Showing entry for Sodium/calcium exchanger 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009635
Protein NameSodium/calcium exchanger 1
Uniport IdP32418
GeneSLC8A1
Gene Id6546
DomainCalx-beta; Na_Ca_ex; Na_Ca_ex_C
Pfam PF03160   PF01699   PF16494  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04020 Calcium signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04022 cGMP-PKG signaling pathway
5. Organismal Systems 5.3 Circulatory system hsa04260 Cardiac muscle contraction
5. Organismal Systems 5.3 Circulatory system hsa04261 Adrenergic signaling in cardiomyocytes
3. Environmental Information Processing 3.2 Signal transduction hsa04371 Apelin signaling pathway
5. Organismal Systems 5.7 Sensory system hsa04740 Olfactory transduction
5. Organismal Systems 5.5 Excretory system hsa04961 Endocrine and other factor-regulated calcium reabsorption
5. Organismal Systems 5.4 Digestive system hsa04974 Protein digestion and absorption
5. Organismal Systems 5.4 Digestive system hsa04978 Mineral absorption
6. Human Diseases 6.6 Cardiovascular diseases hsa05410 Hypertrophic cardiomyopathy (HCM)
6. Human Diseases 6.6 Cardiovascular diseases hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
6. Human Diseases 6.6 Cardiovascular diseases hsa05414 Dilated cardiomyopathy (DCM)
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:1901660 calcium ion export
Biological Process GO:0055074 calcium ion homeostasis
Biological Process GO:0070509 calcium ion import
Biological Process GO:0070588 calcium ion transmembrane transport
Biological Process GO:0060402 calcium ion transport into cytosol
Biological Process GO:0055013 cardiac muscle cell development
Biological Process GO:0060048 cardiac muscle contraction
Biological Process GO:0086064 cell communication by electrical coupling involved in cardiac conduction
Biological Process GO:0006874 cellular calcium ion homeostasis
Biological Process GO:0071313 cellular response to caffeine
Biological Process GO:0071320 cellular response to cAMP
Biological Process GO:0071456 cellular response to hypoxia
Biological Process GO:0034614 cellular response to reactive oxygen species
Biological Process GO:0006883 cellular sodium ion homeostasis
Biological Process GO:0060401 cytosolic calcium ion transport
Biological Process GO:0006811 ion transport
Biological Process GO:0086012 membrane depolarization during cardiac muscle cell action potential
Biological Process GO:0006936 muscle contraction
Biological Process GO:0051481 negative regulation of cytosolic calcium ion concentration
Biological Process GO:0071901 negative regulation of protein serine/threonine kinase activity
Biological Process GO:0030501 positive regulation of bone mineralization
Biological Process GO:0010763 positive regulation of fibroblast migration
Biological Process GO:0098735 positive regulation of the force of heart contraction
Biological Process GO:1903779 regulation of cardiac conduction
Biological Process GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling
Biological Process GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
Biological Process GO:0010649 regulation of cell communication by electrical coupling
Biological Process GO:0010468 regulation of gene expression
Biological Process GO:0002027 regulation of heart rate
Biological Process GO:0002028 regulation of sodium ion transport
Biological Process GO:0002026 regulation of the force of heart contraction
Biological Process GO:0055119 relaxation of cardiac muscle
Biological Process GO:0044557 relaxation of smooth muscle
Biological Process GO:0033198 response to ATP
Biological Process GO:0042493 response to drug
Biological Process GO:0009749 response to glucose
Biological Process GO:0042542 response to hydrogen peroxide
Biological Process GO:0035902 response to immobilization stress
Biological Process GO:0035994 response to muscle stretch
Biological Process GO:0007584 response to nutrient
Biological Process GO:0036376 sodium ion export across plasma membrane
Biological Process GO:0098719 sodium ion import across plasma membrane
Biological Process GO:0035725 sodium ion transmembrane transport
Biological Process GO:0021537 telencephalon development
Biological Process GO:0014829 vascular associated smooth muscle contraction
molecular function GO:0030506 ankyrin binding
molecular function GO:1905060 calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration
molecular function GO:0005432 calcium:sodium antiporter activity
molecular function GO:0005509 calcium ion binding
molecular function GO:0005516 calmodulin binding
molecular function GO:0008092 cytoskeletal protein binding
molecular function GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential
molecular function GO:0044325 ion channel binding
cellular component GO:0030424 axon
cellular component GO:0043679 axon terminus
cellular component GO:0071944 cell periphery
cellular component GO:0030425 dendrite
cellular component GO:0043198 dendritic shaft
cellular component GO:0043197 dendritic spine
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0099055 integral component of postsynaptic membrane
cellular component GO:0014704 intercalated disc
cellular component GO:0005874 microtubule
cellular component GO:0005739 mitochondrion
cellular component GO:0043025 neuronal cell body
cellular component GO:0005654 nucleoplasm
cellular component GO:0005886 plasma membrane
cellular component GO:0014069 postsynaptic density
cellular component GO:0042383 sarcolemma
cellular component GO:0045202 synapse
cellular component GO:0030315 T-tubule
cellular component GO:0030018 Z disc
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-382551 Transport of small molecules
R-HSA-397014 Muscle contraction
R-HSA-418346 Platelet homeostasis
R-HSA-418359 Reduction of cytosolic Ca++ levels
R-HSA-418360 Platelet calcium homeostasis
R-HSA-425393 Transport of inorganic cations/anions and amino acids/oligopeptides
R-HSA-425407 SLC-mediated transmembrane transport
R-HSA-425561 Sodium/Calcium exchangers
R-HSA-5576891 Cardiac conduction
R-HSA-5578775 Ion homeostasis
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001849 BXGD000084 AIDS Dementia Complex Infections; Immune System Diseases; Nervous System Diseases; Mental Disorders
C0002063 BXGD000099 Alkalosis Nutritional and Metabolic Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0005938 BXGD000351 Bone Density
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007193 BXGD000451 Cardiomyopathy, Dilated Cardiovascular Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007785 BXGD000485 Cerebral Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0007786 BXGD000486 Brain Ischemia Nervous System Diseases; Cardiovascular Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010481 BXGD000673 Cushing Syndrome Endocrine System Diseases
C0010692 BXGD000686 Cystitis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013274 BXGD000809 Patent ductus arteriosus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0017178 BXGD001102 Gastrointestinal Diseases Digestive System Diseases
C0017654 BXGD001136 Glomerular Filtration Rate
C0018800 BXGD001225 Cardiomegaly Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0022116 BXGD001531 Ischemia Pathological Conditions, Signs and Symptoms
C0022333 BXGD001534 Jacksonian Seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024143 BXGD001741 Lupus Nephritis Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Male Urogenital Diseases; Immune System Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025149 BXGD001826 Medulloblastoma Neoplasms
C0025160 BXGD001827 Megacolon Digestive System Diseases
C0025267 BXGD001845 Multiple Endocrine Neoplasia Type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Endocrine System Diseases
C0025281 BXGD001848 Meniere Disease Otorhinolaryngologic Diseases
C0026691 BXGD001917 Mucocutaneous Lymph Node Syndrome Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027055 BXGD001964 Myocardial Reperfusion Injury Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027662 BXGD002015 Multiple Endocrine Neoplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Endocrine System Diseases
C0027708 BXGD002025 Nephroblastoma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0035126 BXGD002509 Reperfusion Injury Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036920 BXGD002645 Sezary Syndrome Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0038220 BXGD002740 Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0040264 BXGD002857 Tinnitus Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0042834 BXGD003004 Vital capacity
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085106 BXGD003124 Familial benign pemphigus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0149521 BXGD003328 Pancreatitis, Chronic Digestive System Diseases
C0149721 BXGD003349 Left Ventricular Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0149958 BXGD003395 Complex partial seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151517 BXGD003431 Complete atrioventricular block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0152021 BXGD003520 Congenital heart disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0152105 BXGD003541 Hypertensive heart disease Cardiovascular Diseases
C0152171 BXGD003552 Idiopathic pulmonary hypertension Respiratory Tract Diseases; Cardiovascular Diseases
C0152451 BXGD003597 Chronic glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0155626 BXGD003806 Acute myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0178417 BXGD004025 Anhedonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0221406 BXGD004459 Pituitary-dependent Cushing's disease Nervous System Diseases; Endocrine System Diseases
C0234533 BXGD004687 Generalized seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234535 BXGD004688 Clonic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0270823 BXGD006112 Petit mal status Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270824 BXGD006113 Visual seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270844 BXGD006115 Tonic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270846 BXGD006116 Epileptic drop attack Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0271514 BXGD006207 Low frequency deafness Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0278510 BXGD006526 Childhood Medulloblastoma Neoplasms
C0278876 BXGD006607 Adult Medulloblastoma Neoplasms
C0311335 BXGD006877 Grand Mal Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0339789 BXGD007282 Congenital deafness Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Nervous System Diseases; Otorhinolaryngologic Diseases
C0340278 BXGD007313 Atrial hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0342443 BXGD007481 Adrenal Cushing's syndrome Endocrine System Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0349788 BXGD007956 Arrhythmogenic Right Ventricular Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0393734 BXGD008131 Complex Partial Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0406810 BXGD008374 Carney Complex Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Cardiovascular Diseases
C0409959 BXGD008400 Osteoarthritis, Knee Musculoskeletal Diseases
C0422850 BXGD008457 Seizures, Somatosensory Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422852 BXGD008458 Seizures, Auditory Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422853 BXGD008459 Olfactory seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422854 BXGD008460 Gustatory seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422855 BXGD008461 Vertiginous seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0424574 BXGD008534 Duration of sleep
C0424678 BXGD008537 Lean body mass
C0428883 BXGD008639 Diastolic blood pressure
C0428908 BXGD008641 Sinus Node Dysfunction (disorder) Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0429028 BXGD008646 QT interval feature (observable entity)
C0429087 BXGD008647 Electrocardiogram: P-R interval
C0494463 BXGD009029 Alzheimer Disease, Late Onset Nervous System Diseases; Mental Disorders
C0494475 BXGD009030 Tonic - clonic seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600041 BXGD009685 Infective cystitis Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0685938 BXGD009829 Malignant neoplasm of gastrointestinal tract Digestive System Diseases; Neoplasms
C0694539 BXGD009849 Chronic atrial fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0699949 BXGD009872 airway disease Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0740391 BXGD009987 Middle Cerebral Artery Occlusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0751056 BXGD010306 Non-epileptic convulsion Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751110 BXGD010318 Single Seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751123 BXGD010326 Atonic Absence Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751494 BXGD010472 Convulsive Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751495 BXGD010473 Seizures, Focal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751496 BXGD010474 Seizures, Sensory Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751522 BXGD010488 Status Epilepticus, Subclinical Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751523 BXGD010489 Non-Convulsive Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751524 BXGD010490 Simple Partial Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0853105 BXGD010966 Penis carcinoma Neoplasms; Male Urogenital Diseases
C0853897 BXGD010985 Diabetic Cardiomyopathies Endocrine System Diseases; Cardiovascular Diseases
C0871470 BXGD011316 Systolic Pressure
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332201 BXGD012502 Adult Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1333015 BXGD012581 Childhood Kidney Wilms Tumor Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1335302 BXGD012775 Pancreatic Ductal Adenocarcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1560249 BXGD013361 Adverse Event Associated with Cardiac Arrhythmia
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1868938 BXGD016542 End stage cardiac failure
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2697932 BXGD017440 Loeys-Dietz Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Cardiovascular Diseases
C3203102 BXGD018555 Idiopathic pulmonary arterial hypertension Respiratory Tract Diseases
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3495874 BXGD019008 Nonepileptic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
C4048158 BXGD021890 Convulsions Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4316903 BXGD022711 Absence Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4317109 BXGD022725 Epileptic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4317123 BXGD022727 Myoclonic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4505436 BXGD022962 Generalized Absence Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0006107 alpha-Linolenic acid 278.43
BXGC0014782 Icosapent 302.22
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein