Showing entry for Na(+)/H(+) exchange regulatory cofactor NHE-RF1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004090
Protein NameNa(+)/H(+) exchange regulatory cofactor NHE-RF1
Uniport IdO14745
GeneSLC9A3R1
Gene Id9368
DomainEBP50_C; PDZ_6
Pfam PF09007   PF17820  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04530 Tight junction
5. Organismal Systems 5.2 Endocrine system hsa04928 Parathyroid hormone synthesis, secretion and action
6. Human Diseases 6.9 Infectious diseases: Viral hsa05165 Human papillomavirus infection
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway
Biological Process GO:0060088 auditory receptor cell stereocilium organization
Biological Process GO:0032782 bile acid secretion
Biological Process GO:0030643 cellular phosphate ion homeostasis
Biological Process GO:0090660 cerebrospinal fluid circulation
Biological Process GO:0044782 cilium organization
Biological Process GO:0045198 establishment of epithelial cell apical/basal polarity
Biological Process GO:0051683 establishment of Golgi localization
Biological Process GO:0051939 gamma-aminobutyric acid import
Biological Process GO:0022612 gland morphogenesis
Biological Process GO:0034635 glutathione transport
Biological Process GO:0098739 import across plasma membrane
Biological Process GO:0045199 maintenance of epithelial cell apical/basal polarity
Biological Process GO:0030033 microvillus assembly
Biological Process GO:0002009 morphogenesis of an epithelium
Biological Process GO:0090090 negative regulation of canonical Wnt signaling pathway
Biological Process GO:0030336 negative regulation of cell migration
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0070373 negative regulation of ERK1 and ERK2 cascade
Biological Process GO:0045930 negative regulation of mitotic cell cycle
Biological Process GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling
Biological Process GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway
Biological Process GO:0051898 negative regulation of protein kinase B signaling
Biological Process GO:0032416 negative regulation of sodium:proton antiporter activity
Biological Process GO:0007097 nuclear migration
Biological Process GO:0060158 phospholipase C-activating dopamine receptor signaling pathway
Biological Process GO:0007009 plasma membrane organization
Biological Process GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Biological Process GO:0034767 positive regulation of ion transmembrane transport
Biological Process GO:0065003 protein-containing complex assembly
Biological Process GO:0072659 protein localization to plasma membrane
Biological Process GO:0008360 regulation of cell shape
Biological Process GO:0008361 regulation of cell size
Biological Process GO:0044062 regulation of excretion
Biological Process GO:0045859 regulation of protein kinase activity
Biological Process GO:0032415 regulation of sodium:proton antiporter activity
Biological Process GO:0070293 renal absorption
Biological Process GO:0097291 renal phosphate ion absorption
Biological Process GO:0003096 renal sodium ion transport
Biological Process GO:0007605 sensory perception of sound
Biological Process GO:0150104 transport across blood-brain barrier
Biological Process GO:0016055 Wnt signaling pathway
molecular function GO:0031698 beta-2 adrenergic receptor binding
molecular function GO:0008013 beta-catenin binding
molecular function GO:0017081 chloride channel regulator activity
molecular function GO:0050780 dopamine receptor binding
molecular function GO:0015185 gamma-aminobutyric acid transmembrane transporter activity
molecular function GO:0070851 growth factor receptor binding
molecular function GO:0060090 molecular adaptor activity
molecular function GO:0045159 myosin II binding
molecular function GO:0030165 PDZ domain binding
molecular function GO:0019902 phosphatase binding
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0047485 protein N-terminus binding
molecular function GO:0043621 protein self-association
molecular function GO:0005102 signaling receptor binding
molecular function GO:0031799 type 2 metabotropic glutamate receptor binding
molecular function GO:0031800 type 3 metabotropic glutamate receptor binding
cellular component GO:0015629 actin cytoskeleton
cellular component GO:0016324 apical plasma membrane
cellular component GO:0031526 brush border membrane
cellular component GO:0071944 cell periphery
cellular component GO:0005737 cytoplasm
cellular component GO:0012505 endomembrane system
cellular component GO:0070062 extracellular exosome
cellular component GO:0030175 filopodium
cellular component GO:0016020 membrane
cellular component GO:0045121 membrane raft
cellular component GO:0005902 microvillus
cellular component GO:0031528 microvillus membrane
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0098797 plasma membrane protein complex
cellular component GO:0001726 ruffle
cellular component GO:0097225 sperm midpiece
cellular component GO:0032426 stereocilium tip
cellular component GO:0031982 vesicle
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001430 BXGD000054 Adenoma Neoplasms
C0006118 BXGD000372 Brain Neoplasms Neoplasms; Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007124 BXGD000437 Noninfiltrating Intraductal Carcinoma Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0008325 BXGD000529 Cholecystitis Digestive System Diseases
C0008479 BXGD000544 Chondrosarcoma Neoplasms
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0009451 BXGD000614 Communicating Hydrocephalus Nervous System Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011615 BXGD000738 Dermatitis, Atopic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0014474 BXGD000917 Ependymoma Neoplasms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0019693 BXGD001346 HIV Infections Infections; Immune System Diseases
C0020255 BXGD001369 Hydrocephalus Nervous System Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021367 BXGD001501 Mammary Ductal Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0022104 BXGD001529 Irritable Bowel Syndrome Digestive System Diseases
C0022660 BXGD001571 Kidney Failure, Acute Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023487 BXGD001669 Acute Promyelocytic Leukemia Neoplasms
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024115 BXGD001732 Lung diseases Respiratory Tract Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0025286 BXGD001850 Meningioma Neoplasms; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0041296 BXGD002903 Tuberculosis Infections
C0085413 BXGD003171 Polycystic Kidney, Autosomal Dominant Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0085682 BXGD003238 Hypophosphatemia Nutritional and Metabolic Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0200637 BXGD004042 Monocyte count procedure
C0205769 BXGD004120 Myxopapillary ependymoma Neoplasms
C0206698 BXGD004248 Cholangiocarcinoma Neoplasms
C0206725 BXGD004270 Subependymal Glioma Neoplasms
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238019 BXGD004857 Carcinoma of extrahepatic bile duct Digestive System Diseases; Neoplasms
C0238029 BXGD004859 Ependymoma of brain Neoplasms; Nervous System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0278601 BXGD006547 Inflammatory Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0278874 BXGD006605 Adult Ependymoma Neoplasms
C0278877 BXGD006608 Adult Meningioma Neoplasms; Nervous System Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0279606 BXGD006647 Childhood Hepatocellular Carcinoma Digestive System Diseases; Neoplasms
C0279607 BXGD006648 Adult Hepatocellular Carcinoma Digestive System Diseases; Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0280788 BXGD006762 Anaplastic Ependymoma Neoplasms
C0281361 BXGD006774 Adenocarcinoma of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0282201 BXGD006799 Phosphate Diabetes Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0338593 BXGD007205 Acquired communicating hydrocephalus Nervous System Diseases
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0346153 BXGD007781 Breast Cancer, Familial Neoplasms; Skin and Connective Tissue Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0392525 BXGD008052 Nephrolithiasis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0555198 BXGD009432 Malignant Glioma Neoplasms
C0566602 BXGD009489 Primary sclerosing cholangitis Digestive System Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0733682 BXGD009968 Hypophosphatemic Rickets, X-Linked Dominant Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases; Male Urogenital Diseases
C0740457 BXGD010000 Malignant neoplasm of kidney Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0750880 BXGD010239 Monocyte count result
C0750952 BXGD010263 Biliary Tract Cancer Digestive System Diseases; Neoplasms
C0796611 BXGD010835 Newly Diagnosed Childhood Ependymoma Neoplasms
C0853879 BXGD010982 Invasive carcinoma of breast Neoplasms; Skin and Connective Tissue Diseases
C0947751 BXGD011494 Vascular inflammations Cardiovascular Diseases
C1134719 BXGD011688 Invasive Ductal Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1302401 BXGD012303 Adenoma of large intestine Digestive System Diseases; Neoplasms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1322252 BXGD012452 Chordoid Glioma of the Third Ventricle Neoplasms; Nervous System Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1370510 BXGD012913 Chordoid meningioma Neoplasms; Nervous System Diseases
C1378703 BXGD012933 Renal carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1384406 BXGD012937 Secretory meningioma Neoplasms; Nervous System Diseases
C1390474 BXGD012969 Increased susceptibility to fractures
C1402315 BXGD013017 Vascular lesions
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1710016 BXGD013635 Satellite Nodule
C1762616 BXGD013753 Meningioma, benign, no ICD-O subtype Neoplasms; Nervous System Diseases
C1845169 BXGD014724 Renal phosphate wasting
C1851584 BXGD015221 Childhood Ependymoma Neoplasms
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2363741 BXGD017100 HIV-1 infection
C2676782 BXGD017347 Nephrolithiasis-Osteoporosis, Hypophosphatemic, 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases; Male Urogenital Diseases
C2938924 BXGD018167 Oestrogen receptor positive breast cancer
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3642346 BXGD019245 Luminal B Breast Carcinoma
C3887608 BXGD019903 HYDROCEPHALUS, NONSYNDROMIC, AUTOSOMAL RECESSIVE 1
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
BXGC0004277 Acetic acid 60.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein