Showing entry for Sodium/potassium-transporting ATPase subunit alpha-2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010826
Protein NameSodium/potassium-transporting ATPase subunit alpha-2
Uniport IdP50993
GeneATP1A2
Gene Id477
DomainCation_ATPase; Cation_ATPase_C; Cation_ATPase_N; E1-E2_ATPase
Pfam PF00689   PF00690  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04022 cGMP-PKG signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04024 cAMP signaling pathway
5. Organismal Systems 5.3 Circulatory system hsa04260 Cardiac muscle contraction
5. Organismal Systems 5.3 Circulatory system hsa04261 Adrenergic signaling in cardiomyocytes
5. Organismal Systems 5.2 Endocrine system hsa04911 Insulin secretion
5. Organismal Systems 5.2 Endocrine system hsa04918 Thyroid hormone synthesis
5. Organismal Systems 5.2 Endocrine system hsa04919 Thyroid hormone signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04925 Aldosterone synthesis and secretion
5. Organismal Systems 5.5 Excretory system hsa04960 Aldosterone-regulated sodium reabsorption
5. Organismal Systems 5.5 Excretory system hsa04961 Endocrine and other factor-regulated calcium reabsorption
5. Organismal Systems 5.5 Excretory system hsa04964 Proximal tubule bicarbonate reclamation
5. Organismal Systems 5.4 Digestive system hsa04970 Salivary secretion
5. Organismal Systems 5.4 Digestive system hsa04971 Gastric acid secretion
5. Organismal Systems 5.4 Digestive system hsa04972 Pancreatic secretion
5. Organismal Systems 5.4 Digestive system hsa04973 Carbohydrate digestion and absorption
5. Organismal Systems 5.4 Digestive system hsa04974 Protein digestion and absorption
5. Organismal Systems 5.4 Digestive system hsa04976 Bile secretion
5. Organismal Systems 5.4 Digestive system hsa04978 Mineral absorption
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0008344 adult locomotory behavior
Biological Process GO:0021764 amygdala development
Biological Process GO:0046034 ATP metabolic process
Biological Process GO:0001662 behavioral fear response
Biological Process GO:0060048 cardiac muscle contraction
Biological Process GO:0098655 cation transmembrane transport
Biological Process GO:0086064 cell communication by electrical coupling involved in cardiac conduction
Biological Process GO:0030007 cellular potassium ion homeostasis
Biological Process GO:0071260 cellular response to mechanical stimulus
Biological Process GO:0071383 cellular response to steroid hormone stimulus
Biological Process GO:0006883 cellular sodium ion homeostasis
Biological Process GO:0034220 ion transmembrane transport
Biological Process GO:0040011 locomotion
Biological Process GO:0035641 locomotory exploration behavior
Biological Process GO:0086012 membrane depolarization during cardiac muscle cell action potential
Biological Process GO:0086009 membrane repolarization
Biological Process GO:1903280 negative regulation of calcium:sodium antiporter activity
Biological Process GO:1903170 negative regulation of calcium ion transmembrane transport
Biological Process GO:0051481 negative regulation of cytosolic calcium ion concentration
Biological Process GO:0045822 negative regulation of heart contraction
Biological Process GO:0045988 negative regulation of striated muscle contraction
Biological Process GO:0001504 neurotransmitter uptake
Biological Process GO:0021989 olfactory cortex development
Biological Process GO:0045823 positive regulation of heart contraction
Biological Process GO:1990573 potassium ion import across plasma membrane
Biological Process GO:0071805 potassium ion transmembrane transport
Biological Process GO:0006813 potassium ion transport
Biological Process GO:1902600 proton transmembrane transport
Biological Process GO:0008217 regulation of blood pressure
Biological Process GO:1903779 regulation of cardiac conduction
Biological Process GO:0086004 regulation of cardiac muscle cell contraction
Biological Process GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
Biological Process GO:0051946 regulation of glutamate uptake involved in transmission of nerve impulse
Biological Process GO:0006937 regulation of muscle contraction
Biological Process GO:0002087 regulation of respiratory gaseous exchange by nervous system process
Biological Process GO:0006940 regulation of smooth muscle contraction
Biological Process GO:0006942 regulation of striated muscle contraction
Biological Process GO:0051966 regulation of synaptic transmission, glutamatergic
Biological Process GO:0002026 regulation of the force of heart contraction
Biological Process GO:0019229 regulation of vasoconstriction
Biological Process GO:0055119 relaxation of cardiac muscle
Biological Process GO:0010996 response to auditory stimulus
Biological Process GO:1903416 response to glycoside
Biological Process GO:0035094 response to nicotine
Biological Process GO:0036376 sodium ion export across plasma membrane
Biological Process GO:0035725 sodium ion transmembrane transport
Biological Process GO:0006814 sodium ion transport
Biological Process GO:0150104 transport across blood-brain barrier
Biological Process GO:0008542 visual learning
molecular function GO:0019829 ATPase-coupled cation transmembrane transporter activity
molecular function GO:0005524 ATP binding
molecular function GO:0051087 chaperone binding
molecular function GO:0046872 metal ion binding
molecular function GO:0016791 phosphatase activity
molecular function GO:0046982 protein heterodimerization activity
molecular function GO:0005391 sodium:potassium-exchanging ATPase activity
molecular function GO:1990239 steroid hormone binding
cellular component GO:0005901 caveola
cellular component GO:0042995 cell projection
cellular component GO:0005737 cytoplasm
cellular component GO:0043197 dendritic spine
cellular component GO:0005768 endosome
cellular component GO:1903561 extracellular vesicle
cellular component GO:0014704 intercalated disc
cellular component GO:0016020 membrane
cellular component GO:0043025 neuronal cell body
cellular component GO:0031090 organelle membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0005890 sodium:potassium-exchanging ATPase complex
cellular component GO:0030315 T-tubule
Reactome
Pathway Id Pathway Name
R-HSA-1643685 Disease
R-HSA-382551 Transport of small molecules
R-HSA-397014 Muscle contraction
R-HSA-5576891 Cardiac conduction
R-HSA-5578775 Ion homeostasis
R-HSA-5663205 Infectious disease
R-HSA-936837 Ion transport by P-type ATPases
R-HSA-9679191 Potential therapeutics for SARS
R-HSA-9679506 SARS-CoV Infections
R-HSA-983712 Ion channel transport
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003537 BXGD000208 Aphasia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0003635 BXGD000214 Apraxias Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0003886 BXGD000238 Arthrogryposis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0007095 BXGD000423 Carcinoid Tumor Neoplasms
C0007758 BXGD000475 Cerebellar Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0009421 BXGD000608 Comatose Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0009676 BXGD000619 Confusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0009952 BXGD000639 Febrile Convulsions Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0012569 BXGD000777 Diplopia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0013144 BXGD000800 Drowsiness Mental Disorders
C0013170 BXGD000802 Drug habituation Chemically-Induced Disorders; Mental Disorders
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013421 BXGD000837 Dystonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014548 BXGD000928 Epilepsy, Generalized Nervous System Diseases
C0014556 BXGD000932 Epilepsy, Temporal Lobe Nervous System Diseases
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0016522 BXGD001067 Foramen Ovale, Patent Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018800 BXGD001225 Cardiomegaly Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0018989 BXGD001263 Hemiparesis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0018991 BXGD001264 Hemiplegia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0020305 BXGD001374 Hydrops Fetalis Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Immune System Diseases; Hemic and Lymphatic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0023508 BXGD001675 White Blood Cell Count procedure
C0025362 BXGD001866 Mental Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026650 BXGD001913 Movement Disorders Nervous System Diseases
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0035334 BXGD002539 Retinitis Pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0042571 BXGD002991 Vertigo Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0085583 BXGD003194 Choreoathetosis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0085584 BXGD003195 Encephalopathies Nervous System Diseases
C0149925 BXGD003387 Small cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0149931 BXGD003388 Migraine Disorders Nervous System Diseases
C0151611 BXGD003447 Electroencephalogram abnormal Nervous System Diseases
C0154723 BXGD003737 Migraine with Aura Nervous System Diseases
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0220669 BXGD004318 Familial benign neonatal epilepsy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0220766 BXGD004341 Congenital hypoplasia of adrenal gland Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Endocrine System Diseases
C0234985 BXGD004708 Mental deterioration Mental Disorders
C0238358 BXGD004917 Hypokalemic periodic paralysis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0266464 BXGD005676 Polymicrogyria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0270685 BXGD006084 Cerebral calcification Nutritional and Metabolic Diseases; Nervous System Diseases
C0270816 BXGD006110 epilepsy and migraine
C0270850 BXGD006117 Idiopathic generalized epilepsy Nervous System Diseases
C0270860 BXGD006124 Basilar-Type Migraine Nervous System Diseases
C0270862 BXGD006125 Hemiplegic migraine Nervous System Diseases
C0338480 BXGD007186 Common Migraine Nervous System Diseases
C0338483 BXGD007187 Migraine with Prolonged Aura Nervous System Diseases
C0338484 BXGD007188 Familial Hemiplegic Migraine Nervous System Diseases
C0338488 BXGD007189 Alternating hemiplegia of childhood Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0342482 BXGD007486 X-linked Adrenal Hypoplasia Endocrine System Diseases
C0344232 BXGD007659 Blurred vision Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0344724 BXGD007701 Ostium secundum atrial septal defect Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0375206 BXGD007973 Hemiplegia/hemiparesis
C0376532 BXGD008000 Epilepsy, Rolandic Nervous System Diseases
C0392885 BXGD008071 High density lipoprotein measurement
C0395920 BXGD008173 Migrainous vertigo Nervous System Diseases; Otorhinolaryngologic Diseases
C0424139 BXGD008520 Anxiety and fear
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0428472 BXGD008630 Serum HDL cholesterol measurement
C0428474 BXGD008631 Serum LDL cholesterol measurement
C0477373 BXGD009001 Other forms of migraine Nervous System Diseases
C0494475 BXGD009030 Tonic - clonic seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0521533 BXGD009142 Atrial septal aneurysm Cardiovascular Diseases
C0581882 BXGD009574 Transient neurological symptoms Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0598608 BXGD009668 Hyperhomocysteinemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0742038 BXGD010054 Cerebellar signs
C0973461 BXGD011595 Dysphasia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1306587 BXGD012368 Acute encephalopathy Nervous System Diseases
C1445957 BXGD013081 Serum total cholesterol measurement
C1557375 BXGD013360 Blurred Vision, CTCAE
C1611743 BXGD013456 Familial (FPAH)
C1720189 BXGD013668 Episodic Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1720416 BXGD013672 Episodic ataxia type 2 (disorder) Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C1720983 BXGD013698 Channelopathies Pathological Conditions, Signs and Symptoms
C1735856 BXGD013717 Migraine with Typical Aura Nervous System Diseases
C1832884 BXGD013880 Hemiplegic migraine, familial type 1 Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1832903 BXGD013882 MIGRAINE, SPORADIC HEMIPLEGIC Nervous System Diseases
C1837249 BXGD014210 Malformations of Cortical Development, Group II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1843156 BXGD014561 Progressive sensorineural hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1849265 BXGD015028 Overgrowth
C1863061 BXGD016150 Episodic hemiplegia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1863062 BXGD016151 Episodic quadriplegia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1865322 BXGD016313 MIGRAINE, FAMILIAL HEMIPLEGIC, 2 Nervous System Diseases
C1865323 BXGD016314 Migraine, Familial Basilar Nervous System Diseases
C1865332 BXGD016315 Transient unilateral blurring of vision
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C2349453 BXGD017061 Familial migraine
C2733158 BXGD017562 Cerebral Small Vessel Diseases Nervous System Diseases; Cardiovascular Diseases
C2830004 BXGD017804 Somnolence Pathological Conditions, Signs and Symptoms
C3549447 BXGD019124 ALTERNATING HEMIPLEGIA OF CHILDHOOD 1
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4317109 BXGD022725 Epileptic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003690 Glucokinin 764.94
BXGC0015208 Getiacaulein 288.06
BXGC0020220 panaxatriol 476.39
BXGC0022544 Digoxin 780.43
BXGC0023461 methylswertianin 288.06
BXGC0024770 Digoxigenin 390.24
BXGC0025733 1,3,5,6-Tetrahydroxyxanthen-9-One 260.03
BXGC0031485 digoxigenin-bis(digitoxoside) 650.37
BXGC0036400 1,3,5-Trihydroxyxanthen-9-One 244.04
BXGC0039507 Digitoxigenin 374.25
BXGC0044158 3,4,5-Trihydroxyxanthen-9-One 244.04
BXGC0048644 1,2,3,7-Tetramethoxyxanthone 316.09
BXGC0050699 \N 260.03
BXGC0051524 Ouabain 584.28
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein