Showing entry for Integrin alpha-4


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT007928
Protein NameIntegrin alpha-4
Uniport IdP13612
GeneITGA4
Gene Id3676
DomainFG-GAP; Integrin_alpha2
Pfam PF01839   PF08441  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04151 PI3K-Akt signaling pathway
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04510 Focal adhesion
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04512 ECM-receptor interaction
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04514 Cell adhesion molecules (CAMs)
5. Organismal Systems 5.1 Immune system hsa04640 Hematopoietic cell lineage
5. Organismal Systems 5.1 Immune system hsa04670 Leukocyte transendothelial migration
5. Organismal Systems 5.1 Immune system hsa04672 Intestinal immune network for IgA production
4. Cellular Processes 4.5 Cell motility hsa04810 Regulation of actin cytoskeleton
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05135 Yersinia infection
6. Human Diseases 6.10 Infectious diseases: Parasitic hsa05140 Leishmaniasis
6. Human Diseases 6.9 Infectious diseases: Viral hsa05165 Human papillomavirus infection
6. Human Diseases 6.6 Cardiovascular diseases hsa05410 Hypertrophic cardiomyopathy (HCM)
6. Human Diseases 6.6 Cardiovascular diseases hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
6. Human Diseases 6.6 Cardiovascular diseases hsa05414 Dilated cardiomyopathy (DCM)
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0060385 axonogenesis involved in innervation
Biological Process GO:0030183 B cell differentiation
Biological Process GO:0140039 cell-cell adhesion in response to extracellular stimulus
Biological Process GO:0033631 cell-cell adhesion mediated by integrin
Biological Process GO:0007160 cell-matrix adhesion
Biological Process GO:0003366 cell-matrix adhesion involved in ameboidal cell migration
Biological Process GO:1904646 cellular response to amyloid-beta
Biological Process GO:0071345 cellular response to cytokine stimulus
Biological Process GO:1990771 clathrin-dependent extracellular exosome endocytosis
Biological Process GO:0050904 diapedesis
Biological Process GO:0035987 endodermal cell differentiation
Biological Process GO:0030198 extracellular matrix organization
Biological Process GO:0034113 heterotypic cell-cell adhesion
Biological Process GO:0098657 import into cell
Biological Process GO:0007229 integrin-mediated signaling pathway
Biological Process GO:0007159 leukocyte cell-cell adhesion
Biological Process GO:0050900 leukocyte migration
Biological Process GO:0050901 leukocyte tethering or rolling
Biological Process GO:0090074 negative regulation of protein homodimerization activity
Biological Process GO:1990138 neuron projection extension
Biological Process GO:2000353 positive regulation of endothelial cell apoptotic process
Biological Process GO:1903238 positive regulation of leukocyte tethering or rolling
Biological Process GO:2000406 positive regulation of T cell migration
Biological Process GO:1905564 positive regulation of vascular endothelial cell proliferation
Biological Process GO:0043113 receptor clustering
Biological Process GO:0050776 regulation of immune response
Biological Process GO:0034446 substrate adhesion-dependent cell spreading
molecular function GO:0050839 cell adhesion molecule binding
molecular function GO:0015026 coreceptor activity
molecular function GO:0001968 fibronectin binding
molecular function GO:0005178 integrin binding
molecular function GO:0046872 metal ion binding
molecular function GO:1990405 protein antigen binding
cellular component GO:0009986 cell surface
cellular component GO:0070062 extracellular exosome
cellular component GO:0005925 focal adhesion
cellular component GO:0030426 growth cone
cellular component GO:0034668 integrin alpha4-beta1 complex
cellular component GO:0034669 integrin alpha4-beta7 complex
cellular component GO:0016020 membrane
cellular component GO:0043025 neuronal cell body
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-1280218 Adaptive Immune System
R-HSA-1474244 Extracellular matrix organization
R-HSA-1474244 Extracellular matrix organization
R-HSA-1643685 Disease
R-HSA-168256 Immune System
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-212436 Generic Transcription Pathway
R-HSA-216083 Integrin cell surface interactions
R-HSA-216083 Integrin cell surface interactions
R-HSA-5663205 Infectious disease
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-8878159 Transcriptional regulation by RUNX3
R-HSA-8949275 RUNX3 Regulates Immune Response and Cell Migration
R-HSA-9679191 Potential therapeutics for SARS
R-HSA-9679506 SARS-CoV Infections
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001430 BXGD000054 Adenoma Neoplasms
C0002895 BXGD000152 Anemia, Sickle Cell Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007124 BXGD000437 Noninfiltrating Intraductal Carcinoma Neoplasms
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007780 BXGD000483 Cerebral Embolism Nervous System Diseases; Cardiovascular Diseases
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0008626 BXGD000559 Congenital chromosomal disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0011303 BXGD000712 Demyelinating Diseases Nervous System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011884 BXGD000762 Diabetic Retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0013264 BXGD000808 Muscular Dystrophy, Duchenne Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0014072 BXGD000888 Experimental Autoimmune Encephalomyelitis Immune System Diseases; Nervous System Diseases
C0017601 BXGD001125 Glaucoma Eye Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0017639 BXGD001133 Gliosis Pathological Conditions, Signs and Symptoms
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0023281 BXGD001628 Leishmaniasis Infections; Skin and Connective Tissue Diseases
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023448 BXGD001649 Lymphoid leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0023508 BXGD001675 White Blood Cell Count procedure
C0023518 BXGD001677 Leukocytosis Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0024282 BXGD001755 Lymphocytosis Hemic and Lymphatic Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024314 BXGD001767 Lymphoproliferative Disorders Immune System Diseases; Hemic and Lymphatic Diseases
C0024419 BXGD001769 Waldenstrom Macroglobulinemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0026269 BXGD001897 Mitral Valve Stenosis Cardiovascular Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027697 BXGD002022 Nephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0027859 BXGD002052 Acoustic Neuroma Neoplasms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0031029 BXGD002271 Periapical Granuloma Stomatognathic Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0032914 BXGD002379 Pre-Eclampsia Female Urogenital Diseases and Pregnancy Complications
C0037284 BXGD002679 Skin lesion Skin and Connective Tissue Diseases
C0037822 BXGD002706 Speech Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085605 BXGD003200 Liver Failure Digestive System Diseases
C0085669 BXGD003233 Acute leukemia Pathological Conditions, Signs and Symptoms; Neoplasms
C0149678 BXGD003346 Epstein-Barr Virus Infections Infections
C0153594 BXGD003669 Malignant neoplasm of testis Neoplasms; Male Urogenital Diseases; Endocrine System Diseases
C0153690 BXGD003684 Secondary malignant neoplasm of bone Pathological Conditions, Signs and Symptoms; Neoplasms; Musculoskeletal Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0200637 BXGD004042 Monocyte count procedure
C0200638 BXGD004043 Eosinophil count procedure
C0200641 BXGD004044 Blood basophil count (lab test)
C0206139 BXGD004159 Lichen Planus, Oral Skin and Connective Tissue Diseases; Stomatognathic Diseases
C0206161 BXGD004167 Reticulocyte count (procedure)
C0238198 BXGD004893 Gastrointestinal Stromal Tumors Digestive System Diseases; Neoplasms
C0264408 BXGD005387 Childhood asthma Respiratory Tract Diseases; Immune System Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0339263 BXGD007231 Pseudophakic corneal edema Eye Diseases
C0349631 BXGD007938 Richter's syndrome Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0349667 BXGD007948 Sarcoma of breast Neoplasms; Skin and Connective Tissue Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0393819 BXGD008151 Polyradiculoneuropathy, Chronic Inflammatory Demyelinating Immune System Diseases; Nervous System Diseases
C0432408 BXGD008785 Trisomy 12 Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0497156 BXGD009053 Lymphadenopathy Hemic and Lymphatic Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598935 BXGD009674 Tumor Initiation Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677932 BXGD009736 Progressive Neoplastic Disease
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699949 BXGD009872 airway disease Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0750880 BXGD010239 Monocyte count result
C0751606 BXGD010523 Adult Acute Lymphocytic Leukemia
C0751967 BXGD010657 Multiple Sclerosis, Relapsing-Remitting Immune System Diseases; Nervous System Diseases
C0795845 BXGD010749 Chromosome 12, 12p trisomy Pathological Conditions, Signs and Symptoms
C0855095 BXGD011071 Small Lymphocytic Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0877203 BXGD011341 Respiratory tract infection viral Infections
C0878555 BXGD011370 Diffuse panbronchiolitis Infections; Respiratory Tract Diseases
C0940937 BXGD011490 precancerous lesions
C1269955 BXGD012005 Tumor Cell Invasion
C1302401 BXGD012303 Adenoma of large intestine Digestive System Diseases; Neoplasms
C1302547 BXGD012305 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332309 BXGD012521 Anti-Basement Membrane Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1562113 BXGD013372 Fleck corneal dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1704272 BXGD013537 Benign Prostatic Hyperplasia Male Urogenital Diseases
C1842127 BXGD014496 Retinitis Pigmentosa 26 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C2698259 BXGD017449 Monoclonal B-Cell Lymphocytosis Neoplasms; Hemic and Lymphatic Diseases
C2937365 BXGD018161 Recurrent aphthous ulcer Stomatognathic Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C3539781 BXGD019086 Progressive cGVHD
C3887640 BXGD019908 Astrocytosis Pathological Conditions, Signs and Symptoms
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4048329 BXGD021904 Immunosuppression
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4721208 BXGD023733 Metastatic castration-resistant prostate cancer
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
BXGC0018397 beta-1,4-mannan 180.06
BXGC0050194 alpha-D-Mannose 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein