Showing entry for Tumor susceptibility gene 101 protein


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT019966
Protein NameTumor susceptibility gene 101 protein
Uniport IdQ99816
GeneTSG101
Gene Id7251
DomainUEV; Vps23_core
Pfam PF05743   PF09454  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.1 Transport and catabolism hsa04144 Endocytosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0097352 autophagosome maturation
Biological Process GO:0007050 cell cycle arrest
Biological Process GO:0051301 cell division
Biological Process GO:0016197 endosomal transport
Biological Process GO:0008333 endosome to lysosome transport
Biological Process GO:1990182 exosomal secretion
Biological Process GO:0006858 extracellular transport
Biological Process GO:0075733 intracellular transport of virus
Biological Process GO:0030216 keratinocyte differentiation
Biological Process GO:0016236 macroautophagy
Biological Process GO:0036258 multivesicular body assembly
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0007175 negative regulation of epidermal growth factor-activated receptor activity
Biological Process GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
Biological Process GO:0045892 negative regulation of transcription, DNA-templated
Biological Process GO:1903543 positive regulation of exosomal secretion
Biological Process GO:2000397 positive regulation of ubiquitin-dependent endocytosis
Biological Process GO:1903774 positive regulation of viral budding via host ESCRT complex
Biological Process GO:1902188 positive regulation of viral release from host cell
Biological Process GO:0006513 protein monoubiquitination
Biological Process GO:0015031 protein transport
Biological Process GO:0001558 regulation of cell growth
Biological Process GO:1903551 regulation of extracellular exosome assembly
Biological Process GO:0043405 regulation of MAP kinase activity
Biological Process GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
Biological Process GO:0046755 viral budding
Biological Process GO:0039702 viral budding via host ESCRT complex
Biological Process GO:0019058 viral life cycle
molecular function GO:0048306 calcium-dependent protein binding
molecular function GO:0003677 DNA binding
molecular function GO:0030374 nuclear receptor transcription coactivator activity
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0003714 transcription corepressor activity
molecular function GO:0043130 ubiquitin binding
molecular function GO:0031625 ubiquitin protein ligase binding
molecular function GO:0046790 virion binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005769 early endosome
cellular component GO:0031901 early endosome membrane
cellular component GO:0005768 endosome
cellular component GO:0010008 endosome membrane
cellular component GO:0000813 ESCRT I complex
cellular component GO:0070062 extracellular exosome
cellular component GO:0090543 Flemming body
cellular component GO:0043657 host cell
cellular component GO:0005770 late endosome
cellular component GO:0031902 late endosome membrane
cellular component GO:0005815 microtubule organizing center
cellular component GO:0005771 multivesicular body
cellular component GO:0005730 nucleolus
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-162587 HIV Life Cycle
R-HSA-162588 Budding and maturation of HIV virion
R-HSA-162599 Late Phase of HIV Life Cycle
R-HSA-162906 HIV Infection
R-HSA-1643685 Disease
R-HSA-174490 Membrane binding and targetting of GAG proteins
R-HSA-174495 Synthesis And Processing Of GAG, GAGPOL Polyproteins
R-HSA-175474 Assembly Of The HIV Virion
R-HSA-199991 Membrane Trafficking
R-HSA-5653656 Vesicle-mediated transport
R-HSA-5663205 Infectious disease
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT)
R-HSA-9609646 HCMV Infection
R-HSA-9610379 HCMV Late Events
R-HSA-9612973 Autophagy
R-HSA-9615710 Late endosomal microautophagy
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006413 BXGD000397 Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007115 BXGD000432 Malignant neoplasm of thyroid Neoplasms; Endocrine System Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007959 BXGD000507 Charcot-Marie-Tooth Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0022660 BXGD001571 Kidney Failure, Acute Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027708 BXGD002025 Nephroblastoma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0085293 BXGD003154 Hepatitis E Digestive System Diseases; Infections
C0149925 BXGD003387 Small cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0151650 BXGD003454 Renal fibrosis Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206093 BXGD004154 Neuroectodermal Tumors Neoplasms
C0220613 BXGD004297 Adult Soft Tissue Sarcoma
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0220645 BXGD004307 Childhood Soft Tissue Sarcoma
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0270913 BXGD006130 Charcot-Marie-Tooth disease, Type 1C Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0278764 BXGD006581 Adult Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0278879 BXGD006610 Childhood Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0279651 BXGD006674 Gallbladder adenocarcinoma Digestive System Diseases; Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0280100 BXGD006713 Solid Neoplasm Neoplasms
C0282687 BXGD006826 Hemorrhagic Fever, Ebola Infections
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0343641 BXGD007636 Human papilloma virus infection Infections
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0346153 BXGD007781 Breast Cancer, Familial Neoplasms; Skin and Connective Tissue Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0376618 BXGD008003 Endotoxemia Pathological Conditions, Signs and Symptoms; Infections
C0497169 BXGD009054 hiv-infection/aids Infections
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677886 BXGD009734 Epithelial ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0685938 BXGD009829 Malignant neoplasm of gastrointestinal tract Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1096666 BXGD011638 Thyroid cancer metastatic Neoplasms; Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1153706 BXGD011769 Endometrial adenocarcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C1261473 BXGD011855 Sarcoma Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1333015 BXGD012581 Childhood Kidney Wilms Tumor Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1512409 BXGD013188 Hepatocarcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1608408 BXGD013434 Malignant transformation
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2931822 BXGD018068 Nasopharyngeal carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C3898127 BXGD020061 Non-Metastatic Childhood Soft Tissue Sarcoma
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4551687 BXGD023392 Sarcoma of soft tissue Neoplasms
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000194 Sanguinarine 332.33
BXGC0000952 6-Oxocamphor 457.91
BXGC0003705 Chloride 35.45
BXGC0004277 Acetic acid 60.05
BXGC0004965 Rhein 284.22
BXGC0005057 2-Methoxyxanthone 226.23
BXGC0005721 Bisdemethoxycurcumin 308.33
BXGC0005982 Curcumin 368.38
BXGC0009984 Pyrafoline D 347.45
BXGC0013582 Curcumin 368.13
BXGC0016681 Hispidin 246.05
BXGC0023872 Adenine 135.05
BXGC0024428 3-(1H-Benzimidazol-2-Yl)-7-(Diethylamino)Chromen-2-One 333.15
BXGC0024813 Demethoxycurcumin 338.12
BXGC0026607 epiberberine 336.12
BXGC0031326 Paxilline 435.24
BXGC0032061 Methylmalonic Acid 118.03
BXGC0039397 Athraquinones A 240.04
BXGC0040936 Sid26657808 284.07
BXGC0042035 raubasine 352.18
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein