Showing entry for Melatonin receptor type 1B


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010691
Protein NameMelatonin receptor type 1B
Uniport IdP49286
GeneMTNR1B
Gene Id4544
Domain7tm_1
Pfam PF00001  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
5. Organismal Systems 5.10 Environmental adaptation hsa04713 Circadian entrainment
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0043010 camera-type eye development
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:0042593 glucose homeostasis
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
Biological Process GO:0010754 negative regulation of cGMP-mediated signaling
Biological Process GO:0051481 negative regulation of cytosolic calcium ion concentration
Biological Process GO:1902260 negative regulation of delayed rectifier potassium channel activity
Biological Process GO:0046676 negative regulation of insulin secretion
Biological Process GO:0043524 negative regulation of neuron apoptotic process
Biological Process GO:0051970 negative regulation of transmission of nerve impulse
Biological Process GO:0097755 positive regulation of blood vessel diameter
Biological Process GO:0046010 positive regulation of circadian sleep/wake cycle, non-REM sleep
Biological Process GO:0051971 positive regulation of transmission of nerve impulse
Biological Process GO:0050796 regulation of insulin secretion
Biological Process GO:0098908 regulation of neuronal action potential
molecular function GO:0004930 G protein-coupled receptor activity
molecular function GO:0008502 melatonin receptor activity
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0045202 synapse
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-372790 Signaling by GPCR
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-418594 G alpha (i) signalling events
R-HSA-500792 GPCR ligand binding
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001339 BXGD000041 Acute pancreatitis Digestive System Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0005612 BXGD000317 Birth Weight Pathological Conditions, Signs and Symptoms
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0008487 BXGD000545 Chordoma Neoplasms
C0009319 BXGD000596 Colitis Digestive System Diseases
C0011206 BXGD000703 Delirium Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013080 BXGD000797 Down Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0017741 BXGD001149 Glucose tolerance test
C0018213 BXGD001187 Graves Disease Eye Diseases; Immune System Diseases; Endocrine System Diseases
C0019829 BXGD001350 Hodgkin Disease Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0020443 BXGD001385 Hypercholesterolemia Nutritional and Metabolic Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0021655 BXGD001508 Insulin Resistance Nutritional and Metabolic Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0025281 BXGD001848 Meniere Disease Otorhinolaryngologic Diseases
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029458 BXGD002158 Osteoporosis, Postmenopausal Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0031090 BXGD002280 Periodontal Diseases Stomatognathic Diseases
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0037317 BXGD002689 Sleep disturbances Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0039585 BXGD002821 Androgen-Insensitivity Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0085207 BXGD003140 Gestational Diabetes Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0086132 BXGD003264 Depressive Symptoms Behavior and Behavior Mechanisms
C0162701 BXGD003978 Polysomnography
C0178468 BXGD004029 Autoimmune thyroid disease Immune System Diseases; Endocrine System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0202098 BXGD004070 Insulin measurement
C0268060 BXGD005806 Juvenile hemochromatosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0271650 BXGD006227 Impaired glucose tolerance Nutritional and Metabolic Diseases
C0342276 BXGD007449 Maturity onset diabetes mellitus in young Nutritional and Metabolic Diseases; Endocrine System Diseases
C0342471 BXGD007484 3 beta-Hydroxysteroid dehydrogenase deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0349204 BXGD007892 Nonorganic psychosis Mental Disorders
C0349218 BXGD007895 Recurrent depressive disorder Mental Disorders
C0362046 BXGD007959 Prediabetes syndrome Nutritional and Metabolic Diseases; Endocrine System Diseases
C0410702 BXGD008447 Adolescent idiopathic scoliosis Musculoskeletal Diseases
C0428568 BXGD008633 Fasting blood glucose measurement
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0523465 BXGD009209 Serum albumin measurement
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0686347 BXGD009832 Tardive Dyskinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0746556 BXGD010144 metabolic disturbance
C0812413 BXGD010847 Malignant Pleural Mesothelioma Neoplasms; Respiratory Tract Diseases
C0851578 BXGD010925 Sleep Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0856169 BXGD011096 Endothelial dysfunction
C0917799 BXGD011410 Hypersomnia Nervous System Diseases; Mental Disorders
C0917801 BXGD011412 Sleeplessness Nervous System Diseases; Mental Disorders
C0947785 BXGD011495 [D]Sleep disturbances (& [hypersomnia] or [insomnia])
C0948379 BXGD011533 Impaired insulin secretion
C1136382 BXGD011717 Sclerocystic Ovaries Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1261430 BXGD011853 Fasting blood sugar result
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1305855 BXGD012348 Body mass index
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1561826 BXGD013364 Overweight and obesity
C1611743 BXGD013456 Familial (FPAH)
C1695782 BXGD013498 Cerebral hypoperfusion
C1862939 BXGD016144 AMYOTROPHIC LATERAL SCLEROSIS 1 Nutritional and Metabolic Diseases; Nervous System Diseases
C2362324 BXGD017091 Pediatric Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C2936349 BXGD018109 Plaque, Amyloid Pathological Conditions, Signs and Symptoms
C3714760 BXGD019432 Drug-induced tardive dyskinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Chemically-Induced Disorders
C4049919 BXGD021955 Insulin Sensitivity Measurement
C4275242 BXGD022371 Sudden sensorineural hearing loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C4317171 BXGD022735 Adolescent Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C4521042 BXGD023055 Complete Trisomy 21 Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4703555 BXGD023658 Decreased waist to hip ratio
C4721772 BXGD023767 Postoperative delirium Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4744483 BXGD023943 Recurrent Chordoma Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0001767 (E)-Resveratrol 228.25
BXGC0002916 Melatonin 232.28
BXGC0005867 Serotonin 176.22
BXGC0005871 Dopamine 153.18
BXGC0038577 Magnolol 266.13
BXGC0052798 5-Meo-Dmt 218.14
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein