Showing entry for Folate receptor alpha


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008108
Protein NameFolate receptor alpha
Uniport IdP15328
GeneFOLR1
Gene Id2348
DomainFolate_rec
Pfam PF03024  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
6. Human Diseases 6.12 Drug resistance: Antineoplastic hsa01523 Antifolate resistance
4. Cellular Processes 4.1 Transport and catabolism hsa04144 Endocytosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0061713 anterior neural tube closure
Biological Process GO:0031103 axon regeneration
Biological Process GO:0003253 cardiac neural crest cell migration involved in outflow tract morphogenesis
Biological Process GO:0007155 cell adhesion
Biological Process GO:0071231 cellular response to folic acid
Biological Process GO:0048208 COPII vesicle coating
Biological Process GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
Biological Process GO:1904447 folate import across plasma membrane
Biological Process GO:0046655 folic acid metabolic process
Biological Process GO:0015884 folic acid transport
Biological Process GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization
Biological Process GO:0001947 heart looping
Biological Process GO:0003147 neural crest cell migration involved in heart formation
Biological Process GO:0061626 pharyngeal arch artery morphogenesis
Biological Process GO:0006898 receptor-mediated endocytosis
Biological Process GO:0060828 regulation of canonical Wnt signaling pathway
Biological Process GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
Biological Process GO:0035036 sperm-egg recognition
molecular function GO:0008144 drug binding
molecular function GO:0005542 folic acid binding
molecular function GO:0061714 folic acid receptor activity
molecular function GO:0051870 methotrexate binding
molecular function GO:0038023 signaling receptor activity
cellular component GO:0031362 anchored component of external side of plasma membrane
cellular component GO:0016324 apical plasma membrane
cellular component GO:0016323 basolateral plasma membrane
cellular component GO:0031526 brush border membrane
cellular component GO:0009986 cell surface
cellular component GO:0030136 clathrin-coated vesicle
cellular component GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0005768 endosome
cellular component GO:0012507 ER to Golgi transport vesicle membrane
cellular component GO:0070062 extracellular exosome
cellular component GO:0000139 Golgi membrane
cellular component GO:0016020 membrane
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
cellular component GO:0030133 transport vesicle
Reactome
Pathway Id Pathway Name
R-HSA-199977 ER to Golgi Anterograde Transport
R-HSA-199991 Membrane Trafficking
R-HSA-204005 COPII-mediated vesicle transport
R-HSA-392499 Metabolism of proteins
R-HSA-446203 Asparagine N-linked glycosylation
R-HSA-5653656 Vesicle-mediated transport
R-HSA-5694530 Cargo concentration in the ER
R-HSA-597592 Post-translational protein modification
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-948021 Transport to the Golgi and subsequent modification
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001430 BXGD000054 Adenoma Neoplasms
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002793 BXGD000130 Anaplasia Pathological Conditions, Signs and Symptoms; Neoplasms
C0002878 BXGD000137 Anemia, Hemolytic Hemic and Lymphatic Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0003886 BXGD000238 Arthrogryposis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0004997 BXGD000300 Benign Ovarian Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0006111 BXGD000369 Brain Diseases Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0008073 BXGD000518 Developmental Disabilities Mental Disorders
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011999 BXGD000770 Diastematomyelia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014550 BXGD000930 Myoclonic Epilepsy Nervous System Diseases
C0014556 BXGD000932 Epilepsy, Temporal Lobe Nervous System Diseases
C0014742 BXGD000945 Erythema Multiforme Skin and Connective Tissue Diseases
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0016412 BXGD001058 Folic Acid Deficiency Nutritional and Metabolic Diseases
C0017574 BXGD001122 Gingivitis Infections; Stomatognathic Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0018798 BXGD001223 Congenital Heart Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0020256 BXGD001370 Congenital Hydrocephalus Nervous System Diseases
C0020796 BXGD001468 Profound Mental Retardation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025007 BXGD001821 Measles Infections
C0025149 BXGD001826 Medulloblastoma Neoplasms
C0025286 BXGD001850 Meningioma Neoplasms; Nervous System Diseases
C0025312 BXGD001861 Meningomyelocele Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0025363 BXGD001867 Mental Retardation, Psychosocial Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0025500 BXGD001874 Mesothelioma Neoplasms
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0026650 BXGD001913 Movement Disorders Nervous System Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027404 BXGD001984 Narcolepsy Nervous System Diseases; Mental Disorders
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027746 BXGD002032 Nerve Degeneration Pathological Conditions, Signs and Symptoms
C0027794 BXGD002036 Neural Tube Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0027806 BXGD002039 Neurenteric Cyst Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0029925 BXGD002181 Ovarian Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0031090 BXGD002280 Periodontal Diseases Stomatognathic Diseases
C0031099 BXGD002282 Periodontitis Stomatognathic Diseases
C0031117 BXGD002285 Peripheral Neuropathy Nervous System Diseases
C0032000 BXGD002318 Pituitary Adenoma Neoplasms; Nervous System Diseases; Endocrine System Diseases
C0033922 BXGD002440 Psychomotor Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0035335 BXGD002540 Retinoblastoma Neoplasms; Eye Diseases
C0035372 BXGD002544 Rett Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037284 BXGD002679 Skin lesion Skin and Connective Tissue Diseases
C0038356 BXGD002747 Stomach Neoplasms Digestive System Diseases; Neoplasms
C0080178 BXGD003107 Spina Bifida Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0080218 BXGD003109 Tethered Cord Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0085207 BXGD003140 Gestational Diabetes Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0085584 BXGD003195 Encephalopathies Nervous System Diseases
C0086237 BXGD003273 Epilepsy, Cryptogenic Nervous System Diseases
C0086942 BXGD003315 Rous Sarcoma Neoplasms; Infections; Animal Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0152234 BXGD003566 Iniencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0152426 BXGD003589 Craniorachischisis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0153567 BXGD003665 Uterine Cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0162830 BXGD003987 Dermatitis, Phototoxic Skin and Connective Tissue Diseases
C0175693 BXGD004001 Russell-Silver syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206695 BXGD004246 Carcinoma, Neuroendocrine Neoplasms
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0220810 BXGD004346 Congenital defects
C0235031 BXGD004714 Neurologic Symptoms Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0236018 BXGD004804 Aura Nervous System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0259813 BXGD005225 Drop Attack Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0260037 BXGD005227 Multiple tumors Neoplasms
C0262405 BXGD005237 Cerebral dysfunction Nervous System Diseases
C0266453 BXGD005671 Exencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0266487 BXGD005682 Etat Marbre Nervous System Diseases
C0270846 BXGD006116 Epileptic drop attack Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0278510 BXGD006526 Childhood Medulloblastoma Neoplasms
C0278689 BXGD006563 Recurrent ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0278876 BXGD006607 Adult Medulloblastoma Neoplasms
C0278877 BXGD006608 Adult Meningioma Neoplasms; Nervous System Diseases
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0279671 BXGD006677 Cervical Squamous Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0280100 BXGD006713 Solid Neoplasm Neoplasms
C0282687 BXGD006826 Hemorrhagic Fever, Ebola Infections
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0334277 BXGD007017 Adenocarcinoma, metastatic Neoplasms
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0342276 BXGD007449 Maturity onset diabetes mellitus in young Nutritional and Metabolic Diseases; Endocrine System Diseases
C0342705 BXGD007531 Folate Malabsorption, Hereditary Digestive System Diseases; Nutritional and Metabolic Diseases
C0344479 BXGD007677 Spinal Cord Myelodysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0345967 BXGD007756 Malignant mesothelioma Neoplasms; Respiratory Tract Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376634 BXGD008006 Craniofacial Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0393525 BXGD008081 Progressive cerebellar ataxia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0424230 BXGD008522 Motor retardation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0524528 BXGD009229 Pervasive Development Disorder Mental Disorders
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0543888 BXGD009300 Epileptic encephalopathy Nervous System Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0597645 BXGD009653 Viral Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598608 BXGD009668 Hyperhomocysteinemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677886 BXGD009734 Epithelial ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0702169 BXGD009914 Acrania Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0751111 BXGD010319 Awakening Epilepsy Nervous System Diseases
C0751456 BXGD010448 Developmental Psychomotor Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0751651 BXGD010539 Mitochondrial Diseases Nutritional and Metabolic Diseases
C0752107 BXGD010665 Brain Diseases, Metabolic, Inherited Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0752109 BXGD010666 Brain Diseases, Metabolic, Inborn Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0752110 BXGD010667 Central Nervous System Inborn Metabolic Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0796160 BXGD010807 MENTAL RETARDATION, X-LINKED, SNYDER-ROBINSON TYPE Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0812413 BXGD010847 Malignant Pleural Mesothelioma Neoplasms; Respiratory Tract Diseases
C0854924 BXGD011052 Papillary serous endometrial carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0917816 BXGD011419 Mental deficiency Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1335302 BXGD012775 Pancreatic Ductal Adenocarcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1527358 BXGD013279 Phototoxicity Skin and Connective Tissue Diseases
C1562113 BXGD013372 Fleck corneal dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1709286 BXGD013623 Null Cell Pituitary Gland Adenoma
C1762616 BXGD013753 Meningioma, benign, no ICD-O subtype Neoplasms; Nervous System Diseases
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1836830 BXGD014165 Developmental regression Mental Disorders
C1853144 BXGD015308 Deafness, Congenital, with Inner Ear Agenesis, Microtia, and Microdontia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2751584 BXGD017727 Neurodegeneration Due To Cerebral Folate Transport Deficiency Nervous System Diseases
C2931822 BXGD018068 Nasopharyngeal carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4524268 BXGD023104 Advanced lung cancer
C4688007 BXGD023582 Platinum-Resistant Ovarian Carcinoma
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
BXGC0002591 Potassium 39.1
BXGC0003705 Chloride 35.45
BXGC0007530 Folic acid 441.4
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein