Showing entry for Pituitary-dependent Cushing's disease


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD004459
Disease NamePituitary-dependent Cushing's disease
Disease CUI IdC0221406
MeSH Codes C10   C19  
Disease Class NameNervous System Diseases; Endocrine System Diseases
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id DOID:7   DOID:14566  
Disease Ontology Class Namedisease of anatomical entity; disease of cellular proliferation
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
O00255 BXGT003903 Menin 4221 reviewed
O14733 BXGT004087 Dual specificity mitogen-activated protein kinase kinase 7 5609 reviewed Kinase
O15350 BXGT004154 Tumor protein p73 7161 reviewed Transcription factor
O43678 BXGT004613 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 4695 reviewed Enzyme
O96017 BXGT005415 Serine/threonine-protein kinase Chk2 11200 reviewed Kinase
P00519 BXGT005570 Tyrosine-protein kinase ABL1 25 reviewed Kinase
P00533 BXGT005575 Epidermal growth factor receptor 1956 reviewed Kinase
P01133 BXGT005736 Pro-epidermal growth factor 1950 reviewed
P01189 BXGT005742 Pro-opiomelanocortin 5443 reviewed
P01236 BXGT005744 Prolactin 5617 reviewed Signaling
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P02647 BXGT005908 Apolipoprotein A-I 335 reviewed
P02818 BXGT005969 Osteocalcin 632 reviewed
P04150 BXGT006154 Glucocorticoid receptor 2908 reviewed Nuclear receptor
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P04899 BXGT006281 Guanine nucleotide-binding protein G(i) subunit alpha-2 2771 reviewed Enzyme modulator
P05120 BXGT006319 Plasminogen activator inhibitor 2 5055 reviewed Enzyme modulator
P05121 BXGT006320 Plasminogen activator inhibitor 1 5054 reviewed Enzyme modulator
P05231 BXGT006345 Interleukin-6 3569 reviewed
P06850 BXGT006511 Corticoliberin 1392 reviewed Signaling
P07288 BXGT006591 Prostate-specific antigen 354 reviewed Enzyme
P07900 BXGT006696 Heat shock protein HSP 90-alpha 3320 reviewed Chaperone
P07996 BXGT006710 Thrombospondin-1 7057 reviewed
P08047 BXGT006720 Transcription factor Sp1 6667 reviewed Nucleic acid binding
P08185 BXGT006742 Corticosteroid-binding globulin 866 reviewed Enzyme modulator
P08670 BXGT006810 Vimentin 7431 reviewed
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P10644 BXGT007597 cAMP-dependent protein kinase type I-alpha regulatory subunit 5573 reviewed
P11473 BXGT007709 Vitamin D3 receptor 7421 reviewed Nuclear receptor
P12004 BXGT007766 Proliferating cell nuclear antigen 5111 reviewed Nucleic acid binding
P13647 BXGT007937 Keratin, type II cytoskeletal 5 3852 reviewed
P14416 BXGT008011 D(2) dopamine receptor 1813 reviewed G-protein coupled receptor
P15056 BXGT008075 Serine/threonine-protein kinase B-raf 673 reviewed Kinase
P15538 BXGT008137 Cytochrome P450 11B1, mitochondrial 1584 reviewed
P16455 BXGT008229 Methylated-DNA--protein-cysteine methyltransferase 4255 reviewed
P17612 BXGT008322 cAMP-dependent protein kinase catalytic subunit alpha 5566 reviewed Kinase
P22455 BXGT008772 Fibroblast growth factor receptor 4 2264 reviewed Kinase
P22736 BXGT008800 Nuclear receptor subfamily 4 group A member 1 3164 reviewed Nuclear receptor
P24385 BXGT008965 G1/S-specific cyclin-D1 595 reviewed Enzyme modulator
P24387 BXGT008966 Corticotropin-releasing factor-binding protein 1393 reviewed Signaling
P25440 BXGT009044 Bromodomain-containing protein 2 6046 reviewed Epigenetic regulator
P28482 BXGT009263 Mitogen-activated protein kinase 1 5594 reviewed Kinase
P28845 BXGT009297 Corticosteroid 11-beta-dehydrogenase isozyme 1 3290 reviewed
P29323 BXGT009334 Ephrin type-B receptor 2 2048 reviewed Kinase
P30872 BXGT009474 Somatostatin receptor type 1 6751 reviewed G-protein coupled receptor
P30874 BXGT009475 Somatostatin receptor type 2 6752 reviewed G-protein coupled receptor
P32418 BXGT009635 Sodium/calcium exchanger 1 6546 reviewed Transporter
P34998 BXGT009781 Corticotropin-releasing factor receptor 1 1394 reviewed
P35346 BXGT009813 Somatostatin receptor type 5 6755 reviewed G-protein coupled receptor
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma 5468 reviewed Nuclear receptor
P40763 BXGT010202 Signal transducer and activator of transcription 3 6774 reviewed Nucleic acid binding
P42702 BXGT010335 Leukemia inhibitory factor receptor 3977 reviewed Signaling
P43246 BXGT010371 DNA mismatch repair protein Msh2 4436 reviewed Nucleic acid binding
P46527 BXGT010525 Cyclin-dependent kinase inhibitor 1B 1027 reviewed
P47901 BXGT010596 Vasopressin V1b receptor 553 reviewed G-protein coupled receptor
P49116 BXGT010678 Nuclear receptor subfamily 2 group C member 2 7182 reviewed Nuclear receptor
P51532 BXGT010852 Transcription activator BRG1 6597 reviewed Epigenetic regulator
P52788 BXGT010953 Spermine synthase 6611 reviewed
P63092 BXGT011495 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short 2778 reviewed
P80365 BXGT011895 Corticosteroid 11-beta-dehydrogenase isozyme 2 3291 reviewed Enzyme
Q00613 BXGT012540 Heat shock factor protein 1 3297 reviewed Transcription factor
Q01094 BXGT012568 Transcription factor E2F1 1869 reviewed Nucleic acid binding
Q01718 BXGT012609 Adrenocorticotropic hormone receptor 4158 reviewed G-protein coupled receptor
Q07869 BXGT012945 Peroxisome proliferator-activated receptor alpha 5465 reviewed Nuclear receptor
Q14011 BXGT013436 Cold-inducible RNA-binding protein 1153 reviewed Nucleic acid binding
Q92769 BXGT019370 Histone deacetylase 2 3066 reviewed Epigenetic regulator
Q96EN8 BXGT019649 Molybdenum cofactor sulfurase 55034 reviewed
Q99828 BXGT019967 Calcium and integrin-binding protein 1 10519 reviewed
Q9H227 BXGT020447 Cytosolic beta-glucosidase 57733 reviewed Enzyme
Q9H251 BXGT020449 Cadherin-23 64072 reviewed
Q9NZQ7 BXGT021281 Programmed cell death 1 ligand 1 29126 reviewed Receptor
Q9UPY3 BXGT021802 Endoribonuclease Dicer 23405 reviewed Enzyme
Q92847 BXGT022673 Growth hormone secretagogue receptor type 1 2693 reviewed G-protein coupled receptor
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease