Showing entry for Corticotropin-releasing factor receptor 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009781
Protein NameCorticotropin-releasing factor receptor 1
Uniport IdP34998
GeneCRHR1
Gene Id104909134;1394
Domain7tm_2; HRM
Pfam PF00002   PF02793  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
5. Organismal Systems 5.6 Nervous system hsa04730 Long-term depression
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04934 Cushing syndrome
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007190 activation of adenylate cyclase activity
Biological Process GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological Process GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
Biological Process GO:0007166 cell surface receptor signaling pathway
Biological Process GO:0071376 cellular response to corticotropin-releasing hormone stimulus
Biological Process GO:0051458 corticotropin secretion
Biological Process GO:0007565 female pregnancy
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0006955 immune response
Biological Process GO:1901386 negative regulation of voltage-gated calcium channel activity
Biological Process GO:0007567 parturition
Biological Process GO:0010578 regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway
Biological Process GO:2000852 regulation of corticosterone secretion
molecular function GO:0015056 corticotrophin-releasing factor receptor activity
molecular function GO:0051424 corticotropin-releasing hormone binding
molecular function GO:0043404 corticotropin-releasing hormone receptor activity
molecular function GO:0008528 G protein-coupled peptide receptor activity
molecular function GO:0017046 peptide hormone binding
cellular component GO:0005768 endosome
cellular component GO:0016021 integral component of membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0031226 intrinsic component of plasma membrane
cellular component GO:0043005 neuron projection
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-372790 Signaling by GPCR
R-HSA-373080 Class B/2 (Secretin family receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-418555 G alpha (s) signalling events
R-HSA-500792 GPCR ligand binding
R-HSA-5663205 Infectious disease
R-HSA-9658195 Leishmania infection
R-HSA-9660821 ADORA2B mediated anti-inflammatory cytokines production
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection
R-HSA-9664433 Leishmania parasite growth and survival
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001430 BXGD000054 Adenoma Neoplasms
C0001622 BXGD000065 Adrenal Gland Hyperfunction Endocrine System Diseases
C0001956 BXGD000092 Alcohol Use Disorder Chemically-Induced Disorders; Mental Disorders
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0002792 BXGD000129 anaphylaxis Immune System Diseases
C0003123 BXGD000178 Anorexia Pathological Conditions, Signs and Symptoms
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004936 BXGD000295 Mental disorders Mental Disorders
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0006012 BXGD000360 Borderline Personality Disorder Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006287 BXGD000390 Bronchopulmonary Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases
C0006370 BXGD000394 Bulimia Pathological Conditions, Signs and Symptoms
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0008060 BXGD000516 child abuse behavior
C0008495 BXGD000548 Chorioamnionitis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0009171 BXGD000587 Cocaine Abuse Chemically-Induced Disorders; Mental Disorders
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009374 BXGD000601 Colonic Diseases, Functional Digestive System Diseases
C0011195 BXGD000702 Dejerine-Sottas Disease (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011574 BXGD000731 Involutional Depression Mental Disorders
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011615 BXGD000738 Dermatitis, Atopic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0011616 BXGD000739 Contact Dermatitis Skin and Connective Tissue Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013146 BXGD000801 Drug abuse Chemically-Induced Disorders; Mental Disorders
C0013473 BXGD000845 Eating Disorders Mental Disorders
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0014474 BXGD000917 Ependymoma Neoplasms
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0016667 BXGD001072 Fragile X Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0017638 BXGD001132 Glioma Neoplasms
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019337 BXGD001319 Heroin Dependence Chemically-Induced Disorders; Mental Disorders
C0020429 BXGD001378 Hyperalgesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0020517 BXGD001415 Hypersensitivity Immune System Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021670 BXGD001509 insulinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0021831 BXGD001516 Intestinal Diseases Digestive System Diseases
C0022104 BXGD001529 Irritable Bowel Syndrome Digestive System Diseases
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023646 BXGD001690 Lichen Planus Skin and Connective Tissue Diseases
C0024517 BXGD001780 Major depression, single episode Mental Disorders
C0025193 BXGD001831 Melancholia Mental Disorders
C0025286 BXGD001850 Meningioma Neoplasms; Nervous System Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028043 BXGD002066 Nicotine Dependence Chemically-Induced Disorders; Mental Disorders
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029410 BXGD002138 Osteoarthritis of hip Musculoskeletal Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030201 BXGD002194 Pain, Postoperative Pathological Conditions, Signs and Symptoms
C0030319 BXGD002208 Panic Disorder Mental Disorders
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0031572 BXGD002307 Phobia, Social Mental Disorders
C0032002 BXGD002320 Pituitary Diseases Nervous System Diseases; Endocrine System Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0035335 BXGD002540 Retinoblastoma Neoplasms; Eye Diseases
C0037284 BXGD002679 Skin lesion Skin and Connective Tissue Diseases
C0037769 BXGD002701 West Syndrome Nervous System Diseases
C0038436 BXGD002755 Post-Traumatic Stress Disorder Mental Disorders
C0038443 BXGD002757 Stress, Psychological Behavior and Behavior Mechanisms
C0038868 BXGD002781 Progressive supranuclear palsy Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0040021 BXGD002834 Thromboangiitis Obliterans Cardiovascular Diseases
C0041696 BXGD002932 Unipolar Depression Mental Disorders
C0042109 BXGD002957 Urticaria Skin and Connective Tissue Diseases; Immune System Diseases
C0042693 BXGD002996 Violence
C0042900 BXGD003012 Vitiligo Skin and Connective Tissue Diseases
C0085159 BXGD003133 Seasonal Affective Disorder Mental Disorders
C0085166 BXGD003136 Bacterial Vaginosis Female Urogenital Diseases and Pregnancy Complications; Infections
C0085281 BXGD003152 Addictive Behavior Behavior and Behavior Mechanisms
C0085762 BXGD003251 Alcohol abuse Chemically-Induced Disorders; Mental Disorders
C0086132 BXGD003264 Depressive Symptoms Behavior and Behavior Mechanisms
C0087169 BXGD003321 Withdrawal Symptoms Chemically-Induced Disorders; Mental Disorders
C0149922 BXGD003386 Lichen Simplex Chronicus Skin and Connective Tissue Diseases
C0152459 BXGD003600 Linear atrophy Pathological Conditions, Signs and Symptoms
C0153658 BXGD003676 Malignant neoplasm of endocrine gland Neoplasms; Endocrine System Diseases
C0154409 BXGD003717 Recurrent major depressive episodes Mental Disorders
C0162351 BXGD003938 Contact hypersensitivity Skin and Connective Tissue Diseases
C0178417 BXGD004025 Anhedonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0205682 BXGD004105 Waist-Hip Ratio
C0221406 BXGD004459 Pituitary-dependent Cushing's disease Nervous System Diseases; Endocrine System Diseases
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0233523 BXGD004586 Antisocial behavior Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0236736 BXGD004825 Cocaine-Related Disorders Chemically-Induced Disorders; Mental Disorders
C0238013 BXGD004855 Invasive aspergillosis Infections
C0263338 BXGD005290 Chronic urticaria Skin and Connective Tissue Diseases; Immune System Diseases
C0264408 BXGD005387 Childhood asthma Respiratory Tract Diseases; Immune System Diseases
C0268318 BXGD005896 Cholestasis of pregnancy Digestive System Diseases; Female Urogenital Diseases and Pregnancy Complications
C0270549 BXGD006079 Generalized Anxiety Disorder Mental Disorders
C0271738 BXGD006253 Hypocortisolism secondary to another disorder Endocrine System Diseases
C0338451 BXGD007176 Frontotemporal dementia Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0338908 BXGD007218 Mixed anxiety and depressive disorder Mental Disorders
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0347950 BXGD007864 Asthma attack Respiratory Tract Diseases; Immune System Diseases
C0349204 BXGD007892 Nonorganic psychosis Mental Disorders
C0349217 BXGD007894 Depressive episode, unspecified Mental Disorders; Behavior and Behavior Mechanisms
C0349489 BXGD007911 Fetal Hypoxia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0362046 BXGD007959 Prediabetes syndrome Nutritional and Metabolic Diseases; Endocrine System Diseases
C0375023 BXGD007970 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
C0376280 BXGD007983 Anxiety States, Neurotic Mental Disorders
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0438696 BXGD008805 Suicidal Behavior and Behavior Mechanisms
C0458219 BXGD008903 Complex Regional Pain Syndromes Nervous System Diseases
C0458247 BXGD008904 Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0494463 BXGD009029 Alzheimer Disease, Late Onset Nervous System Diseases; Mental Disorders
C0520459 BXGD009084 Necrotizing Enterocolitis Digestive System Diseases
C0521991 BXGD009187 Symptoms of stress
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0525045 BXGD009255 Mood Disorders Mental Disorders
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0596887 BXGD009648 mathematical ability
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0600427 BXGD009706 Cocaine Dependence Chemically-Induced Disorders; Mental Disorders
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0687132 BXGD009839 heavy drinking
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0751211 BXGD010350 Hyperalgesia, Primary Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751212 BXGD010351 Hyperalgesia, Secondary Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751213 BXGD010352 Tactile Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751214 BXGD010353 Hyperalgesia, Thermal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751217 BXGD010356 Hyperkinesia, Generalized Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751606 BXGD010523 Adult Acute Lymphocytic Leukemia
C0851406 BXGD010921 Anxiety disorders and symptoms Mental Disorders
C0860603 BXGD011236 Anxiety symptoms
C0871388 BXGD011314 social stress Behavior and Behavior Mechanisms
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C0948387 BXGD011535 Secondary Adrenal Insufficiency Endocrine System Diseases
C1257931 BXGD011815 Mammary Neoplasms, Human Neoplasms; Skin and Connective Tissue Diseases
C1261473 BXGD011855 Sarcoma Neoplasms
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1279420 BXGD012122 Anxiety neurosis (finding) Mental Disorders
C1306214 BXGD012356 ACTH-Secreting Pituitary Adenoma Neoplasms; Nervous System Diseases; Endocrine System Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1510472 BXGD013170 Drug Dependence Chemically-Induced Disorders; Mental Disorders
C1527366 BXGD013280 Salaam Seizures Nervous System Diseases
C1533217 BXGD013313 Methamphetamine dependence Chemically-Induced Disorders; Mental Disorders
C1571983 BXGD013425 Involutional paraphrenia Mental Disorders
C1571984 BXGD013426 Psychosis, Involutional Mental Disorders
C1611743 BXGD013456 Familial (FPAH)
C1704374 BXGD013550 Carcinoma of Endocrine Gland Neoplasms; Endocrine System Diseases
C1827396 BXGD013771 Refractory infantile spasms Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1842981 BXGD014547 NEUROTICISM Behavior and Behavior Mechanisms
C1847835 BXGD014892 VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) Skin and Connective Tissue Diseases
C1848296 BXGD014918 DOSAGE-SENSITIVE SEX REVERSAL Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C1956415 BXGD016635 Paroxysmal nocturnal dyspnea Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Cardiovascular Diseases
C1961102 BXGD016673 Precursor Cell Lymphoblastic Leukemia Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2936719 BXGD018130 Mechanical Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2938924 BXGD018167 Oestrogen receptor positive breast cancer
C3854333 BXGD019828 Narrowing
C3887506 BXGD019886 Hyperkinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3887898 BXGD019926 Infantile Spasm Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4049636 BXGD021944 ROSE Cluster 1
C4082937 BXGD022095 Necrotizing enterocolitis in fetus OR newborn Digestive System Diseases
C4083212 BXGD022105 Alopecia, Male Pattern Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4284586 BXGD022439 Perinatal depression in mother Mental Disorders
C4296683 BXGD022516 Emotional neglect
C4528257 BXGD023159 Corpuscular Hemoglobin Concentration Mean
C4551686 BXGD023391 Malignant neoplasm of soft tissue Neoplasms
C4704874 BXGD023682 Mammary Carcinoma, Human Neoplasms; Skin and Connective Tissue Diseases
C4733092 BXGD023907 estrogen receptor-negative breast cancer
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0005513 Hexadecanoic acid 256.42
BXGC0006212 Hypericin 504.44
BXGC0038316 Cholesterol 386.35
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein