoglobin Concentration Mean
C4529962 BXGD023178 Fatty Liver Disease
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000204 Theophylline 180.16
BXGC0001502 Caffeine 194.19
BXGC0005921 Daidzin 416.38
BXGC0047568 Retinol 286.23
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein