Showing entry for Succinate-semialdehyde dehydrogenase, mitochondrial


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010872
Protein NameSuccinate-semialdehyde dehydrogenase, mitochondrial
Uniport IdP51649
GeneALDH5A1
Gene Id7915
DomainAldedh
Pfam PF00171  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.5 Amino acid metabolism hsa00250 Alanine, aspartate and glutamate metabolism
1. Metabolism 1.1 Carbohydrate metabolism hsa00650 Butanoate metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007417 central nervous system development
Biological Process GO:0009450 gamma-aminobutyric acid catabolic process
Biological Process GO:0006536 glutamate metabolic process
Biological Process GO:0042135 neurotransmitter catabolic process
Biological Process GO:0009791 post-embryonic development
Biological Process GO:0006105 succinate metabolic process
molecular function GO:0042802 identical protein binding
molecular function GO:0004777 succinate-semialdehyde dehydrogenase (NAD+) activity
cellular component GO:0005759 mitochondrial matrix
cellular component GO:0005739 mitochondrion
molecular function GO:0009013 succinate-semialdehyde dehydrogenase NAD(P)+ activity
Reactome
Pathway Id Pathway Name
R-HSA-112310 Neurotransmitter release cycle
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-888590 GABA synthesis, release, reuptake and degradation
R-HSA-916853 Degradation of GABA
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001807 BXGD000077 Aggressive behavior Behavior and Behavior Mechanisms
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0006112 BXGD000370 Brain Diseases, Metabolic Nutritional and Metabolic Diseases; Nervous System Diseases
C0007124 BXGD000437 Noninfiltrating Intraductal Carcinoma Neoplasms
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014548 BXGD000928 Epilepsy, Generalized Nervous System Diseases
C0018524 BXGD001200 Hallucinations Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0020796 BXGD001468 Profound Mental Retardation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0025363 BXGD001867 Mental Retardation, Psychosocial Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026650 BXGD001913 Movement Disorders Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027854 BXGD002050 Neurologic Manifestations Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0035372 BXGD002544 Rett Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036857 BXGD002638 Severe intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0038220 BXGD002740 Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0085271 BXGD003148 Self-Injurious Behavior Behavior and Behavior Mechanisms
C0151611 BXGD003447 Electroencephalogram abnormal Nervous System Diseases
C0151888 BXGD003497 Hyporeflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0201850 BXGD004053 Alkaline phosphatase measurement
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0235031 BXGD004714 Neurologic Symptoms Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0268631 BXGD006017 succinic semialdehyde dehydrogenase deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Mental Disorders
C0270850 BXGD006117 Idiopathic generalized epilepsy Nervous System Diseases
C0270853 BXGD006119 Juvenile Myoclonic Epilepsy Nervous System Diseases
C0276289 BXGD006418 Zika Virus Infection Infections
C0393593 BXGD008103 Dystonia Disorders Nervous System Diseases
C0393598 BXGD008104 Idiopathic familial dystonia Nervous System Diseases
C0422837 BXGD008456 Neurological observations Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0423063 BXGD008467 Comitant heterophoria Eye Diseases; Nervous System Diseases
C0424230 BXGD008522 Motor retardation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0424605 BXGD008535 Developmental delay (disorder) Mental Disorders
C0454644 BXGD008850 Delayed speech and language development Behavior and Behavior Mechanisms
C0494475 BXGD009030 Tonic - clonic seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0497202 BXGD009055 Abnormal ocular motility
C0520947 BXGD009126 Clumsiness - motor delay Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0521654 BXGD009156 Neurologic Deficits Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0557874 BXGD009444 Global developmental delay
C0743101 BXGD010076 developmentally delayed
C0743332 BXGD010081 Focal Dystonia Nervous System Diseases
C0746857 BXGD010151 Focal Neurologic Deficits Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0750968 BXGD010267 Central Nervous System Metabolic Disorders Nutritional and Metabolic Diseases; Nervous System Diseases
C0751265 BXGD010370 Learning Disabilities Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0751377 BXGD010419 Neurologic Dysfunction Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751378 BXGD010420 Neurologic Signs Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751743 BXGD010570 Metabolic Disorder, Central Nervous System, Acquired Nutritional and Metabolic Diseases; Nervous System Diseases
C0751744 BXGD010571 Brain Diseases, Metabolic, Acquired Nutritional and Metabolic Diseases; Nervous System Diseases
C0752197 BXGD010686 Adult-Onset Dystonias Nervous System Diseases
C0752198 BXGD010687 Adult-Onset Idiopathic Focal Dystonias Nervous System Diseases
C0752199 BXGD010688 Adult-Onset Idiopathic Torsion Dystonias Nervous System Diseases
C0752200 BXGD010689 Autosomal Dominant Familial Dystonia Nervous System Diseases
C0752201 BXGD010690 Autosomal Recessive Familial Dystonia Nervous System Diseases
C0752202 BXGD010691 Childhood Onset Dystonias Nervous System Diseases
C0752203 BXGD010692 Dystonia, Primary Nervous System Diseases
C0752205 BXGD010693 Dystonia, Secondary Nervous System Diseases
C0752206 BXGD010694 Dystonias, Sporadic Nervous System Diseases
C0752207 BXGD010695 Familial Dystonia Nervous System Diseases
C0752208 BXGD010696 Pseudodystonia Nervous System Diseases
C0917816 BXGD011419 Mental deficiency Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1135773 BXGD011699 Acquired Metabolic Diseases, Nervous System Nutritional and Metabolic Diseases; Nervous System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1301721 BXGD012297 Neurological morbidity
C1849265 BXGD015028 Overgrowth
C1854301 BXGD015391 Motor delay Mental Disorders
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3887506 BXGD019886 Hyperkinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4021759 BXGD020762 Generalized myoclonic seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4021768 BXGD020766 Abnormality of metabolism/homeostasis
C4316810 BXGD022702 Writer's Cramp Nervous System Diseases
C4316903 BXGD022711 Absence Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4317109 BXGD022725 Epileptic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000497 Vanillin 152.15
BXGC0000524 4-Methoxybenzaldehyde 136.15
BXGC0000642 4-Aminobenzoic acid 137.14
BXGC0001380 Succinic acid 118.09
BXGC0001778 Scutellarein 286.24
BXGC0004707 4'-Hydroxyacetophenone 136.15
BXGC0004708 4-Hydroxybenzaldehyde 122.12
BXGC0004711 4-Hydroxybenzoic acid 138.12
BXGC0004715 4-Hydroxybenzylamine 123.15
BXGC0006174 4-Hydroxybenzyl alcohol 124.14
BXGC0028048 helicide 284.09
BXGC0030094 Paroxypropione 150.07
BXGC0035923 gastrodin 286.11
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein