Showing entry for Integrin alpha-5


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006804
Protein NameIntegrin alpha-5
Uniport IdP08648
GeneITGA5
Gene Id3678
DomainFG-GAP; Integrin_alpha2
Pfam PF01839   PF08441  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.1 Transport and catabolism hsa04145 Phagosome
3. Environmental Information Processing 3.2 Signal transduction hsa04151 PI3K-Akt signaling pathway
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04510 Focal adhesion
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04512 ECM-receptor interaction
5. Organismal Systems 5.1 Immune system hsa04640 Hematopoietic cell lineage
4. Cellular Processes 4.5 Cell motility hsa04810 Regulation of actin cytoskeleton
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05100 Bacterial invasion of epithelial cells
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05131 Shigellosis
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05133 Pertussis
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05135 Yersinia infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05165 Human papillomavirus infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05168 Herpes simplex virus 1 infection
6. Human Diseases 6.1 Cancers: Overview hsa05205 Proteoglycans in cancer
6. Human Diseases 6.1 Cancers: Overview hsa05206 MicroRNAs in cancer
6. Human Diseases 6.6 Cardiovascular diseases hsa05410 Hypertrophic cardiomyopathy (HCM)
6. Human Diseases 6.6 Cardiovascular diseases hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
6. Human Diseases 6.6 Cardiovascular diseases hsa05414 Dilated cardiomyopathy (DCM)
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0001525 angiogenesis
Biological Process GO:0023035 CD40 signaling pathway
Biological Process GO:0007155 cell adhesion
Biological Process GO:0033627 cell adhesion mediated by integrin
Biological Process GO:0033631 cell-cell adhesion mediated by integrin
Biological Process GO:0031589 cell-substrate adhesion
Biological Process GO:0007044 cell-substrate junction assembly
Biological Process GO:0035987 endodermal cell differentiation
Biological Process GO:0030198 extracellular matrix organization
Biological Process GO:0007565 female pregnancy
Biological Process GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
Biological Process GO:0034113 heterotypic cell-cell adhesion
Biological Process GO:0007229 integrin-mediated signaling pathway
Biological Process GO:0007159 leukocyte cell-cell adhesion
Biological Process GO:0050900 leukocyte migration
Biological Process GO:0007613 memory
Biological Process GO:2000811 negative regulation of anoikis
Biological Process GO:0030335 positive regulation of cell migration
Biological Process GO:0010811 positive regulation of cell-substrate adhesion
Biological Process GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
Biological Process GO:1903672 positive regulation of sprouting angiogenesis
Biological Process GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
Biological Process GO:0035313 wound healing, spreading of epidermal cells
molecular function GO:0005154 epidermal growth factor receptor binding
molecular function GO:0005178 integrin binding
molecular function GO:0046872 metal ion binding
molecular function GO:0005161 platelet-derived growth factor receptor binding
molecular function GO:0043184 vascular endothelial growth factor receptor 2 binding
molecular function GO:0001618 virus receptor activity
cellular component GO:0071062 alphav-beta3 integrin-vitronectin complex
cellular component GO:0009986 cell surface
cellular component GO:0031410 cytoplasmic vesicle
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0009897 external side of plasma membrane
cellular component GO:0005925 focal adhesion
cellular component GO:0005794 Golgi apparatus
cellular component GO:0034674 integrin alpha5-beta1 complex
cellular component GO:0008305 integrin complex
cellular component GO:0005886 plasma membrane
cellular component GO:0001726 ruffle
cellular component GO:0045202 synapse
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-1266738 Developmental Biology
R-HSA-1474244 Extracellular matrix organization
R-HSA-1474244 Extracellular matrix organization
R-HSA-1566948 Elastic fibre formation
R-HSA-1566977 Fibronectin matrix formation
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-212436 Generic Transcription Pathway
R-HSA-216083 Integrin cell surface interactions
R-HSA-216083 Integrin cell surface interactions
R-HSA-373760 L1CAM interactions
R-HSA-422475 Axon guidance
R-HSA-445144 Signal transduction by L1
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-8878166 Transcriptional regulation by RUNX2
R-HSA-8941332 RUNX2 regulates genes involved in cell migration
R-HSA-9675108 Nervous system development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002448 BXGD000115 Ameloblastoma Neoplasms
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006118 BXGD000372 Brain Neoplasms Neoplasms; Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007138 BXGD000446 Carcinoma, Transitional Cell Neoplasms
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0008312 BXGD000527 Primary biliary cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011644 BXGD000744 Scleroderma Skin and Connective Tissue Diseases
C0013264 BXGD000808 Muscular Dystrophy, Duchenne Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0013274 BXGD000809 Patent ductus arteriosus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0016057 BXGD001042 Fibrosarcoma Neoplasms
C0016514 BXGD001066 Foot-and-Mouth Disease Infections; Animal Diseases
C0017609 BXGD001128 Glaucoma, Neovascular Eye Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0017639 BXGD001133 Gliosis Pathological Conditions, Signs and Symptoms
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019189 BXGD001298 Hepatitis, Chronic Digestive System Diseases
C0020429 BXGD001378 Hyperalgesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0022548 BXGD001551 Keloid Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0024899 BXGD001812 Mastocytosis Neoplasms; Skin and Connective Tissue Diseases; Immune System Diseases
C0025149 BXGD001826 Medulloblastoma Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027626 BXGD002005 Neoplasm Invasiveness Pathological Conditions, Signs and Symptoms; Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0029882 BXGD002177 Otitis Media Otorhinolaryngologic Diseases
C0029925 BXGD002181 Ovarian Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0035126 BXGD002509 Reperfusion Injury Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0036220 BXGD002587 Kaposi Sarcoma Neoplasms; Infections
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0038356 BXGD002747 Stomach Neoplasms Digestive System Diseases; Neoplasms
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0042133 BXGD002960 Uterine Fibroids Neoplasms
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0151650 BXGD003454 Renal fibrosis Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0153594 BXGD003669 Malignant neoplasm of testis Neoplasms; Male Urogenital Diseases; Endocrine System Diseases
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0153690 BXGD003684 Secondary malignant neoplasm of bone Pathological Conditions, Signs and Symptoms; Neoplasms; Musculoskeletal Diseases
C0156181 BXGD003841 Peritoneal adhesion Digestive System Diseases; Skin and Connective Tissue Diseases
C0162810 BXGD003982 Cicatrix, Hypertrophic Pathological Conditions, Signs and Symptoms
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206718 BXGD004264 Ganglioneuroblastoma Neoplasms
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0242596 BXGD005181 Neoplasm, Residual Pathological Conditions, Signs and Symptoms; Neoplasms
C0242852 BXGD005197 Proliferative vitreoretinopathy Eye Diseases
C0243038 BXGD005211 Carcinoma, Lewis Lung Neoplasms
C0264757 BXGD005424 Rheumatic disease of heart valve Infections; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Cardiovascular Diseases
C0278510 BXGD006526 Childhood Medulloblastoma Neoplasms
C0278595 BXGD006545 Adult Fibrosarcoma Neoplasms
C0278687 BXGD006561 Ovarian cancer stage III
C0278876 BXGD006607 Adult Medulloblastoma Neoplasms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0280483 BXGD006750 Adult Anaplastic Astrocytoma Neoplasms
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0334579 BXGD007120 Anaplastic astrocytoma Neoplasms
C0339573 BXGD007271 Glaucoma, Primary Open Angle Eye Diseases
C0346398 BXGD007822 Mixed follicular and papillary thyroid carcinoma
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0376544 BXGD008001 Hematopoietic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0406810 BXGD008374 Carney Complex Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Cardiovascular Diseases
C0494165 BXGD009022 Secondary malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0751633 BXGD010529 Carotid Artery Plaque Nervous System Diseases; Cardiovascular Diseases
C0850666 BXGD010901 Infection caused by Helicobacter pylori Infections
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1290884 BXGD012198 Inflammatory disorder Pathological Conditions, Signs and Symptoms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1319315 BXGD012415 Adenocarcinoma of large intestine Digestive System Diseases; Neoplasms
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1334953 BXGD012746 Neuroblastic tumors Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1519666 BXGD013240 Tumor-Associated Vasculature
C1519670 BXGD013241 Tumor Angiogenesis Pathological Conditions, Signs and Symptoms
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1708349 BXGD013597 Hereditary Diffuse Gastric Cancer Digestive System Diseases; Neoplasms
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1845050 BXGD014703 PIGMENTARY DISORDER, RETICULATE, WITH SYSTEMIC MANIFESTATIONS Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C1865868 BXGD016346 ALZHEIMER DISEASE 5 Nervous System Diseases; Mental Disorders
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2826323 BXGD017790 Refractory Cytopenia of Childhood
C2827407 BXGD017795 Infectious Otitis Media Otorhinolaryngologic Diseases
C2931822 BXGD018068 Nasopharyngeal carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3642347 BXGD019246 Basal-Like Breast Carcinoma
C3714514 BXGD019409 Infection Infections
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
C3887640 BXGD019908 Astrocytosis Pathological Conditions, Signs and Symptoms
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4087504 BXGD022156 Peritoneal dissemination
C4282128 BXGD022420 PATENT DUCTUS ARTERIOSUS 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C4529962 BXGD023178 Fatty Liver Disease
C4551548 BXGD023342 Grade III Childhood Astrocytoma Neoplasms
C4553569 BXGD023544 Stage III Ovarian Cancer AJCC v8
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0001767 (E)-Resveratrol 228.25
BXGC0002586 Calcium 40.08
BXGC0018397 beta-1,4-mannan 180.06
BXGC0050194 alpha-D-Mannose 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein