Showing entry for Disintegrin and metalloproteinase domain-containing protein 8


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011832
Protein NameDisintegrin and metalloproteinase domain-containing protein 8
Uniport IdP78325
GeneADAM8
Gene Id101
DomainADAM_CR; Disintegrin; Pep_M12B_propep; Reprolysin
Pfam PF08516   PF00200   PF01562   PF01421  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0001525 angiogenesis
Biological Process GO:0098609 cell-cell adhesion
Biological Process GO:0000902 cell morphogenesis
Biological Process GO:0071456 cellular response to hypoxia
Biological Process GO:0022617 extracellular matrix disassembly
Biological Process GO:0006954 inflammatory response
Biological Process GO:0002523 leukocyte migration involved in inflammatory response
Biological Process GO:0048247 lymphocyte chemotaxis
Biological Process GO:0043524 negative regulation of neuron apoptotic process
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0002675 positive regulation of acute inflammatory response
Biological Process GO:0045780 positive regulation of bone resorption
Biological Process GO:0045785 positive regulation of cell adhesion
Biological Process GO:2000418 positive regulation of eosinophil migration
Biological Process GO:2000415 positive regulation of fibronectin-dependent thymocyte migration
Biological Process GO:0045089 positive regulation of innate immune response
Biological Process GO:0043406 positive regulation of MAP kinase activity
Biological Process GO:0051044 positive regulation of membrane protein ectodomain proteolysis
Biological Process GO:2000391 positive regulation of neutrophil extravasation
Biological Process GO:0051092 positive regulation of NF-kappaB transcription factor activity
Biological Process GO:0051897 positive regulation of protein kinase B signaling
Biological Process GO:0010954 positive regulation of protein processing
Biological Process GO:0050714 positive regulation of protein secretion
Biological Process GO:0033089 positive regulation of T cell differentiation in thymus
Biological Process GO:0070245 positive regulation of thymocyte apoptotic process
Biological Process GO:2000309 positive regulation of tumor necrosis factor (ligand) superfamily member 11 production
Biological Process GO:0022407 regulation of cell-cell adhesion
molecular function GO:0005509 calcium ion binding
molecular function GO:0050839 cell adhesion molecule binding
molecular function GO:0004222 metalloendopeptidase activity
molecular function GO:0008237 metallopeptidase activity
molecular function GO:0043621 protein self-association
molecular function GO:0004252 serine-type endopeptidase activity
molecular function GO:0008270 zinc ion binding
cellular component GO:0071133 alpha9-beta1 integrin-ADAM8 complex
cellular component GO:0009986 cell surface
cellular component GO:0005737 cytoplasm
cellular component GO:0032127 dense core granule membrane
cellular component GO:0101003 ficolin-1-rich granule membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0032010 phagolysosome
cellular component GO:0005886 plasma membrane
cellular component GO:0002102 podosome
cellular component GO:0042581 specific granule
cellular component GO:0035579 specific granule membrane
cellular component GO:0070820 tertiary granule
cellular component GO:0070821 tertiary granule membrane
Reactome
Pathway Id Pathway Name
R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1474244 Extracellular matrix organization
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-6798695 Neutrophil degranulation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0006118 BXGD000372 Brain Neoplasms Neoplasms; Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007282 BXGD000458 Carotid Stenosis Nervous System Diseases; Cardiovascular Diseases
C0007682 BXGD000471 CNS disorder Nervous System Diseases
C0007965 BXGD000508 Chediak-Higashi Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Immune System Diseases; Hemic and Lymphatic Diseases
C0008479 BXGD000544 Chondrosarcoma Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0017574 BXGD001122 Gingivitis Infections; Stomatognathic Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0019193 BXGD001299 Hepatitis, Toxic Digestive System Diseases; Chemically-Induced Disorders
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025149 BXGD001826 Medulloblastoma Neoplasms
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0030297 BXGD002204 Pancreatic Neoplasm Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0031094 BXGD002281 Periodontal Pocket Stomatognathic Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0039103 BXGD002791 Synovitis Musculoskeletal Diseases
C0042373 BXGD002978 Vascular Diseases Cardiovascular Diseases
C0153633 BXGD003674 Malignant neoplasm of brain Neoplasms; Nervous System Diseases
C0155094 BXGD003769 Corneal pannus Pathological Conditions, Signs and Symptoms; Eye Diseases
C0162871 BXGD003996 Aortic Aneurysm, Abdominal Cardiovascular Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0220650 BXGD004310 Metastatic malignant neoplasm to brain Pathological Conditions, Signs and Symptoms; Neoplasms; Nervous System Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238790 BXGD004956 bone destruction
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0266929 BXGD005722 Chronic Periodontitis Stomatognathic Diseases
C0278510 BXGD006526 Childhood Medulloblastoma Neoplasms
C0278876 BXGD006607 Adult Medulloblastoma Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0333307 BXGD006946 Superficial ulcer Pathological Conditions, Signs and Symptoms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0521158 BXGD009130 Recurrent tumor
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0750974 BXGD010270 Brain Tumor, Primary Neoplasms; Nervous System Diseases
C0860207 BXGD011220 Drug-Induced Liver Disease Digestive System Diseases; Chemically-Induced Disorders
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C1262760 BXGD011886 Hepatitis, Drug-Induced Digestive System Diseases; Chemically-Induced Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1335302 BXGD012775 Pancreatic Ductal Adenocarcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1836653 BXGD014143 Ascending aortic dissection Cardiovascular Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2607914 BXGD017148 Allergic rhinitis (disorder) Respiratory Tract Diseases; Immune System Diseases; Otorhinolaryngologic Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3658290 BXGD019256 Drug-Induced Acute Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
C4277682 BXGD022376 Chemical and Drug Induced Liver Injury Digestive System Diseases; Chemically-Induced Disorders
C4279912 BXGD022378 Chemically-Induced Liver Toxicity Digestive System Diseases; Chemically-Induced Disorders
C4703473 BXGD023650 Atherosclerotic lesion Cardiovascular Diseases
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
BXGC0002591 Potassium 39.1
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein