Showing entry for G1/S-specific cyclin-D3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009416
Protein NameG1/S-specific cyclin-D3
Uniport IdP30281
GeneCCND3
Gene Id896
DomainCyclin_C; Cyclin_N
Pfam PF02984   PF00134  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.2 Cell growth and death hsa04110 Cell cycle
4. Cellular Processes 4.2 Cell growth and death hsa04115 p53 signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04151 PI3K-Akt signaling pathway
4. Cellular Processes 4.2 Cell growth and death hsa04218 Cellular senescence
3. Environmental Information Processing 3.2 Signal transduction hsa04310 Wnt signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04390 Hippo signaling pathway
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04510 Focal adhesion
3. Environmental Information Processing 3.2 Signal transduction hsa04630 Jak-STAT signaling pathway
6. Human Diseases 6.9 Infectious diseases: Viral hsa05162 Measles
6. Human Diseases 6.9 Infectious diseases: Viral hsa05164 Influenza A
6. Human Diseases 6.9 Infectious diseases: Viral hsa05165 Human papillomavirus infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05166 Human T-cell leukemia virus 1 infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05169 Epstein-Barr virus infection
6. Human Diseases 6.1 Cancers: Overview hsa05200 Pathways in cancer
6. Human Diseases 6.1 Cancers: Overview hsa05203 Viral carcinogenesis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0051301 cell division
Biological Process GO:0044772 mitotic cell cycle phase transition
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
Biological Process GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
Biological Process GO:0001934 positive regulation of protein phosphorylation
Biological Process GO:0042127 regulation of cell population proliferation
Biological Process GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
Biological Process GO:0046626 regulation of insulin receptor signaling pathway
Biological Process GO:0007165 signal transduction
Biological Process GO:0042098 T cell proliferation
molecular function GO:0004693 cyclin-dependent protein serine/threonine kinase activity
molecular function GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity
molecular function GO:0019901 protein kinase binding
cellular component GO:0000307 cyclin-dependent protein kinase holoenzyme complex
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0042025 host cell nucleus
cellular component GO:0016020 membrane
cellular component GO:0016604 nuclear body
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-162582 Signal Transduction
R-HSA-1640170 Cell Cycle
R-HSA-1643685 Disease
R-HSA-212436 Generic Transcription Pathway
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-453279 Mitotic G1 phase and G1/S transition
R-HSA-5683057 MAPK family signaling cascades
R-HSA-5687128 MAPK6/MAPK4 signaling
R-HSA-69231 Cyclin D associated events in G1
R-HSA-69236 G1 Phase
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-8878171 Transcriptional regulation by RUNX1
R-HSA-8934593 Regulation of RUNX1 Expression and Activity
R-HSA-9659787 Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects
R-HSA-9661069 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
R-HSA-9675126 Diseases of mitotic cell cycle
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001430 BXGD000054 Adenoma Neoplasms
C0001948 BXGD000091 Alcohol consumption Behavior and Behavior Mechanisms
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006413 BXGD000397 Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014170 BXGD000902 Endometrial Neoplasms Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0014173 BXGD000903 Endometrial Hyperplasia Female Urogenital Diseases and Pregnancy Complications
C0014772 BXGD000948 Red Blood Cell Count measurement
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0020981 BXGD001474 Angioimmunoblastic Lymphadenopathy Immune System Diseases; Hemic and Lymphatic Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0021670 BXGD001509 insulinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023434 BXGD001643 Chronic Lymphocytic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0023479 BXGD001663 Acute myelomonocytic leukemia Neoplasms
C0023493 BXGD001672 Adult T-Cell Lymphoma/Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023508 BXGD001675 White Blood Cell Count procedure
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024301 BXGD001759 Lymphoma, Follicular Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024305 BXGD001763 Lymphoma, Non-Hodgkin Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024419 BXGD001769 Waldenstrom Macroglobulinemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0024668 BXGD001795 Mammary Neoplasms, Experimental Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0026470 BXGD001903 Monoclonal Gammopathy of Undetermined Significance Immune System Diseases; Hemic and Lymphatic Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027126 BXGD001976 Myotonic Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027859 BXGD002052 Acoustic Neuroma Neoplasms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0030354 BXGD002214 Papilloma Neoplasms
C0030552 BXGD002238 Paresis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0035335 BXGD002540 Retinoblastoma Neoplasms; Eye Diseases
C0037286 BXGD002681 Skin Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C0042769 BXGD002999 Virus Diseases Infections
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079772 BXGD003099 T-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0200637 BXGD004042 Monocyte count procedure
C0200638 BXGD004043 Eosinophil count procedure
C0205748 BXGD004117 Dysplastic Nevus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms
C0206161 BXGD004167 Reticulocyte count (procedure)
C0220605 BXGD004294 Adult Non-Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0220612 BXGD004296 Childhood Non-Hodgkin Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238198 BXGD004893 Gastrointestinal Stromal Tumors Digestive System Diseases; Neoplasms
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0266568 BXGD005695 Persistent Hyperplastic Primary Vitreous Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0278764 BXGD006581 Adult Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0278879 BXGD006610 Childhood Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0279583 BXGD006640 Childhood T Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0279680 BXGD006680 Transitional cell carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0280324 BXGD006740 Laryngeal Squamous Cell Carcinoma Neoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0334037 BXGD006980 Intestinal metaplasia
C0334633 BXGD007143 Malignant lymphoma - lymphoplasmacytic Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0334634 BXGD007144 Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0347390 BXGD007856 Skin Papilloma Neoplasms; Skin and Connective Tissue Diseases
C0374997 BXGD007967 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0392885 BXGD008071 High density lipoprotein measurement
C0424678 BXGD008537 Lean body mass
C0427460 BXGD008616 Red cell distribution width determination
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0494165 BXGD009022 Secondary malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0518015 BXGD009068 Hemoglobin measurement
C0524587 BXGD009232 Mean Corpuscular Volume (result)
C0555198 BXGD009432 Malignant Glioma Neoplasms
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0750880 BXGD010239 Monocyte count result
C0855146 BXGD011077 B Lymphoblastic Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1261473 BXGD011855 Sarcoma Neoplasms
C1261502 BXGD011856 Finding of Mean Corpuscular Hemoglobin
C1269955 BXGD012005 Tumor Cell Invasion
C1301194 BXGD012284 Salivary duct carcinoma Neoplasms
C1304746 BXGD012343 RDW - Red blood cell distribution width result
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332201 BXGD012502 Adult Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1335302 BXGD012775 Pancreatic Ductal Adenocarcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1378703 BXGD012933 Renal carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1531608 BXGD013299 Smoldering myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1720860 BXGD013689 Familial Partial Lipodystrophy, Type 2 Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1961099 BXGD016672 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2062441 BXGD016897 Influenza A
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2242826 BXGD017006 Myeloblastic leukemia
C2987142 BXGD018245 Pancreatic Intraepithelial Neoplasia-1A
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4528257 BXGD023159 Corpuscular Hemoglobin Concentration Mean
C4551686 BXGD023391 Malignant neoplasm of soft tissue Neoplasms
C4721414 BXGD023738 Mantle cell lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C4721532 BXGD023752 Lymphoma, Non-Hodgkin, Familial Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0007052 Olomoucine 298.34
BXGC0012352 Chelerythrine 348.12
BXGC0040305 Indirubin 262.07
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein