Showing entry for C4b-binding protein alpha chain


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006124
Protein NameC4b-binding protein alpha chain
Uniport IdP04003
GeneC4BPA
Gene Id722
DomainC4bp_oligo; Sushi
Pfam PF18453   PF00084  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04610 Complement and coagulation cascades
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05133 Pertussis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006958 complement activation, classical pathway
Biological Process GO:0045087 innate immune response
Biological Process GO:0045959 negative regulation of complement activation, classical pathway
Biological Process GO:0045732 positive regulation of protein catabolic process
Biological Process GO:0030449 regulation of complement activation
Biological Process GO:1903027 regulation of opsonization
Biological Process GO:0009609 response to symbiotic bacterium
molecular function GO:0003723 RNA binding
cellular component GO:0072562 blood microparticle
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-166658 Complement cascade
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-977606 Regulation of Complement cascade
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001175 BXGD000029 Acquired Immunodeficiency Syndrome Infections; Immune System Diseases
C0002170 BXGD000105 Alopecia Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0003862 BXGD000230 Arthralgia Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0004943 BXGD000297 Behcet Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Skin and Connective Tissue Diseases; Stomatognathic Diseases; Cardiovascular Diseases
C0005129 BXGD000304 Bernard-Soulier Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0008479 BXGD000544 Chondrosarcoma Neoplasms
C0011334 BXGD000716 Dental caries Stomatognathic Diseases
C0012546 BXGD000776 Diphtheria Infections
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0017495 BXGD001111 Gerstmann-Straussler-Scheinker Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Infections; Nervous System Diseases
C0017601 BXGD001125 Glaucoma Eye Diseases
C0017609 BXGD001128 Glaucoma, Neovascular Eye Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017661 BXGD001139 IGA Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Immune System Diseases
C0018081 BXGD001171 Gonorrhea Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0019061 BXGD001273 Hemolytic-Uremic Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Hemic and Lymphatic Diseases
C0019069 BXGD001277 Hemophilia A Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0020445 BXGD001386 Hypercholesterolemia, Familial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0022336 BXGD001535 Creutzfeldt-Jakob disease Infections; Nervous System Diseases; Mental Disorders
C0023418 BXGD001642 leukemia Neoplasms
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025289 BXGD001851 Meningitis Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0028841 BXGD002090 Ocular Hypotension Eye Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0032027 BXGD002323 Pityriasis Rubra Pilaris Skin and Connective Tissue Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036457 BXGD002617 Scrapie Infections; Nervous System Diseases; Animal Diseases
C0039103 BXGD002791 Synovitis Musculoskeletal Diseases
C0042900 BXGD003012 Vitiligo Skin and Connective Tissue Diseases
C0043194 BXGD003036 Wiskott-Aldrich Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Hemic and Lymphatic Diseases
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0085584 BXGD003195 Encephalopathies Nervous System Diseases
C0085669 BXGD003233 Acute leukemia Pathological Conditions, Signs and Symptoms; Neoplasms
C0149516 BXGD003324 Chronic sinusitis Infections; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0149778 BXGD003362 Soft Tissue Infection Infections
C0151936 BXGD003505 Disorder of tendon Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0162311 BXGD003935 Androgenetic Alopecia Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0162534 BXGD003953 Prion Diseases Infections; Nervous System Diseases
C0200665 BXGD004045 Platelet mean volume determination (procedure)
C0206042 BXGD004145 Fatal Familial Insomnia Infections; Nervous System Diseases
C0232197 BXGD004536 Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0238124 BXGD004883 Necrotizing fasciitis Musculoskeletal Diseases
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0242666 BXGD005185 Protein S Deficiency Hemic and Lymphatic Diseases
C0262404 BXGD005236 Cerebellar degeneration Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0263374 BXGD005295 Lichen striatus Skin and Connective Tissue Diseases
C0263725 BXGD005345 Hemophilic arthropathy Musculoskeletal Diseases
C0263912 BXGD005354 Rotator cuff syndrome Wounds and Injuries
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0302810 BXGD006853 Uremia syndrome Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0311370 BXGD006882 Lupus anticoagulant disorder Pathological Conditions, Signs and Symptoms; Immune System Diseases; Hemic and Lymphatic Diseases
C0333519 BXGD006958 Caries (morphologic abnormality) Pathological Conditions, Signs and Symptoms
C0340978 BXGD007381 May-Hegglin anomaly Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0376329 BXGD007989 New Variant Creutzfeldt-Jakob Disease Infections; Nervous System Diseases; Mental Disorders
C0398642 BXGD008210 Montreal platelet syndrome
C0409959 BXGD008400 Osteoarthritis, Knee Musculoskeletal Diseases
C0542141 BXGD009271 Paralysis radial Nervous System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0677886 BXGD009734 Epithelial ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684275 BXGD009792 Hemophilia, NOS Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0745103 BXGD010114 Hyperlipoproteinemia Type IIa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0751254 BXGD010366 Creutzfeldt-Jakob Disease, Familial Infections; Nervous System Diseases; Mental Disorders
C0814161 BXGD010860 impaired motor coordination
C0861727 BXGD011250 Pancreatic adenocarcinoma metastatic
C1262211 BXGD011876 Diarrhoea predominant irritable bowel syndrome
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306600 BXGD012370 Radial nerve palsy Nervous System Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1456868 BXGD013128 Diabetic foot ulcer Skin and Connective Tissue Diseases; Endocrine System Diseases; Cardiovascular Diseases
C1519670 BXGD013241 Tumor Angiogenesis Pathological Conditions, Signs and Symptoms
C1568272 BXGD013421 Tendinopathy Musculoskeletal Diseases; Wounds and Injuries
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1832097 BXGD013797 EPIDERMAL DIFFERENTIATION COMPLEX
C1847835 BXGD014892 VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) Skin and Connective Tissue Diseases
C1852467 BXGD015283 Creutzfeldt-Jakob Disease, Sporadic Infections; Nervous System Diseases; Mental Disorders
C1854520 BXGD015412 SEBASTIAN SYNDROME Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases; Hemic and Lymphatic Diseases
C1861172 BXGD016016 Venous Thromboembolism Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2931788 BXGD018064 Atypical Hemolytic Uremic Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Hemic and Lymphatic Diseases
C2985280 BXGD018223 Blood Protein Measurement
C3280641 BXGD018849 Decreased serum complement C4b
C3280642 BXGD018850 Complement Component 4a Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases
C3495559 BXGD018994 Juvenile arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C3854629 BXGD019841 Tendon thickening
C4083212 BXGD022105 Alopecia, Male Pattern Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C4281802 BXGD022417 Spongiform encephalopathy Infections; Nervous System Diseases
C4310512 BXGD022597 Sporadic CJD Infections; Nervous System Diseases; Mental Disorders; Animal Diseases
C4552766 BXGD023523 Miscarriage Female Urogenital Diseases and Pregnancy Complications
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002616 Copper 63.55
BXGC0002682 Zinc 65.41
BXGC0003705 Chloride 35.45
BXGC0038991 Selenomethionine 197
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein