Showing entry for Phytanoyl-CoA dioxygenase, peroxisomal


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004104
Protein NamePhytanoyl-CoA dioxygenase, peroxisomal
Uniport IdO14832
GenePHYH
Gene Id5264
DomainPhyH
Pfam PF05721  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.1 Transport and catabolism hsa04146 Peroxisome
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0019606 2-oxobutyrate catabolic process
Biological Process GO:0006103 2-oxoglutarate metabolic process
Biological Process GO:0001561 fatty acid alpha-oxidation
Biological Process GO:0006720 isoprenoid metabolic process
Biological Process GO:0097089 methyl-branched fatty acid metabolic process
Biological Process GO:0006625 protein targeting to peroxisome
molecular function GO:0031406 carboxylic acid binding
molecular function GO:0008198 ferrous iron binding
molecular function GO:0031418 L-ascorbic acid binding
molecular function GO:0048244 phytanoyl-CoA dioxygenase activity
cellular component GO:0097731 9+0 non-motile cilium
cellular component GO:0005829 cytosol
cellular component GO:0005739 mitochondrion
cellular component GO:0005782 peroxisomal matrix
cellular component GO:0005777 peroxisome
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-389599 Alpha-oxidation of phytanate
R-HSA-390918 Peroxisomal lipid metabolism
R-HSA-556833 Metabolism of lipids
R-HSA-8978868 Fatty acid metabolism
R-HSA-9033241 Peroxisomal protein import
R-HSA-9033241 Peroxisomal protein import
R-HSA-9033500 TYSND1 cleaves peroxisomal proteins
R-HSA-9609507 Protein localization
R-HSA-9609507 Protein localization
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003126 BXGD000180 Anosmia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0015397 BXGD000983 Disorder of eye Eye Diseases
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018794 BXGD001222 Heart Block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0018800 BXGD001225 Cardiomegaly Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0020580 BXGD001435 Hypesthesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0020757 BXGD001466 Ichthyoses Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0024143 BXGD001741 Lupus Nephritis Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Male Urogenital Diseases; Immune System Diseases
C0026010 BXGD001886 Microphthalmos Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0026205 BXGD001891 Miosis disorder Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0026760 BXGD001927 Multiple Epiphyseal Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0028077 BXGD002069 Nyctalopia Eye Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0029422 BXGD002142 Osteochondrodysplasias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0034960 BXGD002499 Refsum Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0035229 BXGD002516 Respiratory Insufficiency Respiratory Tract Diseases
C0035304 BXGD002528 Retinal Degeneration Eye Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0035334 BXGD002539 Retinitis Pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0036857 BXGD002638 Severe intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0038002 BXGD002723 Splenomegaly Pathological Conditions, Signs and Symptoms
C0039273 BXGD002806 Talipes cavus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0151888 BXGD003497 Hyporeflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151908 BXGD003502 Dry skin Skin and Connective Tissue Diseases
C0162309 BXGD003934 Adrenoleukodystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Endocrine System Diseases
C0234132 BXGD004623 Pyramidal sign Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0375206 BXGD007973 Hemiplegia/hemiparesis
C0410528 BXGD008430 Skeletal dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0497552 BXGD009067 Congenital neurologic anomalies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0541794 BXGD009262 Skeletal muscle atrophy
C0587246 BXGD009616 Muscle weakness of limb Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0598589 BXGD009667 Inherited neuropathies Nervous System Diseases
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C1112256 BXGD011655 Sensorimotor neuropathy
C1136179 BXGD011712 Hammer Toe Musculoskeletal Diseases
C1565489 BXGD013401 Renal Insufficiency Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1720802 BXGD013682 Refsum Disease, Phytanoyl-CoA Hydroxylase Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C1806780 BXGD013759 Increased CSF protein
C1834405 BXGD013970 Nail dysplasia Pathological Conditions, Signs and Symptoms
C1836830 BXGD014165 Developmental regression Mental Disorders
C1837084 BXGD014195 Short metacarpal
C1839364 BXGD014371 Progressive visual loss
C1848514 BXGD014931 Short fourth metatarsal
C1862475 BXGD016132 Abnormality of retinal pigmentation
C1962966 BXGD016678 Retinopathy, CTCAE
C1963094 BXGD016681 Dry Skin, CTCAE
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C2749345 BXGD017618 Refsum Disease, Adult, 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C2750440 BXGD017660 FATTY LIVER DISEASE, NONALCOHOLIC, SUSCEPTIBILITY TO, 1
C2750441 BXGD017661 LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
C3150651 BXGD018316 FATTY LIVER DISEASE, NONALCOHOLIC, SUSCEPTIBILITY TO, 2
C3279947 BXGD018789 NAIL DISORDER, NONSYNDROMIC CONGENITAL, 9
C4021611 BXGD020697 Abnormality of epiphysis morphology
C4021768 BXGD020766 Abnormality of metabolism/homeostasis
C4023786 BXGD021261 Elevated levels of phytanic acid
C4551714 BXGD023398 Rod-Cone Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000764 L-Ascorbic acid 176.12
BXGC0002485 2-Oxopentanedioic acid 146.1
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein