protein

Showing entry for Porphobilinogen deaminase

General Target Information
BXGT Id	BXGT006768
Protein Name	Porphobilinogen deaminase
Uniport Id	P08397
Gene	HMBS
Gene Id	3145
Domain	Porphobil_deam; Porphobil_deamC
Pfam	PF01379 PF03900
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name
1. Metabolism	1.8 Metabolism of cofactors and vitamins	hsa00860	Porphyrin and chlorophyll metabolism
1. Metabolism	1.0 Global and overview maps	hsa01100	Metabolic pathways

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0006783	heme biosynthetic process
Biological Process	GO:0018160	peptidyl-pyrromethane cofactor linkage
Biological Process	GO:0006782	protoporphyrinogen IX biosynthetic process
molecular function	GO:0004418	hydroxymethylbilane synthase activity
cellular component	GO:0005737	cytoplasm
cellular component	GO:0005829	cytosol

Reactome

Pathway Id	Pathway Name
R-HSA-1430728	Metabolism
R-HSA-189445	Metabolism of porphyrins
R-HSA-189451	Heme biosynthesis

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0000737	BXGD000005	Abdominal Pain	Pathological Conditions, Signs and Symptoms
C0001430	BXGD000054	Adenoma	Neoplasms
C0002395	BXGD000111	Alzheimer's Disease	Nervous System Diseases; Mental Disorders
C0002726	BXGD000125	Amyloidosis	Nutritional and Metabolic Diseases
C0003123	BXGD000178	Anorexia	Pathological Conditions, Signs and Symptoms
C0003467	BXGD000194	Anxiety	Behavior and Behavior Mechanisms
C0003811	BXGD000222	Cardiac Arrhythmia	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0003862	BXGD000230	Arthralgia	Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0004134	BXGD000256	Ataxia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0006142	BXGD000374	Malignant neoplasm of breast	Neoplasms; Skin and Connective Tissue Diseases
C0006826	BXGD000408	Malignant Neoplasms	Neoplasms
C0007194	BXGD000452	Hypertrophic Cardiomyopathy	Cardiovascular Diseases
C0007758	BXGD000475	Cerebellar Ataxia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0009806	BXGD000633	Constipation	Pathological Conditions, Signs and Symptoms
C0010674	BXGD000683	Cystic Fibrosis	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011119	BXGD000698	Decompression Sickness	Wounds and Injuries
C0011581	BXGD000733	Depressive disorder	Mental Disorders
C0011853	BXGD000752	Diabetes Mellitus, Experimental	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860	BXGD000755	Diabetes Mellitus, Non-Insulin-Dependent	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011991	BXGD000766	Diarrhea	Pathological Conditions, Signs and Symptoms
C0013428	BXGD000840	Dysuria	Pathological Conditions, Signs and Symptoms
C0015190	BXGD000968	Euthyroid Sick Syndromes	Endocrine System Diseases
C0015967	BXGD001030	Fever	Pathological Conditions, Signs and Symptoms
C0018524	BXGD001200	Hallucinations	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0018801	BXGD001226	Heart failure	Cardiovascular Diseases
C0018802	BXGD001227	Congestive heart failure	Cardiovascular Diseases
C0019196	BXGD001301	Hepatitis C	Digestive System Diseases; Infections
C0020433	BXGD001379	Hyperbilirubinemia	Pathological Conditions, Signs and Symptoms
C0020435	BXGD001380	Hyperbilirubinemia, Hereditary	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020458	BXGD001393	Hyperhidrosis disorder	Skin and Connective Tissue Diseases
C0020473	BXGD001396	Hyperlipidemia	Nutritional and Metabolic Diseases
C0020538	BXGD001422	Hypertensive disease	Cardiovascular Diseases
C0020546	BXGD001428	Hypertensive crisis	Nervous System Diseases; Cardiovascular Diseases
C0020621	BXGD001449	Hypokalemia	Nutritional and Metabolic Diseases
C0020625	BXGD001451	Hyponatremia	Nutritional and Metabolic Diseases
C0021141	BXGD001485	Inappropriate ADH Syndrome	Nutritional and Metabolic Diseases; Nervous System Diseases; Endocrine System Diseases
C0023380	BXGD001640	Lethargy	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0023418	BXGD001642	leukemia	Neoplasms
C0023473	BXGD001661	Myeloid Leukemia, Chronic	Neoplasms; Hemic and Lymphatic Diseases
C0023827	BXGD001707	liposarcoma	Neoplasms
C0023890	BXGD001713	Liver Cirrhosis	Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023895	BXGD001717	Liver diseases	Digestive System Diseases
C0024299	BXGD001758	Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024408	BXGD001768	Machado-Joseph Disease	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0024620	BXGD001790	Primary Malignant Liver Neoplasm	Digestive System Diseases; Neoplasms
C0025517	BXGD001875	Metabolic Diseases	Nutritional and Metabolic Diseases
C0025521	BXGD001876	Inborn Errors of Metabolism	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0026499	BXGD001905	Monosomy	Pathological Conditions, Signs and Symptoms
C0026764	BXGD001928	Multiple Myeloma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027497	BXGD001993	Nausea	Pathological Conditions, Signs and Symptoms
C0027498	BXGD001994	Nausea and vomiting	Pathological Conditions, Signs and Symptoms
C0027651	BXGD002009	Neoplasms	Neoplasms
C0027721	BXGD002029	Lipoid nephrosis	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027726	BXGD002030	Nephrotic Syndrome	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0028754	BXGD002082	Obesity	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030446	BXGD002225	Paralytic Ileus	Digestive System Diseases
C0030554	BXGD002239	Paresthesia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0030779	BXGD002252	Pelger-Huet Anomaly	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0031117	BXGD002285	Peripheral Neuropathy	Nervous System Diseases
C0032708	BXGD002368	Disorders of Porphyrin Metabolism	Nutritional and Metabolic Diseases
C0035232	BXGD002517	Respiratory Paralysis	Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases
C0036341	BXGD002600	Schizophrenia	Mental Disorders
C0036572	BXGD002625	Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036631	BXGD002626	Seminoma	Neoplasms
C0039231	BXGD002799	Tachycardia	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0040517	BXGD002872	Gilles de la Tourette syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0041341	BXGD002918	Tuberous Sclerosis	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0042024	BXGD002949	Urinary Incontinence	Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0042963	BXGD003018	Vomiting	Pathological Conditions, Signs and Symptoms
C0080274	BXGD003111	Urinary Retention	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0085584	BXGD003195	Encephalopathies	Nervous System Diseases
C0151311	BXGD003412	Cranial nerve palsies	Nervous System Diseases
C0151786	BXGD003475	Muscle Weakness	Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0162530	BXGD003949	Porphyria, Erythropoietic	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0162532	BXGD003951	Variegate Porphyria	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0162533	BXGD003952	Porphyrias, Hepatic	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0162565	BXGD003957	Acute intermittent porphyria	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0162568	BXGD003959	Erythropoietic Protoporphyria	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0162830	BXGD003987	Dermatitis, Phototoxic	Skin and Connective Tissue Diseases
C0205682	BXGD004105	Waist-Hip Ratio
C0206630	BXGD004195	Endometrial Stromal Sarcoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0206682	BXGD004237	Follicular thyroid carcinoma	Neoplasms
C0206698	BXGD004248	Cholangiocarcinoma	Neoplasms
C0220630	BXGD004302	Adult Liver Carcinoma	Digestive System Diseases; Neoplasms
C0221043	BXGD004377	Liddle Syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0221166	BXGD004397	Paraparesis	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0231528	BXGD004496	Myalgia	Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0232744	BXGD004561	Decreased liver function
C0235025	BXGD004713	Peripheral motor neuropathy	Nervous System Diseases
C0235950	BXGD004790	Zinc deficiency	Nutritional and Metabolic Diseases
C0238463	BXGD004938	Papillary thyroid carcinoma	Neoplasms; Endocrine System Diseases
C0268328	BXGD005898	Porphobilinogen synthase deficiency	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0270612	BXGD006081	Leukoencephalopathy	Nervous System Diseases
C0279000	BXGD006622	Liver and Intrahepatic Biliary Tract Carcinoma	Digestive System Diseases; Neoplasms
C0279546	BXGD006633	Adult Undifferentiated Pleomorphic Sarcoma	Neoplasms
C0334463	BXGD007076	Malignant Fibrous Histiocytoma	Neoplasms
C0338113	BXGD007168	Uterine Corpus Sarcoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0338451	BXGD007176	Frontotemporal dementia	Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C0338614	BXGD007208	Psychotic episodes	Mental Disorders
C0342858	BXGD007565	Homozygous acute intermittent porphyria	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0345904	BXGD007745	Malignant neoplasm of liver	Digestive System Diseases; Neoplasms
C0392885	BXGD008071	High density lipoprotein measurement
C0428472	BXGD008630	Serum HDL cholesterol measurement
C0442874	BXGD008814	Neuropathy	Nervous System Diseases
C0522153	BXGD009192	Urine Discoloration	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0524851	BXGD009246	Neurodegenerative Disorders	Nervous System Diseases
C0554980	BXGD009430	Moody (finding)
C0678222	BXGD009749	Breast Carcinoma	Neoplasms; Skin and Connective Tissue Diseases
C0740394	BXGD009989	Hyperuricemia	Pathological Conditions, Signs and Symptoms
C0751072	BXGD010312	Frontotemporal Lobar Degeneration	Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders
C0752304	BXGD010711	Hypoxic-Ischemic Encephalopathy	Nervous System Diseases; Cardiovascular Diseases
C0917801	BXGD011412	Sleeplessness	Nervous System Diseases; Mental Disorders
C1142277	BXGD011747	Brown urine
C1262477	BXGD011882	Weight decreased	Pathological Conditions, Signs and Symptoms
C1268588	BXGD011995	Porphyric polyneuropathy	Nervous System Diseases
C1279945	BXGD012124	Acute interstitial pneumonia	Respiratory Tract Diseases
C1306459	BXGD012361	Primary malignant neoplasm	Neoplasms
C1327920	BXGD012457	Childhood Chronic Myelogenous Leukemia, BCR-ABL1 Positive	Neoplasms; Hemic and Lymphatic Diseases
C1332206	BXGD012504	Adult Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332977	BXGD012569	Childhood Leukemia	Neoplasms
C1332979	BXGD012571	Childhood Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1370723	BXGD012916	Stromal sarcoma
C1527358	BXGD013279	Phototoxicity	Skin and Connective Tissue Diseases
C1565489	BXGD013401	Renal Insufficiency	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1623038	BXGD013475	Cirrhosis	Pathological Conditions, Signs and Symptoms
C1840311	BXGD014445	Laryngeal cleft	Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1848702	BXGD014968	Elevated urinary delta-aminolevulinic acid
C1867969	BXGD016476	Porphyria, Acute Intermittent, Nonerythroid Variant	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C1867971	BXGD016477	Acute episodes of neuropathic symptoms
C2062441	BXGD016897	Influenza A
C2188153	BXGD016937	Undifferentiated/Unclassified Sarcoma
C2239176	BXGD016965	Liver carcinoma	Digestive System Diseases; Neoplasms
C2678065	BXGD017398	Myofibrillar Myopathy	Musculoskeletal Diseases; Nervous System Diseases
C2712360	BXGD017487	Severe hypoxic ischemic encephalopathy	Nervous System Diseases; Cardiovascular Diseases
C2718078	BXGD017526	Deficiency of Uroporphyrinogen III Synthase	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C2936779	BXGD018134	Hydroxymethylbilane Synthase Deficiency	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C3203102	BXGD018555	Idiopathic pulmonary arterial hypertension	Respiratory Tract Diseases
C3665386	BXGD019284	Abnormal vision	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3899638	BXGD020085	Childhood Undifferentiated Pleomorphic Sarcoma	Neoplasms
C4721453	BXGD023744	Peripheral Nervous System Diseases	Nervous System Diseases

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0042510	Fluoxetine		309.13

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}