Showing entry for C-X-C motif chemokine 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT023294
Protein NameC-X-C motif chemokine 2
Uniport IdP19875
GeneCXCL2
Gene Id2920
DomainIL8
Pfam PF00048  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04060 Cytokine-cytokine receptor interaction
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04061 Viral protein interaction with cytokine and cytokine receptor
5. Organismal Systems 5.1 Immune system hsa04062 Chemokine signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04064 NF-kappa B signaling pathway
5. Organismal Systems 5.1 Immune system hsa04621 NOD-like receptor signaling pathway
5. Organismal Systems 5.1 Immune system hsa04657 IL-17 signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04668 TNF signaling pathway
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05120 Epithelial cell signaling in Helicobacter pylori infection
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05132 Salmonella infection
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05134 Legionellosis
6. Human Diseases 6.9 Infectious diseases: Viral hsa05167 Kaposi sarcoma-associated herpesvirus infection
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
Biological Process GO:0071222 cellular response to lipopolysaccharide
Biological Process GO:0070098 chemokine-mediated signaling pathway
Biological Process GO:0006935 chemotaxis
Biological Process GO:0019221 cytokine-mediated signaling pathway
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0006955 immune response
Biological Process GO:0006954 inflammatory response
Biological Process GO:0031640 killing of cells of other organism
Biological Process GO:0030595 leukocyte chemotaxis
Biological Process GO:0030593 neutrophil chemotaxis
Biological Process GO:0002237 response to molecule of bacterial origin
molecular function GO:0008009 chemokine activity
molecular function GO:0045236 CXCR chemokine receptor binding
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
Reactome
Pathway Id Pathway Name
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-162582 Signal Transduction
R-HSA-168256 Immune System
R-HSA-372790 Signaling by GPCR
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-380108 Chemokine receptors bind chemokines
R-HSA-388396 GPCR downstream signalling
R-HSA-418594 G alpha (i) signalling events
R-HSA-449147 Signaling by Interleukins
R-HSA-500792 GPCR ligand binding
R-HSA-6783783 Interleukin-10 signaling
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000833 BXGD000014 Abscess Pathological Conditions, Signs and Symptoms; Infections
C0000880 BXGD000016 Acanthamoeba Keratitis Infections; Eye Diseases
C0001339 BXGD000041 Acute pancreatitis Digestive System Diseases
C0002170 BXGD000105 Alopecia Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0002171 BXGD000106 Alopecia Areata Skin and Connective Tissue Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004623 BXGD000282 Bacterial Infections Infections
C0004626 BXGD000283 Pneumonia, Bacterial Infections; Respiratory Tract Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005974 BXGD000358 Bone Resorption Musculoskeletal Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007758 BXGD000475 Cerebellar Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0008311 BXGD000526 Cholangitis Digestive System Diseases
C0008370 BXGD000534 Cholestasis Digestive System Diseases
C0008372 BXGD000535 Intrahepatic Cholestasis Digestive System Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011615 BXGD000738 Dermatitis, Atopic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0013371 BXGD000823 Shigella Infections Digestive System Diseases; Infections
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0014061 BXGD000883 Tick-Borne Encephalitis Infections; Nervous System Diseases
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0017919 BXGD001150 Glycogen Storage Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0018378 BXGD001190 Guillain-Barre Syndrome Immune System Diseases; Nervous System Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019080 BXGD001279 Hemorrhage Pathological Conditions, Signs and Symptoms
C0019151 BXGD001290 Hepatic Encephalopathy Digestive System Diseases; Nutritional and Metabolic Diseases; Nervous System Diseases
C0019158 BXGD001293 Hepatitis Digestive System Diseases
C0019159 BXGD001294 Hepatitis A Digestive System Diseases; Infections
C0019188 BXGD001297 Hepatitis, Animal Digestive System Diseases; Infections; Animal Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020725 BXGD001465 Type II Mucolipidosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0021122 BXGD001481 Disruptive, Impulse Control, and Conduct Disorders Mental Disorders
C0021368 BXGD001502 Inflammation Pathological Conditions, Signs and Symptoms
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0023212 BXGD001616 Left-Sided Heart Failure Cardiovascular Diseases
C0023364 BXGD001638 Leptospirosis Infections
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023508 BXGD001675 White Blood Cell Count procedure
C0023530 BXGD001683 Leukopenia Hemic and Lymphatic Diseases
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0023896 BXGD001718 Alcoholic Liver Diseases Digestive System Diseases; Chemically-Induced Disorders
C0024115 BXGD001732 Lung diseases Respiratory Tract Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0026691 BXGD001917 Mucocutaneous Lymph Node Syndrome Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0026821 BXGD001933 Muscle Cramp Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027055 BXGD001964 Myocardial Reperfusion Injury Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027947 BXGD002061 Neutropenia Hemic and Lymphatic Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029443 BXGD002152 Osteomyelitis Infections; Musculoskeletal Diseases
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029799 BXGD002170 Other specified forms of pleural effusion, except tuberculous Infections; Respiratory Tract Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0031099 BXGD002282 Periodontitis Stomatognathic Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0032290 BXGD002345 Aspiration Pneumonia Infections; Respiratory Tract Diseases
C0032310 BXGD002349 Pneumonia, Viral Infections; Respiratory Tract Diseases
C0033770 BXGD002417 Prune Belly Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0034186 BXGD002469 Pyelonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0035126 BXGD002509 Reperfusion Injury Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0036472 BXGD002618 Scrub Typhus Infections
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0036982 BXGD002651 Shock, Hemorrhagic Pathological Conditions, Signs and Symptoms
C0037274 BXGD002676 Dermatologic disorders Skin and Connective Tissue Diseases
C0038041 BXGD002732 Spotted Fever Group Rickettsiosis Infections
C0040034 BXGD002836 Thrombocytopenia Hemic and Lymphatic Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0041471 BXGD002926 TYPHUS Infections
C0042769 BXGD002999 Virus Diseases Infections
C0086743 BXGD003308 Osteoarthrosis Deformans Musculoskeletal Diseases
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0152018 BXGD003518 Esophageal carcinoma Digestive System Diseases; Neoplasms
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0155626 BXGD003806 Acute myocardial infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0162820 BXGD003985 Dermatitis, Allergic Contact Skin and Connective Tissue Diseases; Immune System Diseases
C0175697 BXGD004004 Van der Woude syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Musculoskeletal Diseases; Stomatognathic Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206750 BXGD004287 Coronavirus Infections Infections
C0235527 BXGD004753 Heart Failure, Right-Sided Cardiovascular Diseases
C0238198 BXGD004893 Gastrointestinal Stromal Tumors Digestive System Diseases; Neoplasms
C0238281 BXGD004902 Middle Cerebral Artery Syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0242381 BXGD005159 Lyme Arthritis Infections
C0242488 BXGD005170 Acute Lung Injury Respiratory Tract Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0260037 BXGD005227 Multiple tumors Neoplasms
C0262469 BXGD005245 Embolic stroke Nervous System Diseases; Cardiovascular Diseases
C0267941 BXGD005793 Pancreatitis, Acute Necrotizing Digestive System Diseases
C0274861 BXGD006372 Arsenic Poisoning, Inorganic Nervous System Diseases; Chemically-Induced Disorders
C0274862 BXGD006373 Nervous System, Organic Arsenic Poisoning Nervous System Diseases; Chemically-Induced Disorders
C0276289 BXGD006418 Zika Virus Infection Infections
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0280324 BXGD006740 Laryngeal Squamous Cell Carcinoma Neoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0311375 BXGD006883 Arsenic Poisoning Nervous System Diseases; Chemically-Induced Disorders
C0343758 BXGD007645 Typhus group rickettsial disease Infections
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0375023 BXGD007970 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
C0376618 BXGD008003 Endotoxemia Pathological Conditions, Signs and Symptoms; Infections
C0406810 BXGD008374 Carney Complex Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Cardiovascular Diseases
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0520575 BXGD009096 Acute pyelonephritis Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0546837 BXGD009343 Malignant neoplasm of esophagus Digestive System Diseases; Neoplasms
C0549297 BXGD009367 Auricular swelling Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0740376 BXGD009982 Middle Cerebral Artery Thrombosis Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0740391 BXGD009987 Middle Cerebral Artery Occlusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0740392 BXGD009988 Infarction, Middle Cerebral Artery Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0751845 BXGD010605 Middle Cerebral Artery Embolus Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0751846 BXGD010606 Left Middle Cerebral Artery Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0751847 BXGD010607 Embolic Infarction, Middle Cerebral Artery Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0751848 BXGD010608 Thrombotic Infarction, Middle Cerebral Artery Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0751849 BXGD010609 Right Middle Cerebral Artery Infarction Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0751851 BXGD010610 Arsenic Encephalopathy Nervous System Diseases; Chemically-Induced Disorders
C0751852 BXGD010611 Arsenic Induced Polyneuropathy Nervous System Diseases; Chemically-Induced Disorders
C0860207 BXGD011220 Drug-Induced Liver Disease Digestive System Diseases; Chemically-Induced Disorders
C0860564 BXGD011231 Retinoic acid syndrome Pathological Conditions, Signs and Symptoms
C0876973 BXGD011322 Infectious Lung Disorder Infections; Respiratory Tract Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C0948343 BXGD011527 Transfusion-Related Acute Lung Injury Respiratory Tract Diseases; Immune System Diseases; Hemic and Lymphatic Diseases
C1136033 BXGD011703 Cutaneous Mastocytosis Neoplasms; Skin and Connective Tissue Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1257931 BXGD011815 Mammary Neoplasms, Human Neoplasms; Skin and Connective Tissue Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1318485 BXGD012394 Liver regeneration disorder Digestive System Diseases
C1456246 BXGD013110 Bacteroides fragilis infection in conditions classified elsewhere and of unspecified site
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1519670 BXGD013241 Tumor Angiogenesis Pathological Conditions, Signs and Symptoms
C1527303 BXGD013265 Chronic Airflow Obstruction Respiratory Tract Diseases
C1527311 BXGD013268 Brain Edema Nervous System Diseases
C1719672 BXGD013659 Severe Sepsis Pathological Conditions, Signs and Symptoms; Infections
C1720830 BXGD013687 Painful Bladder Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1867982 BXGD016478 KERATODERMA, PALMOPLANTAR, PUNCTATE TYPE II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C1959583 BXGD016637 Myocardial Failure Cardiovascular Diseases
C1960458 BXGD016662 Differentiation syndrome due to and following chemotherapy co-occurrent with acute promyelocytic leukemia Neoplasms
C1961112 BXGD016674 Heart Decompensation Cardiovascular Diseases
C2020625 BXGD016882 Group B Streptococcal Infection Infections
C2062441 BXGD016897 Influenza A
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3280586 BXGD018846 Mannose-Binding Protein Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C3542501 BXGD019106 Acute Infective Polyneuritis Immune System Diseases; Nervous System Diseases
C3665444 BXGD019288 Neutrophilia (disorder) Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
C3831784 BXGD019755 Acute monocytic/monoblastic leukemia Neoplasms; Hemic and Lymphatic Diseases
C4083008 BXGD022100 Guillain-Barre Syndrome, Familial Immune System Diseases; Nervous System Diseases
C4290046 BXGD022507 trachomatis
C4324563 BXGD022772 Neutrophil extracellular trap formation
C4529962 BXGD023178 Fatty Liver Disease
C4704753 BXGD023679 Urinary Bladder, Underactive Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C4704874 BXGD023682 Mammary Carcinoma, Human Neoplasms; Skin and Connective Tissue Diseases
C4721507 BXGD023747 Alveolitis, Fibrosing Respiratory Tract Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein