Showing entry for Ephrin-A5


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010958
Protein NameEphrin-A5
Uniport IdP52803
GeneEFNA5
Gene Id1946
DomainEphrin
Pfam PF00812  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04010 MAPK signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04014 Ras signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04015 Rap1 signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04151 PI3K-Akt signaling pathway
5. Organismal Systems 5.8 Development hsa04360 Axon guidance
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007411 axon guidance
Biological Process GO:0071372 cellular response to follicle-stimulating hormone stimulus
Biological Process GO:1904322 cellular response to forskolin
Biological Process GO:0048668 collateral sprouting
Biological Process GO:0048013 ephrin receptor signaling pathway
Biological Process GO:1900025 negative regulation of substrate adhesion-dependent cell spreading
Biological Process GO:0007399 nervous system development
Biological Process GO:0048672 positive regulation of collateral sprouting
Biological Process GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
Biological Process GO:0001934 positive regulation of protein phosphorylation
Biological Process GO:0051965 positive regulation of synapse assembly
Biological Process GO:0032956 regulation of actin cytoskeleton organization
Biological Process GO:0022407 regulation of cell-cell adhesion
Biological Process GO:0022604 regulation of cell morphogenesis
Biological Process GO:0051893 regulation of focal adhesion assembly
Biological Process GO:0043087 regulation of GTPase activity
Biological Process GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
Biological Process GO:0070507 regulation of microtubule cytoskeleton organization
Biological Process GO:0031290 retinal ganglion cell axon guidance
molecular function GO:0045499 chemorepellent activity
molecular function GO:0046875 ephrin receptor binding
molecular function GO:0005168 neurotrophin TRKA receptor binding
molecular function GO:0005169 neurotrophin TRKB receptor binding
molecular function GO:0005170 neurotrophin TRKC receptor binding
molecular function GO:0030297 transmembrane receptor protein tyrosine kinase activator activity
cellular component GO:0005912 adherens junction
cellular component GO:0031362 anchored component of external side of plasma membrane
cellular component GO:0005604 basement membrane
cellular component GO:0005901 caveola
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-1266738 Developmental Biology
R-HSA-2682334 EPH-Ephrin signaling
R-HSA-2682334 EPH-Ephrin signaling
R-HSA-3928663 EPHA-mediated growth cone collapse
R-HSA-3928663 EPHA-mediated growth cone collapse
R-HSA-3928665 EPH-ephrin mediated repulsion of cells
R-HSA-3928665 EPH-ephrin mediated repulsion of cells
R-HSA-422475 Axon guidance
R-HSA-422475 Axon guidance
R-HSA-9675108 Nervous system development
R-HSA-9675108 Nervous system development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001857 BXGD000085 AIDS related complex Infections; Immune System Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0002902 BXGD000154 Anencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0003838 BXGD000224 Arterial Occlusive Diseases Cardiovascular Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006370 BXGD000394 Bulimia Pathological Conditions, Signs and Symptoms
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007789 BXGD000488 Cerebral Palsy Nervous System Diseases
C0008479 BXGD000544 Chondrosarcoma Neoplasms
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009324 BXGD000597 Ulcerative Colitis Digestive System Diseases
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010308 BXGD000661 Congenital Hypothyroidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0020597 BXGD001439 Hypobetalipoproteinemias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0021704 BXGD001510 Intelligence Behavior and Behavior Mechanisms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0025149 BXGD001826 Medulloblastoma Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028768 BXGD002084 Obsessive-Compulsive Disorder Mental Disorders
C0029182 BXGD002121 orbit (eye disorders) Eye Diseases
C0035126 BXGD002509 Reperfusion Injury Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036646 BXGD002627 Age-related cataract Eye Diseases
C0037369 BXGD002691 Smoking Behavior and Behavior Mechanisms
C0038358 BXGD002748 Gastric ulcer Digestive System Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0039103 BXGD002791 Synovitis Musculoskeletal Diseases
C0040034 BXGD002836 Thrombocytopenia Hemic and Lymphatic Diseases
C0042798 BXGD003003 Low Vision Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0149654 BXGD003343 Conduct Disorder Mental Disorders
C0162871 BXGD003996 Aortic Aneurysm, Abdominal Cardiovascular Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0278510 BXGD006526 Childhood Medulloblastoma Neoplasms
C0278876 BXGD006607 Adult Medulloblastoma Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0521707 BXGD009166 Bilateral cataracts (disorder) Eye Diseases
C0544852 BXGD009317 Hypertrichosis, universal
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0596887 BXGD009648 mathematical ability
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C1270972 BXGD012006 Mild cognitive disorder Mental Disorders
C1305855 BXGD012348 Body mass index
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1533568 BXGD013314 fertility disorders Female Urogenital Diseases and Pregnancy Complications
C1611743 BXGD013456 Familial (FPAH)
C1840362 BXGD014452 HYPERTRICHOSIS UNIVERSALIS CONGENITA, AMBRAS TYPE (disorder) Skin and Connective Tissue Diseases
C1853235 BXGD015318 Sclerocornea Eye Diseases
C1862596 BXGD016135 Familial hypobetalipoproteinemia Nutritional and Metabolic Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C1961102 BXGD016673 Precursor Cell Lymphoblastic Leukemia Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1969372 BXGD016775 Tubulointerstitial fibrosis
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C4049938 BXGD021956 Physical Activity Measurement
C4315130 BXGD022694 Hippocampal atrophy
C4554010 BXGD023556 Isomerism (body) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases; Cardiovascular Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein