Showing entry for Cytochrome P450 11B1, mitochondrial


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008137
Protein NameCytochrome P450 11B1, mitochondrial
Uniport IdP15538
GeneCYP11B1
Gene Id1584
Domainp450
Pfam PF00067  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00140 Steroid hormone biosynthesis
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
5. Organismal Systems 5.2 Endocrine system hsa04927 Cortisol synthesis and secretion
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04934 Cushing syndrome
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0032342 aldosterone biosynthetic process
Biological Process GO:0006700 C21-steroid hormone biosynthetic process
Biological Process GO:0032870 cellular response to hormone stimulus
Biological Process GO:0071375 cellular response to peptide hormone stimulus
Biological Process GO:0035865 cellular response to potassium ion
Biological Process GO:0008203 cholesterol metabolic process
Biological Process GO:0034651 cortisol biosynthetic process
Biological Process GO:0034650 cortisol metabolic process
Biological Process GO:0006704 glucocorticoid biosynthetic process
Biological Process GO:0042593 glucose homeostasis
Biological Process GO:0006955 immune response
Biological Process GO:0008217 regulation of blood pressure
Biological Process GO:0016125 sterol metabolic process
molecular function GO:0047783 corticosterone 18-monooxygenase activity
molecular function GO:0020037 heme binding
molecular function GO:0005506 iron ion binding
molecular function GO:0004507 steroid 11-beta-monooxygenase activity
cellular component GO:0005743 mitochondrial inner membrane
cellular component GO:0005739 mitochondrion
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1643685 Disease
R-HSA-194002 Glucocorticoid biosynthesis
R-HSA-196071 Metabolism of steroid hormones
R-HSA-211859 Biological oxidations
R-HSA-211897 Cytochrome P450 - arranged by substrate type
R-HSA-211945 Phase I - Functionalization of compounds
R-HSA-211976 Endogenous sterols
R-HSA-556833 Metabolism of lipids
R-HSA-5579017 Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
R-HSA-5579029 Metabolic disorders of biological oxidation enzymes
R-HSA-5668914 Diseases of metabolism
R-HSA-8957322 Metabolism of steroids
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001126 BXGD000025 Renal tubular acidosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0001430 BXGD000054 Adenoma Neoplasms
C0001622 BXGD000065 Adrenal Gland Hyperfunction Endocrine System Diseases
C0001623 BXGD000066 Adrenal gland hypofunction Endocrine System Diseases
C0001624 BXGD000067 Adrenal Gland Neoplasms Neoplasms; Endocrine System Diseases
C0001627 BXGD000068 Congenital adrenal hyperplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0001925 BXGD000090 Albuminuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0004775 BXGD000290 Bartter Disease Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0009777 BXGD000630 Conn Adenoma Neoplasms; Endocrine System Diseases
C0010278 BXGD000660 Craniosynostosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0010481 BXGD000673 Cushing Syndrome Endocrine System Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0014591 BXGD000938 Epistaxis Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0016059 BXGD001043 Fibrosis Pathological Conditions, Signs and Symptoms
C0018418 BXGD001192 Gynecomastia Skin and Connective Tissue Diseases
C0018681 BXGD001214 Headache Pathological Conditions, Signs and Symptoms
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0018800 BXGD001225 Cardiomegaly Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019572 BXGD001338 Hirsutism Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0020428 BXGD001377 Hyperaldosteronism Endocrine System Diseases
C0020461 BXGD001395 Hyperkalemia Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020621 BXGD001449 Hypokalemia Nutritional and Metabolic Diseases
C0020625 BXGD001451 Hyponatremia Nutritional and Metabolic Diseases
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027059 BXGD001965 Myocarditis Cardiovascular Diseases
C0027497 BXGD001993 Nausea Pathological Conditions, Signs and Symptoms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0032914 BXGD002379 Pre-Eclampsia Female Urogenital Diseases and Pregnancy Complications
C0034013 BXGD002450 Precocious Puberty Endocrine System Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0040264 BXGD002857 Tinnitus Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0042963 BXGD003018 Vomiting Pathological Conditions, Signs and Symptoms
C0085570 BXGD003186 Hypokalemic alkalosis Nutritional and Metabolic Diseases
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0085602 BXGD003199 Polydipsia Pathological Conditions, Signs and Symptoms
C0149516 BXGD003324 Chronic sinusitis Infections; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0151639 BXGD003452 Decreased fertility in females Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0151640 BXGD003453 Decreased fertility in males Male Urogenital Diseases
C0151699 BXGD003461 Intracranial Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0156394 BXGD003856 Hypertrophy of clitoris Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0162834 BXGD003988 Hyperpigmentation Skin and Connective Tissue Diseases
C0175754 BXGD004015 Agenesis of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0206667 BXGD004228 Adrenal Cortical Adenoma Neoplasms; Endocrine System Diseases
C0206686 BXGD004241 Adrenocortical carcinoma Neoplasms; Endocrine System Diseases
C0220766 BXGD004341 Congenital hypoplasia of adrenal gland Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Endocrine System Diseases
C0220983 BXGD004350 Metabolic alkalosis Nutritional and Metabolic Diseases
C0221043 BXGD004377 Liddle Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0221406 BXGD004459 Pituitary-dependent Cushing's disease Nervous System Diseases; Endocrine System Diseases
C0232466 BXGD004543 Feeding difficulties
C0241240 BXGD005089 Tall stature
C0241355 BXGD005092 Small testicle
C0266275 BXGD005641 Ectopic adrenal gland Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0266362 BXGD005657 Ambiguous Genitalia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0266399 BXGD005663 Infantile uterus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0268287 BXGD005884 Deficiency of steroid 21-monooxygenase Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0268292 BXGD005886 Congenital adrenal hyperplasia due to 11-Beta-hydroxylase deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0268293 BXGD005887 Corticosterone Methyl Oxidase Type I Deficiency Endocrine System Diseases
C0269011 BXGD006049 Increased size of penis Male Urogenital Diseases
C0282160 BXGD006797 Aplasia Cutis Congenita Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0302280 BXGD006836 Adrenogenital Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0337432 BXGD007156 Androstenedione measurement
C0342443 BXGD007481 Adrenal Cushing's syndrome Endocrine System Diseases
C0342482 BXGD007486 X-linked Adrenal Hypoplasia Endocrine System Diseases
C0342494 BXGD007489 Adrenocortical hyperplasia Endocrine System Diseases
C0342546 BXGD007502 Premature adrenarche
C0342549 BXGD007504 Familial Testotoxicosis Endocrine System Diseases
C0345309 BXGD007725 Hypoplasia of vagina Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0349588 BXGD007933 Short stature
C0405580 BXGD008325 Adrenal cortical hypofunction Endocrine System Diseases
C0431663 BXGD008700 Bilateral Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0520463 BXGD009085 Chronic active hepatitis Digestive System Diseases
C0522055 BXGD009189 Electrocardiogram abnormal Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0524528 BXGD009229 Pervasive Development Disorder Mental Disorders
C0541764 BXGD009259 Delayed bone age
C0545053 BXGD009323 Advanced bone age
C0546817 BXGD009342 Fluid overload Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Cardiovascular Diseases
C0546884 BXGD009345 Hypovolemia Pathological Conditions, Signs and Symptoms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0740457 BXGD010000 Malignant neoplasm of kidney Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0852654 BXGD010947 21-hydroxylase deficiency
C0854258 BXGD011011 Pseudoprecocious puberty
C0857898 BXGD011165 Abnormal circulating aldosterone
C0857899 BXGD011166 Decreased circulating aldosterone level Immune System Diseases; Endocrine System Diseases
C0877008 BXGD011325 Enzyme inhibition disorder
C1112442 BXGD011668 Female sexual dysfunction
C1260386 BXGD011828 Glucocorticoid-remediable aldosteronism Endocrine System Diseases
C1291314 BXGD012209 Deficiency of monooxygenase
C1298820 BXGD012252 Aneurysm of aortic root Cardiovascular Diseases
C1378703 BXGD012933 Renal carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1384514 BXGD012940 Conn Syndrome Endocrine System Diseases
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1621895 BXGD013466 Adrenal hyperplasia Pathological Conditions, Signs and Symptoms; Neoplasms; Endocrine System Diseases
C1836623 BXGD014139 Decreased circulating cortisol level Immune System Diseases; Endocrine System Diseases
C1837532 BXGD014246 Fused labia minora
C1845206 BXGD014727 Decreased circulating renin level
C1846347 BXGD014802 Renal salt wasting
C1848296 BXGD014918 DOSAGE-SENSITIVE SEX REVERSAL Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C1855106 BXGD015459 Neonatal onset
C1857276 BXGD015688 Trichohepatoenteric Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C1859049 BXGD015846 CCHS WITH HIRSCHSPRUNG DISEASE Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases
C1859979 BXGD015947 Precocious puberty in males Endocrine System Diseases
C1860825 BXGD016004 Accelerated bone age after puberty
C2919142 BXGD017867 Short Stature, CTCAE
C2936858 BXGD018147 Congenital adrenal hyperplasia due to 21 hydroxylase deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C3178782 BXGD018536 Aortic Stiffness
C3463917 BXGD018902 Corticosterone Methyl Oxidase Type II Deficiency
C3669121 BXGD019323 11-Beta-hydroxylase deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C3671887 BXGD019330 Hypernatriuria
C3713420 BXGD019402 Familial Hyperaldosteronism Endocrine System Diseases
C3838731 BXGD019760 Familial hyperaldosteronism type 1 Endocrine System Diseases
C4021038 BXGD020529 Abnormal circulating renin
C4021124 BXGD020560 Adrenocorticotropic hormone excess Nervous System Diseases; Endocrine System Diseases
C4021125 BXGD020561 Secretory adrenocortical adenoma Neoplasms; Endocrine System Diseases
C4021740 BXGD020748 Increased circulating ACTH level
C4021821 BXGD020806 Abnormality of the urinary system Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C4021972 BXGD020849 Urogenital sinus anomaly
C4022554 BXGD020915 Hyperpigmented genitalia
C4022695 BXGD020962 Abnormality of the labia majora
C4023396 BXGD021174 Abnormality of hair growth rate
C4024641 BXGD021355 Enlarged polycystic ovaries Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4024878 BXGD021453 Generalized hyperpigmentation Skin and Connective Tissue Diseases
C4025797 BXGD021795 Abnormality of prenatal development or birth
C4025888 BXGD021848 Abnormality of the menstrual cycle Pathological Conditions, Signs and Symptoms
C4025891 BXGD021849 Ambiguous genitalia, female Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C4072893 BXGD022014 Increased circulating androgen level
C4329672 BXGD022788 Classic Congenital Adrenal Hyperplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0008676 Haem 616.49
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein