Showing entry for Low-density lipoprotein receptor-related protein 6


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005136
Protein NameLow-density lipoprotein receptor-related protein 6
Uniport IdO75581
GeneLRP6
Gene Id4040
DomainFXa_inhibition; Ldl_recept_a; Ldl_recept_b
Pfam PF00057   PF00058  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04150 mTOR signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04310 Wnt signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04928 Parathyroid hormone synthesis, secretion and action
6. Human Diseases 6.1 Cancers: Overview hsa05200 Pathways in cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05224 Breast cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05225 Hepatocellular carcinoma
6. Human Diseases 6.2 Cancers: Specific types hsa05226 Gastric cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0009952 anterior/posterior pattern specification
Biological Process GO:0090245 axis elongation involved in somitogenesis
Biological Process GO:1904886 beta-catenin destruction complex disassembly
Biological Process GO:0060349 bone morphogenesis
Biological Process GO:0046849 bone remodeling
Biological Process GO:0060444 branching involved in mammary gland duct morphogenesis
Biological Process GO:0060070 canonical Wnt signaling pathway
Biological Process GO:0044335 canonical Wnt signaling pathway involved in neural crest cell differentiation
Biological Process GO:0044340 canonical Wnt signaling pathway involved in regulation of cell proliferation
Biological Process GO:0098609 cell-cell adhesion
Biological Process GO:0071397 cellular response to cholesterol
Biological Process GO:0021587 cerebellum morphogenesis
Biological Process GO:0021987 cerebral cortex development
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:0060026 convergent extension
Biological Process GO:0071542 dopaminergic neuron differentiation
Biological Process GO:0048596 embryonic camera-type eye morphogenesis
Biological Process GO:0030326 embryonic limb morphogenesis
Biological Process GO:0009880 embryonic pattern specification
Biological Process GO:0060059 embryonic retina morphogenesis in camera-type eye
Biological Process GO:0035261 external genitalia morphogenesis
Biological Process GO:0060325 face morphogenesis
Biological Process GO:0001702 gastrulation with mouth forming second
Biological Process GO:0030901 midbrain development
Biological Process GO:1904948 midbrain dopaminergic neuron differentiation
Biological Process GO:0030917 midbrain-hindbrain boundary development
Biological Process GO:0090090 negative regulation of canonical Wnt signaling pathway
Biological Process GO:0006469 negative regulation of protein kinase activity
Biological Process GO:0001933 negative regulation of protein phosphorylation
Biological Process GO:0071901 negative regulation of protein serine/threonine kinase activity
Biological Process GO:0034392 negative regulation of smooth muscle cell apoptotic process
Biological Process GO:0014033 neural crest cell differentiation
Biological Process GO:0014029 neural crest formation
Biological Process GO:0001843 neural tube closure
Biological Process GO:0042475 odontogenesis of dentin-containing tooth
Biological Process GO:0003344 pericardium morphogenesis
Biological Process GO:0045787 positive regulation of cell cycle
Biological Process GO:0007204 positive regulation of cytosolic calcium ion concentration
Biological Process GO:0051091 positive regulation of DNA-binding transcription factor activity
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0090009 primitive streak formation
Biological Process GO:0072659 protein localization to plasma membrane
Biological Process GO:0090118 receptor-mediated endocytosis involved in cholesterol transport
Biological Process GO:0030278 regulation of ossification
Biological Process GO:0043434 response to peptide hormone
Biological Process GO:0060021 roof of mouth development
Biological Process GO:0021794 thalamus development
Biological Process GO:0060535 trachea cartilage morphogenesis
Biological Process GO:0016055 Wnt signaling pathway
Biological Process GO:1904953 Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
Biological Process GO:0090244 Wnt signaling pathway involved in somitogenesis
molecular function GO:0034185 apolipoprotein binding
molecular function GO:0015026 coreceptor activity
molecular function GO:1904928 coreceptor activity involved in canonical Wnt signaling pathway
molecular function GO:0071936 coreceptor activity involved in Wnt signaling pathway
molecular function GO:0005109 frizzled binding
molecular function GO:0042802 identical protein binding
molecular function GO:0019210 kinase inhibitor activity
molecular function GO:0005041 low-density lipoprotein particle receptor activity
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0005102 signaling receptor binding
molecular function GO:0019534 toxin transmembrane transporter activity
molecular function GO:0042813 Wnt-activated receptor activity
molecular function GO:0017147 Wnt-protein binding
cellular component GO:0009986 cell surface
cellular component GO:0031410 cytoplasmic vesicle
cellular component GO:0031901 early endosome membrane
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005576 extracellular region
cellular component GO:0016021 integral component of membrane
cellular component GO:0045121 membrane raft
cellular component GO:0043025 neuronal cell body
cellular component GO:0005886 plasma membrane
cellular component GO:0045202 synapse
cellular component GO:1990851 Wnt-Frizzled-LRP5/6 complex
cellular component GO:1990909 Wnt signalosome
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-195721 Signaling by WNT
R-HSA-195721 Signaling by WNT
R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
R-HSA-4641263 Regulation of FZD by ubiquitination
R-HSA-4791275 Signaling by WNT in cancer
R-HSA-5340588 RNF mutants show enhanced WNT signaling and proliferation
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000846 BXGD000015 Agenesis
C0001430 BXGD000054 Adenoma Neoplasms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002793 BXGD000130 Anaplasia Pathological Conditions, Signs and Symptoms; Neoplasms
C0003175 BXGD000187 Anthrax disease Infections
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003872 BXGD000235 Arthritis, Psoriatic Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004936 BXGD000295 Mental disorders Mental Disorders
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005940 BXGD000352 Bone Diseases Musculoskeletal Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0011884 BXGD000762 Diabetic Retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0015393 BXGD000981 Eye Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0015696 BXGD001014 Fatty Liver, Alcoholic Digestive System Diseases; Chemically-Induced Disorders
C0016057 BXGD001042 Fibrosarcoma Neoplasms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0018099 BXGD001172 Gout Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0020443 BXGD001385 Hypercholesterolemia Nutritional and Metabolic Diseases
C0020473 BXGD001396 Hyperlipidemia Nutritional and Metabolic Diseases
C0020492 BXGD001404 Hyperostosis Musculoskeletal Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020557 BXGD001432 Hypertriglyceridemia Nutritional and Metabolic Diseases
C0020608 BXGD001443 Hypodontia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0020630 BXGD001454 Hypophosphatasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025990 BXGD001884 Micrognathism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027794 BXGD002036 Neural Tube Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0027832 BXGD002048 Neurofibromatosis 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0029434 BXGD002146 Osteogenesis Imperfecta Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0029464 BXGD002161 Osteosclerosis Musculoskeletal Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0032580 BXGD002362 Adenomatous Polyposis Coli Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0038013 BXGD002725 Ankylosing spondylitis Musculoskeletal Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0042373 BXGD002978 Vascular Diseases Cardiovascular Diseases
C0080178 BXGD003107 Spina Bifida Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0085298 BXGD003155 Sudden Cardiac Death Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0149782 BXGD003365 Squamous cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0162309 BXGD003934 Adrenoleukodystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Endocrine System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238790 BXGD004956 bone destruction
C0239337 BXGD004978 Deformity of limb
C0240310 BXGD005030 Hypoplasia of the maxilla
C0240340 BXGD005031 Microdontia (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0271650 BXGD006227 Impaired glucose tolerance Nutritional and Metabolic Diseases
C0278595 BXGD006545 Adult Fibrosarcoma Neoplasms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0342885 BXGD007575 Secondary hypercholesterolemia Nutritional and Metabolic Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0349566 BXGD007928 Squamous cell carcinoma of tongue Neoplasms; Stomatognathic Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0432252 BXGD008755 Osteoporosis with pseudoglioma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0494463 BXGD009029 Alzheimer Disease, Late Onset Nervous System Diseases; Mental Disorders
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0740404 BXGD009991 Limb defects
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1290511 BXGD012188 Anodontia of Permanent Dentition Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1384583 BXGD012942 Congenital absence of germinal epithelium of testes Male Urogenital Diseases
C1449563 BXGD013086 Cardiomyopathy, Familial Idiopathic Cardiovascular Diseases
C1512409 BXGD013188 Hepatocarcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1611743 BXGD013456 Familial (FPAH)
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1845026 BXGD014700 Neural tube defects X-linked Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1845027 BXGD014701 Spina Bifida, X-Linked Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1866558 BXGD016409 Neural tube defect, folate-sensitive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1866559 BXGD016410 Spina Bifida, Folate-Sensitive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1970440 BXGD016835 CORONARY ARTERY DISEASE, AUTOSOMAL DOMINANT 2 (disorder) Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2699510 BXGD017460 Split-Hand/Foot Malformation Pathological Conditions, Signs and Symptoms
C2750331 BXGD017656 Enamel defects
C3489532 BXGD018934 Cone-Rod Dystrophy 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C4023106 BXGD021109 Obstructive azoospermia Male Urogenital Diseases
C4024202 BXGD021303 Reduced number of teeth
C4082304 BXGD022090 Oligodontia
C4083050 BXGD022102 Tooth agenesis
C4225231 BXGD022184 TOOTH AGENESIS, SELECTIVE, 7
C4551485 BXGD023312 Clinodactyly
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C4755308 BXGD024094 Familial cervical artery dissection
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002586 Calcium 40.08
BXGC0003705 Chloride 35.45
BXGC0005757 Ethyl gallate 198.17
BXGC0018397 beta-1,4-mannan 180.06
BXGC0050194 alpha-D-Mannose 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein